Invitrogen

Phospho-NR4A1 (Ser351) Polyclonal Antibody

View all (30) NR4A1 (Nur77) antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-105155

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NR4A1(Accession P22736), corresponding to amino acid residues around phosphorylated Ser351.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816628

Product Specific Information

Antibody detects endogenous levels of NUR77 only when phosphorylated at Ser351.

Target Information

NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. NGFI-B-alpha is expressed in brain, adrenal, thyroid, liver, testis, ovary, thymus, muscle, lung and prostate. Its expression is induced in response to various stress stimuli and growth factors. The encoded protein acts as a nuclear transcription factor involved in mediating apoptotic signaling in thymocytes and tumor cells, as well as having a role in signaling in the hypothalamic-pituitary axis. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Three transcript variants encoding two distinct isoforms have been identified for this NR4A1. Variant (3), also known as TRC beta, contains multiple differences compared to variant 1. The resulting isoform b contains a shorter and distinct C-terminus compared to isoform a. RXR has been shown to be a partner for NR4A1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Early response protein NAK1; growth factor-inducible nuclear protein N10; hormone receptor; immediate early gene transcription factor NGFI-B; MGC9485; nerve growth factor IB nuclear receptor variant 1; nerve growth factor induced protein I-B; Nerve growth factor-induced protein I-B; NGFI-B; Nuclear hormone receptor NUR/77; Nuclear protein N10; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4, group A, member 1; Nuclear receptor subfamily 4immunitygroup A member 1; NUR77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; Orphan receptor tr3; ST-59; steroid receptor TR3; Testicular receptor 3; TR3 orphan receptor

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Gene Aliases: Gfrp; GFRP1; Hbr-1; Hbr1; HMR; N10; NAK-1; NAK1; NGFI-B; NGFIB; NP10; NR4A1; NUR77; TIS1; TR3

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UniProt ID: (Human) P22736, (Rat) P22829, (Mouse) P12813

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Entrez Gene ID: (Human) 3164, (Rat) 79240, (Mouse) 15370

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Function(s)
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding sequence-specific DNA binding protein heterodimerization activity protein homodimerization activity transcription factor activity, sequence-specific DNA binding metal ion binding
Process(es)
positive regulation of endothelial cell proliferation cell migration involved in sprouting angiogenesis transcription, DNA-templated transcription from RNA polymerase II promoter apoptotic process intracellular receptor signaling pathway endothelial cell chemotaxis skeletal muscle cell differentiation cellular response to vascular endothelial growth factor stimulus positive regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process steroid hormone mediated signaling pathway cellular response to fibroblast growth factor stimulus positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cellular response to organic substance transcription initiation from RNA polymerase II promoter signal transduction fat cell differentiation negative regulation of cell cycle regulation of type B pancreatic cell proliferation cellular response to corticotropin-releasing hormone stimulus regulation of transcription, DNA-templated response to inorganic substance
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