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Invitrogen
Phospho-Naked2 (Tyr247) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-Naked2 (Tyr247) Antibody (PA5-105098) in ICC/IF
Immunofluorescent analysis of Phospho-Naked2 (Tyr247) in HepG2 cells(4h of LPS treatment). Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-Naked2 (Tyr247) polyclonal antibody (Product # PA5-105098) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor... View More
Product Details
PA5-105098
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NKD2(Accession Q969F2), corresponding to amino acid residues around phosphorylated Tyr247.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2816571
Product Specific Information
Antibody detects endogenous levels of NAKED2 only when phosphorylated at Tyr247.
Target Information
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dvl-binding protein NKD2; hNkd2; mNkd2; naked cuticle 1 homolog; naked cuticle 2 homolog; naked cuticle-2; Naked-2; Protein naked cuticle homolog 2
Gene Aliases: 2210403L10Rik; AW212591; Naked2; NKD2
UniProt ID: (Human) Q969F2, (Mouse) Q8VE28
Entrez Gene ID: (Human) 85409, (Rat) 308068, (Mouse) 72293
exocytosis
positive regulation of protein processing
Wnt signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Golgi vesicle fusion to target membrane
protein targeting to plasma membrane
positive regulation of establishment of protein localization to plasma membrane
negative regulation of canonical Wnt signaling pathway
transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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