Invitrogen

Phospho-PAK2 (Ser20) Polyclonal Antibody

View all (23) PAK2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-110143

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic phosphorylated peptide around S20 of human PAK2 (NP_002568.2).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.07 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2855554

Product Specific Information

Immunogen sequence: MSSTI

Target Information

PAK2 (serine/threonine-protein kinase PAK2) is a serine/threonine kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis, or proliferation. It acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformation change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha-PAK; Beta-PAK; gamma pak; Gamma-PAK; Oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p58; p65-PAK; PAK alpha; PAK beta; PAK gamma; PAK-1; PAK-2; PAK-3; PAK1; PAK3; PAK65; S6/H4 kinase; Serine/threonine-protein kinase PAK 2

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Gene Aliases: 5330420P17Rik; A130002K10Rik; AI836325; D16Ertd269e; mKIAA4182; PAK-2; PAK2; PAK65; PAKgamma

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UniProt ID: (Human) Q13177, (Mouse) Q8CIN4

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Entrez Gene ID: (Human) 5062, (Mouse) 224105

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Function(s)
protein kinase activity protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity protein binding ATP binding protein kinase binding protein tyrosine kinase activator activity identical protein binding cadherin binding involved in cell-cell adhesion nucleotide binding catalytic activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups Rac GTPase binding
Process(es)
protein phosphorylation apoptotic process Rho protein signal transduction regulation of mitotic cell cycle metabolic process phosphorylation cell migration peptidyl-serine phosphorylation signal transduction by protein phosphorylation actin cytoskeleton organization stress-activated protein kinase signaling cascade activation of protein kinase activity regulation of growth negative regulation of apoptotic process regulation of MAPK cascade protein autophosphorylation positive regulation of peptidyl-tyrosine phosphorylation dendritic spine development positive regulation of protein tyrosine kinase activity cellular response to organic cyclic compound positive regulation of extrinsic apoptotic signaling pathway negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis mitotic cell cycle stimulatory C-type lectin receptor signaling pathway negative regulation of protein kinase activity signal transduction viral process T cell costimulation Fc-epsilon receptor signaling pathway vascular endothelial growth factor receptor signaling pathway regulation of defense response to virus by virus T cell receptor signaling pathway cell-cell adhesion
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