Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 3
Positive test controls include: NIH/3T3. The target is usually found in the following locations: Cytoplasm, Membrane, Nucleus, Peripheral membrane protein.
Immunogen sequence: VLTPP
Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: aging-associated gene 6; PKC-A; PKC-alpha; PKC-B; PKC-beta; PRKC Pan; Protein kinase C alpha type; protein kinase C beta I; protein kinase C beta II; Protein kinase C beta type; protein kinase C beta-II; protein kinase C, alpha; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; protein kinase c-alpha
Gene Aliases: A130082F03Rik; AAG6; AI875142; PKC-alpha; PKC-Beta; PKCA; PKCB; PRKACA; PRKCA; PRKCB; PRKCB1; PRKCB2
UniProt ID: (Human) P17252, (Human) P05771, (Mouse) P20444, (Mouse) P68404, (Rat) P68403
Entrez Gene ID: (Human) 5578, (Human) 5579, (Mouse) 18750, (Rat) 24680, (Mouse) 18751, (Rat) 25023
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support