Invitrogen

Phospho-PKC alpha/delta (Thr410) Recombinant Rabbit Monoclonal Antibody (5W5G1)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-55196

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

5W5G1

Immunogen

A synthetic phosphorylated peptide around T410 of human PRKCZ.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.41 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

RRID

AB_3667441

Product Specific Information

Immunogen Sequence: TTSTFC

Target Information

PKC alpha/delta refers to the protein kinase C isoforms alpha and delta, which are gene targets involved in various cellular processes and signaling pathways. Protein kinase C (PKC) is a family of enzymes that play a crucial role in regulating cell growth, differentiation, and intracellular signaling. PKC alpha and delta isoforms are widely expressed in different tissues and have distinct functions. PKC alpha is involved in cell proliferation, apoptosis, and cell cycle regulation, while PKC delta is implicated in cellular responses to stress, DNA damage, and apoptosis. These isoforms are activated by various stimuli, including second messengers and receptor-mediated signaling, leading to the phosphorylation of downstream targets and modulation of cellular processes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: aging-associated gene 6; nPKC-delta; PKC-A; PKCA; PRKACA; Protein kinase C; Protein kinase C alpha type; Protein kinase C delta type; protein kinase C delta VIII; protein kinase C, alpha; protein kinase C, delta; Tyrosine-protein kinase PRKCD

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Gene Aliases: AAG6; ALPS3; CVID9; MAY1; nPKC-delta; PKC-alpha; PKCA; PKCD; PRKACA; PRKCA; PRKCD

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UniProt ID: (Human) P17252, (Human) Q05655

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Entrez Gene ID: (Human) 5578, (Human) 5580

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-dependent protein kinase C activity protein binding ATP binding zinc ion binding enzyme binding histone kinase activity (H3-T6 specific) calcium-independent protein kinase C activity non-membrane spanning protein tyrosine kinase activity enzyme activator activity kinase binding protein kinase binding insulin receptor substrate binding metal ion binding
Process(es)
stimulatory C-type lectin receptor signaling pathway protein phosphorylation apoptotic process cellular component disassembly involved in execution phase of apoptosis cell cycle signal transduction activation of phospholipase C activity intrinsic apoptotic signaling pathway in response to oxidative stress regulation of receptor activity immunoglobulin mediated immune response histone phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation termination of signal transduction platelet activation negative regulation of actin filament polymerization positive regulation of endodeoxyribonuclease activity negative regulation of protein binding activation of protein kinase activity interleukin-10 production interleukin-12 production positive regulation of superoxide anion generation regulation of actin cytoskeleton organization negative regulation of glial cell apoptotic process positive regulation of protein dephosphorylation Fc-gamma receptor signaling pathway involved in phagocytosis B cell proliferation neutrophil activation positive regulation of protein import into nucleus defense response to bacterium negative regulation of MAP kinase activity regulation of mRNA stability negative regulation of insulin receptor signaling pathway negative regulation of inflammatory response negative regulation of peptidyl-tyrosine phosphorylation protein stabilization negative regulation of filopodium assembly cell chemotaxis interferon-gamma-mediated signaling pathway cellular response to hydrogen peroxide cellular response to hydroperoxide negative regulation of platelet aggregation cellular senescence positive regulation of phospholipid scramblase activity cellular response to angiotensin positive regulation of ceramide biosynthetic process positive regulation of glucosylceramide catabolic process positive regulation of sphingomyelin catabolic process positive regulation of response to DNA damage stimulus positive regulation of apoptotic signaling pathway angiogenesis positive regulation of endothelial cell proliferation desmosome assembly mitotic nuclear envelope disassembly cell adhesion activation of adenylate cyclase activity negative regulation of adenylate cyclase activity positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy positive regulation of cell migration positive regulation of lipopolysaccharide-mediated signaling pathway histone H3-T6 phosphorylation intracellular signal transduction positive regulation of blood vessel endothelial cell migration positive regulation of macrophage differentiation positive regulation of angiogenesis positive regulation of cell adhesion positive regulation of mitotic cell cycle regulation of insulin secretion positive regulation of ERK1 and ERK2 cascade response to interleukin-1 regulation of platelet aggregation apoptotic signaling pathway positive regulation of dense core granule biogenesis
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