Invitrogen

Phospho-PPAR delta (Thr256) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-105082

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PPARD(Accession Q03181), corresponding to amino acid residues around phosphorylated Thr256.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816555

Product Specific Information

Antibody detects endogenous levels of PPARD only when phosphorylated at Thr256.

Target Information

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MGC3931; NUC1; NUCI; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor delta; peroxisome proliferator activator receptor beta; peroxisome proliferator activator receptor, delta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta; PPARdelta/beta

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Gene Aliases: FAAR; NR1C2; NUC-1; NUC1; NUCI; NUCII; PPAR-beta; PPAR-delta; PPAR[b]; PPARB; Pparb/d; PPARD; PPARdelta

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UniProt ID: (Human) Q03181, (Mouse) P35396

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Entrez Gene ID: (Human) 5467, (Pig) 397297, (Rat) 25682, (Mouse) 19015

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Function(s)
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding transcription factor binding drug binding zinc ion binding lipid binding sequence-specific DNA binding protein heterodimerization activity NF-kappaB binding linoleic acid binding fatty acid binding enzyme activator activity prostacyclin receptor activity metal ion binding retinoid X receptor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter placenta development proteoglycan metabolic process lipid metabolic process fatty acid beta-oxidation vitamin A metabolic process heart development embryo implantation cell proliferation positive regulation of cell proliferation axon ensheathment phospholipid biosynthetic process mRNA transcription response to glucose response to organic substance positive regulation of phosphatidylinositol 3-kinase signaling response to activity negative regulation of smooth muscle cell migration fatty acid transport fatty acid oxidation cell differentiation negative regulation of cell growth intracellular receptor signaling pathway cell-substrate adhesion positive regulation of insulin secretion negative regulation of collagen biosynthetic process response to vitamin A wound healing regulation of cell proliferation negative regulation of apoptotic process steroid hormone mediated signaling pathway keratinocyte proliferation regulation of fat cell differentiation positive regulation of epidermis development positive regulation of transcription, DNA-templated positive regulation of vasodilation decidualization negative regulation of smooth muscle cell proliferation negative regulation of epithelial cell proliferation negative regulation of inflammatory response keratinocyte migration adipose tissue development cellular response to hypoxia apoptotic signaling pathway glucose metabolic process generation of precursor metabolites and energy regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter apoptotic process cholesterol metabolic process fatty acid catabolic process regulation of skeletal muscle satellite cell proliferation glucose transport positive regulation of skeletal muscle tissue regeneration positive regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of transcription, DNA-templated cellular response to lipopolysaccharide negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of myoblast proliferation transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter G-protein coupled receptor signaling pathway epidermis development cellular process anagen positive regulation of catalytic activity regulation of insulin secretion
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