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Product Details
BS-5584R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide derived from mouse PRKCQ around the phosphorylation site of Ser695.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Protein Kinase C (PKC) isoforms are serine/threonine kinases involved in signal transduction pathways that govern a wide range of physiological processes including differentiation, proliferation, gene expression, brain function, membrane transport and the organization of cytoskeletal and extracellular matrix proteins. Increasing evidence from studies using in vitro and in vivo systems points to PKC as a key regulator of critical cell cycle transitions, including cell cycle entry and exit and the G1 and G2 checkpoints. PKC-mediated control of these transitions can be negative or positive, depending on the timing of PKC activation during the cell cycle and on the specific PKC isozymes involve. There have been at least 12 different PKC isoforms identified in humans to date, including alpha, beta I, beta II, gamma, delta, epsilon, zeta, eta, theta, iota, lambda, and mu. The different PKC isoforms vary in structure, subcellular localization, tissue distribution and response to extracellular signals. PKC beta II has been shown to be expressed, in part, in cardiac muscle, intestinal epithelium, kidney and pancreas. PKC beta II has been shown to be involved in cell cycle progression and cancer proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.11.13; kinase nPKC-theta; KPCT; MGC126514; MGC141919; nPKC-theta; PKC theta; Protein kinase C theta type; RP11-563J2.1
Gene Aliases: A130035A12Rik; AW494342; PKC-0; PKC-theta; Pkcq; PKCtheta; Prkcq
UniProt ID: (Mouse) Q02111
Entrez Gene ID: (Mouse) 18761, (Rat) 85420
immune system process
regulation of transcription, DNA-templated
protein phosphorylation
membrane protein ectodomain proteolysis
inflammatory response
regulation of G2/M transition of mitotic cell cycle
phosphorylation
positive regulation of interleukin-17 production
positive regulation of interleukin-4 production
intracellular signal transduction
positive regulation of T cell proliferation
positive regulation of NF-kappaB import into nucleus
positive regulation of interleukin-2 biosynthetic process
negative regulation of insulin receptor signaling pathway
positive regulation of protein secretion
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
positive regulation of filopodium assembly
positive regulation of stress fiber assembly
negative regulation of T cell apoptotic process
regulation of platelet aggregation
positive regulation of T-helper 17 type immune response
positive regulation of T-helper 2 cell activation
response to hypoxia
aging
response to heat
response to glucose
response to organic cyclic compound
regulation of vasoconstriction
neuron differentiation
response to insulin
tissue regeneration
respiratory burst
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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