Invitrogen

Phospho-Phospholamban (Ser16, Ser17) Recombinant Rabbit Monoclonal Antibody (8 H4L6)

View all (20) Phospholamban antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

702369

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

8 H4L6

Immunogen

Peptide corresponding to Human Phospholamban (aa 13-21)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2633017

Product Specific Information

This antibody is predicted to react with Rat, Rabbit and Mouse

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1 to 25) contains the phosphorylation sites and is highly basic and readily cleaved by proteases whereas the transmembrane domain (residues 25 to 52) is mostly hydrophobic, protease resistant and stabilizes the pentamer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cardiac CMH18; cardiac phospholamban; Phospholamban; PLB

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Gene Aliases: CMD1P; CMH18; PLB; Plm; PLN

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UniProt ID: (Human) P26678, (Rat) P61016, (Mouse) P61014

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Entrez Gene ID: (Human) 5350, (Rat) 64672, (Mouse) 18821

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Function(s)
enzyme inhibitor activity calcium channel regulator activity protein binding ATPase inhibitor activity identical protein binding ATPase binding
Process(es)
regulation of the force of heart contraction calcium ion transport cellular calcium ion homeostasis regulation of heart contraction response to zinc ion negative regulation of heart rate regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion negative regulation of ATPase activity response to insulin response to testosterone negative regulation of heart contraction cardiac muscle tissue development protein homooligomerization regulation of calcium ion transport negative regulation of calcium ion transport regulation of ryanodine-sensitive calcium-release channel activity regulation of cardiac muscle cell contraction adrenergic receptor signaling pathway involved in heart process regulation of the force of heart contraction by cardiac conduction regulation of calcium ion import negative regulation of calcium ion transmembrane transporter activity regulation of relaxation of muscle negative regulation of calcium ion binding regulation of calcium-transporting ATPase activity negative regulation of calcium-transporting ATPase activity Notch signaling pathway negative regulation of catalytic activity blood circulation regulation of cytosolic calcium ion concentration relaxation of cardiac muscle regulation of cardiac muscle cell membrane potential negative regulation of calcium ion import regulation of relaxation of cardiac muscle negative regulation of calcium ion import into sarcoplasmic reticulum regulation of cardiac conduction
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