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Invitrogen
Phospho-RAB29 (Thr71) Polyclonal Antibody
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FIGURE: 1 / 4
Phospho-RAB29 (Thr71) Antibody (PA5-114631) in ICC/IF
Immunocytochemistry analysis of Phospho-RAB29 (Thr71) in HepG2 cells (serum starvation treatment). Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-114631). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488... View More
Product Details
PA5-114631
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human Rab7L1 around the phosphorylation site of Rab29.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2899267
Product Specific Information
Antibody detects endogenous levels of RAB7L1 only when phosphorylated at Rab29.
Target Information
Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. {ECO:0000269; PubMed:22042847, ECO:0000269; PubMed:24788816}.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Rab-7-like protein 1; RAB7, member RAS oncogene family-like 1; Ras-related GTP-binding protein Rab29; Ras-related protein Rab-29; Ras-related protein Rab-7L1
Gene Aliases: RAB29; RAB7L; RAB7L1
UniProt ID: (Human) O14966, (Rat) Q63481
Entrez Gene ID: (Human) 8934, (Mouse) 226422, (Rat) 171122
transport
intracellular protein transport
Golgi organization
small GTPase mediated signal transduction
protein transport
cell differentiation
melanosome organization
Rab protein signal transduction
retrograde transport, plasma membrane to Golgi
positive regulation of intracellular protein transport
ER to Golgi vesicle-mediated transport
metabolic process
Golgi to endosome transport
response to bacterium
negative regulation of neuron projection development
symbiont intracellular protein transport in host
retrograde transport, endosome to Golgi
protein localization to membrane
regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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