Invitrogen

Phospho-RAC1 (Ser71) Polyclonal Antibody

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View all (12) RAC1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-104640

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human RAC1(Accession P63000), corresponding to amino acid residues around phosphorylated Ser71.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816115

Product Specific Information

Antibody detects endogenous levels of Rac1/cdc42 only when phosphorylated at Ser71.

Target Information

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Cell migration-inducing gene 5 protein; MGC111543; p21-Rac1; Ras-like protein TC25; Ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1); rho family, small GTP binding protein Rac1

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Gene Aliases: AL023026; D5Ertd559e; MIG5; p21-Rac1; Rac; Rac-1; RAC1; TC-25; TC25

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UniProt ID: (Human) P63000, (Mouse) P63001, (Rat) Q6RUV5

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Entrez Gene ID: (Human) 5879, (Mouse) 19353, (Rat) 363875

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Function(s)
GTPase activity protein binding GTP binding Rab GTPase binding enzyme binding protein kinase binding GTP-dependent protein binding thioesterase binding histone deacetylase binding Rho GDP-dissociation inhibitor binding nucleotide binding
Process(es)
positive regulation of protein phosphorylation auditory receptor cell morphogenesis mast cell chemotaxis epithelial cell morphogenesis endocytosis phagocytosis, engulfment chemotaxis hyperosmotic response cytoskeleton organization actin filament organization cell adhesion G-protein coupled receptor signaling pathway small GTPase mediated signal transduction axon guidance metabolic process cell proliferation positive regulation of lamellipodium assembly regulation of fibroblast migration positive regulation of cell-substrate adhesion regulation of neuron maturation dendrite development cell migration cerebral cortex radially oriented cell migration embryonic olfactory bulb interneuron precursor migration cerebral cortex GABAergic interneuron development regulation of cell morphogenesis lamellipodium assembly actin cytoskeleton organization actin filament polymerization regulation of cell migration positive regulation of actin filament polymerization ruffle organization negative regulation of interleukin-23 production substrate adhesion-dependent cell spreading positive regulation of phosphatidylinositol 3-kinase activity engulfment of apoptotic cell cell-cell junction organization bone resorption positive regulation of DNA replication anatomical structure arrangement dendrite morphogenesis cell motility homeostasis of number of cells within a tissue positive regulation of stress fiber assembly localization within membrane positive regulation of focal adhesion assembly synaptic transmission, GABAergic Wnt signaling pathway, planar cell polarity pathway regulation of respiratory burst cellular response to mechanical stimulus semaphorin-plexin signaling pathway dopaminergic neuron differentiation protein localization to plasma membrane positive regulation of neutrophil chemotaxis cochlea morphogenesis ruffle assembly positive regulation of substrate adhesion-dependent cell spreading movement of cell or subcellular component inflammatory response cell-matrix adhesion blood coagulation regulation of cell size response to wounding anatomical structure morphogenesis regulation of hydrogen peroxide metabolic process platelet activation T cell costimulation positive regulation of Rho protein signal transduction intracellular signal transduction Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of apoptotic process vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway negative regulation of receptor-mediated endocytosis regulation of defense response to virus by virus regulation of small GTPase mediated signal transduction Rac protein signal transduction
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