Invitrogen

Phospho-RAD50 (Ser635) Polyclonal Antibody

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-64708

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:300
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human RAD50 (Phospho-Ser635)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2663076

Product Specific Information

Phospho-RAD50 (Ser635) Polyclonal Antibody detects endogenous levels of RAD50 only when phosphorylated at Ser635.

Target Information

Rad50-13B3 recognizes human Rad50, a 153a protein involved in DNA double strand break repair. Rad50 is associated with Mre11 and p95 (Nibrin) to form a multiprotein complex involved in the double strand break repair process. Upon DNA damage, Rad50 and Mre11 redistribute and are co-localized within the nucleus of damaged cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DNA repair protein RAD50; hRAD50; hsRAD50; mRad50; RAD50 2; RAD50 homolog, double strand break repair protein; RAD50 PEN; RAD50-2; RAD50-3

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Gene Aliases: hRad50; Mrell; NBSLD; RAD50; RAD502; Rad50l

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UniProt ID: (Human) Q92878, (Rat) Q9JIL8

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Entrez Gene ID: (Human) 10111, (Mouse) 19360, (Rat) 64012

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Function(s)
single-stranded DNA endodeoxyribonuclease activity DNA binding double-stranded telomeric DNA binding ATP-dependent DNA helicase activity adenylate kinase activity protein binding ATP binding 3'-5' exonuclease activity protein binding, bridging single-stranded telomeric DNA binding metal ion binding G-quadruplex DNA binding nucleotide binding double-stranded DNA binding hydrolase activity ATPase activity
Process(es)
regulation of mitotic recombination telomere maintenance DNA repair double-strand break repair DNA recombination cellular response to DNA damage stimulus telomere maintenance via telomerase cell cycle regulation of mitotic cell cycle positive regulation of protein autophosphorylation DNA duplex unwinding positive regulation of kinase activity negative regulation of viral entry into host cell chromosome organization protein heterooligomerization meiotic cell cycle chromosome organization involved in meiotic cell cycle nucleic acid phosphodiester bond hydrolysis DNA catabolic process, endonucleolytic reciprocal meiotic recombination telomere maintenance via recombination double-strand break repair via homologous recombination DNA double-strand break processing DNA synthesis involved in DNA repair strand displacement DNA replication double-strand break repair via nonhomologous end joining viral process telomeric 3' overhang formation positive regulation of telomere maintenance nucleotide phosphorylation regulation of signal transduction by p53 class mediator negative regulation of telomere capping
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