Invitrogen

Phospho-ROC1 (Thr9) Polyclonal Antibody

View all (16) ROC1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-105076

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human RBX1(Accession P62877), corresponding to amino acid residues around phosphorylated Thr9.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2816549

Product Specific Information

Antibody detects endogenous levels of RBX1 only when phosphorylated at Thr9.

Target Information

This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase RBX1; E3 ubiquitin-protein transferase RBX1; Protein ZYP; Rbx1; Regulator of cullins 1; RING box protein 1; RING finger protein 75; ring-box 1, E3 ubiquitin protein ligase; RING-box protein 1; ROC1; ZYP protein

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Gene Aliases: 1500002P15Rik; AA517855; BA554C12.1; RBX1; RNF75; ROC1

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UniProt ID: (Human) P62877, (Mouse) P62878

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Entrez Gene ID: (Human) 9978, (Mouse) 56438, (Rat) 300084

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Function(s)
ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity NEDD8 transferase activity ubiquitin protein ligase binding protein complex binding ubiquitin-ubiquitin ligase activity ubiquitin protein ligase activity cullin family protein binding eukaryotic initiation factor 4E binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
Process(es)
DNA repair ubiquitin-dependent protein catabolic process protein monoubiquitination cellular response to DNA damage stimulus protein ubiquitination protein catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination involved in ubiquitin-dependent protein catabolic process protein neddylation MAPK cascade protein polyubiquitination nucleotide-excision repair, DNA damage recognition nucleotide-excision repair, DNA duplex unwinding transcription-coupled nucleotide-excision repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion viral process Wnt signaling pathway nucleotide-excision repair, DNA incision DNA damage response, detection of DNA damage proteasome-mediated ubiquitin-dependent protein catabolic process regulation of transcription from RNA polymerase II promoter in response to hypoxia global genome nucleotide-excision repair negative regulation of canonical Wnt signaling pathway
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