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Invitrogen
Phospho-ROR2 (Ser449) Polyclonal Antibody
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Phospho-ROR2 (Ser449) Antibody (PA5-106151) in WB
Western blot analysis of Phospho-ROR2 (Ser449) in TNF-alpha treated HeLa whole cell lysate (absence (-) or presence (+) of non-phospho and phospho peptide). Samples were incubated with Phospho-ROR2 (Ser449) polyclonal antibody (Product # PA5-106151).
Product Details
PA5-106151
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ROR2(Accession Q01974), corresponding to amino acid residues around phosphorylated Ser449.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2817549
Product Specific Information
Antibody detects endogenous levels of ROR2 only when phosphorylated at Ser449.
Target Information
ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. It is thought to be involved in the early formation of the chondrocytes and cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: neurotrophic tyrosine kinase receptor-related 2; neurotrophic tyrosine kinase, receptor related 2; Neurotrophic tyrosine kinase, receptor-related 2; receptor tyrosine kinase-like orphan receptor 2; Tyrosine-protein kinase transmembrane receptor ROR2
Gene Aliases: BDB; BDB1; mRor2; NTRKR2; ROR2
UniProt ID: (Human) Q01974
Entrez Gene ID: (Human) 4920, (Mouse) 26564
transmembrane receptor protein tyrosine kinase activity
frizzled binding
protein binding
ATP binding
Wnt-protein binding
metal ion binding
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
cartilage condensation
somitogenesis
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
Wnt signaling pathway, calcium modulating pathway
smoothened signaling pathway
JNK cascade
multicellular organism development
negative regulation of cell proliferation
peptidyl-tyrosine phosphorylation
positive regulation of cell migration
BMP signaling pathway
embryonic genitalia morphogenesis
inner ear morphogenesis
embryonic digit morphogenesis
cell fate commitment
positive regulation of transcription, DNA-templated
Wnt signaling pathway, planar cell polarity pathway
SMAD protein signal transduction
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
skeletal system development
protein phosphorylation
phosphorylation
cell differentiation
regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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