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Product Details
BS-3368R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide derived from human RSK2 around the phosphorylation site of Tyr529.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
RPS6KA3 (RSK2) is a serine/threonine kinase that modulates many cellular processes including transcription, adhesion, growth, survival, and proliferation. RPS6KA3 contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in the gene have been associated with Coffin-Lowry syndrome (CLS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 90 kDa ribosomal protein S6 kinase 3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; p90-RSK 3; pp90RSK2; ribosomal protein S6 kinase 2; Ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; Ribosomal S6 kinase 2; RSK-2; S6K-alpha-3
Gene Aliases: C130006E23; CLS; HU-3; ISPK-1; ISPK1; MAPKAPK-1b; MAPKAPK1B; MPK-9; MRX19; p90-RSK2; p90RSK3; pp90RSK2; Rps6ka-rs1; RPS6KA3; RSK; RSK2; S6K-alpha3
UniProt ID: (Human) P51812, (Mouse) P18654
Entrez Gene ID: (Human) 6197, (Mouse) 110651
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
protein kinase binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
nucleotide binding
ribosomal protein S6 kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
toll-like receptor signaling pathway
regulation of translation
protein phosphorylation
cell cycle
phosphorylation
response to lipopolysaccharide
intracellular signal transduction
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of transcription from RNA polymerase II promoter
skeletal system development
apoptotic process
signal transduction
central nervous system development
positive regulation of cell growth
negative regulation of apoptotic process
regulation of translation in response to stress
regulation of DNA-templated transcription in response to stress
positive regulation of cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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