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Invitrogen
Phospho-SHIP2 (Tyr497) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-SHIP2 (Tyr497) Antibody (PA5-23331) in IHC (P)
Immunohistochemical analysis of Phospho-SHIP2 (Tyr497) in formalin-fixed, paraffin-embedded human brain tissue. Samples were incubated in Phospho-SHIP2 (Tyr497) polyclonal antibody (Product # PA5-23331) using a dilution of 5 µg/mL. Isotype control (top) and this antibody (bottom).
Product Details
PA5-23331
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Horse,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide (490 KELTDLD(Y)RPIAMQS 504) of Phospho-SHIP2 pTyr497 protein.
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2540855
Target Information
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodeling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 51C protein; ablSH3-binding protein; inositol polyphosphate phosphatase-like 1; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SH2-containing inositol phosphatase 2; SHIP-2
Gene Aliases: 51C; BOS_14953; INPPL1; OPSMD; SHIP2
UniProt ID: (Human) O15357, (Rat) Q9WVR3, (Mouse) Q6P549
Entrez Gene ID: (Bovine) 783833, (Human) 3636, (Dog) 485209, (Rat) 65038, (Mouse) 16332
actin binding
protein binding
SH3 domain binding
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
SH2 domain binding
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
inositol-polyphosphate 5-phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate binding
hydrolase activity
endochondral ossification
immune system process
glucose metabolic process
phosphatidylinositol biosynthetic process
endocytosis
actin filament organization
cell adhesion
negative regulation of cell proliferation
post-embryonic development
negative regulation of gene expression
response to insulin
inositol phosphate metabolic process
phosphatidylinositol dephosphorylation
ruffle assembly
brain development
negative regulation of DNA replication
negative regulation of platelet-derived growth factor receptor signaling pathway
negative regulation of neuron projection development
inositol trisphosphate metabolic process
response to drug
negative regulation of MAP kinase activity
negative regulation of insulin-like growth factor receptor signaling pathway
cellular lipid metabolic process
negative regulation of insulin receptor signaling pathway
dephosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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