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Invitrogen
Phospho-SIK1 (Thr182) Polyclonal Antibody
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Phospho-SIK1 (Thr182) Antibody (PA5-64610) in WB
Molecular metabolism 2020 -
Chronic treatment of phanginin A improved metabolic disorders in ob/ob mice. Male ob/ob mice were treated with phanginin A (100 mg/kg, once daily, p. o. ), metformin (250 mg/kg, once daily, p. o. ), or vehicle for 26 days. (A-B) Random (A) and fasting blood glucose levels (B) were detected on days 4, 8, 12, 16, 20, 23, and 26. (C) Oral glucose tolerance tests were conducted on day 23. (D) HbA1c was determin... View More
Product Details
PA5-64610
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SIK (Phospho-Thr182)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2663013
Product Specific Information
Phospho-SIK1 (Thr182) Polyclonal Antibody detects endogenous levels of SIK1 only when phosphorylated at Thr182.
Target Information
SIK1 may mediate the physiological effects of LKB1, including its tumor suppressor function. SIK1 is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK that are related to AMPK. Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane. This results in an increase in intracellular sodium in intact mammalian cells. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: myocardial SNF1-like kinase; Protein kinase KID2; Salt-inducible kinase 1; salt-inducible protein kinase 1; serine/threonine protein kinase; Serine/threonine-protein kinase SIK1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK; SIK-1; SNF1-like kinase
Gene Aliases: EIEE30; Kid2; MSK; SIK; SIK1; SNF1LK
UniProt ID: (Human) P57059, (Rat) Q9R1U5
Entrez Gene ID: (Human) 150094, (Rat) 59329
negative regulation of transcription from RNA polymerase II promoter
regulation of sodium ion transport
protein phosphorylation
regulation of mitotic cell cycle
regulation of myotube differentiation
negative regulation of triglyceride biosynthetic process
negative regulation of CREB transcription factor activity
intracellular signal transduction
entrainment of circadian clock by photoperiod
anoikis
regulation of cell differentiation
negative regulation of gluconeogenesis
protein autophosphorylation
rhythmic process
cardiac muscle cell differentiation
positive regulation of anoikis
cell cycle
cellular response to hormone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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