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Invitrogen
Phospho-SRC3 (Ser857) Polyclonal Antibody
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Product Details
PA5-64836
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NCoA3 (Phospho-Ser857)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2662017
Product Specific Information
Phospho-SRC3 (Ser857) Polyclonal Antibody detects endogenous levels of SRC3 only when phosphorylated at Ser857.
Target Information
AIB1-AC3 recognizes AIB1, a member of the SRC-1 family of nuclear receptor coactivators with an apparent molecular weight of 160kDa. The AIB1 gene has been mapped to region 20q12 and has been shown to be amplified in breast tumors and pancreatic cancer cell lines. AIB1 interacts in a ligand-dependent fashion with the estrogen receptor to enhance estrogen-dependent transcriptional gene activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACTR; AIB-1; Amplified in breast cancer 1 protein; amplified in breast cancer-1 protein homolog; bHLHe42; CBP-interacting protein; Class E basic helix-loop-helix protein 42; MGC141848; NCoA-3; Nuclear receptor coactivator 3; OTTHUMP00000031716; pCIP; RAC-3; Receptor-associated coactivator 3; RP5-1049G16.3; SRC-3; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TRAM-1
Gene Aliases: 2010305B15Rik; ACTR; AIB-1; AIB1; AW321064; BHLHE42; CAGH16; CTG26; KAT13B; NCOA3; p/Cip; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1; TRAM1
UniProt ID: (Human) Q9Y6Q9
Entrez Gene ID: (Human) 8202, (Mouse) 17979
transcription coactivator activity
histone acetyltransferase activity
protein binding
ligand-dependent nuclear receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
nuclear hormone receptor binding
thyroid hormone receptor binding
protein dimerization activity
protein N-terminus binding
androgen receptor binding
RNA polymerase II regulatory region DNA binding
chromatin binding
signal transducer activity
transferase activity
transferase activity, transferring acyl groups
estrogen receptor binding
protein complex binding
peroxisome proliferator activated receptor binding
transcription, DNA-templated
regulation of transcription, DNA-templated
signal transduction
positive regulation of gene expression
histone acetylation
positive regulation of cell growth
cellular response to hormone stimulus
positive regulation of intracellular steroid hormone receptor signaling pathway
positive regulation of intracellular estrogen receptor signaling pathway
multicellular organism growth
negative regulation of apoptotic process
positive regulation of keratinocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
developmental growth
positive regulation of sequence-specific DNA binding transcription factor activity
vagina development
labyrinthine layer morphogenesis
mammary gland branching involved in thelarche
cellular response to estradiol stimulus
regulation of RNA biosynthetic process
androgen receptor signaling pathway
intracellular receptor signaling pathway
receptor transactivation
positive regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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