Fabgennix

Phospho-Smad1 (Ser453, Ser455) Polyclonal Antibody, Biotin

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PMAD-BIOTIN

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Fruit fly

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 405-455 on D. melanogaster Mothers against dpp protein.
View immunogen

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: apang; CG12399-PA; CG12399-PB; DWFC; hSMAD1; JV5-1; Mad-PA; Mad-PB; MADH5; mother against decapentaplegic; mother against Dpp; mothers against decapentaplegi; mothers against decapentaplegic; mothers against dpp; Mothers-against-DPP-related-1; OTTHUMP00000220456; phospho-Smad; phosphorylated smad; phosphoSmad; Protein mothers against dpp; SMAD; SMAD5

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Gene Aliases: 2/23; apg; c28; CG12399; dMAD; Dmel\CG12399; Dmel_CG12399; E(zen)2; En(vvl); l(2)K00237; MAD; Mat; P-Mad; PMad; pSmad; Smad; Smad1

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UniProt ID: (Fruit fly) P42003

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Entrez Gene ID: (Fruit fly) 33529

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Function(s)
RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity sequence-specific DNA binding
Process(es)
compound eye morphogenesis regulation of transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway dorsal closure ventral cord development open tracheal system development imaginal disc-derived wing morphogenesis imaginal disc-derived leg morphogenesis histoblast morphogenesis heart development imaginal disc-derived wing vein morphogenesis negative regulation of gene expression ovarian follicle cell development germ-line stem cell population maintenance somatic stem cell population maintenance trunk segmentation germ-line stem cell division regulation of cell differentiation negative regulation of salivary gland boundary specification positive regulation of synaptic growth at neuromuscular junction positive regulation of transcription from RNA polymerase II promoter wing disc anterior/posterior pattern formation regulation of synapse structure or activity transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification BMP signaling pathway involved in Malpighian tubule cell chemotaxis negative regulation of G1/S transition of mitotic cell cycle
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