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FIGURE: 1 / 1
Phospho-TAOK2 (Ser181) Antibody (PA1-4643) in WB
Western blot of TAOK2 in rat cortical lysate showing specific immunolabeling of a band at ~120 kDa corresponding to Phospho-TAOK2 (Ser181) polyclonal antibody (Product # PA1-4643) in the first lane (-). Phosphospecificity is shown in the second lane (+) where the immunolabeling is completely eliminated by blot treatment with lambda phosphatase (1,200 units for 30 minutes).
Product Details
PA1-4643
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser181 of human TAOK2 conjugated to KLH
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2200024
Product Specific Information
This antibody is predicted to react with zebrafish, Xenopus, finch and canine based on 100% sequence homology.
This antibody is specific for the ~120 kDa TAO2 phosphorylated at Ser181 in Western blots of rat hippocampal lysate.
Target Information
TAOK2 (TAO1) is a serine/threonine kinase that may be an important regulator of the stress-responsive p38 MAP kinase pathway. In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEK ) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonist to the stress -responsive p38 MAPK (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hKFC-C; Kinase from chicken homolog C; prostate derived STE20-like kinase PSK; prostate-derived STE20-like kinase 1; Prostate-derived sterile 20-like kinase 1; PSK-1; serine-threonine kinase; serine/threonine protein kinase TAO2; Serine/threonine-protein kinase TAO2; tao; TAO kinase 2TAO kinase 2; Thousand and one amino acid protein 2; Thousand and one amino acid protein kinase 2
Gene Aliases: 1110033K02Rik; B230344N16; KIAA0881; MAP3K17; mKIAA0881; PSK; PSK1; PSK1-BETA; TAO1; TAO2; TAOK2; UNQ2971/PRO7431
UniProt ID: (Human) Q9UL54, (Mouse) Q6ZQ29, (Rat) Q9JLS3
Entrez Gene ID: (Human) 9344, (Mouse) 381921, (Rat) 64666
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
ATP binding
mitogen-activated protein kinase kinase binding
nucleotide binding
protein kinase activity
MAP kinase kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
MAPK cascade
activation of MAPKK activity
protein phosphorylation
response to stress
cellular response to DNA damage stimulus
regulation of mitotic cell cycle
regulation of cell shape
phosphorylation
signal transduction by protein phosphorylation
actin cytoskeleton organization
stress-activated protein kinase signaling cascade
G2 DNA damage checkpoint
positive regulation of stress-activated MAPK cascade
regulation of apoptotic process
positive regulation of JNK cascade
focal adhesion assembly
stress-activated MAPK cascade
regulation of cell growth
protein targeting to membrane
apoptotic process
cell migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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