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Phospho-TEM8 (Tyr382) Antibody (PA5-12976) in DB
Dot blot analysis of Phospho-TEM8 (Tyr382). Samples were incubated with Phospho-TEM8 (Tyr382) polyclonal antibody (Product # PA5-12976) using a dilution of 0.5 µg/mL. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed on nitrocellulose membrane.
Product Details
PA5-12976
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y382 of human ANTXR1
Conjugate
Form
Liquid
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10978292
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2310008J16Rik; 2810405N18Rik; anthrax toxin receptor; Anthrax toxin receptor 1; FLJ10601; FLJ11298; FLJ21776; Tem-8; Tumor endothelial marker 8
Gene Aliases: ANTXR1; ATR; GAPO; TEM8
UniProt ID: (Human) Q9H6X2
Entrez Gene ID: (Human) 84168
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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