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Invitrogen
Phospho-TNK1 (Tyr277) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-TNK1 (Tyr277) Antibody (PA5-104671) in WB
Western blot analysis of Phospho-TNK1 (Tyr277) in L-540cells (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-TNK1 (Tyr277) polyclonal antibody (Product # PA5-104671).
Product Details
PA5-104671
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TNK1(Accession Q13470), corresponding to amino acid residues around phosphorylated Tyr277.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2816146
Product Specific Information
Antibody detects endogenous levels of TNK1 only when phosphorylated at Tyr277.
Target Information
TNK1 tyrosine kinase, non-receptor 1 belongs to the tyrosine protein kinase family and as such is an important regulator of intracellular signal transduction pathways mediating cellular proliferation, survival, and development. TNK1 is highly expressed in fetal tissues and at lower levels in a few adult tissues. TNK1 may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. TNK1 plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD38 negative kinase 1; Kinase of embryonic stem cells; MGC46193; non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase TNK1; TNK1; tyrosine kinase, non-receptor 1; tyrosine kinase, non-receptor, 1
Gene Aliases: Kos1; TNK1; Tnk1a; Tnk1b
UniProt ID: (Human) Q13470, (Mouse) Q99ML2
Entrez Gene ID: (Human) 8711, (Rat) 303247, (Mouse) 83813
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
signal transducer activity
receptor binding
protein binding
ATP binding
hormone receptor binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
cell differentiation
negative regulation of cell growth
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
innate immune response
negative regulation of Ras protein signal transduction
protein autophosphorylation
cell migration
peptidyl-tyrosine phosphorylation
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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