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Invitrogen
Phospho-TOB1 (Ser164) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-TOB1 (Ser164) Antibody (PA5-37780) in IHC (P)
Immunohistochemical analysis of Phospho-TOB1 (Ser164) in paraffin-embedded Human brain tissue using Phospho-TOB1 (Ser164) Polyclonal Antibody (Product # PA5-37780) (left) or the same antibody preincubated with blocking peptide (right).
Product Details
PA5-37780
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of Serine 164(A-V-S(p)-P-T) derived from Human TOB1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2554388
Product Specific Information
A suggested positive control for Western blot is HeLa or A549 cells; suggested positive control for IHC is human brain tissue.
Target Information
This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC104792; MGC34446; proliferation-inducing gene 49; Protein Tob1; Transducer of erbB-2 1; transducer of erbB2; transducer of ERBB2, 1
Gene Aliases: APRO5; APRO6; PIG49; TOB; TOB1; TROB; TROB1
UniProt ID: (Human) P50616, (Mouse) Q61471
Entrez Gene ID: (Human) 10140, (Mouse) 22057, (Rat) 170842
SMAD protein import into nucleus
negative regulation of cell proliferation
negative regulation of translation
negative regulation of BMP signaling pathway
negative regulation of osteoblast differentiation
negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of nucleic acid-templated transcription
positive regulation of signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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