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Bioss
Phospho-TPH (Ser260) Polyclonal Antibody
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Product Details
BS-5601R
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide derived from human TPH around the phosphorylation site of Ser260.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin) (Martinez et al., 2001). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CAM K II) (Jiang et al., 2000; Johansen et al., 1996). Both PKA and CAM K II phosphorylate Ser58 which lies within the regulatory domain of TPH (Kuhn et al., 1997).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: indoleacetic acid-5-hydroxylase; L-tryptophan hydroxylase; MGC119994; Neuronal tryptophan hydroxylase; Tryptophan 5-hydroxylase 1; Tryptophan 5-hydroxylase 2; Tryptophan 5-monooxygenase 1; Tryptophan 5-monooxygenase 2; tryptophan hydroxylase (tryptophan 5-monooxygenase)
Gene Aliases: ADHD7; AU043594; NTPH; TPH; TPH1; TPH2; TPRH; TRPH
UniProt ID: (Human) P17752, (Human) Q8IWU9, (Mouse) P17532, (Rat) P09810, (Mouse) Q8CGV2, (Rat) Q8CGU9
Entrez Gene ID: (Human) 7166, (Human) 121278, (Mouse) 21990, (Rat) 24848, (Mouse) 216343, (Rat) 317675
tryptophan 5-monooxygenase activity
iron ion binding
amino acid binding
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
metal ion binding
molecular_function
circadian rhythm
aromatic amino acid family metabolic process
negative regulation of ossification
response to immobilization stress
serotonin biosynthetic process
positive regulation of fat cell differentiation
indolalkylamine biosynthetic process
bone remodeling
oxidation-reduction process
mammary gland alveolus development
response to activity
response to nutrient levels
response to estrogen
response to glucocorticoid
response to calcium ion
cellular response to lithium ion
serotonin biosynthetic process from tryptophan
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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