Invitrogen

Phospho-TRAF2 (Ser11) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-104673

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TRAF2(Accession Q12933), corresponding to amino acid residues around phosphorylated Ser11.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816148

Product Specific Information

Antibody detects endogenous levels of TRAF2 only when phosphorylated at Ser11.

Target Information

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase TRAF2; OTTHUMP00000064745; RING-type E3 ubiquitin transferase TRAF2; TNF receptor-associated factor 2; tumor necrosis factor type 2 receptor associated protein 3; Tumor necrosis factor type 2 receptor-associated protein 3

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Gene Aliases: AI325259; MGC:45012; TRAF2; TRAP; TRAP3

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UniProt ID: (Human) Q12933, (Mouse) P39429

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Entrez Gene ID: (Human) 7186, (Mouse) 22030, (Rat) 311786

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Function(s)
ubiquitin-protein transferase activity signal transducer activity tumor necrosis factor receptor binding CD40 receptor binding protein binding zinc ion binding ligase activity enzyme binding protein kinase binding protein phosphatase binding mitogen-activated protein kinase kinase kinase binding ubiquitin protein ligase binding thioesterase binding protein complex binding identical protein binding sphingolipid binding receptor binding lipid binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
Process(es)
positive regulation of T cell cytokine production protein complex assembly apoptotic process signal transduction activation of NF-kappaB-inducing kinase activity protein catabolic process positive regulation of interleukin-2 production tumor necrosis factor-mediated signaling pathway negative regulation of glial cell apoptotic process regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JUN kinase activity cellular protein complex assembly regulation of JNK cascade regulation of immunoglobulin secretion positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein heterooligomerization protein autoubiquitination protein homotrimerization protein K63-linked ubiquitination cellular response to nitric oxide positive regulation of protein homodimerization activity programmed necrotic cell death positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of I-kappaB phosphorylation positive regulation of extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic process I-kappaB kinase/NF-kappaB signaling regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death response to endoplasmic reticulum stress positive regulation of T cell activation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress death-inducing signaling complex assembly activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway negative regulation of neuron death regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
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