Product References
DLK-MAPK Signaling Coupled with DNA Damage Promotes Intrinsic Neurotoxicity Associated with Non-Mutated Tau.
Molecular neurobiology
Li S,Roy ER,Wang Y,Watkins T,Cao W
MN1020 was used in Immunocytochemistry to establish a cellular tauopathy model highly relevant to AD and identified a functional synergy between the DLK-MAPK axis and DNA damage response in the neuronal degenerative process.
Wed May 01 00:00:00 UTC 2024
Spatial characterization of tangle-bearing neurons and ghost tangles in the human inferior temporal gyrus with three-dimensional imaging.
Brain communications
Zwang TJ,Woost B,Bailey J,Hoglund Z,Richardson DS,Bennett RE,Hyman BT
MN1020 was used in Immunohistochemistry to find that ghost tangles are more likely to be found in cortical layers 3 and 5 (49/57), with a select few scattered across other layers 1, 2, 4 and 6.
Sat May 04 00:00:00 UTC 2024
Cell Cycle Reactivation, at the Start of Neurodegeneration, Induced by Forskolin and Aniline in Differentiated Neuroblastoma Cells.
International journal of molecular sciences
Sturiale V,Bruno F,Brancato D,D'Amico AG,Maugeri G,D'Agata V,Saccone S,Federico C
MN1020 was used in Immunocytochemistry to test the possible neuroprotective effects of natural molecules.
Thu Sep 21 00:00:00 UTC 2023
Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation.
The Journal of biological chemistry
Park G,Xu K,Chea L,Kim K,Safarta L,Song KH,Wu J,Park S,Min H,Hiramatsu N,Han J,Lin JH
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to identify small-molecule augmentation of protein kinase R-like endoplasmic reticulum kinase signaling as an attractive therapeutic strategy to treat tauopathies by preventing tau pathology.
Wed Feb 01 00:00:00 UTC 2023
Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases.
Acta neuropathologica
Manca M,Standke HG,Browne DF,Huntley ML,Thomas OR,Orrú CD,Hughson AG,Kim Y,Zhang J,Tatsuoka C,Zhu X,Hiniker A,Coughlin DG,Galasko D,Kraus A
MN1020 was used in Immunohistochemistry to further define disease subtypes.
Sat Jul 01 00:00:00 UTC 2023
Tau accumulation in degradative organelles is associated to lysosomal stress.
Scientific reports
Piovesana E,Magrin C,Ciccaldo M,Sola M,Bellotto M,Molinari M,Papin S,Paganetti P
MN1020 was used in Immunohistochemistry to show in human primary fibroblasts that Tau seeds isolated from the brain of Alzheimer's disease induce Tau accumulation in acidic degradative organelles and lysosomal stress.
Sat Oct 21 00:00:00 UTC 2023
Tau accumulation in degradative organelles is associated to lysosomal stress.
Scientific reports
Piovesana E,Magrin C,Ciccaldo M,Sola M,Bellotto M,Molinari M,Papin S,Paganetti P
MN1020 was used in Immunohistochemistry to show in human primary fibroblasts that Tau seeds isolated from the brain of Alzheimer's disease induce Tau accumulation in acidic degradative organelles and lysosomal stress.
Sat Oct 21 00:00:00 UTC 2023
Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells.
eLife
Cecon E,Oishi A,Luka M,Ndiaye-Lobry D,François A,Lescuyer M,Panayi F,Dam J,Machado P,Jockers R
MN1020 was used in Immunohistochemistry and Western Blotting to develop a series of inter- and intramolecular tau biosensors based on the highly sensitive Nanoluciferase (Nluc) binary technology (NanoBiT) able to monitor the pathological conformational change and self-interaction of tau in living cells.
Tue Mar 14 00:00:00 UTC 2023
Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells.
eLife
Cecon E,Oishi A,Luka M,Ndiaye-Lobry D,François A,Lescuyer M,Panayi F,Dam J,Machado P,Jockers R
MN1020 was used in Immunohistochemistry and Western Blotting to develop a series of inter- and intramolecular tau biosensors based on the highly sensitive Nanoluciferase (Nluc) binary technology (NanoBiT) able to monitor the pathological conformational change and self-interaction of tau in living cells.
Tue Mar 14 00:00:00 UTC 2023
Laser-Induced Axotomy of Human iPSC-Derived and Murine Primary Neurons Decreases Somatic Tau and AT8 Tau Phosphorylation: A Single-Cell Approach to Study Effects of Acute Axonal Damage.
Cellular and molecular neurobiology
Bell-Simons M,Buchholz S,Klimek J,Zempel H
MN1020 was used in Immunocytochemistry to develop a laser-based axotomy model suitable for studying the impact of different Tau sorting mechanisms in a highly controllable and reproducible setting, and we provide evidence that acute axon loss does not induce somatic Tau accumulation and AT8 Tau phosphorylation.
Sun Oct 01 00:00:00 UTC 2023
Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration.
Acta neuropathologica communications
Giannini LA,Mol MO,Rajicic A,van Buuren R,Sarkar L,Arezoumandan S,Ohm DT,Irwin DJ,Rozemuller AJ,van Swieten JC,Seelaar H
MN1020 was used in Immunohistochemistry to demonstrate that tau pathology and neuronal degeneration are present already at the presymptomatic/early-stage of FTLD-MAPT, though less severely compared to intermediate/end-stage disease.
Wed Aug 02 00:00:00 UTC 2023
Viral Entry Inhibitors Protect against SARS-CoV-2-Induced Neurite Shortening in Differentiated SH-SY5Y Cells.
Viruses
Mignolet M,Gilloteaux J,Halloin N,Gueibe M,Willemart K,De Swert K,Bielarz V,Suain V,Pastushenko I,Gillet NA,Nicaise C
MN1020 was used in Western Blot to characterize the associated cellular responses caused by a pre-alpha SARS-CoV-2 strain on differentiated SH-SY5Y and to prevent its cytopathic effect by using a set of entry inhibitors.
Thu Sep 28 00:00:00 UTC 2023
Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy.
Nature communications
Hussong SA,Banh AQ,Van Skike CE,Dorigatti AO,Hernandez SF,Hart MJ,Ferran B,Makhlouf H,Gaczynska M,Osmulski PA,McAllen SA,Dineley KT,Ungvari Z,Perez VI,Kayed R,Galvan V
MN1020 was used in Immunohistochemistry-immunofluorescence to suggest that soluble pathogenic tau aggregates mediate AD-like brain microvascular deficits in a mouse model of tauopathy, which may arise from endothelial cell senescence and eNOS dysfunction triggered by internalization of soluble tau aggregates.
Tue Apr 25 00:00:00 UTC 2023
Comparative assessment of regional tau distribution by Tau-PET and Post-mortem neuropathology in a representative set of Alzheimer's & frontotemporal lobar degeneration patients.
PloS one
Gatto RG,Carlos AF,Reichard RR,Lowe VJ,Whitwell JL,Josephs KA
MN1020 was used in Immunohistochemistry to compare regional flortaucipir PET uptake with tau burden using an anti-AT8 antibody.
Mon May 15 00:00:00 UTC 2023
A brainstem to circadian system circuit links Tau pathology to sundowning-related disturbances in an Alzheimer's disease mouse model.
Nature communications
Warfield AE,Gupta P,Ruhmann MM,Jeffs QL,Guidone GC,Rhymes HW,Thompson MI,Todd WD
MN1020 was used in Immunohistochemistry-immunofluorescence to examine Alzheimer's disease (AD)-related pathology and circadian dysfunction in the APPSwe-Tau (TAPP) model of AD.
Fri Aug 18 00:00:00 UTC 2023
Purified Serum IgG from a Patient with Anti-IgLON5 Antibody Cause Long-Term Movement Disorders with Impaired Dopaminergic Pathways in Mice.
Biomedicines
Gao Y,Li H,Luo H,Ni Y,Feng Y,He L,Zhou Q,Hu J,Chen S
MN1020 was used in Western Blot to explore the underlying mechanisms of movement disorders caused by anti-IgLON5 antibodies for the first time.
Thu Sep 07 00:00:00 UTC 2023
Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation.
Scientific reports
Williams D,Yan BQ,Wang H,Negm L,Sackmann C,Verkuyl C,Rezai-Stevens V,Eid S,Vediya N,Sato C,Watts JC,Wille H,Schmitt-Ulms G
MN1020 was used in Western Blotting to find that Sst had no influence on whole brain neprilysin transcript, protein or activity levels, an observation that cannot be accounted for by a compensatory upregulation of the Sst paralog, cortistatin (Cort), that we observed in 15-month-old Sst-deficient mice.
Thu Feb 09 00:00:00 UTC 2023
Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration.
Nature protocols
Kang YJ,Diep YN,Tran M,Tran VTA,Ambrin G,Ngo H,Cho H
MN1020 was used in Immunocytochemistry-immunofluorescence to show that our human BoCs serve as reliable and valuable platforms to investigate pathological mechanisms involving neuroinflammation and to assess therapeutic strategies modulating neuroinflammation in neurological disorders.
Fri Sep 01 00:00:00 UTC 2023
The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system.
Nature communications
Saha I,Yuste-Checa P,Da Silva Padilha M,Guo Q,Körner R,Holthusen H,Trinkaus VA,Dudanova I,Fernández-Busnadiego R,Baumeister W,Sanders DW,Gautam S,Diamond MI,Hartl FU,Hipp MS
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to identify VCP as a core component of the machinery for the removal of neurodegenerative disease aggregates and suggest that its activity can be associated with enhanced aggregate spreading in tauopathies.
Thu Feb 02 00:00:00 UTC 2023
Microstructural mapping of dentate gyrus pathology in Alzheimer's disease: A 16.4 Tesla MRI study.
NeuroImage. Clinical
Shih NC,Kurniawan ND,Cabeen RP,Korobkova L,Wong E,Chui HC,Clark KA,Miller CA,Hawes D,Jones KT,Sepehrband F
MN1020 was used in Immunohistochemistry to find that quantitative MRI measures were significantly correlated with neurofilament and phosphorylated Tau density, suggesting sensitivity to layer-specific changes in the DG of AD tissues.
Tue Mar 21 00:00:00 UTC 2023
Plasmon-activated water as a therapeutic strategy in Alzheimer's disease by altering gut microbiota.
Aging
Cheng CH,Liu YC,Yang YSH,Lin KJ,Wu D,Liu YR,Chang CC,Hong CT,Hu CJ
MN1020 was used in Immunohistochemistry-immunofluorescence to show the machinery of gut-brain axis, and plasmon-activated water might be a potential therapeutic strategy in Alzheimer's disease.
Mon May 08 00:00:00 UTC 2023
pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data.
The journal of pathology. Clinical research
Pattle SB,O'Shaughnessy J,Kantelberg O,Rifai OM,Pate J,Nellany K,Hays N,Arends MJ,Horrocks MH,Waldron FM,Gregory JM
MN1020 was used in Immunohistochemistry to identify pTDP-43 aggregates in multiple cell types of the GI tract from archivial surgiacal biposies of ALS patients, implying potential for early ALS diagnosis through the occult proteins.
Sun Jan 01 00:00:00 UTC 2023
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
Acta neuropathologica communications
Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P
MN1020 was used in Immunohistochemistry and Western Blotting to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.
Mon Jun 19 00:00:00 UTC 2023
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
Acta neuropathologica communications
Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P
MN1020 was used in Immunohistochemistry and Western Blotting to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.
Mon Jun 19 00:00:00 UTC 2023
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
Acta neuropathologica communications
Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P
MN1020 was used in Immunohistochemistry and Western Blotting to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.
Mon Jun 19 00:00:00 UTC 2023
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
Acta neuropathologica communications
Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P
MN1020 was used in Immunohistochemistry and Western Blotting to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.
Mon Jun 19 00:00:00 UTC 2023
Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer's disease.
Acta neuropathologica communications
Khan KM,Balasubramanian N,Gaudencio G,Wang R,Selvakumar GP,Kolling L,Pierson S,Tadinada SM,Abel T,Hefti M,Marcinkiewcz CA
MN1020 was used in Immunohistochemistry to suggest that tau pathology in brainstem monoaminergic nuclei and the resulting loss of serotonergic and/or noradrenergic drive may underpin depressive- and anxiety-like behaviors in the early stages of AD.
Mon Apr 03 00:00:00 UTC 2023
Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta.
Movement disorders : official journal of the Movement Disorder Society
Wang EW,Brown GL,Lewis MM,Jellen LC,Pu C,Johnson ML,Chen H,Kong L,Du G,Huang X
MN1020 was used in Immunohistochemistry to test whether susceptibility MRI metrics in parkinsonisms are associated with SNc neuropathologic features of dopaminergic neuron loss, gliosis, and α-synuclein and tau burden.
Wed Mar 01 00:00:00 UTC 2023
Ballooned neurons in semi-recent severe traumatic brain injury.
Acta neuropathologica communications
Michaud J,Plu I,Parai J,Bourgault A,Tanguay C,Seilhean D,Woulfe J
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to report the finding of ballooned neurons, predominantly in the anterior cingulum, in three patients who sustained severe TBI and remained comatose until death, 2 ½ weeks to 2 ½ months after the traumatic impact.
Fri Mar 10 00:00:00 UTC 2023
Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson's disease.
Cell reports
Schmit KJ,Garcia P,Sciortino A,Aho VTE,Pardo Rodriguez B,Thomas MH,Gérardy JJ,Bastero Acha I,Halder R,Cialini C,Heurtaux T,Ostahi I,Busi SB,Grandmougin L,Lowndes T,Singh Y,Martens EC,Mittelbronn M,Buttini M,Wilmes P
MN1020 was used in Immunohistochemistry to study whether fiber deprivation and exposure to bacterial curli, a protein cross-seeding with αSyn, individually or together, exacerbate disease in the enteric and central nervous systems of a transgenic PD mouse model.
Tue Sep 26 00:00:00 UTC 2023
Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity.
GeroScience
Arputhasamy C,Foulger AC,Lucanic M,Rane A,Schmidt M,Garrett T,Broussalian M,Battistoni E,Brem RB,Lithgow GJ,Chamoli M,Andersen JK
MN1020 was used in Western Blot to support the potential use of sodium polystyrene sulfonate as a prospective geroprotective intervention.
Sat Apr 01 00:00:00 UTC 2023
The mitochondrial protein TSPO in Alzheimer's disease: relation to the severity of AD pathology and the neuroinflammatory environment.
Journal of neuroinflammation
Garland EF,Dennett O,Lau LC,Chatelet DS,Bottlaender M,Nicoll JAR,Boche D
MN1020 was used in Immunohistochemistry to establish the neuroinflammatory differences between the temporal cortex and cerebellar cortex, including The 18kD translocator protein (TSPO) expression.
Mon Aug 14 00:00:00 UTC 2023
TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo.
Cells
Lee-Gosselin A,Jury-Garfe N,You Y,Dabin L,Soni D,Dutta S,Rochet JC,Kim J,Oblak AL,Lasagna-Reeves CA
MN1020 was used in Immunohistochemistry to investigate the effects of TREM2 deficiency on tau spreading using a mouse model in which endogenous tau is seeded to produce AD-like tau features.
Sat Jun 10 00:00:00 UTC 2023
Accurate digital quantification of tau pathology in progressive supranuclear palsy.
Acta neuropathologica communications
Pansuwan T,Quaegebeur A,Kaalund SS,Hidari E,Briggs M,Rowe JB,Rittman T
MN1020 was used in Immunohistochemistry to gain insights into the pathogenesis and progression of tauopathies.
Thu Nov 09 00:00:00 UTC 2023
The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities.
Molecular neurobiology
Brandimarti R,Irollo E,Meucci O
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to introduce a new method to limit APP misprocessing and its cellular consequences without directly targeting secretase activity, offering a novel tool to reduce cognitive decline in pathologies such as Alzheimer's disease and HIV-associated neurocognitive disorders.
Sat Apr 01 00:00:00 UTC 2023
Intraneuronal tau aggregation induces the integrated stress response in astrocytes.
Journal of molecular cell biology
Batenburg KL,Kasri NN,Heine VM,Scheper W
MN1020 was used in Immunocytochemistry to identify the astrocytic integrated stress response as a novel disease mechanism activated by intraneuronal tau aggregation.
Wed Mar 29 00:00:00 UTC 2023
Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer's disease.
GeroScience
Ballesteros-Álvarez J,Nguyen W,Sivapatham R,Rane A,Andersen JK
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate the effects of urolithin A (UA), a metabolite generated from ellagic acid via its metabolism by gut bacteria, as an autophagy activator with potential neuroprotective activity.
Sat Apr 01 00:00:00 UTC 2023
Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neuropathological Analysis of Human Brain Tissue.
Methods in molecular biology (Clifton, N.J.)
Latimer CS,Melief EJ,Ariza-Torres J,Howard K,Keen AR,Keene LM,Schantz AM,Sytsma TM,Wilson AM,Grabowski TJ,Darvas M,O'Connor KD,Nolan AL,Edlow BL,Mac Donald CL,Keene CD
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to describe our current protocols for the procurement and characterization of fixed brain tissue, to enable systematic and precisely targeted diagnoses, and describe the novel, quantitative molecular, and neuroanatomical studies that broadly expand the use of formalin-fixed, paraffin-embedded (FFPE) tissue that will further our understanding of the mechanisms underlying human neuropathologies.
Tue Nov 22 00:00:00 UTC 2022
Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy.
eLife
Casillas-Espinosa PM,Anderson A,Harutyunyan A,Li C,Lee J,Braine EL,Brady RD,Sun M,Huang C,Barlow CK,Shah AD,Schittenhelm RB,Mychasiuk R,Jones NC,Shultz SR,O'Brien TJ
MN1020 was used in Western Blot to provide evidence that treatment with sodium selenate results in a sustained disease-modifying effect in chronically epileptic rats in the post-KA SE model of TLE, including improved comorbid learning and memory deficits.
Thu Mar 09 00:00:00 UTC 2023
The relationship between hippocampal amyloid beta burden and spatial distribution of neurofibrillary degeneration.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Walker JM,Goette W,Farrell K,Iida MA,Karlovich E,White CL,Crary JF,Richardson TE
MN1020 was used in Immunohistochemistry-paraffin to indicate that the presence and extent of medial temporal lobe Aβ may determine the distribution and spread of neurofibrillary degeneration.
Sat Jul 01 00:00:00 UTC 2023
The Pesticide Chlordecone Promotes Parkinsonism-like Neurodegeneration with Tau Lesions in Midbrain Cultures and C. elegans Worms.
Cells
Parrales-Macias V,Michel PP,Tourville A,Raisman-Vozari R,Haïk S,Hunot S,Bizat N,Lannuzel A
MN1020 was used in Immunocytochemistry to promote atypical forms of Parkinsonism characterized by tau pathology than classical synucleinopathy-associated PD.
Sun May 07 00:00:00 UTC 2023
Differential vulnerability of the dentate gyrus to tauopathies in dementias.
Acta neuropathologica communications
Kawles A,Minogue G,Zouridakis A,Keszycki R,Gill N,Nassif C,Coventry C,Zhang H,Rogalski E,Flanagan ME,Castellani R,Bigio EH,Mesulam MM,Geula C,Gefen T
MN1020 was used in Immunohistochemistry to conclude that the DG is differentially vulnerable to pathologic tau accumulation, raising intriguing questions about the structural integrity and functional significance of hippocampal circuits in neurodegenerative dementias.
Tue Jan 03 00:00:00 UTC 2023
Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer's Disease-like Neuropathology in a Mouse Model for Down Syndrome.
Antioxidants (Basel, Switzerland)
Tramutola A,Lanzillotta S,Aceto G,Pagnotta S,Ruffolo G,Cifelli P,Marini F,Ripoli C,Palma E,Grassi C,Di Domenico F,Perluigi M,Barone E
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that KYCCSRK rescued insulin signaling activation, increased mitochondrial complexes levels (OXPHOS) and reduced oxidative stress levels in the brain of Ts2Cje mice.
Mon Jan 02 00:00:00 UTC 2023
Mutant β1-adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy.
Proceedings of the National Academy of Sciences of the United States of America
Dong Q,Ptáček LJ,Fu YH
MN1020 was used in Immunohistochemistry and Western Blotting to test the effect of another familial natural short sleep (FNSS) gene variant, Adrb1-A187V, by crossing mice with this mutation onto the PS19 background.
Tue Apr 11 00:00:00 UTC 2023
Mutant β1-adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy.
Proceedings of the National Academy of Sciences of the United States of America
Dong Q,Ptáček LJ,Fu YH
MN1020 was used in Immunohistochemistry and Western Blotting to test the effect of another familial natural short sleep (FNSS) gene variant, Adrb1-A187V, by crossing mice with this mutation onto the PS19 background.
Tue Apr 11 00:00:00 UTC 2023
Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection.
Brain pathology (Zurich, Switzerland)
Henao-Restrepo J,López-Murillo C,Valderrama-Carmona P,Orozco-Santa N,Gomez J,Gutiérrez-Vargas J,Moraga R,Toledo J,Littau JL,Härtel S,Arboleda-Velásquez JF,Sepulveda-Falla D,Lopera F,Cardona-Gómez GP,Villegas A,Posada-Duque R
MN1020 was used in Immunohistochemistry to provide new insights into the potential relevance of the gliovasculature in the development and protection of AD.
Wed Mar 01 00:00:00 UTC 2023
Cholinergic-like neurons and cerebral spheroids bearing the PSEN1 p.Ile416Thr variant mirror Alzheimer's disease neuropathology.
Scientific reports
Gomez-Sequeda N,Mendivil-Perez M,Jimenez-Del-Rio M,Lopera F,Velez-Pardo C
MN1020 was used in Immunocytochemistry to demonstrate that menstrual stromal cells (MenSCs)-derived planar (2D) PSEN 1 I416T cholinergic-like cells (ChLNS) and (3D) cerebral spheroids (CSs) reproduce the typical neuropathological markers of Familial Alzheimer's disease in 4 post-transdifferentiating or 11 days of transdifferentiating, respectively.
Tue Aug 08 00:00:00 UTC 2023
Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer's disease tau.
Cell & bioscience
Hromadkova L,Kim C,Haldiman T,Peng L,Zhu X,Cohen M,de Silva R,Safar JG
MN1020 was used in Immunohistochemistry (Paraffin) to demonstrate markedly different time courses of endogenous tau misfolding and differential patterns of post-synaptic alterations.
Mon Sep 18 00:00:00 UTC 2023
Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer's disease tau.
Cell & bioscience
Hromadkova L,Kim C,Haldiman T,Peng L,Zhu X,Cohen M,de Silva R,Safar JG
MN1020 was used in Immunohistochemistry (Paraffin) to demonstrate markedly different time courses of endogenous tau misfolding and differential patterns of post-synaptic alterations.
Mon Sep 18 00:00:00 UTC 2023
Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys.
Signal transduction and targeted therapy
Tu Z,Yan S,Han B,Li C,Liang W,Lin Y,Ding Y,Wei H,Wang L,Xu H,Ye J,Li B,Li S,Li XJ
MN1020 was used in Western Blot to demonstrate for the first time that tauopathy can trigger Aβ pathology in the primate spinal cord and provide new insight into the pathogenesis and treatment of tauopathy.
Fri Sep 22 00:00:00 UTC 2023
Moesin is an effector of tau-induced actin overstabilization, cell cycle activation, and neurotoxicity in Alzheimer's disease.
iScience
Beckmann A,Ramirez P,Gamez M,Gonzalez E,De Mange J,Bieniek KF,Ray WJ,Frost B
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to identify novel parallels between tauopathy and cancer.
Fri Mar 17 00:00:00 UTC 2023
Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: Possible implication for Alzheimer's disease.
Progress in neurobiology
Denechaud M,Geurs S,Comptdaer T,Bégard S,Garcia-Núñez A,Pechereau LA,Bouillet T,Vermeiren Y,De Deyn PP,Perbet R,Deramecourt V,Maurage CA,Vanderhaegen M,Vanuytven S,Lefebvre B,Bogaert E,Déglon N,Voet T,Colin M,Buée L,Dermaut B,Galas MC
MN1020 was used in Immunocytochemistry to propose a tau-dependent protective effect of neuronal cell cycle reactivation in AD brains and challenges the current view that the neuronal cell cycle is an early mediator of tau pathology.
Sat Apr 01 00:00:00 UTC 2023
Detection, visualization and quantification of protein complexes in human Alzheimer's disease brains using proximity ligation assay.
Scientific reports
Romero-Fernandez W,Carvajal-Tapia C,Prusky A,Katdare KA,Wang E,Shostak A,Ventura-Antunes L,Harmsen HJ,Lippmann ES,Fuxe K,MacGurn JA,Borroto-Escuela DO,Schrag MS
MN1020 was used in Proximity Ligation Assay (PLA) to refine PLA for use in human neuropathology, which has revealed a profound change in the distribution of ubiquitin in AD brain and its association with characteristic tau pathologies.
Mon Jul 24 00:00:00 UTC 2023
Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy brains.
Molecular psychiatry
Malarte ML,Gillberg PG,Kumar A,Bogdanovic N,Lemoine L,Nordberg A
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate different binding properties among the second-generation tau PET tracers, which may assist in further understanding of tau heterogeneity in AD versus non-AD tauopathies and suggests potential for development of pure selective 4R tau PET tracers.
Wed Mar 01 00:00:00 UTC 2023
RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.
Acta neuropathologica
Kim YA,Siddiqui T,Blaze J,Cosacak MI,Winters T,Kumar A,Tein E,Sproul AA,Teich AF,Bartolini F,Akbarian S,Kizil C,Hargus G,Santa-Maria I
MN1020 was used in Western Blot to indicate that neuronal NSun2 deficiency promotes dysregulation of miR-125b and tau phosphorylation in AD and highlights a novel avenue for therapeutic targeting.
Sun Jan 01 00:00:00 UTC 2023
Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.
Molecules (Basel, Switzerland)
Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S
MN1020 was used in Western Blotting and Immunohistochemsitry to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.
Mon May 08 00:00:00 UTC 2023
Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.
Molecules (Basel, Switzerland)
Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S
MN1020 was used in Western Blotting and Immunohistochemsitry to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.
Mon May 08 00:00:00 UTC 2023
Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.
Molecules (Basel, Switzerland)
Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S
MN1020 was used in Western Blotting and Immunohistochemsitry to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.
Mon May 08 00:00:00 UTC 2023
Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.
Molecules (Basel, Switzerland)
Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S
MN1020 was used in Western Blotting and Immunohistochemsitry to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.
Mon May 08 00:00:00 UTC 2023
Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer's disease.
Acta neuropathologica communications
Jang J,Yeo S,Baek S,Jung HJ,Lee MS,Choi SH,Choe Y
MN1020 was used in Immunohistochemistry to suggest that DNs in AD are initiated by the ectopic accumulation of EVs at the neuronal axon terminals, which is affected by neuronal primary cilia.
Mon Sep 04 00:00:00 UTC 2023
INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model.
iScience
Iguchi A,Takatori S,Kimura S,Muneto H,Wang K,Etani H,Ito G,Sato H,Hori Y,Sasaki J,Saito T,Saido TC,Ikezu T,Takai T,Sasaki T,Tomita T
MN1020 was used in Western Blotting to suggest that INPP5D acts downstream of TREM2/TYROBP to regulate the microglial barrier against Aβ toxicity, thereby modulates Aβ-dependent pathological conversion of tau.
Fri Apr 21 00:00:00 UTC 2023
Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline.
iScience
Jadiya P,Cohen HM,Kolmetzky DW,Kadam AA,Tomar D,Elrod JW
MN1020 was used in Western Blotting to demonstrate that loss of NCLX-dependent mCa2+ efflux alone is sufficient to induce an Alzheimer's disease-like pathology and highlights the promise of therapies targeting mCa2+ exchange.
Fri Mar 17 00:00:00 UTC 2023
Tau protein binds to the P53 E3 ubiquitin ligase MDM2.
Scientific reports
Sola M,Rendon-Angel A,Rojo Martinez V,Sgrignani J,Magrin C,Piovesana E,Cavalli A,Paganetti P,Papin S
MN1020 was used in Immunohistochemistry-immunofluorescence to report the existence in cells and brain of a Tau-MDM2 complex that, in vitro, exhibits reduced P53 ubiquitination activity in a manner sensitive to a Tau mutation.
Fri Jun 23 00:00:00 UTC 2023
Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer's disease hallmarks.
Aging cell
Dave N,Judd JM,Decker A,Winslow W,Sarette P,Villarreal Espinosa O,Tallino S,Bartholomew SK,Bilal A,Sandler J,McDonough I,Winstone JK,Blackwood EA,Glembotski C,Karr T,Velazquez R
MN1020 was used in Immunohistochemistry to highlight that dietary choline intake is necessary to prevent systems-wide organ pathology and reduce hallmark AD pathologies.
Wed Feb 01 00:00:00 UTC 2023
Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons.
eNeuro
Keefe AJ,Gabrych DR,Zhu Y,Vocadlo DJ,Silverman MA
MN1020 was used in Immunocytochemistry to investigate whether lysosomal trafficking in axons was altered by inhibition of glucocerebrosidase with the pharmacological agent Conduritol B Epoxide (CBE).
Sun Oct 01 00:00:00 UTC 2023
Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males.
Nature communications
Abou-El-Hassan H,Rezende RM,Izzy S,Gabriely G,Yahya T,Tatematsu BK,Habashy KJ,Lopes JR,de Oliveira GLV,Maghzi AH,Yin Z,Cox LM,Krishnan R,Butovsky O,Weiner HL
MN1020 was used in Immunohistochemistry to provide new insights on the role of different γδ T cell subsets after brain injury and lay down the principles for the development of targeted γδ T-cell-based therapy for TBI.
Tue Jul 18 00:00:00 UTC 2023
Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology.
Acta neuropathologica
Smith AM,Davey K,Tsartsalis S,Khozoie C,Fancy N,Tang SS,Liaptsi E,Weinert M,McGarry A,Muirhead RCJ,Gentleman S,Owen DR,Matthews PM
MN1020 was used in Western Blot to define roles that astrocytes and microglia play in Alzheimer's disease (AD) and characterise transcriptomes in astrocyte and microglia nuclei selectively enriched during isolation post-mortem from neuropathologically defined AD and control brains with a range of amyloid-beta and phospho-tau (pTau) pathology.
Sat Jan 01 00:00:00 UTC 2022
Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia.
Acta neuropathologica
Sepulveda-Falla D,Sanchez JS,Almeida MC,Boassa D,Acosta-Uribe J,Vila-Castelar C,Ramirez-Gomez L,Baena A,Aguillon D,Villalba-Moreno ND,Littau JL,Villegas A,Beach TG,White CL,Ellisman M,Krasemann S,Glatzel M,Johnson KA,Sperling RA,Reiman EM,Arboleda-Velasquez JF,Kosik KS,Lopera F,Quiroz YT
MN1020 was used in Immunohistochemistry to describe in vivo follow-up PET imaging and postmortem findings from an autosomal dominant Alzheimer's disease (ADAD) PSEN1 E280A carrier who was also homozygous for the APOE3 Christchurch (APOE3ch) variant and was protected against Alzheimer's symptoms for almost three decades beyond the expected age of onset.
Thu Sep 01 00:00:00 UTC 2022
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.
Brain : a journal of neurology
Peris L,Parato J,Qu X,Soleilhac JM,Lanté F,Kumar A,Pero ME,Martínez-Hernández J,Corrao C,Falivelli G,Payet F,Gory-Fauré S,Bosc C,Blanca Ramirez M,Sproul A,Brocard J,Di Cara B,Delagrange P,Buisson A,Goldberg Y,Moutin MJ,Bartolini F,Andrieux A
MN1020 was used in Immunohistochemistry to demonstrate that a balanced tyrosination/detyrosination tubulin cycle is necessary for the maintenance of synaptic plasticity, is protective against amyloid β peptide-induced synaptic damage, and that this balance is lost in Alzheimer's disease, providing evidence that defective tubulin retyrosination may contribute to circuit dysfunction during neurodegeneration in Alzheimer's disease.
Fri Jul 29 00:00:00 UTC 2022
Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.
Molecular therapy : the journal of the American Society of Gene Therapy
Danis C,Dupré E,Zejneli O,Caillierez R,Arrial A,Bégard S,Mortelecque J,Eddarkaoui S,Loyens A,Cantrelle FX,Hanoulle X,Rain JC,Colin M,Buée L,Landrieu I
MN1020 was used in Immunohistochemistry to show that VHH Z70, by targeting Tau inside brain neurons, where most of the pathological Tau resides, provides an immunological tool to target the intra-cellular compartment in tauopathies.
Wed Apr 06 00:00:00 UTC 2022
Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures.
Biological psychiatry
Kazim SF,Sharma A,Saroja SR,Seo JH,Larson CS,Ramakrishnan A,Wang M,Blitzer RD,Shen L,Peña CJ,Crary JF,Shimoda LA,Zhang B,Nestler EJ,Pereira AC
MN1020 was used in Immunohistochemistry to conclude that CIH-induced increase in pathologic human tau seeding and spread and exacerbation of other AD-related impairments provide new insights into the role of CIH and obstructive sleep apnea in AD pathogenesis.
Tue Feb 15 00:00:00 UTC 2022
Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway.
Aging cell
Jung ES,Suh K,Han J,Kim H,Kang HS,Choi WS,Mook-Jung I
MN1020 was used in Immunohistochemistry to suggest that repurposing of FA for inhibiting microglial activation of the NLRP3 inflammasome is a potential treatment for AD.
Sun May 01 00:00:00 UTC 2022
Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography.
European journal of nuclear medicine and molecular imaging
Vagenknecht P,Luzgin A,Ono M,Ji B,Higuchi M,Noain D,Maschio CA,Sobek J,Chen Z,Konietzko U,Gerez JA,Riek R,Razansky D,Klohs J,Nitsch RM,Dean-Ben XL,Ni R
MN1020 was used in Immunohistochemistry to demonstrate non-invasive whole-brain imaging of tau in P301L mice with vMSOT system using PBB5 at a previously unachieved ~ 115 µm spatial resolution.
Wed Jun 01 00:00:00 UTC 2022
Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease.
Cellular and molecular life sciences : CMLS
Marengo L,Armbrust F,Schoenherr C,Storck SE,Schmitt U,Zampar S,Wirths O,Altmeppen H,Glatzel M,Kaether C,Weggen S,Becker-Pauly C,Pietrzik CU
MN1020 was used in Immunohistochemistry (Paraffin) to report the generation of the transgenic APP/lon mouse model of AD lacking the Mep1b gene (APP/lon × Mep1b-/-).
Wed Mar 02 00:00:00 UTC 2022
Arterial spin labeling demonstrates preserved regional cerebral blood flow in the P301L mouse model of tauopathy.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Kindler D,Maschio C,Ni R,Zerbi V,Razansky D,Klohs J
MN1020 was used in Immunohistochemistry to investigate the role of tau in vascular dysfunction.
Fri Apr 01 00:00:00 UTC 2022
TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans.
Disease models & mechanisms
Latimer CS,Stair JG,Hincks JC,Currey HN,Bird TD,Keene CD,Kraemer BC,Liachko NF
MN1020 was used in Western Blot to study how the synergistic interactions among Aβ, tau, and TDP-43 may be responsible for worsened Alzheimer's disease outcomes.
Fri Apr 01 00:00:00 UTC 2022
Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation.
Frontiers in aging neuroscience
Jiang J,Yang C,Ai JQ,Zhang QL,Cai XL,Tu T,Wan L,Wang XS,Wang H,Pan A,Manavis J,Gai WP,Che C,Tu E,Wang XP,Li ZY,Yan XX
MN1020 was used in Immunohistochemistry, Immunocytochemistry to consider intraneuronal sortilin aggregation an aging/stress-related change implicating protein sorting deficit, which can activate protein clearance responses including via enhanced phosphorylation and hydrolysis, thereby promoting GVD, sorfra, and Tau pathogenesis, and ultimately, neuronal destruction and death.
Fri Aug 19 00:00:00 UTC 2022
Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation.
Frontiers in aging neuroscience
Jiang J,Yang C,Ai JQ,Zhang QL,Cai XL,Tu T,Wan L,Wang XS,Wang H,Pan A,Manavis J,Gai WP,Che C,Tu E,Wang XP,Li ZY,Yan XX
MN1020 was used in Immunohistochemistry, Immunocytochemistry to consider intraneuronal sortilin aggregation an aging/stress-related change implicating protein sorting deficit, which can activate protein clearance responses including via enhanced phosphorylation and hydrolysis, thereby promoting GVD, sorfra, and Tau pathogenesis, and ultimately, neuronal destruction and death.
Fri Aug 19 00:00:00 UTC 2022
Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy.
Frontiers in aging neuroscience
Mate V,Smolek T,Kazmerova ZV,Jadhav S,Brezovakova V,Jurkanin B,Uhrinova I,Basheer N,Zilka N,Katina S,Novak P
MN1020 was used in Immunohistochemistry to show that EE seems to be able to slow down tau pathology progression, indicating the possible utility of similar interventions in early stages of AD where tangle loads are still low.
Mon Sep 02 00:00:00 UTC 2024
Patient-Derived Fibroblasts With Presenilin-1 Mutations, That Model Aspects of Alzheimer's Disease Pathology, Constitute a Potential Object for Early Diagnosis.
Frontiers in aging neuroscience
Lopez-Toledo G,Silva-Lucero MD,Herrera-Díaz J,García DE,Arias-Montaño JA,Cardenas-Aguayo MD
MN1020 was used in Western Blotting to indicate that fibroblasts from patients with FAD-PS1 present alterations in signaling pathways related to cellular stress, autophagy, lysosomes, and tau phosphorylation.
Tue Jul 19 00:00:00 UTC 2022
Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer's Disease.
Molecular neurobiology
Fagan SG,Bechet S,Dev KK
MN1020 was used in Western Blot to investigate the action of the disease-modifying oral neuroimmunomodulatory therapeutic used in patients with multiple sclerosis, fingolimod, in the triple transgenic 3xTg-AD mouse model of Alzheimer's disease.
Tue Mar 01 00:00:00 UTC 2022
Long-Term Sequelae of COVID-19 in Experimental Mice.
Molecular neurobiology
Paidas MJ,Cosio DS,Ali S,Kenyon NS,Jayakumar AR
MN1020 was used in Immunohistochemistry-immunofluorescence to suggest that COVID-19 may result in long-term, irreversible changes predominantly in the brain, lung, and heart.
Sat Oct 01 00:00:00 UTC 2022
Borrelia burgdorferi Co-Localizing with Amyloid Markers in Alzheimer's Disease Brain Tissues.
Journal of Alzheimer's disease : JAD
Senejani AG,Maghsoudlou J,El-Zohiry D,Gaur G,Wawrzeniak K,Caravaglia C,Khatri VA,MacDonald A,Sapi E
MN1020 was used in Western Blot, Immunohistochemistry to provide evidence for a likely association between B. burgdorferi infections and biofilm formation, AD pathology, and chronic neurodegenerative diseases.
Mon Feb 28 00:00:00 UTC 2022
Borrelia burgdorferi Co-Localizing with Amyloid Markers in Alzheimer's Disease Brain Tissues.
Journal of Alzheimer's disease : JAD
Senejani AG,Maghsoudlou J,El-Zohiry D,Gaur G,Wawrzeniak K,Caravaglia C,Khatri VA,MacDonald A,Sapi E
MN1020 was used in Western Blot, Immunohistochemistry to provide evidence for a likely association between B. burgdorferi infections and biofilm formation, AD pathology, and chronic neurodegenerative diseases.
Mon Feb 28 00:00:00 UTC 2022
Pathological Nuclear Hallmarks in Dentate Granule Cells of Alzheimer's Patients: A Biphasic Regulation of Neurogenesis.
International journal of molecular sciences
Gil L,Chi-Ahumada E,Niño SA,Capdeville G,Méndez-Torres AM,Guerrero C,Rebolledo AB,Olazabal IM,Jiménez-Capdeville ME
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to find nuclear alterations in granular cells in autopsied human brains, detected by immunohistochemistry.
Tue Oct 25 00:00:00 UTC 2022
Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages.
Acta neuropathologica communications
Taddei RN,Sanchez-Mico MV,Bonnar O,Connors T,Gaona A,Denbow D,Frosch MP,Gómez-Isla T
MN1020 was used in Immunohistochemistry-immunofluorescence to suggest that changes in glial phenotypes in cortical and subcortical regions represent an early phenomenon that precedes overt tau deposition and likely contributes to cell damage and loss of brain function predicting the cognitive status of individuals at intermediate stages of tau aggregate burden (Braak III-IV).
Mon May 09 00:00:00 UTC 2022
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.
Cell stem cell
Capano LS,Sato C,Ficulle E,Yu A,Horie K,Kwon JS,Burbach KF,Barthélemy NR,Fox SG,Karch CM,Bateman RJ,Houlden H,Morimoto RI,Holtzman DM,Duff KE,Yoo AS
MN1020 was used in Immunocytochemistry to demonstrate the utility of miRNA-induced neuronal reprogramming to recapitulate endogenous tau regulation comparable with the adult brain in health and disease.
Thu Jun 02 00:00:00 UTC 2022
High altitude is associated with pTau deposition, neuroinflammation, and myelin loss.
Scientific reports
Iacono D,Murphy EK,Sherman PM,Chapapas H,Cerqueira B,Christensen C,Perl DP,Sladky J
MN1020 was used in Immunohistochemistry to illustrate, for the first time, changes occurring in large mammalian brains after exposure to nonhypoxic-hypobaria and open new pathophysiological views on the interaction among hypobaria, pTau accumulation, neuroinflammation, and myelination in large mammals exposed to HA.
Wed Apr 27 00:00:00 UTC 2022
Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau.
The Journal of biological chemistry
Wischhof L,Adhikari A,Mondal M,Marsal-Cots A,Biernat J,Mandelkow EM,Mandelkow E,Ehninger D,Nicotera P,Bano D
MN1020 was used in Immunoprecipitation, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that tau interacts with AHCYL1/IRBIT and potentially modulates AHCYL1/IRBIT function.
Fri Apr 01 00:00:00 UTC 2022
Altered low-frequency brain rhythms precede changes in gamma power during tauopathy.
iScience
Rodrigues FR,Papanikolaou A,Holeniewska J,Phillips KG,Saleem AB,Solomon SG
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to study how brain rhythms are affected in rTg4510 mouse model of tauopathy, at an early stage of tauopathy (5 months), and at a more advanced stage (8 months).
Fri Oct 21 00:00:00 UTC 2022
Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration.
Acta neuropathologica
Giannini LAA,Ohm DT,Rozemuller AJM,Dratch L,Suh E,van Deerlin VM,Trojanowski JQ,Lee EB,van Swieten JC,Grossman M,Seelaar H,Irwin DJ
MN1020 was used in Immunohistochemistry to study grey matter tau burden, its relation to neuronal degeneration, and regional patterns of pathology in different isoform groups of FTLD-MAPT.
Thu Dec 01 00:00:00 UTC 2022
Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.
Nature biomedical engineering
Xie C,Zhuang XX,Niu Z,Ai R,Lautrup S,Zheng S,Jiang Y,Han R,Gupta TS,Cao S,Lagartos-Donate MJ,Cai CZ,Xie LM,Caponio D,Wang WW,Schmauck-Medina T,Zhang J,Wang HL,Lou G,Xiao X,Zheng W,Palikaras K,Yang G,Caldwell KA,Caldwell GA,Shen HM,Nilsen H,Lu JH,Fang EF
MN1020 was used in Immunohistochemistry, Western Blot to report the combined use of unsupervised machine learning and a cross-species approach for the screening and experimental validation of new mitophagy-inducing compounds.
Sat Jan 01 00:00:00 UTC 2022
Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.
Nature biomedical engineering
Xie C,Zhuang XX,Niu Z,Ai R,Lautrup S,Zheng S,Jiang Y,Han R,Gupta TS,Cao S,Lagartos-Donate MJ,Cai CZ,Xie LM,Caponio D,Wang WW,Schmauck-Medina T,Zhang J,Wang HL,Lou G,Xiao X,Zheng W,Palikaras K,Yang G,Caldwell KA,Caldwell GA,Shen HM,Nilsen H,Lu JH,Fang EF
MN1020 was used in Immunohistochemistry, Western Blot to report the combined use of unsupervised machine learning and a cross-species approach for the screening and experimental validation of new mitophagy-inducing compounds.
Sat Jan 01 00:00:00 UTC 2022
Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.
Nature biomedical engineering
Xie C,Zhuang XX,Niu Z,Ai R,Lautrup S,Zheng S,Jiang Y,Han R,Gupta TS,Cao S,Lagartos-Donate MJ,Cai CZ,Xie LM,Caponio D,Wang WW,Schmauck-Medina T,Zhang J,Wang HL,Lou G,Xiao X,Zheng W,Palikaras K,Yang G,Caldwell KA,Caldwell GA,Shen HM,Nilsen H,Lu JH,Fang EF
MN1020 was used in Immunohistochemistry, Western Blot to report the combined use of unsupervised machine learning and a cross-species approach for the screening and experimental validation of new mitophagy-inducing compounds.
Sat Jan 01 00:00:00 UTC 2022
Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow.
Nature biomedical engineering
Xie C,Zhuang XX,Niu Z,Ai R,Lautrup S,Zheng S,Jiang Y,Han R,Gupta TS,Cao S,Lagartos-Donate MJ,Cai CZ,Xie LM,Caponio D,Wang WW,Schmauck-Medina T,Zhang J,Wang HL,Lou G,Xiao X,Zheng W,Palikaras K,Yang G,Caldwell KA,Caldwell GA,Shen HM,Nilsen H,Lu JH,Fang EF
MN1020 was used in Immunohistochemistry, Western Blot to report the combined use of unsupervised machine learning and a cross-species approach for the screening and experimental validation of new mitophagy-inducing compounds.
Sat Jan 01 00:00:00 UTC 2022
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease.
Acta neuropathologica communications
Chen S,Chang Y,Li L,Acosta D,Li Y,Guo Q,Wang C,Turkes E,Morrison C,Julian D,Hester ME,Scharre DW,Santiskulvong C,Song SX,Plummer JT,Serrano GE,Beach TG,Duff KE,Ma Q,Fu H
MN1020 was used in Immunohistochemistry-immunofluorescence to utilize the 10 Visium platform to define the spatial transcriptomic profile in both AD and control (CT) MTG.
Wed Dec 21 00:00:00 UTC 2022
Mutations in SORL1 and MTHFDL1 possibly contribute to the development of Alzheimer's disease in a multigenerational Colombian Family.
PloS one
Tejada Moreno JA,Villegas Lanau A,Madrigal Zapata L,Baena Pineda AY,Velez Hernandez J,Campo Nieto O,Soto Ospina A,Araque Marín P,Rishishwar L,Norris ET,Chande AT,Jordan IK,Bedoya Berrio G
MN1020 was used in Immunohistochemistry to evaluate a family of 97 members, spanning three generations, with a familiar AD, and without mutations in APP, PSEN1, or PSEN2.
Mon Nov 20 00:00:00 UTC 2023
Traumatic brain injury recapitulates developmental changes of axons.
Progress in neurobiology
Song H,Chen C,Kelley B,Tomasevich A,Lee H,Dolle JP,Cheng J,Garcia B,Meaney DF,Smith DH
MN1020 was used in Immunohistochemistry to examine axonal changes in the developing brain in young rats and after traumatic brain injury in adult rat.
Sat Oct 01 00:00:00 UTC 2022
Cognitive resilience to three dementia-related neuropathologies in an oldest-old man: A case report from The 90+ Study.
Neurobiology of aging
Melikyan ZA,Corrada MM,Leiby AM,Sajjadi SA,Bukhari S,Montine TJ,Kawas CH
MN1020 was used in Immunohistochemistry to describe the only participant of The 90+ Study, among 367 autopsies, who maintained normal cognition despite intermediate-high levels of 3 dementia-related neuropathologic changes, advanced age, and comorbidities associated with cognitive impairment.
Mon Aug 01 00:00:00 UTC 2022
Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV.
Brain : a journal of neurology
Di Liberto G,Egervari K,Kreutzfeldt M,Schürch CM,Hewer E,Wagner I,Du Pasquier R,Merkler D
MN1020 was used in Immunohistochemistry to elucidate some of the molecular signatures adopted by CNS phagocytes in HIV-positive patients and contribute to the understanding of how HIV might pave the way to other forms of cognitive decline in ageing HIV patient populations.
Sat Aug 27 00:00:00 UTC 2022
Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response.
Journal of neuroinflammation
Manet C,Mansuroglu Z,Conquet L,Bortolin V,Comptdaer T,Segrt H,Bourdon M,Menidjel R,Stadler N,Tian G,Herit F,Niedergang F,Souès S,Buée L,Galas MC,Montagutelli X,Bonnefoy E
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that ZIKV-infected mature neurons display an inability to stop viral replication in link with a delayed IFNB expression, accumulating pTau and overall reflecting tauopathy-like phenotype.
Tue Dec 20 00:00:00 UTC 2022
Long-Term Depression-Inducing Low Frequency Stimulation Enhances p-Tau181 and p-Tau217 in an Age-Dependent Manner in Live Rats.
Journal of Alzheimer's disease : JAD
Zhang Y,Yang Y,Hu Z,Zhu M,Qin S,Yu P,Li B,Xu J,Ondrejcak T,Klyubin I,Rowan MJ,Hu NW
MN1020 was used in Immunohistochemistry to uncover brain plasticity-related cellular and molecular processes of tau phosphorylation at key sites in health and aging.
Thu Sep 08 00:00:00 UTC 2022
Evidence of traumatic brain injury in headbutting bovids.
Acta neuropathologica
Ackermans NL,Varghese M,Williams TM,Grimaldi N,Selmanovic E,Alipour A,Balchandani P,Reidenberg JS,Hof PR
MN1020 was used in Immunohistochemistry-immunofluorescence to indicate that muskoxen and possibly other headbutting bovids suffer from chronic or acute brain trauma and that the males' thicker skulls may protect them to a certain extent.
Fri Jul 01 00:00:00 UTC 2022
Norovirus Intestinal Infection and Lewy Body Disease in an Older Patient with Acute Cognitive Impairment.
International journal of molecular sciences
Moreno-Valladares M,Moncho-Amor V,Bernal-Simon I,Agirre-Iturrioz E,Álvarez-Satta M,Matheu A
MN1020 was used in Immunohistochemistry to report a concomitant norovirus infection with synthesis of alpha-synuclein in the gastrointestinal mucosa and Lewy pathology in the CNS, which might support Braak's hypothesis about the pathogenic mechanisms underlying synucleinopathies.
Fri Jul 29 00:00:00 UTC 2022
Repetitive mild TBI causes pTau aggregation in nigra without altering preexisting fibril induced Parkinson's-like pathology burden.
Acta neuropathologica communications
Delic V,Karp JH,Guzman M,Arismendi GR,Stalnaker KJ,Burton JA,Murray KE,Stamos JP,Beck KD,Sokratian A,West AB,Citron BA
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that r-mTBI induced pTau aggregate deposition in dopaminergic neurons may create an environment conducive to aSyn pathology nucleation and may add to preexisting proteinaceous aggregate burden.
Sat Nov 26 00:00:00 UTC 2022
Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old.
Acta neuropathologica
Wang SJ,Guo Y,Ervin JF,Lusk JB,Luo S
MN1020 was used in Immunohistochemistry to compare the neuropathological associations of LATE-NC and contribution of LATE-NC to cognitive impairment between the oldest-old and younger-old.
Fri Jul 01 00:00:00 UTC 2022
REM Sleep Behavior Disorder and Visual Hallucinations in a Pathologically Confirmed Case of Corticobasal Degeneration.
Movement disorders clinical practice
Cullinane PW,Jaunmuktane Z,Lees AJ,Warner TT
MN1020 was used in Immunohistochemistry to show REM Sleep Behavior Disorder and Visual Hallucinations in a Pathologically Confirmed Case of Corticobasal Degeneration.
Fri Apr 01 00:00:00 UTC 2022
Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling.
Acta neuropathologica communications
Walker JM,Kazempour Dehkordi S,Fracassi A,Vanschoiack A,Pavenko A,Taglialatela G,Woltjer R,Richardson TE,Zare H,Orr ME
MN1020 was used in Immunohistochemistry (Paraffin) to investigate the protein expression differences comparing individuals with dementia and Alzheimer disease neuropathologic change to resilient individuals, using NanoString GeoMx™ Digital Spatial Profiler (DSP) technology.
Mon Feb 14 00:00:00 UTC 2022
Synthesis and Bioactivity Evaluation of a Novel 1,2,4-Oxadiazole Derivative in vitro and in 3×Tg Mice.
Drug design, development and therapy
Luo Z,Wang Y,Pang S,Gao S,Liu N,Gao X,Zhang L,Qi X,Yang Y,Zhang L
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate wyc-7-20 was potent in AD therapy.
Tue Oct 04 00:00:00 UTC 2022
A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency.
Cell reports. Medicine
Andersen OM,Bøgh N,Landau AM,Pløen GG,Jensen AMG,Monti G,Ulhøi BP,Nyengaard JR,Jacobsen KR,Jørgensen MM,Holm IE,Kristensen ML,Alstrup AKO,Hansen ESS,Teunissen CE,Breidenbach L,Droescher M,Liu Y,Pedersen HS,Callesen H,Luo Y,Bolund L,Brooks DJ,Laustsen C,Small SA,Mikkelsen LF,Sørensen CB
MN1020 was used in Immunohistochemistry (Paraffin) to provide functional support for the theory that SORL1 haploinsufficiency leads to endosome cytopathology with biofluid hallmarks of autosomal dominant AD.
Tue Sep 20 00:00:00 UTC 2022
Effects of toxic apolipoprotein E fragments on Tau phosphorylation and cognitive impairment in neonatal mice under sevoflurane anesthesia.
Brain and behavior
Yu Y,Yang M,Zhuang X,Pan J,Zhao Y,Yu Y
MN1020 was used in Western Blotting and Immunohistochemistry to suggest that elevated ApoE fragments rather than full-length ApoE might be one of the underlying mechanisms of age-dependent Tau phosphorylation and cognitive impairment in young mice following sevoflurane anesthesia.
Mon Aug 01 00:00:00 UTC 2022
Effects of toxic apolipoprotein E fragments on Tau phosphorylation and cognitive impairment in neonatal mice under sevoflurane anesthesia.
Brain and behavior
Yu Y,Yang M,Zhuang X,Pan J,Zhao Y,Yu Y
MN1020 was used in Western Blotting and Immunohistochemistry to suggest that elevated ApoE fragments rather than full-length ApoE might be one of the underlying mechanisms of age-dependent Tau phosphorylation and cognitive impairment in young mice following sevoflurane anesthesia.
Mon Aug 01 00:00:00 UTC 2022
Synaptosome microRNAs regulate synapse functions in Alzheimer's disease.
NPJ genomic medicine
Kumar S,Orlov E,Gowda P,Bose C,Swerdlow RH,Lahiri DK,Reddy PH
MN1020 was used in Western Blotting to describe synaptic versus cytosolic miRNAs in Alzheimer's disease and their significance in synapse function.
Mon Aug 08 00:00:00 UTC 2022
Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease.
Molecular neurodegeneration
Zhang G,Meng L,Wang Z,Peng Q,Chen G,Xiong J,Zhang Z
MN1020 was used in Immunohistochemistry (Paraffin) to examine the presence of islet amyloid polypeptide IAPP in the neurofibrillary tangles of Alzheimer's disease patients. Then test the effect of IAPP on tau aggregation.
Sat Jan 29 00:00:00 UTC 2022
Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease.
Molecular neurodegeneration
Zhang G,Meng L,Wang Z,Peng Q,Chen G,Xiong J,Zhang Z
MN1020 was used in Immunohistochemistry (Paraffin) to examine the presence of islet amyloid polypeptide IAPP in the neurofibrillary tangles of Alzheimer's disease patients. Then test the effect of IAPP on tau aggregation.
Sat Jan 29 00:00:00 UTC 2022
Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer's disease.
Molecular neurodegeneration
Zhang G,Meng L,Wang Z,Peng Q,Chen G,Xiong J,Zhang Z
MN1020 was used in Immunohistochemistry (Paraffin) to examine the presence of islet amyloid polypeptide IAPP in the neurofibrillary tangles of Alzheimer's disease patients. Then test the effect of IAPP on tau aggregation.
Sat Jan 29 00:00:00 UTC 2022
Association of plasma biomarkers of amyloid and neurodegeneration with cerebrovascular disease and Alzheimer's disease.
Neurobiology of aging
Graff-Radford J,Mielke MM,Hofrenning EI,Kouri N,Lesnick TG,Moloney CM,Rabinstein A,Cabrera-Rodriguez JN,Rothberg DM,Przybelski SA,Petersen RC,Knopman DS,Dickson DW,Jack CR,Algeciras-Schimnich A,Nguyen AT,Murray ME,Vemuri P
MN1020 was used in Immunohistochemistry to determine the differential mapping of plasma biomarkers to postmortem neuropathology measures.
Tue Nov 01 00:00:00 UTC 2022
Axonal degeneration in the anterior insular cortex is associated with Alzheimer's co-pathology in Parkinson's disease and dementia with Lewy bodies.
Translational neurodegeneration
Fathy YY,Jonkman LE,Bol JJ,Timmermans E,Jonker AJ,Rozemuller AJM,van de Berg WDJ
MN1020 was used in Immunohistochemistry-immunofluorescence to highlight the selective vulnerability of the anterior insular sub-regions to various converging pathologies, leading to impaired axonal integrity in PD, PDD and DLB, disrupting their functional properties and potentially contributing to cognitive, emotional, and autonomic deficits.
Wed Dec 07 00:00:00 UTC 2022
Tau protein is differentially phosphorylated in young- and old-aged rats with experimentally induced hyperthyroidism.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
Tan B,Babur E,Toy N,Günaydın B,Dursun N,Süer C
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to study long-term potentiation (LTP) and accompanying phosphorylation of Tau protein in different residues in the hippocampus of young and old rats with experimentally induced hyperthyroidism.
Tue Nov 01 00:00:00 UTC 2022
Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins.
Scientific reports
Suzuki C,Yamaguchi J,Sanada T,Oliva Trejo JA,Kakuta S,Shibata M,Tanida I,Uchiyama Y
MN1020 was used in Immunohistochemistry to propose thatt the CtsD-CKO mouse is a useful mouse model to investigate the contribution of cathepsin D to the early phases of neurodegenerative diseases in relation to lipofuscins, proteinopathy-related proteins and activation of microglia and astrocytes.
Fri Jul 08 00:00:00 UTC 2022
FSH blockade improves cognition in mice with Alzheimer's disease.
Nature
Xiong J,Kang SS,Wang Z,Liu X,Kuo TC,Korkmaz F,Padilla A,Miyashita S,Chan P,Zhang Z,Katsel P,Burgess J,Gumerova A,Ievleva K,Sant D,Yu SP,Muradova V,Frolinger T,Lizneva D,Iqbal J,Goosens KA,Gera S,Rosen CJ,Haroutunian V,Ryu V,Yuen T,Zaidi M,Ye K
MN1020 was used in Western Blotting and Immunohistochemistry to suggest a causal role for rising serum FSH levels in the exaggerated Alzheimer's disease pathophysiology during menopause, but also reveal an opportunity for treating Alzheimer's disease, obesity, osteoporosis and dyslipidaemia with a single FSH-blocking agent.
Tue Mar 01 00:00:00 UTC 2022
FSH blockade improves cognition in mice with Alzheimer's disease.
Nature
Xiong J,Kang SS,Wang Z,Liu X,Kuo TC,Korkmaz F,Padilla A,Miyashita S,Chan P,Zhang Z,Katsel P,Burgess J,Gumerova A,Ievleva K,Sant D,Yu SP,Muradova V,Frolinger T,Lizneva D,Iqbal J,Goosens KA,Gera S,Rosen CJ,Haroutunian V,Ryu V,Yuen T,Zaidi M,Ye K
MN1020 was used in Western Blotting and Immunohistochemistry to suggest a causal role for rising serum FSH levels in the exaggerated Alzheimer's disease pathophysiology during menopause, but also reveal an opportunity for treating Alzheimer's disease, obesity, osteoporosis and dyslipidaemia with a single FSH-blocking agent.
Tue Mar 01 00:00:00 UTC 2022
Tau nuclear translocation is a leading step in tau pathology process through P53 stabilization and nucleolar dispersion.
Journal of neuroscience research
Roqanian S,Ahmadian S,Nabavi SM,Pakdaman H,Shafiezadeh M,Goudarzi G,Shahpasand K
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that P-tau nuclear translocation results in p53-dependent apoptosis and nucleolar dispersion, which is consistent with neurodegeneration.
Fri Apr 01 00:00:00 UTC 2022
Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease.
Bioactive materials
Xu S,Yang P,Qian K,Li Y,Guo Q,Wang P,Meng R,Wu J,Cao J,Cheng Y,Xu M,Zhang Q
MN1020 was used in Western Blot, Immunohistochemistry to demonstrate a promising strategy to restore autophagic flux and improve neuronal proteostasis by rationally-engineered nano-systems for delaying the progression of AD.
Sun May 01 00:00:00 UTC 2022
Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease.
Bioactive materials
Xu S,Yang P,Qian K,Li Y,Guo Q,Wang P,Meng R,Wu J,Cao J,Cheng Y,Xu M,Zhang Q
MN1020 was used in Western Blot, Immunohistochemistry to demonstrate a promising strategy to restore autophagic flux and improve neuronal proteostasis by rationally-engineered nano-systems for delaying the progression of AD.
Sun May 01 00:00:00 UTC 2022
Biomarkers Analysis and Clinical Manifestations in Comorbid Creutzfeldt-Jakob Disease: A Retrospective Study in 215 Autopsy Cases.
Biomedicines
Jankovska N,Rusina R,Keller J,Kukal J,Bruzova M,Parobkova E,Olejar T,Matej R
MN1020 was used in Immunohistochemistry to conclude that comorbid neuropathologies can impact disease manifestation and can complicate the clinical diagnosis of Creutzfeldt-Jakob disease (CJD).
Wed Mar 16 00:00:00 UTC 2022
Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models.
Alzheimer's research & therapy
Lee HY,Yoon S,Lee JH,Park K,Jung Y,Cho I,Lee D,Shin J,Kim K,Kim S,Kim J,Kim K,Han SH,Kim SM,Kim HJ,Kim HY,Kim I,Kim YS
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that YIAD002 interferes with intermolecular ß-sheet fibrillation by directly interacting with KLVFFA and IGLMVG domains of Aß.
Tue Nov 29 00:00:00 UTC 2022
Independent distribution between tauopathy secondary to subacute sclerotic panencephalitis and measles virus: An immunohistochemical analysis in autopsy cases including cases treated with aggressive antiviral therapies.
Brain pathology (Zurich, Switzerland)
Miyahara H,Akagi A,Riku Y,Sone J,Otsuka Y,Sakai M,Kuru S,Hasegawa M,Yoshida M,Kakita A,Iwasaki Y
MN1020 was used in Immunohistochemistry to investigate the efficacy of antiviral therapies on Subacute sclerotic panencephalitis patients.
Tue Nov 01 00:00:00 UTC 2022
Trem2 deletion enhances tau dispersion and pathology through microglia exosomes.
Molecular neurodegeneration
Zhu B,Liu Y,Hwang S,Archuleta K,Huang H,Campos A,Murad R,Piña-Crespo J,Xu H,Huang TY
MN1020 was used in Immunohistochemistry to reveal a role for Trem2 in suppressing exosomal tau pathogenicity, and demonstrates that Trem2 deletion can enhance tau trafficking, distribution and seeding through microglial exosomes.
Fri Sep 02 00:00:00 UTC 2022
Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model.
Nature communications
Rickner HD,Jiang L,Hong R,O'Neill NK,Mojica CA,Snyder BJ,Zhang L,Shaw D,Medalla M,Wolozin B,Cheng CS
MN1020 was used in Simple Western - Size to conclude that treatment with the HSP90 inhibitor PU-H71 is used to address the putative dysfunctional HSP chaperone system and produces a strong reduction of pathology and neurodegeneration, highlighting the potential of AstTau as a rapid and reproducible tool for drug discovery.
Fri Oct 21 00:00:00 UTC 2022
Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model.
Nature communications
Rickner HD,Jiang L,Hong R,O'Neill NK,Mojica CA,Snyder BJ,Zhang L,Shaw D,Medalla M,Wolozin B,Cheng CS
MN1020 was used in Simple Western - Size to conclude that treatment with the HSP90 inhibitor PU-H71 is used to address the putative dysfunctional HSP chaperone system and produces a strong reduction of pathology and neurodegeneration, highlighting the potential of AstTau as a rapid and reproducible tool for drug discovery.
Fri Oct 21 00:00:00 UTC 2022
Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease.
Acta neuropathologica communications
Wander CM,Tsujimoto THM,Ervin JF,Wang C,Maranto SM,Bhat V,Dallmeier JD,Wang SJ,Lin FC,Scott WK,Holtzman DM,Cohen TJ
MN1020 was used in Immunohistochemistry to investigate the link between Corpora amylacea and age-related neurodegenerative diseases, particularly Alzheimer's disease (AD).
Mon Aug 08 00:00:00 UTC 2022
Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models.
Cell reports
Rangan P,Lobo F,Parrella E,Rochette N,Morselli M,Stephen TL,Cremonini AL,Tagliafico L,Persia A,Caffa I,Monacelli F,Odetti P,Bonfiglio T,Nencioni A,Pigliautile M,Boccardi V,Mecocci P,Pike CJ,Cohen P,LaDu MJ,Pellegrini M,Xia K,Tran K,Ann B,Chowdhury D,Longo VD
MN1020 was used in Immunohistochemistry to we show that fasting-mimicking diet cycles reduce cognitive decline and Alzheimer's disease (AD) pathology in E4FAD and 3xTg AD mouse models, with effects superior to those caused by protein restriction cycles.
Tue Sep 27 00:00:00 UTC 2022
Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons.
Frontiers in molecular neuroscience
Sabui A,Biswas M,Somvanshi PR,Kandagiri P,Gorla M,Mohammed F,Tammineni P
MN1020 was used in Western Blotting to indicate that decreased kinesin-mediated transport coupled with sustained retrograde transport might reduce axonal mitochondria in tauopathy neurons, thus contributing to the synaptic deficits in Alzheimer's disease (AD) and other tauopathies.
Wed Oct 19 00:00:00 UTC 2022
Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons.
Frontiers in molecular neuroscience
Sabui A,Biswas M,Somvanshi PR,Kandagiri P,Gorla M,Mohammed F,Tammineni P
MN1020 was used in Western Blotting to indicate that decreased kinesin-mediated transport coupled with sustained retrograde transport might reduce axonal mitochondria in tauopathy neurons, thus contributing to the synaptic deficits in Alzheimer's disease (AD) and other tauopathies.
Wed Oct 19 00:00:00 UTC 2022
Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer's disease.
Neuron
Otero-Garcia M,Mahajani SU,Wakhloo D,Tang W,Xue YQ,Morabito S,Pan J,Oberhauser J,Madira AE,Shakouri T,Deng Y,Allison T,He Z,Lowry WE,Kawaguchi R,Swarup V,Cobos I
MN1020 was used in Flow Cytometry to demonstrate methods for the high-throughput isolation and transcriptome profiling of single somas with NFTs from the human Alzheimer's disease (AD) brain, quantify the susceptibility of 20 neocortical subtypes for NFT formation and death, and identify both shared and cell-type-specific signatures.
Wed Sep 21 00:00:00 UTC 2022
SYK coordinates neuroprotective microglial responses in neurodegenerative disease.
Cell
Ennerfelt H,Frost EL,Shapiro DA,Holliday C,Zengeler KE,Voithofer G,Bolte AC,Lammert CR,Kulas JA,Ulland TK,Lukens JR
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to study the critical intracellular molecules that orchestrate neuroprotective functions of microglia.
Thu Oct 27 00:00:00 UTC 2022
Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model.
iScience
Manos JD,Preiss CN,Venkat N,Tamm J,Reinhardt P,Kwon T,Wu J,Winter AD,Jahn TR,Yanamandra K,Titterton K,Karran E,Langlois X
MN1020 was used in Immunocytochemistry to define the minimal requirements to achieve endogenous tau aggregation in functional neurons utilizing human induced pluripotent stem cell (hiPSC) technology.
Fri Jan 21 00:00:00 UTC 2022
Mice expressing P301S mutant human tau have deficits in interval timing.
Behavioural brain research
Larson T,Khandelwal V,Weber MA,Leidinger MR,Meyerholz DK,Narayanan NS,Zhang Q
MN1020 was used in Immunohistochemistry to evaluate interval timing performance of P301S transgenic mice, a widely studied model of tauopathy that overexpresses human tau with the P301S mutation.
Fri Aug 26 00:00:00 UTC 2022
Differential expression of tau species and the association with cognitive decline and synaptic loss in Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Saroja SR,Sharma A,Hof PR,Pereira AC
MN1020 was used in Western Blotting to propose that tau species from NFT-predominant tissues possess greater levels of degenerative properties, thereby causing synaptic loss and cognitive decline.
Thu Sep 01 00:00:00 UTC 2022
Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice.
The European journal of neuroscience
Lyons CE,Zhou X,Razzoli M,Chen M,Xia W,Ashe K,Zhang B,Bartolomucci A
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to compare the differentially expressed proteins (DEPs) of subordinate mice to those of patients at varying stages of dementia.
Sun May 01 00:00:00 UTC 2022
Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice.
The European journal of neuroscience
Lyons CE,Zhou X,Razzoli M,Chen M,Xia W,Ashe K,Zhang B,Bartolomucci A
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to compare the differentially expressed proteins (DEPs) of subordinate mice to those of patients at varying stages of dementia.
Sun May 01 00:00:00 UTC 2022
Neural stem cell transplantation alleviates functional cognitive deficits in a mouse model of tauopathy.
Neural regeneration research
Zhang HA,Yuan CX,Liu KF,Yang QF,Zhao J,Li H,Yang QH,Song D,Quan ZZ,Qing H
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to reveal that NSC transplantation reduced the abnormal aggregation of tau, resulting in significant improvements in the short-term memory of the tauopathy model mice.
Sat Jan 01 00:00:00 UTC 2022
Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis.
Molecular biology of the cell
Samluk L,Ostapczuk P,Dziembowska M
MN1020 was used in Western Blotting to indicate that long-term mitochondrial stress may induce early steps of Tau protein aggregation by affecting oxidative balance and cellular proteostasis.
Fri Jul 01 00:00:00 UTC 2022
Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation.
CNS neuroscience & therapeutics
Li L,Miao J,Chu D,Jin N,Tung YC,Dai CL,Hu W,Gong CX,Iqbal K,Liu F
MN1020 was used in Immunohistochemistry and Western Blotting to indicate that 77G7 can effectively suppress the seeding activity of AD O-tau and thus could be developed as a potential immunotherapeutic drug to inhibit the propagation of tau pathology in AD and related tauopathies.
Thu Dec 01 00:00:00 UTC 2022
Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation.
CNS neuroscience & therapeutics
Li L,Miao J,Chu D,Jin N,Tung YC,Dai CL,Hu W,Gong CX,Iqbal K,Liu F
MN1020 was used in Immunohistochemistry and Western Blotting to indicate that 77G7 can effectively suppress the seeding activity of AD O-tau and thus could be developed as a potential immunotherapeutic drug to inhibit the propagation of tau pathology in AD and related tauopathies.
Thu Dec 01 00:00:00 UTC 2022
Association of Retromer Deficiency and Tau Pathology in Down Syndrome.
Annals of neurology
Curtis ME,Smith T,Yu D,Praticò D
MN1020 was used in Western Blotting to investigate retromer deficiency in Down syndrome.
Fri Apr 01 00:00:00 UTC 2022
Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration.
Neuron
Adaikkan C,Wang J,Abdelaal K,Middleton SJ,Bozzelli PL,Wickersham IR,McHugh TJ,Tsai LH
MN1020 was used in Immunohistochemistry to reveal a hitherto uncharacterized CH circuit in the visual cortex, establishing a causal link between this circuit and novelty discrimination behavior and highlighting its impairment in mouse models of neurodegeneration.
Wed Oct 05 00:00:00 UTC 2022
Prevalence of chronic traumatic encephalopathy in the Sydney Brain Bank.
Brain communications
McCann H,Bahar AY,Burkhardt K,Gardner AJ,Halliday GM,Iverson GL,Shepherd CE
MN1020 was used in Immunohistochemistry to suggest that isolated traumatic brain injury in the general population is unlikely to cause chronic traumatic encephalopathy neuropathologic change but may be associated with increased brain ageing.
Sat Aug 13 00:00:00 UTC 2022
The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer's Pathogenesis via Specific Pathways.
Frontiers in aging neuroscience
Wu H,Qiu W,Zhu X,Li X,Xie Z,Carreras I,Dedeoglu A,Van Dyke T,Han YW,Karimbux N,Tu Q,Cheng L,Chen J
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to identify the pathways through which F. nucleatum modulates molecular elements in enhancing AD symptoms and signs.
Sat Aug 31 00:00:00 UTC 2024
The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer's Pathogenesis via Specific Pathways.
Frontiers in aging neuroscience
Wu H,Qiu W,Zhu X,Li X,Xie Z,Carreras I,Dedeoglu A,Van Dyke T,Han YW,Karimbux N,Tu Q,Cheng L,Chen J
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to identify the pathways through which F. nucleatum modulates molecular elements in enhancing AD symptoms and signs.
Sat Aug 31 00:00:00 UTC 2024
Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease.
Journal of neuroinflammation
Muñoz-Castro C,Noori A,Magdamo CG,Li Z,Marks JD,Frosch MP,Das S,Hyman BT,Serrano-Pozo A
MN1020 was used in Immunohistochemistry to enable a comprehensive morphological quantitative characterization of astrocytes and microglia in the context of their spatial relationships with plaques and tangles.
Wed Feb 02 00:00:00 UTC 2022
Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Steuer EL,Kemper LJ,Hlynialuk CJW,Leinonen-Wright K,Montonye ML,Lapcinski IP,Forster CL,Ashe KH,Liu P
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that htau transgene expression occurs primarily in the forebrain at similar levels in rT2 and rT3 mice.
Wed Jun 08 00:00:00 UTC 2022
Tau Pathology in Chronic Traumatic Encephalopathy is Primarily Neuronal.
Journal of neuropathology and experimental neurology
Butler MLMD,Dixon E,Stein TD,Alvarez VE,Huber B,Buckland ME,McKee AC,Cherry JD
MN1020 was used in Immunohistochemistry-immunofluorescence to support neuronal degeneration as a driving feature of CTE and will help inform future research and the development of fluid biomarkers for the detection of neuronal degeneration in CTE.
Mon Sep 19 00:00:00 UTC 2022
Downregulating PTBP1 Fails to Convert Astrocytes into Hippocampal Neurons and to Alleviate Symptoms in Alzheimer's Mouse Models.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Guo T,Pan X,Jiang G,Zhang D,Qi J,Shao L,Wang Z,Xu H,Zhao Y
MN1020 was used in Immunohistochemistry-immunofluorescence to suggest that cell fate conversion strategy for neurodegenerative disease therapy through manipulating one single gene, such as PTBP1, warrants more rigorous scrutiny.
Wed Sep 21 00:00:00 UTC 2022
Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer's disease in TgF344-AD rats.
Alzheimer's research & therapy
van den Berg M,Adhikari MH,Verschuuren M,Pintelon I,Vasilkovska T,Van Audekerke J,Missault S,Heymans L,Ponsaerts P,De Vos WH,Van der Linden A,Keliris GA,Verhoye M
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate how whole-brain networks are influenced at pre- and early-plague stages of AD and if these manifestations are associated with concomitant cellular and synaptic deficits.
Mon Oct 10 00:00:00 UTC 2022
Three-dimensional-engineered bioprinted in vitro human neural stem cell self-assembling culture model constructs of Alzheimer's disease.
Bioactive materials
Zhang Y,Chen H,Long X,Xu T
MN1020 was used in Immunohistochemistry to develop 3D core-shell Alzheimer's disease model to investigate pathogenic cascade of Alzheimer's disease (AD) characterized by amyloid-β protein accumulation.
Sun May 01 00:00:00 UTC 2022
Differential Vulnerability of Hippocampal Subfields in Primary Age-Related Tauopathy and Chronic Traumatic Encephalopathy.
Journal of neuropathology and experimental neurology
Farrell K,Iida MA,Cherry JD,Casella A,Stein TD,Bieniek KF,Walker JM,Richardson TE,White CL,Alvarez VE,Huber BR,Dickson DW,Insausti R,Dams-O'Connor K,McKee AC,Crary JF
MN1020 was used in Immunohistochemistry to demonstrate differences in hippocampal p-tau burden and regional distribution in CTE compared to PART that might be helpful in differential diagnosis and reveal insights into disease pathogenesis.
Mon Sep 19 00:00:00 UTC 2022
Alzheimer PHF-tau aggregates do not spread tau pathology to the brain via the Retino-tectal projection after intraocular injection in male mouse models.
Neurobiology of disease
de Fisenne MA,Yilmaz Z,De Decker R,Suain V,Buée L,Ando K,Brion JP,Leroy K
MN1020 was used in Western Blotting to suggest that retinal ganglion cells exhibit a resistance to develop a tau pathology, and that eye surgery is not a major iatrogenic risk of transmission of tau pathology, contrary to what has been observed for transmission of infectious prions in prion diseases.
Tue Nov 01 00:00:00 UTC 2022
A surrogate marker for very early-stage tau pathology is detectable by molecular magnetic resonance imaging.
Theranostics
Parekh P,Mu Q,Badachhape A,Bhavane R,Srivastava M,Devkota L,Sun X,Bhandari P,Eriksen JL,Tanifum E,Ghaghada K,Annapragada A
MN1020 was used in Immunohistochemistry to hypothesize that hyperphosphorylative conditions may result in unique cell surface markers.
Tue Aug 02 00:00:00 UTC 2022
Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease.
Neurobiology of aging
Dahl MJ,Mather M,Werkle-Bergner M,Kennedy BL,Guzman S,Hurth K,Miller CA,Qiao Y,Shi Y,Chui HC,Ringman JM
MN1020 was used in Immunohistochemistry to find lower rostral locus coeruleus integrity in symptomatic participants.
Fri Apr 01 00:00:00 UTC 2022
Alpha-synuclein and tau are abundantly expressed in the ENS of the human appendix and monkey cecum.
PloS one
Zinnen AD,Vichich J,Metzger JM,Gambardella JC,Bondarenko V,Simmons HA,Emborg ME
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to provide critical translational evidence that the common marmoset and rhesus macaque ceca are remarkably similar to the human appendix and, thus, that these NHP species are suitable for studying the development of PD linked to a-syn and tau pathological changes in the ENS.
Tue Jun 14 00:00:00 UTC 2022
Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement system.
Neural regeneration research
Zhu XC,Liu L,Dai WZ,Ma T
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that Crry silencing in the P301S mouse model reduces tau protein phosphorylation by reducing the levels of neuroinflammation and complement components, thereby improving cognitive function.
Mon Aug 01 00:00:00 UTC 2022
Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement system.
Neural regeneration research
Zhu XC,Liu L,Dai WZ,Ma T
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that Crry silencing in the P301S mouse model reduces tau protein phosphorylation by reducing the levels of neuroinflammation and complement components, thereby improving cognitive function.
Mon Aug 01 00:00:00 UTC 2022
HIV and FIV glycoproteins increase cellular tau pathology via cGMP-dependent kinase II activation.
Journal of cell science
Sathler MF,Doolittle MJ,Cockrell JA,Nadalin IR,Hofmann F,VandeWoude S,Kim S
MN1020 was used in Western Blotting to reveal that viral glycoprotein-induced cellular tau pathology requires cGKII activation.
Wed Jun 15 00:00:00 UTC 2022
Proteomic Assessment of C57BL/6 Hippocampi after Non-Selective Pharmacological Inhibition of Nitric Oxide Synthase Activity: Implications of Seizure-like Neuronal Hyperexcitability Followed by Tauopathy.
Biomedicines
Hendrickx JO,Adams C,Sieben A,Laukens K,Van Dam D,De Meyer GRY
MN1020 was used in Immunohistochemistry to investigate the progressive molecular signatures in hippocampal tissue via LC-MS/MS proteomic analysis.
Fri Jul 22 00:00:00 UTC 2022
APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons.
Molecular psychiatry
Wu CI,Vinton EA,Pearse RV,Heo K,Aylward AJ,Hsieh YC,Bi Y,Adeleye S,Fancher S,Duong DM,Seyfried NT,Schwarz TL,Young-Pearse TL
MN1020 was used in Western Blotting to provide insights into the initial molecular alterations within neurons that ultimately lead to synaptic loss and axonal degeneration in Down syndrome and early-onset AD. © 2022.
Fri Apr 01 00:00:00 UTC 2022
Nuclear and cellular, micro and nano calcification in Alzheimer's disease patients and correlation to phosphorylated Tau.
Acta biomaterialia
Tsolaki E,Csincsik L,Xue J,Lengyel I,Bertazzo S
MN1020 was used in Immunohistochemistry to show here that AD patients' brains present microcalcification associated with the neuronal cell nuclei and cell projections, and that these are related to the presence of pTau.
Fri Apr 15 00:00:00 UTC 2022
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Molecular neurodegeneration
Xia D,Lianoglou S,Sandmann T,Calvert M,Suh JH,Thomsen E,Dugas J,Pizzo ME,DeVos SL,Earr TK,Lin CC,Davis S,Ha C,Leung AW,Nguyen H,Chau R,Yulyaningsih E,Lopez I,Solanoy H,Masoud ST,Liang CC,Lin K,Astarita G,Khoury N,Zuchero JY,Thorne RG,Shen K,Miller S,Palop JJ,Garceau D,Sasner M,Whitesell JD,Harris JA,Hummel S,Gnörich J,Wind K,Kunze L,Zatcepin A,Brendel M,Willem M,Haass C,Barnett D,Zimmer TS,Orr AG,Scearce-Levie K,Lewcock JW,Di Paolo G,Sanchez PE
MN1020 was used in Immunohistochemistry-immunofluorescence to demonstrate that fibrillar Aβ in microglia is associated with lipid dyshomeostasis consistent with lysosomal dysfunction and foam cell phenotypes as well as profound immuno-metabolic perturbations, opening new avenues to further investigate metabolic pathways at play in microglia responding to AD-relevant pathogenesis.
Sat Jun 11 00:00:00 UTC 2022
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation.
Nature structural & molecular biology
Kang SS,Meng L,Zhang X,Wu Z,Mancieri A,Xie B,Liu X,Weinshenker D,Peng J,Zhang Z,Ye K
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that DOPEGAL, a monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE), reacts directly with the primary amine on the Lys353 residue of tau to stimulate its aggregation and facilitate its propagation.
Fri Apr 01 00:00:00 UTC 2022
Preferential Involvement of BRCA1/BARD1, Not Tip60/Fe65, in DNA Double-Strand Break Repair in Presenilin-1 P117L Alzheimer Models.
Neural plasticity
Authiat MM,Gruz-Gibelli E,Colas J,Bianchi E,Garcia-Arauzo M,Marin P,Herrmann FR,Savioz A
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate DSBs in cells and murine models of Alzheimer's disease carrying the preseniline-1 (PS1) P117L mutation and suggest that at earlier stages of the disease, similarly to PS1 P117L cells, a compensatory mechanism exists that decreases DSB levels via an activation of the BRCA1/BARD1 pathway.
Thu Apr 07 00:00:00 UTC 2022
P38 initiates degeneration of midbrain GABAergic and glutamatergic neurons in diabetes models.
The European journal of neuroscience
Farhadi A,Totonchi M,Nabavi SM,Baharvand H,Pakdaman H,Hajizadeh-Saffar E,Mousavi SA,Hadi F,Al-Sinawi H,Li Q,Zhang JS,Tahamtani Y,Shahpasand K
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to elucidate accumulation of cis P-tau in midbrain and corpus callosum, and establish P38 as a central mediator of diabetes mellitus-induced tau pathology.
Fri Jul 01 00:00:00 UTC 2022
The Interplay between GSK3β and Tau Ser262 Phosphorylation during the Progression of Tau Pathology.
International journal of molecular sciences
Song L,Oseid DE,Wells EA,Robinson AS
MN1020 was used in Immunocytochemistry to investigate the effect of glycogen synthase kinase 3β (GSK3β) on tau pathology.
Sat Oct 01 00:00:00 UTC 2022
The Interplay between GSK3β and Tau Ser262 Phosphorylation during the Progression of Tau Pathology.
International journal of molecular sciences
Song L,Oseid DE,Wells EA,Robinson AS
MN1020 was used in Immunocytochemistry to investigate the effect of glycogen synthase kinase 3β (GSK3β) on tau pathology.
Sat Oct 01 00:00:00 UTC 2022
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.
ACS chemical neuroscience
Permanne B,Sand A,Ousson S,Nény M,Hantson J,Schubert R,Wiessner C,Quattropani A,Beher D
MN1020 was used in Inhibition Assays to provide a strong rationale for the development of OGA inhibitors as disease-modifying agents in both tauopathies and α-synucleinopathies.
Wed Apr 20 00:00:00 UTC 2022
Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation.
Acta neuropathologica communications
Liu AJ,Lusk JB,Ervin J,Burke J,O'Brien R,Wang SJ
MN1020 was used in Immunohistochemistry to show that Tuberous Sclerosis Complex Associated Neuropsychiatric Disorder symptoms are due to the accumulation of the phosphorylated tau isoform seen in Alzheimer's disease.
Thu Mar 03 00:00:00 UTC 2022
Tau deposition patterns are associated with functional connectivity in primary tauopathies.
Nature communications
Franzmeier N,Brendel M,Beyer L,Slemann L,Kovacs GG,Arzberger T,Kurz C,Respondek G,Lukic MJ,Biel D,Rubinski A,Frontzkowski L,Hummel S,Müller A,Finze A,Palleis C,Joseph E,Weidinger E,Katzdobler S,Song M,Biechele G,Kern M,Scheifele M,Rauchmann BS,Perneczky R,Rullman M,Patt M,Schildan A,Barthel H,Sabri O,Rumpf JJ,Schroeter ML,Classen J,Villemagne V,Seibyl J,Stephens AW,Lee EB,Coughlin DG,Giese A,Grossman M,McMillan CT,Gelpi E,Molina-Porcel L,Compta Y,van Swieten JC,Laat LD,Troakes C,Al-Sarraj S,Robinson JL,Xie SX,Irwin DJ,Roeber S,Herms J,Simons M,Bartenstein P,Lee VM,Trojanowski JQ,Levin J,Höglinger G,Ewers M
MN1020 was used in Immunohistochemistry to provides combined in vivo tau-PET and histopathological evidence that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
Tue Mar 15 00:00:00 UTC 2022
Differences in Tau Seeding in Newborn and Adult Wild-Type Mice.
International journal of molecular sciences
Ferrer I,Andrés-Benito P,Garcia-Esparcia P,López-Gonzalez I,Valiente D,Jordán-Pirla M,Carmona M,Sala-Jarque J,Gil V,Del Rio JA
MN1020 was used in Western Blotting and Immunohistochemistry to show that (a) differences in tau seeding between newborn and young adults may be related to the ratios between 3Rtau and 4Rtau, and the shift to 4Rtau predominance in adults, together with the immaturity of connections in newborn mice, and (b) intracerebral inoculation of sAD PHFs in newborn mice does not protect from tau seeding following intracerebral inoculation of sAD PHFs in young/adult mice.
Tue Apr 26 00:00:00 UTC 2022
Differences in Tau Seeding in Newborn and Adult Wild-Type Mice.
International journal of molecular sciences
Ferrer I,Andrés-Benito P,Garcia-Esparcia P,López-Gonzalez I,Valiente D,Jordán-Pirla M,Carmona M,Sala-Jarque J,Gil V,Del Rio JA
MN1020 was used in Western Blotting and Immunohistochemistry to show that (a) differences in tau seeding between newborn and young adults may be related to the ratios between 3Rtau and 4Rtau, and the shift to 4Rtau predominance in adults, together with the immaturity of connections in newborn mice, and (b) intracerebral inoculation of sAD PHFs in newborn mice does not protect from tau seeding following intracerebral inoculation of sAD PHFs in young/adult mice.
Tue Apr 26 00:00:00 UTC 2022
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
Cell
Bourdenx M,Martín-Segura A,Scrivo A,Rodriguez-Navarro JA,Kaushik S,Tasset I,Diaz A,Storm NJ,Xin Q,Juste YR,Stevenson E,Luengo E,Clement CC,Choi SJ,Krogan NJ,Mosharov EV,Santambrogio L,Grueninger F,Collin L,Swaney DL,Sulzer D,Gavathiotis E,Cuervo AM
MN1020 was used in Enzyme-linked immunosorbent assay to conclude that functional CMA is essential for neuronal proteostasis through the maintenance of a subset of the proteome with a higher risk of misfolding than the general proteome.
Thu May 13 00:00:00 UTC 2021
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
The Journal of clinical investigation
Sandusky-Beltran LA,Kovalenko A,Placides DS,Ratnasamy K,Ma C,Hunt JB,Liang H,Calahatian JIT,Michalski C,Fahnestock M,Blair LJ,Darling AL,Baker JD,Fontaine SN,Dickey CA,Gamsby JJ,Nash KR,Abner E,Selenica MB,Lee DC
MN1020 was used in Immunohistochemistry to report a unique interaction between polyamine metabolism, behavioral impairment, and tau fate.
Mon Feb 15 00:00:00 UTC 2021
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components.
Neuron
Lester E,Ooi FK,Bakkar N,Ayers J,Woerman AL,Wheeler J,Bowser R,Carlson GA,Prusiner SB,Parker R
MN1020 was used in Immunohistochemistry to identify tau alteration of nuclear speckles as a feature of tau aggregation that may contribute to the pathology of tau aggregates.
Wed May 19 00:00:00 UTC 2021
Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons.
Brain : a journal of neurology
Ruan Z,Pathak D,Venkatesan Kalavai S,Yoshii-Kitahara A,Muraoka S,Bhatt N,Takamatsu-Yukawa K,Hu J,Wang Y,Hersh S,Ericsson M,Gorantla S,Gendelman HE,Kayed R,Ikezu S,Luebke JI,Ikezu T
MN1020 was used in Immunohistochemistry to propose a novel mechanism for the spread of tau in hippocampal GABAergic interneurons via brain-derived extracellular vesicles and their subsequent neuronal dysfunction.
Fri Feb 12 00:00:00 UTC 2021
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.
Molecular psychiatry
Pérez MJ,Ivanyuk D,Panagiotakopoulou V,Di Napoli G,Kalb S,Brunetti D,Al-Shaana R,Kaeser SA,Fraschka SA,Jucker M,Zeviani M,Viscomi C,Deleidi M
MN1020 was used in Immunohistochemistry to support a mechanistic link between mitochondrial function and common neurodegenerative proteinopathies.
Fri Oct 01 00:00:00 UTC 2021
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Autophagy
Chambraud B,Daguinot C,Guillemeau K,Genet M,Dounane O,Meduri G,Poüs C,Baulieu EE,Giustiniani J
MN1020 was used in Immunocytochemistry-immunoflourescence to demonstrate that FKBP4 decrease in a human neuronal cell line (SH-SY5Y) and in dorsal root ganglion (DRG) neurons from human MAPTP301S transgenic mice affected the function of the autophagy-lysosomal system under MAPT induced proteotoxic stress conditions.
Mon Nov 01 00:00:00 UTC 2021
Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading.
Proceedings of the National Academy of Sciences of the United States of America
Xu Y,Propson NE,Du S,Xiong W,Zheng H
MN1020 was used in Western Blot, Immunohistochemistry to report that Atg7 plays an essential role in the regulation of microglial lipid metabolism and neuroinflammation.
Tue Jul 06 00:00:00 UTC 2021
Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading.
Proceedings of the National Academy of Sciences of the United States of America
Xu Y,Propson NE,Du S,Xiong W,Zheng H
MN1020 was used in Western Blot, Immunohistochemistry to report that Atg7 plays an essential role in the regulation of microglial lipid metabolism and neuroinflammation.
Tue Jul 06 00:00:00 UTC 2021
RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation.
Cell death and differentiation
Zhao D,Zhou Y,Huo Y,Meng J,Xiao X,Han L,Zhang X,Luo H,Can D,Sun H,Huang TY,Wang X,Zhang J,Liu FR,Xu H,Zhang YW
MN1020 was used in Western Blot to observe retarded axon outgrowth, elevated p35 and p25 protein levels, and increased tau phosphorylation at major Cdk5 phosphorylation sites in Rps23rg1 knockout (KO) mice.
Fri Jan 01 00:00:00 UTC 2021
Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease.
Aging cell
Zhang J,Wu N,Wang S,Yao Z,Xiao F,Lu J,Chen B
MN1020 was used in Immunohistochemistry to contribute to our understanding of the relationship between neuronal loss and Aβ deposits in the absence of pathologic tau.
Tue Jun 01 00:00:00 UTC 2021
ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease.
Progress in neurobiology
Wang ZH,Xia Y,Liu P,Liu X,Edgington-Mitchell L,Lei K,Yu SP,Wang XC,Ye K
MN1020 was used in Immunohistochemistry to investigate how ApoE4 contributes to Alzheimer's Disease pathogenesis.
Thu Jul 01 00:00:00 UTC 2021
Distinguishing Amnestic Mild Cognitive Impairment From HIV-Associated Neurocognitive Disorders.
The Journal of infectious diseases
Sundermann EE,Bondi MW,Campbell LM,Gouaux B,Moore RC,Soontornniyomkij V,Moore DJ
MN1020 was used in Immunohistochemistry (Paraffin) to conclude that amnestic mild cognitive impairment criteria that include recognition impairment may help to detect AD-like cognitive/biomarker profiles among PWH.
Mon Aug 02 00:00:00 UTC 2021
Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer's and small vessel disease pathologies.
Brain pathology (Zurich, Switzerland)
Waller R,Narramore R,Simpson JE,Heath PR,Verma N,Tinsley M,Barnes JR,Haris HT,Henderson FE,Matthews FE,Richardson CD,Brayne C,Ince PG,Kalaria RN,Wharton SB
MN1020 was used in Immunohistochemistry to conclude that understanding the heterogeneity in white matter neuroinflammation will be important for the therapeutic targeting of age-associated white matter damage.
Sat May 01 00:00:00 UTC 2021
Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration.
Brain pathology (Zurich, Switzerland)
Briel N,Pratsch K,Roeber S,Arzberger T,Herms J
MN1020 was used in Immunocytochemistry to highlight astrocytic pTau as an important subject of prospective research and as a potential cellular target for therapeutic approaches in the primary tauopathies PSP and CBD.
Thu Jul 01 00:00:00 UTC 2021
Distribution of tau hyperphosphorylation in canine dementia resembles early Alzheimer's disease and other tauopathies.
Brain pathology (Zurich, Switzerland)
Abey A,Davies D,Goldsbury C,Buckland M,Valenzuela M,Duncan T
MN1020 was used in Immunohistochemistry to investigate phosphorylated tau (p-tau) in six Canine Cognitive Dysfunction brains and six controls using the AT8 antibody (later stage neurofibrillary pathology), and an antibody against Serine 396 p-tau (earlier stage tau dysfunction).
Fri Jan 01 00:00:00 UTC 2021
PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.
Brain pathology (Zurich, Switzerland)
Reimer L,Betzer C,Kofoed RH,Volbracht C,Fog K,Kurhade C,Nilsson E,Överby AK,Jensen PH
MN1020 was used in Western Blot to indicate that PKR, independent of other kinases and upon acute brain inflammation, is capable of triggering pathological modulation of tau, which, in turn, might form the initial pathologic seed in several tauopathies such as Alzheimer's disease and Chronic traumatic encephalopathy where inflammation is severe.
Fri Jan 01 00:00:00 UTC 2021
Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Takamura R,Mizuta K,Sekine Y,Islam T,Saito T,Sato M,Ohkura M,Nakai J,Ohshima T,Saido TC,Hayashi Y
MN1020 was used in Immunohistochemistry to investigate how spatial and temporal information encoded and represented in the hippocampal neuron are impaired under amyloid β pathology.
Wed Jun 16 00:00:00 UTC 2021
Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology.
Neuropathology and applied neurobiology
de Pablo-Fernández E,Courtney R,Rockliffe A,Gentleman S,Holton JL,Warner TT
MN1020 was used in Immunohistochemistry to conclude that pre-existing type 2 diabetes contributes to faster disease progression and reduced survival in Parkinson's disease which is not driven by increased vascular, Lewy or Alzheimer's pathologies.
Wed Dec 01 00:00:00 UTC 2021
MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.
Neuropathology and applied neurobiology
Bettencourt C,Miki Y,Piras IS,de Silva R,Foti SC,Talboom JS,Revesz T,Lashley T,Balazs R,Viré E,Warner TT,Huentelman MJ,Holton JL
MN1020 was used in Immunohistochemistry to support a role for DNA methylation in downregulation of MOBP mRNA in MSA. Most importantly, the identification of MOBP and HIP1 as new constituents of GCIs emphasizes the relevance of these two loci to the pathogenesis of MSA.
Sun Aug 01 00:00:00 UTC 2021
The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Zuliani I,Lanzillotta C,Tramutola A,Francioso A,Pagnotta S,Barone E,Perluigi M,Di Domenico F
MN1020 was used in Western Blotting to determine the role of protein O-GlcNacylation in the down syndrome brain.
Fri Jan 01 00:00:00 UTC 2021
Cerebellar Calcium-Binding Protein and Neurotrophin Receptor Defects in Down Syndrome and Alzheimer's Disease.
Frontiers in aging neuroscience
Miguel JC,Perez SE,Malek-Ahmadi M,Mufson EJ
MN1020 was used in Immunohistochemistry to suggest that disturbances in calcium binding proteins play a critical role in cerebellar neuronal dysfunction in adults with DS.
Fri May 03 00:00:00 UTC 2024
Does Chronic Sleep Fragmentation Lead to Alzheimer's Disease in Young Wild-Type Mice?
Frontiers in aging neuroscience
Ba L,Huang L,He Z,Deng S,Xie Y,Zhang M,Jacob C,Antonecchia E,Liu Y,Xiao W,Xie Q,Huang Z,Yi C,D'Ascenzo N,Ding F
MN1020 was used in Immunohistochemistry, Western Blot to show whether SF could eventually lead to chronic neurodegeneration if the stress condition is prolonged in time.
Sat Jan 08 00:00:00 UTC 2022
Does Chronic Sleep Fragmentation Lead to Alzheimer's Disease in Young Wild-Type Mice?
Frontiers in aging neuroscience
Ba L,Huang L,He Z,Deng S,Xie Y,Zhang M,Jacob C,Antonecchia E,Liu Y,Xiao W,Xie Q,Huang Z,Yi C,D'Ascenzo N,Ding F
MN1020 was used in Immunohistochemistry, Western Blot to show whether SF could eventually lead to chronic neurodegeneration if the stress condition is prolonged in time.
Sat Jan 08 00:00:00 UTC 2022
Hepcidin Increases Cytokines in Alzheimer's Disease and Down's Syndrome Dementia: Implication of Impaired Iron Homeostasis in Neuroinflammation.
Frontiers in aging neuroscience
Raha AA,Ghaffari SD,Henderson J,Chakraborty S,Allinson K,Friedland RP,Holland A,Zaman SH,Mukaetova-Ladinska EB,Raha-Chowdhury R
MN1020 was used in Immunohistochemistry to study levels of ferritin, hepcidin, and IL-16 in patients with Alzheimer's disease and Down's syndrome.
Tue May 18 00:00:00 UTC 2021
Increased MANF Expression in the Inferior Temporal Gyrus in Patients With Alzheimer Disease.
Frontiers in aging neuroscience
Liu XC,Qi XH,Fang H,Zhou KQ,Wang QS,Chen GH
MN1020 was used in Immunohistochemistry to show Alzheimer patients show increased MANF Expression.
Tue May 18 00:00:00 UTC 2021
Multi-Target Effects of the Cannabinoid CP55940 on Familial Alzheimer's Disease PSEN1 E280A Cholinergic-Like Neurons: Role of CB1 Receptor.
Journal of Alzheimer's disease : JAD
Soto-Mercado V,Mendivil-Perez M,Jimenez-Del-Rio M,Velez-Pardo C
MN1020 was used in Immunocytochemistry-immunoflourescence to evaluate the effect of the synthetic cannabinoid CP55940 (CP) on PSEN1 E280A cholinergic-like nerve cells (PSEN1 ChLNs)-a natural model of familial Alzheimer's disease.
Thu Sep 23 00:00:00 UTC 2021
Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice.
Journal of Alzheimer's disease : JAD
Stojakovic A,Chang SY,Nesbitt J,Pichurin NP,Ostroot MA,Aikawa T,Kanekiyo T,Trushina E
MN1020 was used in Western Blotting to investigate the effect of specific MCI inhibitor tricyclic pyrone compound CP2 on levels of human pTau, memory function, long term potentiation (LTP), and energy homeostasis in 18-month-old 3xTg-AD mice and explore the potential mechanisms.
Mon Sep 27 00:00:00 UTC 2021
Phosphorylated Tau protein in the myenteric plexus of the ileum and colon of normothermic rats and during synthetic torpor.
Cell and tissue research
Chiocchetti R,Hitrec T,Giancola F,Sadeghinezhad J,Squarcio F,Galiazzo G,Piscitiello E,De Silva M,Cerri M,Amici R,Luppi M
MN1020 was used in Immunohistochemistry to strengthen the hypothesis of a common cellular mechanism triggered by ST, natural hibernation and tauopathies occurring in ENS neurons.
Sat May 01 00:00:00 UTC 2021
Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice.
Neuroscience
Walker CK,Greathouse KM,Boros BD,Poovey EH,Clearman KR,Ramdas R,Muhammad HM,Herskowitz JH
MN1020 was used in Immunohistochemistry to study whether hyperphosphorylated tau is associated with detrimental changes in the hippocampus or prefrontal cortex and if these events correspond to tau accumulation in synaptic compartments.
Wed Feb 10 00:00:00 UTC 2021
Novel TUBA4A Variant Associated With Familial Frontotemporal Dementia.
Neurology. Genetics
Mol MO,Wong TH,Melhem S,Basu S,Viscusi R,Galjart N,Rozemuller AJM,Fallini C,Landers JE,Kaat LD,Seelaar H,van Rooij JGJ,van Swieten JC
MN1020 was used in Immunohistochemistry to investigate the underlying genetic cause of autosomal dominant frontotemporal dementia.
Tue Jun 01 00:00:00 UTC 2021
Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau.
Journal of neuropathology and experimental neurology
Dickson JR,Yoon H,Frosch MP,Hyman BT
MN1020 was used in Immunohistochemistry (Paraffin) to provide evidence that tau induces mislocalization of RPB1 in Alzheimer disease, and since RPB1 is essential for transcription, this raises the possibility that RPB1 mislocalization could lead to fundamental alterations in neuronal health.
Fri Jun 04 00:00:00 UTC 2021
Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy.
Journal of neuropathology and experimental neurology
Walker JM,Richardson TE,Farrell K,Iida MA,Foong C,Shang P,Attems J,Ayalon G,Beach TG,Bigio EH,Budson A,Cairns NJ,Corrada M,Cortes E,Dickson DW,Fischer P,Flanagan ME,Franklin E,Gearing M,Glass J,Hansen LA,Haroutunian V,Hof PR,Honig L,Kawas C,Keene CD,Kofler J,Kovacs GG,Lee EB,Lutz MI,Mao Q,Masliah E,McKee AC,McMillan CT,Mesulam MM,Murray M,Nelson PT,Perrin R,Pham T,Poon W,Purohit DP,Rissman RA,Sakai K,Sano M,Schneider JA,Stein TD,Teich AF,Trojanowski JQ,Troncoso JC,Vonsattel JP,Weintraub S,Wolk DA,Woltjer RL,Yamada M,Yu L,White CL,Crary JF
MN1020 was used in Immunohistochemistry to highlight the need for a better understanding of the contribution of PART to cognitive impairment and how neurofibrillary degeneration interacts with Aβ pathology in AD and PART.
Wed Jan 20 00:00:00 UTC 2021
Oral Amylin Treatment Reduces the Pathological Cascade of Alzheimer's Disease in a Mouse Model.
American journal of Alzheimer's disease and other dementias
Na H,Tian H,Zhang Z,Li Q,Yang JB,Mcparland L,Gan Q,Qiu WQ
MN1020 was used in Western Blot, Immunohistochemistry to study the potential for an oral-delivered amylin analogue for patients suffering from Alzheimer's disease.
Fri Jun 25 00:00:00 UTC 2021
Oral Amylin Treatment Reduces the Pathological Cascade of Alzheimer's Disease in a Mouse Model.
American journal of Alzheimer's disease and other dementias
Na H,Tian H,Zhang Z,Li Q,Yang JB,Mcparland L,Gan Q,Qiu WQ
MN1020 was used in Western Blot, Immunohistochemistry to study the potential for an oral-delivered amylin analogue for patients suffering from Alzheimer's disease.
Fri Jun 25 00:00:00 UTC 2021
Evaluation of the neuroprotective effect of donepezil in type 2 diabetic rats.
Fundamental & clinical pharmacology
Gomaa AA,Makboul RM,El-Mokhtar MA,Abdel-Rahman EA,Ahmed EA,Nicola MA
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that donepezil treatment could ameliorate learning and memory impairment in T2D rats through reversal of some of the AD-related alterations, including reduction of amyloid-ß burden and ChE activity as well as restoration of glutamate receptor expression.
Mon Feb 01 00:00:00 UTC 2021
Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of Aβ and Tau fibrils in Alzheimer's disease.
The EMBO journal
Chen C,Zhou Y,Wang H,Alam A,Kang SS,Ahn EH,Liu X,Jia J,Ye K
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that inflammation activates C/EBPß/d-secretase and initiates AD-associated pathologies in the gut, which are subsequently transmitted to the brain via the vagus nerve.
Wed Sep 01 00:00:00 UTC 2021
Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's Disease.
Acta neuropathologica communications
Latina V,Giacovazzo G,Cordella F,Balzamino BO,Micera A,Varano M,Marchetti C,Malerba F,Florio R,Ercole BB,La Regina F,Atlante A,Coccurello R,Di Angelantonio S,Calissano P,Amadoro G
MN1020 was used in Western Blotting to find that 12A12mAb administration also exerts a beneficial action on biochemical, morphological and metabolic parameters (i.e. APP/Aβ processing, tau hyperphosphorylation, neuroinflammation, synaptic proteins, microtubule stability, mitochondria-based energy production, neuronal death) associated with ocular injury in the AD phenotype.
Tue Mar 09 00:00:00 UTC 2021
Erythropoietin-derived peptide treatment reduced neurological deficit and neuropathological changes in a mouse model of tauopathy.
Alzheimer's research & therapy
Choi YB,Dunn-Meynell AA,Marchese M,Blumberg BM,Gaindh D,Dowling PC,Lu W
MN1020 was used in Western Blot, Immunohistochemistry to investigate the effect of chronic JM4 treatment on the PS19 mouse that carries the P301S mutant human tau gene, linked to a form of frontotemporal dementia.
Wed Jan 27 00:00:00 UTC 2021
Erythropoietin-derived peptide treatment reduced neurological deficit and neuropathological changes in a mouse model of tauopathy.
Alzheimer's research & therapy
Choi YB,Dunn-Meynell AA,Marchese M,Blumberg BM,Gaindh D,Dowling PC,Lu W
MN1020 was used in Western Blot, Immunohistochemistry to investigate the effect of chronic JM4 treatment on the PS19 mouse that carries the P301S mutant human tau gene, linked to a form of frontotemporal dementia.
Wed Jan 27 00:00:00 UTC 2021
Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.
Journal of neuroinflammation
Sun XY,Li LJ,Dong QX,Zhu J,Huang YR,Hou SJ,Yu XL,Liu RT
MN1020 was used in Immunohistochemistry (Paraffin) to show that in combination with the previously reported therapeutic effects of rutin on Aβ pathology, rutin is a promising drug candidate for AD treatment based its combinatorial targeting of tau and Aβ.
Fri Jun 11 00:00:00 UTC 2021
Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.
Science translational medicine
Delpech JC,Pathak D,Varghese M,Kalavai SV,Hays EC,Hof PR,Johnson WE,Ikezu S,Medalla M,Luebke JI,Ikezu T
MN1020 was used in Immunohistochemistry-immunofluorescence to demonstrate tau transfer from the ECII to CA1 in mouse brain and provides an early Braak stage preclinical model of AD.
Wed Sep 15 00:00:00 UTC 2021
Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease.
Molecular neurobiology
Hashem J,Hu M,Zhang J,Gao F,Chen C
MN1020 was used in Western Blotting to show that JZL184, a potent monoacylglycerol lipase inhibitor, significantly reduced proinflammatory cytokines, astrogliosis, phosphorylated GSK3β and tau, cleaved caspase-3, and phosphorylated NF-kB while it elevated PPARγ in P301S/PS19 mice, a tau mouse model of Alzheimer's disease.
Sun Aug 01 00:00:00 UTC 2021
The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration.
Cell reports
Puigdellívol M,Milde S,Vilalta A,Cockram TOJ,Allendorf DH,Lee JY,Dundee JM,Pampuščenko K,Borutaite V,Nuthall HN,Brelstaff JH,Spillantini MG,Brown GC
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that injection of amyloid beta (Aß) into mouse brain induces microglial phagocytosis of neurons, followed by neuronal and memory loss, and this is all prevented by knockout of P2Y6R.
Tue Dec 28 00:00:00 UTC 2021
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.
Nature communications
Subramanian M,Hyeon SJ,Das T,Suh YS,Kim YK,Lee JS,Song EJ,Ryu H,Yu K
MN1020 was used in Western Blot to demonstrate that UBE4B, a miR-9 target gene, promotes autophagy-mediated Tau degradation together with STUB1, and is thus an innovative therapeutic approach for AD.
Wed Jun 02 00:00:00 UTC 2021
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.
eLife
Zhang X,Zou L,Meng L,Xiong M,Pan L,Chen G,Zheng Y,Xiong J,Wang Z,Duong DM,Zhang Z,Cao X,Wang T,Tang L,Ye K,Zhang Z
MN1020 was used in Western Blot to demonstrate that Amphiphysin I mediates tau phosphorylation and synaptic dysfunction in Alzheimer's disease.
Fri May 21 00:00:00 UTC 2021
Layer-Specific Vesicular Glutamate Transporter 1 Immunofluorescence Levels Delineate All Layers of the Human Hippocampus Including the Stratum lucidum.
Frontiers in cellular neuroscience
Woelfle S,Boeckers TM
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to propose the vesicular glutamate transporter 1 (VGLUT1) as a molecular marker for the CA3 region.
Tue Dec 28 00:00:00 UTC 2021
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.
Nature communications
Yuste-Checa P,Trinkaus VA,Riera-Tur I,Imamoglu R,Schaller TF,Wang H,Dudanova I,Hipp MS,Bracher A,Hartl FU
MN1020 was used in Western Blot, Immunocytochemistry to conclude that upregulation of Clusterin, as observed in AD patients, may enhance Tau seeding and possibly accelerate the spreading of Tau pathology.
Wed Aug 11 00:00:00 UTC 2021
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.
Nature communications
Yuste-Checa P,Trinkaus VA,Riera-Tur I,Imamoglu R,Schaller TF,Wang H,Dudanova I,Hipp MS,Bracher A,Hartl FU
MN1020 was used in Western Blot, Immunocytochemistry to conclude that upregulation of Clusterin, as observed in AD patients, may enhance Tau seeding and possibly accelerate the spreading of Tau pathology.
Wed Aug 11 00:00:00 UTC 2021
Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor.
Science advances
Cornblath EJ,Li HL,Changolkar L,Zhang B,Brown HJ,Gathagan RJ,Olufemi MF,Trojanowski JQ,Bassett DS,Lee VMY,Henderson MX
MN1020 was used in Immunohistochemistry to study tau pathology spread in the brains of nontransgenic mice with Alzheimer's disease tau.
Tue Jun 01 00:00:00 UTC 2021
Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology.
Acta neuropathologica communications
Ravikumar S,Wisse LEM,Lim S,Ittyerah R,Xie L,Bedard ML,Das SR,Lee EB,Tisdall MD,Prabhakaran K,Lane J,Detre JA,Mizsei G,Trojanowski JQ,Robinson JL,Schuck T,Grossman M,Artacho-Pérula E,de Onzoño Martin MMI,Del Mar Arroyo Jiménez M,Muñoz M,Romero FJM,Del Pilar Marcos Rabal M,Sánchez SC,González JCD,de la Rosa Prieto C,Parada MC,Irwin DJ,Wolk DA,Insausti R,Yushkevich PA
MN1020 was used in Immunohistochemistry to find strong associations between tau pathology and thickness in the ERC, SRLM and the subiculum/cornu ammonis 1 (CA1) subfields of the hippocampus, consistent with early Braak stages.
Sun Oct 24 00:00:00 UTC 2021
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates.
Scientific reports
Herrmann F,Hessmann M,Schaertl S,Berg-Rosseburg K,Brown CJ,Bursow G,Chiki A,Ebneth A,Gehrmann M,Hoeschen N,Hotze M,Jahn S,Johnson PD,Khetarpal V,Kiselyov A,Kottig K,Ladewig S,Lashuel H,Letschert S,Mills MR,Petersen K,Prime ME,Scheich C,Schmiedel G,Wityak J,Liu L,Dominguez C,Muñoz-Sanjuán I,Bard JA
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to present an in-depth pharmacological investigation of the binding characteristics of high-affinity small-molecule binders of HTT oligomerized/amyloid-containing species that could serve as either cellular and in vivo imaging tools or potential therapeutic agents.
Thu Sep 09 00:00:00 UTC 2021
The anesthetic sevoflurane induces tau trafficking from neurons to microglia.
Communications biology
Dong Y,Liang F,Huang L,Fang F,Yang G,Tanzi RE,Zhang Y,Quan Q,Xie Z
MN1020 was used in Western Blotting to assess mice and neurons treated with anesthetics sevoflurane and desflurane, and apply nanobeam-sensor technology, an ultrasensitive method, to measure tau/p-tau amounts.
Wed May 12 00:00:00 UTC 2021
Deep learning reveals disease-specific signatures of white matter pathology in tauopathies.
Acta neuropathologica communications
Vega AR,Chkheidze R,Jarmale V,Shang P,Foong C,Diamond MI,White CL,Rajaram S
MN1020 was used in Immunohistochemistry to suggest that tau pathology in white matter is informative, disease-specific, and linked to gray matter pathology.
Thu Oct 21 00:00:00 UTC 2021
Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease.
Frontiers in neuroscience
Javonillo DI,Tran KM,Phan J,Hingco E,Kramár EA,da Cunha C,Forner S,Kawauchi S,Milinkeviciute G,Gomez-Arboledas A,Neumann J,Banh CE,Huynh M,Matheos DP,Rezaie N,Alcantara JA,Mortazavi A,Wood MA,Tenner AJ,MacGregor GR,Green KN,LaFerla FM
MN1020 was used in Immunohistochemistry to demonstrate the utility of a characterization pipeline that generates robust and standardized information relevant to investigating and comparing disease etiologies of current and future models of AD.
Sat Dec 17 00:00:00 UTC 2022
Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation.
Antioxidants (Basel, Switzerland)
Cores Á,Abril S,Michalska P,Duarte P,Olives AI,Martín MA,Villacampa M,León R,Menéndez JC
MN1020 was used in Immunocytochemistry to describe the synthesis of a library of derivatives of the 4-arylmethylen-2-pyrrolin-5-one framework by sequential application of a three-component reaction of primary amines, β-dicarbonyl compounds, and α-haloketones and a Knoevenagel condensation.
Thu Jun 10 00:00:00 UTC 2021
Behavioural Functions and Cerebral Blood Flow in a P301S Tauopathy Mouse Model: A Time-Course Study.
International journal of molecular sciences
Ahmad F,Mein H,Jing Y,Zhang H,Liu P
MN1020 was used in Western Blot to investigate how behavioural functions, resting cerebral blood flow (CBF) and tau pathology change in PS19 mice at 2, 4, 6, 8 and 12 months of age in a single study under one experimental condition, allowing for the cumulative assessment of age- and genotype-dependent changes.
Wed Sep 08 00:00:00 UTC 2021
Oral Pathogenic Bacteria-Inducing Neurodegenerative Microgliosis in Human Neural Cell Platform.
International journal of molecular sciences
Tran VTA,Kang YJ,Kim HK,Kim HR,Cho H
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that the mouth-brain axis may contribute to the pathogenesis of AD.
Mon Jun 28 00:00:00 UTC 2021
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology.
Nature aging
Dehkordi SK,Walker J,Sah E,Bennett E,Atrian F,Frost B,Woost B,Bennett RE,Orr TC,Zhou Y,Andhey PS,Colonna M,Sudmant PH,Xu P,Wang M,Zhang B,Zare H,Orr ME
MN1020 was used in Immunohistochemistry-immunofluorescence to show that CDKN2D/p19-expressing neurons with NFTs represent a unique cellular population in human AD with a senescence phenotype.
Wed Dec 01 00:00:00 UTC 2021
Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau.
Cell reports
Taylor HBC,Emptage NJ,Jeans AF
MN1020 was used in Western Blotting to study that an Aβo-mediated increase in glutamate release probability causes enhancement of synaptically evoked NMDAR dependent long-term depression.
Tue Aug 31 00:00:00 UTC 2021
Early alterations of neurovascular unit in the retina in mouse models of tauopathy.
Acta neuropathologica communications
Xia F,Ha Y,Shi S,Li Y,Li S,Luisi J,Kayed R,Motamedi M,Liu H,Zhang W
MN1020 was used in Immunohistochemistry (Frozen) to study molecular mechanisms of neurodegeneration.
Wed Mar 24 00:00:00 UTC 2021
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Acta neuropathologica communications
Miller LVC,Mukadam AS,Durrant CS,Vaysburd MJ,Katsinelos T,Tuck BJ,Sanford S,Sheppard O,Knox C,Cheng S,James LC,Coleman MP,McEwan WA
MN1020 was used in Immunohistochemistry to ask whether tau assemblies share with classical pathogens the characteristic of particulate behaviour.
Fri Mar 12 00:00:00 UTC 2021
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Acta neuropathologica communications
Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Marcilla I,Marti-Andres G,Caballero MC,Riverol M,Tuñon MT,Fraser PE,Luquin MR
MN1020 was used in Immunohistochemistry to show that the involvement of amylin, pancreatic α-synuclein, Aβ, PrP and tau in the complex pathophysiology of type two diabetes and in the appearance of insulin resistance in Alzheimer's and Parkinson's disease.
Thu Apr 08 00:00:00 UTC 2021
The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function.
Redox biology
Jaillard C,Ouechtati F,Clérin E,Millet-Puel G,Corsi M,Aït-Ali N,Blond F,Chevy Q,Gales L,Farinelli M,Dalkara D,Sahel JA,Portais JC,Poncer JC,Léveillard T
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate the link between NXNL2 and tauopathies.
Thu Nov 25 00:00:00 UTC 2021
Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature.
Acta neuropathologica communications
Kahriman A,Bouley J,Smith TW,Bosco DA,Woerman AL,Henninger N
MN1020 was used in Immunohistochemistry to compare the mouse closed-head traumatic brain injury model with human traumatic brain injury-associated tauopathy.
Tue Jun 29 00:00:00 UTC 2021
Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies.
Journal of Alzheimer's disease reports
Pitera AP,Hartnell IJ,Scullard L,Williamson KL,Boche D,O'Connor V,Deinhardt K
MN1020 was used in Immunohistochemistry to show that different markers of UPR are not changed at the late stage of any of the human tauopathies investigated. Interestingly, UPR signatures were often observed in non-demented controls.
Sat Apr 30 00:00:00 UTC 2022
A Synergistic Engineering Approach to Build Human Brain Spheroids.
Methods in molecular biology (Clifton, N.J.)
von Maydell D,Jorfi M
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to generate large-scale arrays of homogeneously sized 3D brain spheroids derived from human-induced pluripotent stem cells (hiPSCs) or immortalized neural progenitor cells to recapitulate Alzheimer's disease (AD) pathology in vitro.
Wed Mar 31 00:00:00 UTC 2021
Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model.
Science advances
Sato H,Takado Y,Toyoda S,Tsukamoto-Yasui M,Minatohara K,Takuwa H,Urushihata T,Takahashi M,Shimojo M,Ono M,Maeda J,Orihara A,Sahara N,Aoki I,Karakawa S,Isokawa M,Kawasaki N,Kawasaki M,Ueno S,Kanda M,Nishimura M,Suzuki K,Mitsui A,Nagao K,Kitamura A,Higuchi M
MN1020 was used in Western Blot, Immunohistochemistry to show that a low-protein diet resulted in down-regulated expression of synaptic components.
Fri Oct 22 00:00:00 UTC 2021
Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model.
Science advances
Sato H,Takado Y,Toyoda S,Tsukamoto-Yasui M,Minatohara K,Takuwa H,Urushihata T,Takahashi M,Shimojo M,Ono M,Maeda J,Orihara A,Sahara N,Aoki I,Karakawa S,Isokawa M,Kawasaki N,Kawasaki M,Ueno S,Kanda M,Nishimura M,Suzuki K,Mitsui A,Nagao K,Kitamura A,Higuchi M
MN1020 was used in Western Blot, Immunohistochemistry to show that a low-protein diet resulted in down-regulated expression of synaptic components.
Fri Oct 22 00:00:00 UTC 2021
Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models.
ACS chemical neuroscience
McMurray L,Macdonald JA,Ramakrishnan NK,Zhao Y,Williamson DW,Tietz O,Zhou X,Kealey S,Fagan SG,Smolek T,Cubinkova V,Žilka N,Spillantini MG,Tolkovsky AM,Goedert M,Aigbirhio FI
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to improve the development of PET imaging probes for visualizing tau pathology in transgenic models of neurodegeneration.
Wed Jun 02 00:00:00 UTC 2021
IntelliCage Automated Behavioral Phenotyping Reveals Behavior Deficits in the 3xTg-AD Mouse Model of Alzheimer's Disease Associated With Brain Weight.
Frontiers in aging neuroscience
Winslow W,McDonough I,Tallino S,Decker A,Vural AS,Velazquez R
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to examine d the behavioral performance of 3xTg-AD mice in the IntelliCage o study mechanisms of pathogenesis and connect these mechanisms with cognitive decline.
Thu Apr 14 00:00:00 UTC 2022
Extracellular Prion Protein Aggregates in Nine Gerstmann-Sträussler-Scheinker Syndrome Subjects with Mutation P102L: A Micromorphological Study and Comparison with Literature Data.
International journal of molecular sciences
Jankovska N,Matej R,Olejar T
MN1020 was used in Immunohistochemistry to study GSS plaques' micromorphology and protein composition. Found small, condensed plaques dominate; dystrophic neuritic changes with tau or Aβ rare and unrelated to GSS development.
Fri Dec 10 00:00:00 UTC 2021
Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.
Alzheimer's & dementia (New York, N. Y.)
Omoluabi T,Torraville SE,Maziar A,Ghosh A,Power KD,Reinhardt C,Harley CW,Yuan Q
MN1020 was used in Immunohistochemistry, Western Blot to argue that variations in environmental experiences associated with differing LC activity patterns may account for individual susceptibility to development of AD in humans.
Fri Apr 05 00:00:00 UTC 2024
Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.
Alzheimer's & dementia (New York, N. Y.)
Omoluabi T,Torraville SE,Maziar A,Ghosh A,Power KD,Reinhardt C,Harley CW,Yuan Q
MN1020 was used in Immunohistochemistry, Western Blot to argue that variations in environmental experiences associated with differing LC activity patterns may account for individual susceptibility to development of AD in humans.
Fri Apr 05 00:00:00 UTC 2024
ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease.
Acta neuropathologica
Kang SS,Ahn EH,Liu X,Bryson M,Miller GW,Weinshenker D,Ye K
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that ApoE4 selectively binds to the vesicular monoamine transporter 2 (VMAT2) and inhibits neurotransmitter uptake and that ApoE4 exacerbates Tau neurotoxicity by increasing VMAT2 vesicle leakage and facilitating AEP-mediated Tau proteolytic cleavage in the LC via DOPEGAL.
Thu Jul 01 00:00:00 UTC 2021
Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model.
Scientific reports
Shin J,Park S,Lee H,Kim Y
MN1020 was used in Immunohistochemistry to reveal that, in addition to amyloid plaques, 5XFAD mice express ThS-positive phospho-tau (p-tau) aggregates.
Fri Jan 15 00:00:00 UTC 2021
Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway.
Clinical and translational medicine
Wu D,Gao D,Yu H,Pi G,Xiong R,Lei H,Wang X,Liu E,Ye J,Yu H,Gao Y,He T,Jiang T,Sun F,Su J,Song G,Peng W,Yang Y,Wang JZ
MN1020 was used in Western Blot to observe an aberrant tau accumulation in the medial septum (MS) of 3xTg and 5xFAD mice, especially in their cholinergic neurons.
Tue Jun 01 00:00:00 UTC 2021
Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast.
Acta neuropathologica communications
Perez Garcia G,De Gasperi R,Gama Sosa MA,Perez GM,Otero-Pagan A,Pryor D,Abutarboush R,Kawoos U,Hof PR,Dickstein DL,Cook DG,Gandy S,Ahlers ST,Elder GA
MN1020 was used in Western Blotting to test the hypothesis that region-specific patterns of Thr181 phosphorylation correlate with behavioral measures also previously determined and reported in the same animals.
Mon Mar 01 00:00:00 UTC 2021
Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.
Journal of clinical medicine
Raha-Chowdhury R,Raha AA,Henderson J,Ghaffari SD,Grigorova M,Beresford-Webb J,Allinson K,Chakraborty S,Holland A,Zaman SH
MN1020 was used in Immunohistochemistry, Western Blot to determine whether genetic variants and inflammatory proteins are involved in haematopoiesis and cellular processes in Down syndrome compared with age-matched control participants, particularly with respect to neuroinflammation and accelerated ageing.
Tue Jun 29 00:00:00 UTC 2021
Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.
Journal of clinical medicine
Raha-Chowdhury R,Raha AA,Henderson J,Ghaffari SD,Grigorova M,Beresford-Webb J,Allinson K,Chakraborty S,Holland A,Zaman SH
MN1020 was used in Immunohistochemistry, Western Blot to determine whether genetic variants and inflammatory proteins are involved in haematopoiesis and cellular processes in Down syndrome compared with age-matched control participants, particularly with respect to neuroinflammation and accelerated ageing.
Tue Jun 29 00:00:00 UTC 2021
Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice.
Neurobiology of aging
Evans AK,Park HH,Saw NL,Singhal K,Ogawa G,Leib RD,Shamloo M
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to examine effects of age and acute beta-blocker administration on LC and hippocampus pathology, neuroinflammation and learning and memory behavior in mice.
Fri Oct 01 00:00:00 UTC 2021
Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice.
Neurobiology of aging
Evans AK,Park HH,Saw NL,Singhal K,Ogawa G,Leib RD,Shamloo M
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to examine effects of age and acute beta-blocker administration on LC and hippocampus pathology, neuroinflammation and learning and memory behavior in mice.
Fri Oct 01 00:00:00 UTC 2021
Corticosteroid-binding-globulin (CBG)-deficient mice show high pY216-GSK3β and phosphorylated-Tau levels in the hippocampus.
PloS one
Gulfo J,Pérez de San Román J,Ledda A,Junyent F,Ramírez MJ,Gil-Bea FJ,Esteve M,Grasa M
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that CBG deficiency triggers metabolic imbalance which could lead to damage and long-term neurological pathologies.
Wed Aug 04 00:00:00 UTC 2021
Defining early changes in Alzheimer's disease from RNA sequencing of brain regions differentially affected by pathology.
Scientific reports
Guennewig B,Lim J,Marshall L,McCorkindale AN,Paasila PJ,Patrick E,Kril JJ,Halliday GM,Cooper AA,Sutherland GT
MN1020 was used in Flow Cytometry to conclude that the synaptic deficits that characterise AD may begin with the somatostatin division of inhibitory neurotransmission.
Mon Mar 01 00:00:00 UTC 2021
Identification of multiple system atrophy mimicking Parkinson's disease or progressive supranuclear palsy.
Brain : a journal of neurology
Miki Y,Tsushima E,Foti SC,Strand KM,Asi YT,Yamamoto AK,Bettencourt C,Oliveira MCB,De Pablo-Fernández E,Jaunmuktane Z,Lees AJ,Wakabayashi K,Warner TT,Quinn N,Holton JL,Ling H
MN1020 was used in Immunohistochemistry-paraffin to develop decision tree algorithms with combinations of clinical pointers to differentiate clinically atypical cases of multiple system atrophy from Parkinson's disease or progressive supranuclear palsy.
Fri May 07 00:00:00 UTC 2021
Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease.
Translational psychiatry
Lyra E Silva NM,Gonçalves RA,Pascoal TA,Lima-Filho RAS,Resende EPF,Vieira ELM,Teixeira AL,de Souza LC,Peny JA,Fortuna JTS,Furigo IC,Hashiguchi D,Miya-Coreixas VS,Clarke JR,Abisambra JF,Longo BM,Donato J,Fraser PE,Rosa-Neto P,Caramelli P,Ferreira ST,De Felice FG
MN1020 was used in Immunocytochemistry to point to IL-6 as a link between cognitive impairment and peripheral metabolic alterations in Alzheimer's disease.
Wed Apr 28 00:00:00 UTC 2021
Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor.
Brain communications
Maeda J,Minamihisamatsu T,Shimojo M,Zhou X,Ono M,Matsuba Y,Ji B,Ishii H,Ogawa M,Akatsu H,Kaneda D,Hashizume Y,Robinson JL,Lee VM,Saito T,Saido TC,Trojanowski JQ,Zhang MR,Suhara T,Higuchi M,Sahara N
MN1020 was used in Immunohistochemistry (Paraffin) to suggest that the down-regulation of microglia P2Y12 receptor, which is characteristic of disease-associated microglia, is intimately associated with tau rather than amyloid-β pathologies from an early stage and could be a sensitive index for neuroinflammatory responses to Alzheimer's disease-related neurodegenerative processes.
Wed Mar 03 00:00:00 UTC 2021
Application of deep learning to understand resilience to Alzheimer's disease pathology.
Brain pathology (Zurich, Switzerland)
Lee CS,Latimer CS,Henriksen JC,Blazes M,Larson EB,Crane PK,Keene CD,Lee AY
MN1020 was used in Immunohistochemistry to suggest that the burden of NFTs is more strongly associated with cognitive impairment than the more diffuse neuritic tau commonly seen with tangle pathology and suggest that additional factors may underlie resilience mechanisms defined by traditional means.
Mon Nov 01 00:00:00 UTC 2021
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Molecular neurodegeneration
Bichmann M,Prat Oriol N,Ercan-Herbst E,Schöndorf DC,Gomez Ramos B,Schwärzler V,Neu M,Schlüter A,Wang X,Jin L,Hu C,Tian Y,Ried JS,Haberkant P,Gasparini L,Ehrnhoefer DE
MN1020 was used in ELISA to demonstrate that methylated Tau levels increase with Tau pathology stage in human AD samples as well as in a mouse model of Tauopathy.
Fri Jul 02 00:00:00 UTC 2021
The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer's disease.
Acta neuropathologica
Hondius DC,Koopmans F,Leistner C,Pita-Illobre D,Peferoen-Baert RM,Marbus F,Paliukhovich I,Li KW,Rozemuller AJM,Hoozemans JJM,Smit AB
MN1020 was used in Immunohistochemistry-immunofluorescence to provide a comprehensive human based quantitative assessment of protein abundances in GVD and tangle bearing neurons.
Mon Mar 01 00:00:00 UTC 2021
Extracellular Protein Aggregates Colocalization and Neuronal Dystrophy in Comorbid Alzheimer's and Creutzfeldt-Jakob Disease: A Micromorphological Pilot Study on 20 Brains.
International journal of molecular sciences
Jankovska N,Olejar T,Matej R
MN1020 was used in Immunohistochemistry (Paraffin) to show that PrPSc aggregation could dominate during co-aggregation with non-compact Aβ in the periphery of Aβ plaques.
Sat Feb 20 00:00:00 UTC 2021
Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model.
Scientific reports
Kang S,Kim J,Chang KA
MN1020 was used in Immunohistochemistry to develope and evaluate a novel AD mouse model (6xTg-AD, 6xTg) by crossbreeding 5xFAD mice with mice expressing mutant (P301L) tau protein (MAPT).
Thu Jan 14 00:00:00 UTC 2021
Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau.
Journal of inflammation research
Filippone A,Smith T,Pratico D
MN1020 was used in Western Blot to demonstrate that in brain endothelial cells retromer complex dysfunction by influencing endosome-lysosome degradation pathways results in altered proteostasis.
Sat Jul 16 00:00:00 UTC 2022
Initiation of Parkinson's disease from gut to brain by δ-secretase.
Cell research
Ahn EH,Kang SS,Liu X,Chen G,Zhang Z,Chandrasekharan B,Alam AM,Neish AS,Cao X,Ye K
MN1020 was used in Immunohistochemistry to conclude that δ-secretase plays a crucial role in initiating PD pathology progression from the ENS to the CNS.
Wed Jan 01 00:00:00 UTC 2020
Initiation of Parkinson's disease from gut to brain by δ-secretase.
Cell research
Ahn EH,Kang SS,Liu X,Chen G,Zhang Z,Chandrasekharan B,Alam AM,Neish AS,Cao X,Ye K
MN1020 was used in Immunohistochemistry to conclude that δ-secretase plays a crucial role in initiating PD pathology progression from the ENS to the CNS.
Wed Jan 01 00:00:00 UTC 2020
Distribution patterns of tau pathology in progressive supranuclear palsy.
Acta neuropathologica
Kovacs GG,Lukic MJ,Irwin DJ,Arzberger T,Respondek G,Lee EB,Coughlin D,Giese A,Grossman M,Kurz C,McMillan CT,Gelpi E,Compta Y,van Swieten JC,Laat LD,Troakes C,Al-Sarraj S,Robinson JL,Roeber S,Xie SX,Lee VM,Trojanowski JQ,Höglinger GU
MN1020 was used in Immunohistochemistry to determine whether or not sequential distribution patterns can be recognized for progressive supranuclear palsy pathology.
Sat Aug 01 00:00:00 UTC 2020
Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.
Brain : a journal of neurology
Bevan-Jones WR,Cope TE,Jones PS,Kaalund SS,Passamonti L,Allinson K,Green O,Hong YT,Fryer TD,Arnold R,Coles JP,Aigbirhio FI,Larner AJ,Patterson K,O'Brien JT,Rowe JB
MN1020 was used in Immunohistochemistry to investigate how neuroinflammation relates to the localization of tau and TDP-43 pathology, and to the heterogeneity of clinical disease.
Sun Mar 01 00:00:00 UTC 2020
Hippocampal α-synuclein pathology correlates with memory impairment in multiple system atrophy.
Brain : a journal of neurology
Miki Y,Foti SC,Hansen D,Strand KM,Asi YT,Tsushima E,Jaunmuktane Z,Lees AJ,Warner TT,Quinn N,Ling H,Holton JL
MN1020 was used in Immunohistochemistry to provide evidence that neuronal cytoplasmic inclusion burden in the hippocampus and parahippocampus is associated with the occurrence of memory impairment in multiple system atrophy.
Mon Jun 01 00:00:00 UTC 2020
Phosphorylated tau interactome in the human Alzheimer's disease brain.
Brain : a journal of neurology
Drummond E,Pires G,MacMurray C,Askenazi M,Nayak S,Bourdon M,Safar J,Ueberheide B,Wisniewski T
MN1020 was used in Immunohistochemistry (Paraffin) to determine the phosphorylated tau interactome.
Tue Sep 01 00:00:00 UTC 2020
Modeling Controlled Cortical Impact Injury in 3D Brain-Like Tissue Cultures.
Advanced healthcare materials
Liaudanskaya V,Chung JY,Mizzoni C,Rouleau N,Berk AN,Wu L,Turner JA,Georgakoudi I,Whalen MJ,Nieland TJF,Kaplan DL
MN1020 was used in Western Blot to develop a 3D in vitro contusion model using murine cortical neurones, to study traumatic brain injury.
Mon Jun 01 00:00:00 UTC 2020
Tau-induced upregulation of C/EBPβ-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration.
Aging cell
Ye J,Yin Y,Yin Y,Zhang H,Wan H,Wang L,Zuo Y,Gao D,Li M,Li J,Liu Y,Ke D,Wang JZ
MN1020 was used in Immunocytochemistry to show that increasing intracellular tau could upregulate mRNA and protein levels of TRPC1 (transient receptor potential channel 1) with an activated store-operated calcium entry (SOCE), an increased intraneuronal steady-state [Ca2+ ]i , an enhanced endoplasmic reticulum (ER) stress, an imbalanced protein kinases and phosphatase, and an aggravated tauopathy.
Tue Sep 01 00:00:00 UTC 2020
Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice.
Aging and disease
Guo X,Liu Y,Morgan D,Zhao LR
MN1020 was used in Immunohistochemistry-immunofluorescence to determine the therapeutic efficacy of stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) (SCF+G-CSF) in aged APPswe/PS1dE9 (APP/PS1) mice.
Tue Dec 01 00:00:00 UTC 2020
Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice.
Anesthesiology
Yu Y,Yang Y,Tan H,Boukhali M,Khatri A,Yu Y,Hua F,Liu L,Li M,Yang G,Dong Y,Zhang Y,Haas W,Xie Z
MN1020 was used in Western Blotting to test the hypothesis that differences in brain Tau amounts and in the activity of mitochondria-adenosine triphosphate (ATP)-Nuak1-Tau cascade between the neonatal and adult mice contribute to the age-dependent effects of sevoflurane on cognitive function.
Tue Sep 01 00:00:00 UTC 2020
Effect of Melatonin on Tau aggregation and Tau-mediated cell surface morphology.
International journal of biological macromolecules
Das R,Balmik AA,Chinnathambi S
MN1020 was used in Immunocytochemistry-immunoflourescence to suggest that Melatonin administration shows mild anti-aggregation and cytoprotective effects.
Mon Jun 01 00:00:00 UTC 2020
Correlative x-ray phase-contrast tomography and histology of human brain tissue affected by Alzheimer's disease.
NeuroImage
Töpperwien M,van der Meer F,Stadelmann C,Salditt T
MN1020 was used in Immunohistochemistry to use x-ray phase-contrast tomography to obtain three-dimensional reconstructions of human hippocampal tissue affected by Alzheimer's disease.
Wed Apr 15 00:00:00 UTC 2020
Reproductive status impact on tau phosphorylation induced by chronic stress.
Neurobiology of stress
Muñoz-Mayorga D,Rissman RA,Morales T
MN1020 was used in Immunohistochemistry to test the hypothesis that reproductive status can impact hippocampal pTau induced by chronic stress.
Sun Nov 01 00:00:00 UTC 2020
Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R.
Neurobiology of disease
Sandberg A,Ling H,Gearing M,Dombroski B,Cantwell L,R'Bibo L,Levey A,Schellenberg GD,Hardy J,Wood N,Fernius J,Nyström S,Svensson S,Thor S,Hammarström P,Revesz T,Mok KY
MN1020 was used in Immunohistochemistry to suggest that the G273R mutation induces a shift in pool of 4R tau by lower F-actin affinity, alters the conformation of MT bound 4R tau, while increasing chaperoning of 3R tau by binding stronger to F-actin.
Tue Dec 01 00:00:00 UTC 2020
Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shimojo M,Takuwa H,Takado Y,Tokunaga M,Tsukamoto S,Minatohara K,Ono M,Seki C,Maeda J,Urushihata T,Minamihisamatsu T,Aoki I,Kawamura K,Zhang MR,Suhara T,Sahara N,Higuchi M
MN1020 was used in Western Blot, Immunohistochemistry to indicate that selective degeneration of inhibitory synapse with hyperexcitability in the cortical circuit constitutes the critical early pathophysiology of tauopathy in mice.
Wed Apr 22 00:00:00 UTC 2020
Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shimojo M,Takuwa H,Takado Y,Tokunaga M,Tsukamoto S,Minatohara K,Ono M,Seki C,Maeda J,Urushihata T,Minamihisamatsu T,Aoki I,Kawamura K,Zhang MR,Suhara T,Sahara N,Higuchi M
MN1020 was used in Western Blot, Immunohistochemistry to indicate that selective degeneration of inhibitory synapse with hyperexcitability in the cortical circuit constitutes the critical early pathophysiology of tauopathy in mice.
Wed Apr 22 00:00:00 UTC 2020
Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fan Q,He W,Gayen M,Benoit MR,Luo X,Hu X,Yan R
MN1020 was used in Western Blot to explore the potential of CX3CL1 as a target for Alzheimer's disease or related neurodegenerative disease.
Wed Jan 29 00:00:00 UTC 2020
Profiling Microglia From Alzheimer's Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue.
Frontiers in molecular neuroscience
Alsema AM,Jiang Q,Kracht L,Gerrits E,Dubbelaar ML,Miedema A,Brouwer N,Hol EM,Middeldorp J,van Dijk R,Woodbury M,Wachter A,Xi S,Möller T,Biber KP,Kooistra SM,Boddeke EWGM,Eggen BJL
MN1020 was used in Immunohistochemistry to identify seven human microglial subpopulations with heterogeneity in gene expression.
Sun Nov 12 00:00:00 UTC 2023
Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy.
Frontiers in cell and developmental biology
Gao Y,Zheng J,Jiang T,Pi G,Sun F,Xiong R,Wang W,Wu D,Li S,Lei H,Yu H,Zhou Q,Yang Y,Zhang H,Wang JZ
MN1020 was used in Western Blot, Immunocytochemistry to prove that abnormal tau accumulation plays a pivotal role in the epileptic seizures and the epilepsy-associated spatial memory impairments, which provides new molecular target for the therapeutics.
Wed Mar 10 00:00:00 UTC 2021
Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy.
Frontiers in cell and developmental biology
Gao Y,Zheng J,Jiang T,Pi G,Sun F,Xiong R,Wang W,Wu D,Li S,Lei H,Yu H,Zhou Q,Yang Y,Zhang H,Wang JZ
MN1020 was used in Western Blot, Immunocytochemistry to prove that abnormal tau accumulation plays a pivotal role in the epileptic seizures and the epilepsy-associated spatial memory impairments, which provides new molecular target for the therapeutics.
Wed Mar 10 00:00:00 UTC 2021
Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy.
Molecular neurobiology
Koller EJ,Gonzalez De La Cruz E,Weinrich M,Williams T,Cruz PE,Ryu D,Golde TE,Sullivan PM,Lewis J,Borchelt DR,Chakrabarty P
MN1020 was used in Immunohistochemistry to indicate that over-expression of APOE4 in neurons, using an AAV-mediated approache, is not sufficient to accelerate or otherwise alter the inherent tau pathology that occurs in mice overexpressing mutant human tau.
Wed Apr 01 00:00:00 UTC 2020
Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease.
Journal of neurochemistry
Hou TY,Zhou Y,Zhu LS,Wang X,Pang P,Wang DQ,Liuyang ZY,Man H,Lu Y,Zhu LQ,Liu D
MN1020 was used in Western Blot to investigate the potential role of miR-124/PTPN1 in the tau pathology of AD.
Sat Aug 01 00:00:00 UTC 2020
Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS.
Neuroscience bulletin
Wen X,An P,Li H,Zhou Z,Sun Y,Wang J,Ma L,Lu B
MN1020 was used in Western Blotting to investigate the effect of reducing a tau protein homologue on neurodegeneration, motor performance and impairments.
Tue Dec 01 00:00:00 UTC 2020
Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model.
Neurobiology of aging
van Olst L,Verhaege D,Franssen M,Kamermans A,Roucourt B,Carmans S,Ytebrouck E,van der Pol SMA,Wever D,Popovic M,Vandenbroucke RE,Sobrino T,Schouten M,de Vries HE
MN1020 was used in Western Blotting to address at which tauopathy stage neuroinflammation starts and to study the related microglial phenotype.
Fri May 01 00:00:00 UTC 2020
Two pathologically confirmed cases of novel mutations in the MAPT gene causing frontotemporal dementia.
Neurobiology of aging
Shafei R,Woollacott IOC,Mummery CJ,Bocchetta M,Guerreiro R,Bras J,Warren JD,Lashley T,Jaunmuktane Z,Rohrer JD
MN1020 was used in Immunohistochemistry to describe 2 novel MAPT mutations, D252V and G389_I392del, each presenting in a patient with behavioral variant FTD and associated language and cognitive deficits.
Sun Mar 01 00:00:00 UTC 2020
Isolation and characterization of antibody fragment selective for human Alzheimer's disease brain-derived tau variants.
Neurobiology of aging
Venkataraman L,He P,Schulz P,Sierks MR
MN1020 was used in Immunoprecipitation to identify and explore 6 scFvs [Alzheimer's disease tau (ADT)-1 through 6] that are readily distinguished between Alzheimer's disease and control tissue and sera samples.
Thu Oct 01 00:00:00 UTC 2020
Genetic screening in early-onset Alzheimer's disease identified three novel presenilin mutations.
Neurobiology of aging
Wong TH,Seelaar H,Melhem S,Rozemuller AJM,van Swieten JC
MN1020 was used in Immunohistochemistry to identify new variants in the presenilin 1 and 2 genes implicated in early-onset Alzheimer's disease.
Sat Feb 01 00:00:00 UTC 2020
Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment.
Human molecular genetics
Guarascio R,Salih D,Yasvoina M,Edwards FA,Cheetham ME,van der Spuy J
MN1020 was used in Immunohistochemistry to investigate if negative regulator of ubiquitin-like protein 1 plays a role in regulating the autophagy-lysosomal pathway when the ubiquitin proteasome system is compromised, thus contributing to the mechanisms targeting the removal of aggregation-prone proteins upon proteasomal impairment.
Wed Jan 01 00:00:00 UTC 2020
Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment.
Human molecular genetics
Guarascio R,Salih D,Yasvoina M,Edwards FA,Cheetham ME,van der Spuy J
MN1020 was used in Immunohistochemistry to investigate if negative regulator of ubiquitin-like protein 1 plays a role in regulating the autophagy-lysosomal pathway when the ubiquitin proteasome system is compromised, thus contributing to the mechanisms targeting the removal of aggregation-prone proteins upon proteasomal impairment.
Wed Jan 01 00:00:00 UTC 2020
Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment.
Human molecular genetics
Guarascio R,Salih D,Yasvoina M,Edwards FA,Cheetham ME,van der Spuy J
MN1020 was used in Immunohistochemistry to investigate if negative regulator of ubiquitin-like protein 1 plays a role in regulating the autophagy-lysosomal pathway when the ubiquitin proteasome system is compromised, thus contributing to the mechanisms targeting the removal of aggregation-prone proteins upon proteasomal impairment.
Wed Jan 01 00:00:00 UTC 2020
Co-Existence of tau and α-synuclein pathology in fetal graft tissue at autopsy: A case report.
Parkinsonism & related disorders
Ornelas AS,Adler CH,Serrano GE,Curry JR,Shill HA,Kopyov O,Beach TG
MN1020 was used in Immunohistochemistry to analyze fetal graft tissue at autopsy and demostrate 6 cases of α-synuclein pathology in PD patients, one case with both α-synuclein and tau pathology in a PD patient, and two cases of tau pathology within a Huntington's Disease patient..
Sat Feb 01 00:00:00 UTC 2020
Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy.
Biomedical optics express
Ni R,Chen Z,Gerez JA,Shi G,Zhou Q,Riek R,Nilsson KPR,Razansky D,Klohs J
MN1020 was used in Immunohistochemistry to report a transcranial detection of tauopathy over the entire cortex of P301L tauopathy mice using large-field multifocal illumination (LMI) fluorescence microscopy technique and luminescent conjugated oligothiophenes.
Tue Sep 01 00:00:00 UTC 2020
Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer's disease pathology: a clinicopathological study.
EJNMMI research
Pontecorvo MJ,Keene CD,Beach TG,Montine TJ,Arora AK,Devous MD,Navitsky M,Kennedy I,Joshi AD,Lu M,Serrano GE,Sue LI,Intorcia AJ,Rose SE,Wilson A,Hellstern L,Coleman N,Flitter M,Aldea P,Fleisher AS,Mintun MA,Siderowf A
MN1020 was used in Immunohistochemistry to make a quantitative comparison of flortaucipir PET retention with pathological tau and β-amyloid across a range of brain regions at autopsy.
Mon Jun 15 00:00:00 UTC 2020
Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons.
Molecular medicine reports
Yang M,Lian N,Yu Y,Wang Y,Xie K,Yu Y
MN1020 was used in Immunocytochemistry-immunoflourescence to reveal the role of ApoE in the pathogenesis of tau protein hyperphosphorylation and neuroinflammation enhancement caused by sevoflurane anesthesia, as well as the protective mechanism of CoQ10 in an anesthetic sevoflurane treatment model of primary mouse hippocampal neurons.
Wed Jul 01 00:00:00 UTC 2020
Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons.
Molecular medicine reports
Yang M,Lian N,Yu Y,Wang Y,Xie K,Yu Y
MN1020 was used in Immunocytochemistry-immunoflourescence to reveal the role of ApoE in the pathogenesis of tau protein hyperphosphorylation and neuroinflammation enhancement caused by sevoflurane anesthesia, as well as the protective mechanism of CoQ10 in an anesthetic sevoflurane treatment model of primary mouse hippocampal neurons.
Wed Jul 01 00:00:00 UTC 2020
Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases.
Journal of neuropathology and experimental neurology
Trejo-Lopez JA,Sorrentino ZA,Riffe CJ,Prokop S,Dickson DW,Yachnis AT,Giasson BI
MN1020 was used in Western Blotting to provide utility in both research and diagnostic efforts.
Wed Apr 01 00:00:00 UTC 2020
Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity.
Journal of neuropathology and experimental neurology
Iacono D,Lee P,Edlow BL,Gray N,Fischl B,Kenney K,Lew HL,Lozanoff S,Liacouras P,Lichtenberger J,Dams-O'Connor K,Cifu D,Hinds SR,Perl DP
MN1020 was used in Immunohistochemistry to describe clinicopathologic findings in 4 military veterans with early-onset dementia (EOD) who had varying histories of blunt- and blast-TBI, cognitive decline, behavioral abnormalities, post-traumatic stress disorder, suicidal ideation, and suicide.
Sat Feb 01 00:00:00 UTC 2020
Neuroprotection against Amyloid-β-Induced DNA Double-Strand Breaks Is Mediated by Multiple Retinoic Acid-Dependent Pathways.
Neural plasticity
Colas J,Chessel N,Ouared A,Gruz-Gibelli E,Marin P,Herrmann FR,Savioz A
MN1020 was used in Western Blot to show that RA can not only repair Aβ 1-42-induced DSBs but also prevent them via the RARα/β/γ and PPARβ/δ receptors.
Wed Apr 07 00:00:00 UTC 2021
β-amyloid and tau pathology in the aging feline brain.
The Journal of comparative neurology
Fiock KL,Smith JD,Crary JF,Hefti MM
MN1020 was used in Immunohistochemistry (Paraffin) to propose that the development of β-amyloid and tau pathology in ageing domestic cats is similar to human Alzheimer's disease and could serve as a model.
Wed Jan 01 00:00:00 UTC 2020
Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model.
Science advances
Chen C,Ahn EH,Kang SS,Liu X,Alam A,Ye K
MN1020 was used in Western Blotting to support the hypothesis that C/EBPβ/AEP signaling is activated by gut dysbiosis, implicated in AD pathologies in the gut.
Wed Jul 01 00:00:00 UTC 2020
Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression.
International journal of molecular sciences
Nam E,Lee YB,Moon C,Chang KA
MN1020 was used in Western Blotting to suggest that serum tau proteins, especially NEX tau proteins, are useful biomarkers for monitoring AD progression.
Wed Jul 15 00:00:00 UTC 2020
Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer's disease and related murine models.
PloS one
Neddens J,Daurer M,Flunkert S,Beutl K,Loeffler T,Walker L,Attems J,Hutter-Paier B
MN1020 was used in Immunocytochemistry to show that Aβ-pE(3) and ptau Ser202/Thr205 levels strongly correlate in human as well as murine tissues, suggesting that tau phosphorylation might be amplified by Aβ-pE(3).
Mon Sep 07 00:00:00 UTC 2020
Yeast surface display of full-length human microtubule-associated protein tau.
Biotechnology progress
Wang S,Cho YK
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Flow Cytometry to show that yeast-displayed tau enables robust measurement of protein interactions and is of particular interest for characterizing conformational change.
Wed Jan 01 00:00:00 UTC 2020
The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease.
Journal of neuroinflammation
Sun Y,Guo Y,Feng X,Jia M,Ai N,Dong Y,Zheng Y,Fu L,Yu B,Zhang H,Wu J,Yu X,Wu H,Kong W
MN1020 was used in Western Blot, Immunohistochemistry (Paraffin) to elucidate the pathogenic mechanisms underlying AD and evaluate therapeutic approaches targeting tau.
Mon Feb 24 00:00:00 UTC 2020
The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease.
Journal of neuroinflammation
Sun Y,Guo Y,Feng X,Jia M,Ai N,Dong Y,Zheng Y,Fu L,Yu B,Zhang H,Wu J,Yu X,Wu H,Kong W
MN1020 was used in Western Blot, Immunohistochemistry (Paraffin) to elucidate the pathogenic mechanisms underlying AD and evaluate therapeutic approaches targeting tau.
Mon Feb 24 00:00:00 UTC 2020
Reductive stress promotes protein aggregation and impairs neurogenesis.
Redox biology
S Narasimhan KK,Devarajan A,Karan G,Sundaram S,Wang Q,van Groen T,Monte FD,Rajasekaran NS
MN1020 was used in Immunocytochemistry to show that either acute or chronic RS could hamper neurogenesis through GSK3β/TAU signaling and proteotoxicity.
Thu Oct 01 00:00:00 UTC 2020
Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy.
Frontiers in neuroscience
LeBlang CJ,Medalla M,Nicoletti NW,Hays EC,Zhao J,Shattuck J,Cruz AL,Wolozin B,Luebke JI
MN1020 was used in Immunohistochemistry to demonstrate that TIA1 plays an important role in the neuroimmune response to chronic stress in the form of tauopathy.
Tue Dec 03 00:00:00 UTC 2024
Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences.
Scientific reports
Murphy EK,Iacono D,Pan H,Grimes JB,Parks S,Raiciulescu S,Leonessa F,Perl DP
MN1020 was used in Western Blot, Immunohistochemistry to identify molecular, histopathological, and behavioral changes in rats 2 weeks after explosive-driven double-blast exposure.
Thu Oct 15 00:00:00 UTC 2020
Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences.
Scientific reports
Murphy EK,Iacono D,Pan H,Grimes JB,Parks S,Raiciulescu S,Leonessa F,Perl DP
MN1020 was used in Western Blot, Immunohistochemistry to identify molecular, histopathological, and behavioral changes in rats 2 weeks after explosive-driven double-blast exposure.
Thu Oct 15 00:00:00 UTC 2020
Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice.
NPJ vaccines
Takeuchi H,Imamura K,Ji B,Tsukita K,Enami T,Takao K,Miyakawa T,Hasegawa M,Sahara N,Iwata N,Inoue M,Hara H,Tabira T,Ono M,Trojanowski JQ,Lee VM,Takahashi R,Suhara T,Higuchi M,Inoue H
MN1020 was used in Immunohistochemistry to determine that nasal drop tau vaccines induced tissue tau-immunoreactive antibody production and ameliorated cognitive impairment in frontotemporal lobar degeneration tauopathy model mice.
Mon Aug 16 00:00:00 UTC 2021
Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice.
NPJ vaccines
Takeuchi H,Imamura K,Ji B,Tsukita K,Enami T,Takao K,Miyakawa T,Hasegawa M,Sahara N,Iwata N,Inoue M,Hara H,Tabira T,Ono M,Trojanowski JQ,Lee VM,Takahashi R,Suhara T,Higuchi M,Inoue H
MN1020 was used in Immunohistochemistry to determine that nasal drop tau vaccines induced tissue tau-immunoreactive antibody production and ameliorated cognitive impairment in frontotemporal lobar degeneration tauopathy model mice.
Mon Aug 16 00:00:00 UTC 2021
Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice.
NPJ vaccines
Takeuchi H,Imamura K,Ji B,Tsukita K,Enami T,Takao K,Miyakawa T,Hasegawa M,Sahara N,Iwata N,Inoue M,Hara H,Tabira T,Ono M,Trojanowski JQ,Lee VM,Takahashi R,Suhara T,Higuchi M,Inoue H
MN1020 was used in Immunohistochemistry to determine that nasal drop tau vaccines induced tissue tau-immunoreactive antibody production and ameliorated cognitive impairment in frontotemporal lobar degeneration tauopathy model mice.
Mon Aug 16 00:00:00 UTC 2021
Fyn Kinase Controls Tau Aggregation In Vivo.
Cell reports
Briner A,Götz J,Polanco JC
MN1020 was used in Western Blot to identify Fyn as a key regulator of tau pathology independently of Aβ-induced toxicity.
Tue Aug 18 00:00:00 UTC 2020
Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates.
Science advances
Bourdenx M,Nioche A,Dovero S,Arotcarena ML,Camus S,Porras G,Thiolat ML,Rougier NP,Prigent A,Aubert P,Bohic S,Sandt C,Laferrière F,Doudnikoff E,Kruse N,Mollenhauer B,Novello S,Morari M,Leste-Lasserre T,Damas IT,Goillandeau M,Perier C,Estrada C,Garcia-Carrillo N,Recasens A,Vaikath NN,El-Agnaf OMA,Herrero MT,Derkinderen P,Vila M,Obeso JA,Dehay B,Bezard E
MN1020 was used in Dot blot to identify unique signatures of neurodegeneration in monkeys induced by distinct α-syn pathogenic structures derived from patients with Parkinson''s disease (PD).
Fri May 01 00:00:00 UTC 2020
APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes.
Scientific reports
Giarratana AO,Zheng C,Reddi S,Teng SL,Berger D,Adler D,Sullivan P,Thakker-Varia S,Alder J
MN1020 was used in Immunohistochemistry to demonstrate that APOE4 is a risk factor for poor outcomes after rmTBI and highlights how personalized therapeutics can be a powerful treatment option.
Mon Nov 16 00:00:00 UTC 2020
IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network.
International journal of molecular sciences
Martins S,Müller-Schiffmann A,Erichsen L,Bohndorf M,Wruck W,Sleegers K,Van Broeckhoven C,Korth C,Adjaye J
MN1020 was used in Western Blotting to study the molecular mechanisms underlying the etiology of late-onset Alzheimer´s disease (LOAD).
Thu Jun 25 00:00:00 UTC 2020
Fulminant corticobasal degeneration: a distinct variant with predominant neuronal tau aggregates.
Acta neuropathologica
Ling H,Gelpi E,Davey K,Jaunmuktane Z,Mok KY,Jabbari E,Simone R,R'Bibo L,Brandner S,Ellis MJ,Attems J,Mann D,Halliday GM,Al-Sarraj S,Hedreen J,Ironside JW,Kovacs GG,Kovari E,Love S,Vonsattel JPG,Allinson KSJ,Hansen D,Bradshaw T,Setó-Salvia N,Wray S,de Silva R,Morris HR,Warner TT,Hardy J,Holton JL,Revesz T
MN1020 was used in Immunohistochemistry to investigate the neuropathological characteristics of corticobasal degeneration.
Wed Apr 01 00:00:00 UTC 2020
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
Scientific reports
Dominguez-Meijide A,Vasili E,König A,Cima-Omori MS,Ibáñez de Opakua A,Leonov A,Ryazanov S,Zweckstetter M,Griesinger C,Outeiro TF
MN1020 was used in Western Blotting to assess the effects of different pharmacological interventions on the aggregation and internalization of tau and aSyn.
Thu Jul 30 00:00:00 UTC 2020
Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds.
Acta neuropathologica communications
Perez-Rando M,Dujardin S,Bennett RE,Commins C,Nibhanupudy T,Hyman BT
MN1020 was used in Immunohistochemistry to suggest that tau propagation impacts neuronal functional integrity.
Mon Oct 19 00:00:00 UTC 2020
Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
The Journal of biological chemistry
Crowe A,Henderson MJ,Anderson J,Titus SA,Zakharov A,Simeonov A,Buist A,Delay C,Moechars D,Trojanowski JQ,Lee VM,Brunden KR
MN1020 was used in Western Blotting to suggest that neurons, the cells most affected by tau pathology in AD, are very suitable for screening for tau inclusion inhibitors.
Fri Mar 20 00:00:00 UTC 2020
Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning.
Journal of neuroinflammation
Eckenweber F,Medina-Luque J,Blume T,Sacher C,Biechele G,Wind K,Deussing M,Briel N,Lindner S,Boening G,von Ungern-Sternberg B,Unterrainer M,Albert NL,Zwergal A,Levin J,Bartenstein P,Cumming P,Rominger A,Höglinger GU,Herms J,Brendel M
MN1020 was used in Immunohistochemistry to conclude that the contribution of microglial response to pathology accompanying amyloid-β and tau over-expression merits further investigation.
Mon Jul 13 00:00:00 UTC 2020
Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer's disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications.
PloS one
Soto-Mercado V,Mendivil-Perez M,Velez-Pardo C,Lopera F,Jimenez-Del-Rio M
MN1020 was used in Immunocytochemistry-immunoflourescence to demonstrate that FAD MSC-derived cholinergic neurons with the PSEN1 E280A mutation provide important clues for the identification of targetable pathological molecules.
Wed Sep 09 00:00:00 UTC 2020
Effects of IgLON5 Antibodies on Neuronal Cytoskeleton: A Link between Autoimmunity and Neurodegeneration.
Annals of neurology
Landa J,Gaig C,Plagumà J,Saiz A,Antonell A,Sanchez-Valle R,Dalmau J,Graus F,Sabater L
MN1020 was used in Immunohistochemistry-immunofluorescence to suggest that IgLON5 IgG, unlike other cell-surface antibodies, disrupts neuronal cytoskeleton maintenance, providing a link between autoimmunity and neurodegeneration.
Sun Nov 01 00:00:00 UTC 2020
Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity.
Acta neuropathologica communications
Kaalund SS,Passamonti L,Allinson KSJ,Murley AG,Robbins TW,Spillantini MG,Rowe JB
MN1020 was used in Immunohistochemistry to test the hypothesis that tau pathology and neuronal loss are associated with clinical heterogeneity and severity in progressive supranuclear palsy.
Tue Feb 04 00:00:00 UTC 2020
Altered striatal dopamine levels in Parkinson's disease VPS35 D620N mutant transgenic aged mice.
Molecular brain
Vanan S,Zeng X,Chia SY,Varnäs K,Jiang M,Zhang K,Saw WT,Padmanabhan P,Yu WP,Zhou ZD,Halldin C,Gulyás B,Tan EK,Zeng L
MN1020 was used in Western Blotting to find that VPS35 D620N Tg mice displayed a significantly higher dopamine level than NTg counterparts.
Tue Dec 01 00:00:00 UTC 2020
Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice.
Cell death & disease
Wu Z,Liu X,Cheng L,Ye K
MN1020 was used in Western Blot, Immunohistochemistry to establish a new mouse Alzheimer's disease model with both human wild-type amyloid-β precursor protein and Tau.
Sat Dec 12 00:00:00 UTC 2020
Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice.
Cell death & disease
Wu Z,Liu X,Cheng L,Ye K
MN1020 was used in Western Blot, Immunohistochemistry to establish a new mouse Alzheimer's disease model with both human wild-type amyloid-β precursor protein and Tau.
Sat Dec 12 00:00:00 UTC 2020
(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model.
Cell death & disease
Chiu CC,Weng YH,Huang YZ,Chen RS,Liu YC,Yeh TH,Lu CS,Lin YW,Chen YJ,Hsu CC,Chiu CH,Wang YT,Chen WS,Liu SY,Wang HL
MN1020 was used in Western Blot, Immunohistochemistry (Frozen) to suggest that PARK17 mutant (D620N) VPS35 impairs activity of Wnt/β-catenin signaling pathway and causes abnormal morphology and dysfunction of mitochondria, which could lead to neurodegeneration of SNpc DAergic cells.
Mon Nov 30 00:00:00 UTC 2020
(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model.
Cell death & disease
Chiu CC,Weng YH,Huang YZ,Chen RS,Liu YC,Yeh TH,Lu CS,Lin YW,Chen YJ,Hsu CC,Chiu CH,Wang YT,Chen WS,Liu SY,Wang HL
MN1020 was used in Western Blot, Immunohistochemistry (Frozen) to suggest that PARK17 mutant (D620N) VPS35 impairs activity of Wnt/β-catenin signaling pathway and causes abnormal morphology and dysfunction of mitochondria, which could lead to neurodegeneration of SNpc DAergic cells.
Mon Nov 30 00:00:00 UTC 2020
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species.
The Journal of biological chemistry
Nachman E,Wentink AS,Madiona K,Bousset L,Katsinelos T,Allinson K,Kampinga H,McEwan WA,Jahn TR,Melki R,Mogk A,Bukau B,Nussbaum-Krammer C
MN1020 was used in Immunohistochemistry to show that an ATP-dependent human chaperone system disassembles Tau fibrils in vitro We found that this function is mediated by the core chaperone HSC70, assisted by specific cochaperones, in particular class B J-domain proteins and a heat shock protein 110 (Hsp110)-type nucleotide exchange factor (NEF).
Fri Jul 10 00:00:00 UTC 2020
Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.
Acta neuropathologica communications
Tang SJ,Fesharaki-Zadeh A,Takahashi H,Nies SH,Smith LM,Luo A,Chyung A,Chiasseu M,Strittmatter SM
MN1020 was used in Immunohistochemistry to discover whether pharmacological Fyn inhibition alters Tauopathy.
Wed Jul 01 00:00:00 UTC 2020
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
Nature communications
Lee JY,Han SH,Park MH,Song IS,Choi MK,Yu E,Park CM,Kim HJ,Kim SH,Schuchman EH,Jin HK,Bae JS
MN1020 was used in Immunohistochemistry to identify a role of N-AS in the dysfunction of microglia in AD.
Tue May 12 00:00:00 UTC 2020
Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization.
PloS one
Yadikar H,Torres I,Aiello G,Kurup M,Yang Z,Lin F,Kobeissy F,Yost R,Wang KK
MN1020 was used in Western Blotting to provide a comprehensive view of potential drug candidates (TBB, CsA, AR, and Saracatinib), and their efficacy against tau hyperphosphorylation and oligomerization processes.
Fri Sep 04 00:00:00 UTC 2020
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.
Nature communications
Zhao J,Fu Y,Yamazaki Y,Ren Y,Davis MD,Liu CC,Lu W,Wang X,Chen K,Cherukuri Y,Jia L,Martens YA,Job L,Shue F,Nguyen TT,Younkin SG,Graff-Radford NR,Wszolek ZK,Brafman DA,Asmann YW,Ertekin-Taner N,Kanekiyo T,Bu G
MN1020 was used in Western Blot, Immunohistochemistry to suggest APOE4-related degenerative pathways contributing to AD pathogenesis, using human iPSC-organoids recapitulates APOE4-related phenotypes.
Mon Nov 02 00:00:00 UTC 2020
APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.
Nature communications
Zhao J,Fu Y,Yamazaki Y,Ren Y,Davis MD,Liu CC,Lu W,Wang X,Chen K,Cherukuri Y,Jia L,Martens YA,Job L,Shue F,Nguyen TT,Younkin SG,Graff-Radford NR,Wszolek ZK,Brafman DA,Asmann YW,Ertekin-Taner N,Kanekiyo T,Bu G
MN1020 was used in Western Blot, Immunohistochemistry to suggest APOE4-related degenerative pathways contributing to AD pathogenesis, using human iPSC-organoids recapitulates APOE4-related phenotypes.
Mon Nov 02 00:00:00 UTC 2020
Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures.
The Journal of biological chemistry
Katsikoudi A,Ficulle E,Cavallini A,Sharman G,Guyot A,Zagnoni M,Eastwood BJ,Hutton M,Bose S
MN1020 was used in Western Blotting to show that a small molecule inhibitor of aggregation can block the trans-neuronal transfer of Tau aggregates, suggesting that the system can be used to evaluate mechanisms of Tau transfer and find therapeutic interventions.
Fri Sep 11 00:00:00 UTC 2020
The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging.
iScience
Wander CM,Tseng JH,Song S,Al Housseiny HA,Tart DS,Ajit A,Ian Shih YY,Lobrovich R,Song J,Meeker RB,Irwin DJ,Cohen TJ
MN1020 was used in Western Blotting to supports neuroimmune dysfunction as a precipitating event in tau pathogenesis.
Fri Jul 24 00:00:00 UTC 2020
Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases.
Journal of neuroinflammation
Biechele G,Franzmeier N,Blume T,Ewers M,Luque JM,Eckenweber F,Sacher C,Beyer L,Ruch-Rubinstein F,Lindner S,Gildehaus FJ,von Ungern-Sternberg B,Cumming P,Bartenstein P,Rominger A,Höglinger GU,Herms J,Brendel M
MN1020 was used in Immunohistochemistry to investigate the impact of sex on microglial activation in amyloid and tau mouse models and wild-type controls.
Mon Dec 14 00:00:00 UTC 2020
Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in.
Neurobiology of disease
Chiasseu M,Fesharaki-Zadeh A,Saito T,Saido TC,Strittmatter SM
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to reveal that rmCHI enhances accumulation of amyloid-ß and hyperphosphorylated tau inclusions, as well as neuroinflammation in AppNL-F/NL-F mice.
Sun Nov 01 00:00:00 UTC 2020
Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice.
International journal of molecular sciences
Roda AR,Montoliu-Gaya L,Serra-Mir G,Villegas S
MN1020 was used in Immunohistochemistry to assess the effects of scFv-h3D6 on Aβ and tau pathologies in 22-month-old 3xTg-AD mice. Briefly, 3xTg-AD female mice were treated for 2 weeks with scFv-h3D6 and compared with 3xTg-AD and non-transgenic (NTg) mice treated with PBS..
Thu Sep 10 00:00:00 UTC 2020
Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease.
Brain pathology (Zurich, Switzerland)
Lauterborn JC,Cox CD,Chan SW,Vanderklish PW,Lynch G,Gall CM
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate marked synaptic disturbances in two actin regulatory proteins in adult DS and AD brains, with greater effects in individuals with AD alone.
Sun Mar 01 00:00:00 UTC 2020
Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing.
Translational psychiatry
Ghosh A,Mizuno K,Tiwari SS,Proitsi P,Gomez Perez-Nievas B,Glennon E,Martinez-Nunez RT,Giese KP
MN1020 was used in Immunohistochemistry to study the mRNA translation and its underlying signalling and whether they are altered during early AD using a mouse model and studying any pathological features.
Tue Jun 16 00:00:00 UTC 2020
Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized With DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins.
Vaccines
García-Arriaza J,Marín MQ,Merchán-Rubira J,Mascaraque SM,Medina M,Ávila J,Hernández F,Esteban M
MN1020 was used in Western Blot to present the generation and characterization of the first MVA vectors expressing human tau genes; the full-length 4R2N tau protein or a 3RC tau fragment containing 3 tubulin-binding motifs and the C-terminal region.
Fri Mar 13 00:00:00 UTC 2020
Tauopathy Analysis in P301S Mouse Model of Alzheimer Disease Immunized With DNA and MVA Poxvirus-Based Vaccines Expressing Human Full-Length 4R2N or 3RC Tau Proteins.
Vaccines
García-Arriaza J,Marín MQ,Merchán-Rubira J,Mascaraque SM,Medina M,Ávila J,Hernández F,Esteban M
MN1020 was used in Western Blot to present the generation and characterization of the first MVA vectors expressing human tau genes; the full-length 4R2N tau protein or a 3RC tau fragment containing 3 tubulin-binding motifs and the C-terminal region.
Fri Mar 13 00:00:00 UTC 2020
Effects of Aerobic Exercise on Tau and Related Proteins in Rats with the Middle Cerebral Artery Occlusion.
International journal of molecular sciences
Mankhong S,Kim S,Moon S,Lee KH,Jeon HE,Hwang BH,Beak JW,Joa KL,Kang JH
MN1020 was used in Western Blotting to evaluate the effects of aerobic exercise on the phosphorylation and acetylation of tau and the expressions of tau-related proteins, after middle cerebral artery occlusion (MCAO) stroke.
Fri Aug 14 00:00:00 UTC 2020
Identification of Alzheimer's disease-associated rare coding variants in the ECE2 gene.
JCI insight
Liao X,Cai F,Sun Z,Zhang Y,Wang J,Jiao B,Guo J,Li J,Liu X,Guo L,Zhou Y,Wang J,Yan X,Jiang H,Xia K,Li J,Tang B,Shen L,Song W
MN1020 was used in Immunohistochemistry to indicate that ECE2 is a risk gene for AD development and pharmacological activation of ECE2 could be a promising strategy for AD treatment.
Thu Feb 27 00:00:00 UTC 2020
Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies.
Cell death & disease
Puangmalai N,Bhatt N,Montalbano M,Sengupta U,Gaikwad S,Ventura F,McAllen S,Ellsworth A,Garcia S,Kayed R
MN1020 was used in Western Blotting to demonstrate that the HSPG-mediated pathway regulates internalization of BDTOs from AD and DLB, while HSPG-mediated and other alternative pathways are involved in the internalization of PSP-derived tau oligomers.
Mon May 04 00:00:00 UTC 2020
Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques.
Molecular neurodegeneration
Natunen T,Martiskainen H,Marttinen M,Gabbouj S,Koivisto H,Kemppainen S,Kaipainen S,Takalo M,Svobodová H,Leppänen L,Kemiläinen B,Ryhänen S,Kuulasmaa T,Rahunen E,Juutinen S,Mäkinen P,Miettinen P,Rauramaa T,Pihlajamäki J,Haapasalo A,Leinonen V,Tanila H,Hiltunen M
MN1020 was used in Immunohistochemistry to suggest that the diabetic phenotype in mice and humans mechanistically associates with abnormally reduced microglial responses to β-amyloid pathology and further suggest that AD and T2D share overlapping pathomechanisms, likely involving altered immune function in the brain.
Tue Nov 10 00:00:00 UTC 2020
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice.
Acta neuropathologica communications
McMillan P,Wheeler J,Gatlin RE,Taylor L,Strovas T,Baum M,Bird TD,Latimer C,Keene CD,Kraemer BC,Liachko NF
MN1020 was used in Immunohistochemistry (Paraffin) to characterize the consequences of neuronal TTBK1 upregulation in adult brains.
Mon Nov 23 00:00:00 UTC 2020
Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission.
Cell stem cell
Zheng J,Li HL,Tian N,Liu F,Wang L,Yin Y,Yue L,Ma L,Wan Y,Wang JZ
MN1020 was used in Immunohistochemistry to evidence that intracellular accumulation of tau in GABAergic interneurons impairs AHN by suppressing GABAergic transmission and disinhibiting neural circuits within the neurogenic niche, suggesting a potential of GABAergic potentiators for pro-neurogenic or cell therapies of AD.
Thu Mar 05 00:00:00 UTC 2020
Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease.
Science advances
Cao Q,Wang W,Williams JB,Yang F,Wang ZJ,Yan Z
MN1020 was used in Western Blot, Immunohistochemistry to find a novel epigenetic mechanism and a potential therapeutic strategy for AD and related neurodegenerative disorders.
Tue Dec 01 00:00:00 UTC 2020
Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease.
Science advances
Cao Q,Wang W,Williams JB,Yang F,Wang ZJ,Yan Z
MN1020 was used in Western Blot, Immunohistochemistry to find a novel epigenetic mechanism and a potential therapeutic strategy for AD and related neurodegenerative disorders.
Tue Dec 01 00:00:00 UTC 2020
A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.
Molecular neurodegeneration
Li JG,Chiu J,Ramanjulu M,Blass BE,Praticò D
MN1020 was used in Immunohistochemistry and Western Blotting to demonstrate that vacuolar protein sorting 35 genetic manipulation modulates the phenotype of mouse models of Alzheimer's disease.
Wed Jan 22 00:00:00 UTC 2020
A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.
Molecular neurodegeneration
Li JG,Chiu J,Ramanjulu M,Blass BE,Praticò D
MN1020 was used in Immunohistochemistry and Western Blotting to demonstrate that vacuolar protein sorting 35 genetic manipulation modulates the phenotype of mouse models of Alzheimer's disease.
Wed Jan 22 00:00:00 UTC 2020
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.
Nature medicine
Swarup V,Hinz FI,Rexach JE,Noguchi KI,Toyoshiba H,Oda A,Hirai K,Sarkar A,Seyfried NT,Cheng C,Haggarty SJ,Grossman M,Van Deerlin VM,Trojanowski JQ,Lah JJ,Levey AI,Kondou S,Geschwind DH
MN1020 was used in Western Blotting to identify small molecules that can normalize the disease-associated modules.
Tue Jan 01 00:00:00 UTC 2019
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
Nature
Falcon B,Zivanov J,Zhang W,Murzin AG,Garringer HJ,Vidal R,Crowther RA,Newell KL,Ghetti B,Goedert M,Scheres SHW
MN1020 was used in Immunohistochemistry to provide a unifying neuropathological criterion for CTE, and support the hypothesis that the formation and propagation of distinct conformers of assembled tau underlie different neurodegenerative diseases.
Mon Apr 01 00:00:00 UTC 2019
Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia.
Acta neuropathologica
Perez SE,Miguel JC,He B,Malek-Ahmadi M,Abrahamson EE,Ikonomovic MD,Lott I,Doran E,Alldred MJ,Ginsberg SD,Mufson EJ
Fri Mar 01 00:00:00 UTC 2019
Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia.
Acta neuropathologica
Perez SE,Miguel JC,He B,Malek-Ahmadi M,Abrahamson EE,Ikonomovic MD,Lott I,Doran E,Alldred MJ,Ginsberg SD,Mufson EJ
Fri Mar 01 00:00:00 UTC 2019
Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia.
Acta neuropathologica
Perez SE,Miguel JC,He B,Malek-Ahmadi M,Abrahamson EE,Ikonomovic MD,Lott I,Doran E,Alldred MJ,Ginsberg SD,Mufson EJ
Fri Mar 01 00:00:00 UTC 2019
In vivo imaging reveals reduced activity of neuronal circuits in a mouse tauopathy model.
Brain : a journal of neurology
Marinković P,Blumenstock S,Goltstein PM,Korzhova V,Peters F,Knebl A,Herms J
MN1020 was used in Immunohistochemistry to investigate the effects of various pathological tau species on neuronal network functioning.
Mon Apr 01 00:00:00 UTC 2019
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Brain : a journal of neurology
Mancuso R,Fryatt G,Cleal M,Obst J,Pipi E,Monzón-Sandoval J,Ribe E,Winchester L,Webber C,Nevado A,Jacobs T,Austin N,Theunis C,Grauwen K,Daniela Ruiz E,Mudher A,Vicente-Rodriguez M,Parker CA,Simmons C,Cash D,Richardson J,Jones DNC,Lovestone S,Gómez-Nicola D,Perry VH
MN1020 was used in Immunohistochemistry to tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 in the P301S mouse tauopathy model.
Tue Oct 01 00:00:00 UTC 2019
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Brain : a journal of neurology
Mancuso R,Fryatt G,Cleal M,Obst J,Pipi E,Monzón-Sandoval J,Ribe E,Winchester L,Webber C,Nevado A,Jacobs T,Austin N,Theunis C,Grauwen K,Daniela Ruiz E,Mudher A,Vicente-Rodriguez M,Parker CA,Simmons C,Cash D,Richardson J,Jones DNC,Lovestone S,Gómez-Nicola D,Perry VH
MN1020 was used in Immunohistochemistry to tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 in the P301S mouse tauopathy model.
Tue Oct 01 00:00:00 UTC 2019
Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling.
The EMBO journal
Evans HT,Benetatos J,van Roijen M,Bodea LG,Götz J
MN1020 was used in Immunohistochemistry - Free Floating to present a potential pathomechanism by which pathological tau interferes with cellular functions through the dysregulation of ribosomal protein synthesis.
Mon Jul 01 00:00:00 UTC 2019
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.
Molecular psychiatry
Audrain M,Haure-Mirande JV,Wang M,Kim SH,Fanutza T,Chakrabarty P,Fraser P,St George-Hyslop PH,Golde TE,Blitzer RD,Schadt EE,Zhang B,Ehrlich ME,Gandy S
MN1020 was used in Western Blotting to characterise in mice the effects of TYROBP deficiency on the phenotypic and pathological evolution of tauopathy.
Sun Sep 01 00:00:00 UTC 2019
TDP43 pathology in the brain, spinal cord, and dorsal root ganglia of a patient with FOSMN.
Neurology
Rossor AM,Jaunmuktane Z,Rossor MN,Hoti G,Reilly MM
MN1020 was used in Immunohistochemistry to describe the histopathologic features of a case of facial-onset sensory and motor neuronopathy.
Tue Feb 26 00:00:00 UTC 2019
Amylin as a potential link between type 2 diabetes and alzheimer disease.
Annals of neurology
Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Riverol M,Marcilla I,de Andrea CE,Sánchez-Arias JA,Del Mar Carmona-Abellan M,Marti G,Erro ME,Martínez-Vila E,Tuñon MT,Luquin MR
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to assess ed whether tau and ß-amyloid (Aß) deposits might be present in pancreatic tissue of subjects with Alzheimer's disease, and whether amylin, an amyloidogenic protein deposited in the pancreas of T2DM patients, might accumulate in the brain of Alzheimer's disease patients.
Tue Oct 01 00:00:00 UTC 2019
Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice.
Aging cell
Belfiore R,Rodin A,Ferreira E,Velazquez R,Branca C,Caccamo A,Oddo S
MN1020 was used in Immunohistochemistry to indicate a consistent and predictable progression of the AD-like pathology in female 3xTg-AD mice, and will facilitate the design of future studies using these mice.
Fri Feb 01 00:00:00 UTC 2019
Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies.
Aging cell
Zhang J,Chen B,Lu J,Wu Y,Wang S,Yao Z,Zhu L,Qiao Y,Sun Q,Qin W,Zhao Q,Jia J,Wei C
MN1020 was used in Immunohistochemistry to indicate that the cerebral amyloid beta dimer plats an important role in Alzheimer's disease pathogenesis, so targeting this dimer is a promising strategy for preventing this disease.
Thu Aug 01 00:00:00 UTC 2019
Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies.
Aging cell
Zhang J,Chen B,Lu J,Wu Y,Wang S,Yao Z,Zhu L,Qiao Y,Sun Q,Qin W,Zhao Q,Jia J,Wei C
MN1020 was used in Immunohistochemistry to indicate that the cerebral amyloid beta dimer plats an important role in Alzheimer's disease pathogenesis, so targeting this dimer is a promising strategy for preventing this disease.
Thu Aug 01 00:00:00 UTC 2019
Early-life exposure to high-fat diet influences brain health in aging mice.
Aging cell
Di Meco A,Praticò D
MN1020 was used in Western Blotting to investigate the effect that maternal high-fat diet during gestation has on brain health of the offspring later in life.
Sun Dec 01 00:00:00 UTC 2019
Early-life exposure to high-fat diet influences brain health in aging mice.
Aging cell
Di Meco A,Praticò D
MN1020 was used in Western Blotting to investigate the effect that maternal high-fat diet during gestation has on brain health of the offspring later in life.
Sun Dec 01 00:00:00 UTC 2019
Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.
European journal of nuclear medicine and molecular imaging
Kroth H,Oden F,Molette J,Schieferstein H,Capotosti F,Mueller A,Berndt M,Schmitt-Willich H,Darmency V,Gabellieri E,Boudou C,Juergens T,Varisco Y,Vokali E,Hickman DT,Tamagnan G,Pfeifer A,Dinkelborg L,Muhs A,Stephens A
MN1020 was used in Immunohistochemistry to characterise the novel compound [18F]PI-2620 and use it to assess the pathology of tau in Alzheimer's disease.
Sun Sep 01 00:00:00 UTC 2019
A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology.
International journal of stroke : official journal of the International Stroke Society
Humphreys CA,Jansen MA,Muñoz Maniega S,González-Castro V,Pernet C,Deary IJ,Al-Shahi Salman R,Wardlaw JM,Smith C
MN1020 was used in Immunohistochemistry to identify and define the cellular characteristics of small vessel disease lesions in human post-mortem brain tissue, in relation to the lesions seen on neuroimaging.
Mon Apr 01 00:00:00 UTC 2019
Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bonds JA,Shetti A,Bheri A,Chen Z,Disouky A,Tai L,Mao M,Head BP,Bonini MG,Haus JM,Minshall RD,Lazarov O
MN1020 was used in Western Blotting to show that the expression of caveolin-1 (Cav-1) is reduced in the brain in Type 2 diabetes mellitus.
Wed Oct 23 00:00:00 UTC 2019
Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lee JY,Kim MJ,Thomas S,Oorschot V,Ramm G,Aui PM,Sekine Y,Deliyanti D,Wilkinson-Berka J,Niego B,Harvey AR,Theotokis P,McLean C,Strittmatter SM,Petratos S
MN1020 was used in Immunohistochemistry-immunofluorescence to identify that abrogating the NgR1/pCRMP2 signaling cascade can maintain Kinesin-1-dependent anterograde axonal transport to limit inflammatory-mediated axonopathy and demyelination.
Wed Jul 10 00:00:00 UTC 2019
Amyloid β Induces Early Changes in the Ribosomal Machinery, Cytoskeletal Organization and Oxidative Phosphorylation in Retinal Photoreceptor Cells.
Frontiers in molecular neuroscience
Deng L,Pushpitha K,Joseph C,Gupta V,Rajput R,Chitranshi N,Dheer Y,Amirkhani A,Kamath K,Pascovici D,Wu JX,Salekdeh GH,Haynes PA,Graham SL,Gupta VK,Mirzaei M
MN1020 was used in Western Blot to investigate the proteins and biochemical networks that are affected by amyloid Β in the 661 W photoreceptor cells in culture.
Sun Jul 14 00:00:00 UTC 2024
In vivo Bioluminescence Imaging Used to Monitor Disease Activity and Therapeutic Response in a Mouse Model of Tauopathy.
Frontiers in aging neuroscience
Dunn-Meynell AA,Dowling P,Marchese M,Rodriguez E,Blumberg B,Choi YB,Gaindh D,Lu W
MN1020 was used in Immunohistochemistry to use serial bioluminescent images to define the onset and the time course of astrogliosis in mice.
Sat Oct 14 00:00:00 UTC 2023
Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo.
Frontiers in aging neuroscience
Miao J,Shi R,Li L,Chen F,Zhou Y,Tung YC,Hu W,Gong CX,Iqbal K,Liu F
MN1020 was used in Western Blotting to speculate that AD P-tau seeds hyperphosphorylated tau to form aggregates, which resist to the dephosphorylation by PP2A, resulting in hyperphosphorylation and pathology of tau.
Thu Oct 01 00:00:00 UTC 2020
Correlations Between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in Alzheimer's Disease Among Han Chinese.
Neuroscience bulletin
Yang Q,Chen K,Zhang H,Zhang W,Gong C,Zhang Q,Liu P,Sun T,Xu Y,Qian X,Qiu W,Ma C
MN1020 was used in Immunohistochemistry to examine the distribution of five Alzheimer's disease (AD)-related single nucleotide polymorphisms (SNPs) in the Han population.
Mon Apr 01 00:00:00 UTC 2019
Repetitive Concussive and Subconcussive Injury in a Human Tau Mouse Model Results in Chronic Cognitive Dysfunction and Disruption of White Matter Tracts, But Not Tau Pathology.
Journal of neurotrauma
Gangolli M,Benetatos J,Esparza TJ,Fountain EM,Seneviratne S,Brody DL
MN1020 was used in Immunohistochemistry to determine the effect of repetitive brain trauma in adult mice and observe changes in tau tangle accumulation.
Fri Mar 01 00:00:00 UTC 2019
The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice.
Molecular and cellular neurosciences
Young ML,Franklin JL
MN1020 was used in Immunohistochemistry (Paraffin) to support a role for the involvement of mitochondria-derived oxidative stress in the etiology of AD and suggest that mitochondria-targeted antioxidants may lessen symptoms in AD patients.
Sun Dec 01 00:00:00 UTC 2019
Hypertrophy of nigral neurons in Torsin1A deletion (DYT1) carriers manifesting dystonia.
Parkinsonism & related disorders
Iacono D,Geraci-Erck M,Peng H,Rabin ML,Kurlan R
MN1020 was used in Immunohistochemistry to individuate morphometric changes and prevalent types of intraneuronal inclusions in nigral neurons of DYT1 dystonia autopsy-brains.
Tue Jan 01 00:00:00 UTC 2019
Phospho-Tau Changes in the Human CA1 During Alzheimer's Disease Progression.
Journal of Alzheimer's disease : JAD
Regalado-Reyes M,Furcila D,Hernández F,Ávila J,DeFelipe J,León-Espinosa G
MN1020 was used in Immunohistochemistry to study the molecular and structural changes responsible for neurofibrillary tangle development.
Wed Sep 09 00:00:00 UTC 2020
Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimer's Disease.
Journal of Alzheimer's disease : JAD
Reed MJ,Damodarasamy M,Pathan JL,Chan CK,Spiekerman C,Wight TN,Banks WA,Day AJ,Vernon RB,Keene CD
MN1020 was used in Immunohistochemistry to indicate a positive correlation between HA accumulation and AD neuropathology, and suggest a possible role for HA synthesis and metabolism in AD progression.
Mon Mar 02 00:00:00 UTC 2020
BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes.
Frontiers in neurology
Giarratana AO,Teng S,Reddi S,Zheng C,Adler D,Thakker-Varia S,Alder J
MN1020 was used in Immunohistochemistry to investigate the effect of a single nucleotide polymorphism in Brain-derived neurotrophic factor at amino acid 66 on recovery after traumatic brain injury.
Mon Sep 28 00:00:00 UTC 2020
Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling.
Frontiers in neurology
Wan W,Cao L,Kalionis B,Murthi P,Xia S,Guan Y
MN1020 was used in Western Blot to observe that ferrous (Fe2+) chloride led to aberrant phosphorylation of tau, and decreased tyrosine phosphorylation levels of insulin receptor β (IRβ), insulin signal substrate 1 (IRS-1) and phosphoinositide 3-kinase p85α (PI3K p85α), in primary cultured neurons.
Wed Sep 30 00:00:00 UTC 2020
Associations of regional amyloid-β plaque and phospho-tau pathology with biological factors and neuropsychological functioning among HIV-infected adults.
Journal of neurovirology
Soontornniyomkij V,Moore DJ,Gouaux B,Soontornniyomkij B,Sinsheimer JS,Levine AJ
MN1020 was used in Immunohistochemistry to conclude that Aβ plaque or p-tau pathology in different brain regions was predicted by different sets of biological factors.
Sun Dec 01 00:00:00 UTC 2019
Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer's Disease.
Frontiers in neuroanatomy
Furcila D,Domínguez-Álvaro M,DeFelipe J,Alonso-Nanclares L
MN1020 was used in Immunohistochemistry to examine the possible relationship of both Aβ plaques and NFTs with neuronal loss in several hippocampal fields (DG, CA3, CA1, and subiculum) of 11 demented AD patients.
Thu Oct 01 00:00:00 UTC 2020
Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.
Frontiers in neuroanatomy
Bullmann T,Feneberg E,Kretzschmann TP,Ogunlade V,Holzer M,Arendt T
MN1020 was used in Immunohistochemistry to conclude that hibernation is associated with a specific olfactory memory deficit, which might not be attributed to the formation of PHF-like phosphorylated tau within the olfactory bulb as seen in Alzheimer's Disease.
Fri Oct 13 00:00:00 UTC 2023
Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.
Frontiers in neuroanatomy
Bullmann T,Feneberg E,Kretzschmann TP,Ogunlade V,Holzer M,Arendt T
MN1020 was used in Immunohistochemistry to conclude that hibernation is associated with a specific olfactory memory deficit, which might not be attributed to the formation of PHF-like phosphorylated tau within the olfactory bulb as seen in Alzheimer's Disease.
Fri Oct 13 00:00:00 UTC 2023
Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.
Frontiers in neuroanatomy
Bullmann T,Feneberg E,Kretzschmann TP,Ogunlade V,Holzer M,Arendt T
MN1020 was used in Immunohistochemistry to conclude that hibernation is associated with a specific olfactory memory deficit, which might not be attributed to the formation of PHF-like phosphorylated tau within the olfactory bulb as seen in Alzheimer's Disease.
Fri Oct 13 00:00:00 UTC 2023
Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.
Frontiers in neuroanatomy
Bullmann T,Feneberg E,Kretzschmann TP,Ogunlade V,Holzer M,Arendt T
MN1020 was used in Immunohistochemistry to conclude that hibernation is associated with a specific olfactory memory deficit, which might not be attributed to the formation of PHF-like phosphorylated tau within the olfactory bulb as seen in Alzheimer's Disease.
Fri Oct 13 00:00:00 UTC 2023
Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice.
Neural plasticity
Liu Y,Cao L,Zhang X,Liang Y,Xu Y,Zhu C
MN1020 was used in Western Blotting to investigate the effects of memantine, an uncompetitive N-methyl-D-aspartate receptor antagonist, on chronic restraint stress- induced tau phosphorylation in mice.
Mon May 13 00:00:00 UTC 2019
Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees.
The Journal of comparative neurology
Munger EL,Edler MK,Hopkins WD,Ely JJ,Erwin JM,Perl DP,Mufson EJ,Hof PR,Sherwood CC,Raghanti MA
MN1020 was used in Immunohistochemistry to examine the relationships among aging, Alzheimer''s disease-type pathology, and astrocyte activation in chimpanzees.
Wed May 01 00:00:00 UTC 2019
In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer's brain.
Prion
Nam WH,Choi YP
MN1020 was used in Immunocytochemistry-immunoflourescence to characterise how in vitro generated tau aggregates are conformationally distinct from parent seeds of Alzheimer's brain.
Tue Jan 01 00:00:00 UTC 2019
Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade.
Frontiers in cellular neuroscience
Chiu CC,Yeh TH,Chen RS,Chen HC,Huang YZ,Weng YH,Cheng YC,Liu YC,Cheng AJ,Lu YC,Chen YJ,Lin YW,Hsu CC,Chen YL,Lu CS,Wang HL
MN1020 was used in Western Blotting to study the role of microRNA (miR-204-5p) in dopaminergic neurone death in Parkinson's disease.
Thu Oct 01 00:00:00 UTC 2020
Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
Cell reports
Paonessa F,Evans LD,Solanki R,Larrieu D,Wray S,Hardy J,Jackson SP,Livesey FJ
MN1020 was used in Immunocytochemistry-immunoflourescence to study the underlying pathogenic mechanisms in inherited frontotemporal dementia.
Tue Jan 15 00:00:00 UTC 2019
Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype.
Acta neuropathologica communications
Hesse R,Hurtado ML,Jackson RJ,Eaton SL,Herrmann AG,Colom-Cadena M,Tzioras M,King D,Rose J,Tulloch J,McKenzie CA,Smith C,Henstridge CM,Lamont D,Wishart TM,Spires-Jones TL
MN1020 was used in Immunohistochemistry to identify over 5500 proteins in human synaptoneurosomes and highlighted disease, brain region and apolipoprotein E epsilon 4-associated changes in multiple molecular pathways.
Fri Dec 20 00:00:00 UTC 2019
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Nature communications
Jadiya P,Kolmetzky DW,Tomar D,Di Meco A,Lombardi AA,Lambert JP,Luongo TS,Ludtmann MH,Praticò D,Elrod JW
MN1020 was used in Western Blotting to provide a link between the calcium dysregulation and metabolic dysfunction hypotheses of Alzheimer's disease (AD) and suggest mCa2+ exchange as potential therapeutic target in AD.
Thu Aug 29 00:00:00 UTC 2019
A 4R tauopathy develops without amyloid deposits in aged cat brains.
Neurobiology of aging
Poncelet L,Ando K,Vergara C,Mansour S,Suain V,Yilmaz Z,Reygel A,Gilissen E,Brion JP,Leroy K
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that the presence of a tau pathology in aged cat brains that develop independently of amyloid deposits.
Sun Sep 01 00:00:00 UTC 2019
A 4R tauopathy develops without amyloid deposits in aged cat brains.
Neurobiology of aging
Poncelet L,Ando K,Vergara C,Mansour S,Suain V,Yilmaz Z,Reygel A,Gilissen E,Brion JP,Leroy K
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that the presence of a tau pathology in aged cat brains that develop independently of amyloid deposits.
Sun Sep 01 00:00:00 UTC 2019
USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells.
Scientific reports
Piatnitskaia S,Takahashi M,Kitaura H,Katsuragi Y,Kakihana T,Zhang L,Kakita A,Iwakura Y,Nawa H,Miura T,Ikeuchi T,Hara T,Fujii M
MN1020 was used in Immunohistochemistry on paraffin embedded tissues to suggest that USP10 plays a key role in the initiation of pathogenic Tau aggregation in AD through SG formation.
Mon Jul 22 00:00:00 UTC 2019
USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells.
Scientific reports
Piatnitskaia S,Takahashi M,Kitaura H,Katsuragi Y,Kakihana T,Zhang L,Kakita A,Iwakura Y,Nawa H,Miura T,Ikeuchi T,Hara T,Fujii M
MN1020 was used in Immunohistochemistry on paraffin embedded tissues to suggest that USP10 plays a key role in the initiation of pathogenic Tau aggregation in AD through SG formation.
Mon Jul 22 00:00:00 UTC 2019
A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation.
The Journal of biological chemistry
Ajit D,Trzeciakiewicz H,Tseng JH,Wander CM,Chen Y,Ajit A,King DP,Cohen TJ
MN1020 was used in Western Blotting to indicate that a complex tau PTM code likely regulates tau pathogenesis, highlighting the potential utility of manipulating and detoxifying tau strains through site-specific tau-targeting approaches.
Fri Nov 08 00:00:00 UTC 2019
Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin.
Cells
Walker DG,Lue LF,Beach TG,Tooyama I
MN1020 was used in Immunohistochemistry to identify subtypes of activated microglia.
Tue Jul 23 00:00:00 UTC 2019
Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus.
Journal of neurosurgery
Abu Hamdeh S,Virhammar J,Sehlin D,Alafuzoff I,Cesarini KG,Marklund N
MN1020 was used in Immunohistochemistry to test if the cortical brain tissue levels of soluble amyloid beta (Aβ) reflect the propensity of cortical Aβ aggregate formation and may be an additional factor predicting surgical outcome following idiopathic normal pressure hydrocephalus (iNPH) treatment.
Tue Jan 01 00:00:00 UTC 2019
Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia.
Acta neuropathologica communications
Harrison IF,Whitaker R,Bertelli PM,O'Callaghan JM,Csincsik L,Bocchetta M,Ma D,Fisher A,Ahmed Z,Murray TK,O'Neill MJ,Rohrer JD,Lythgoe MF,Lengyel I
MN1020 was used in Immunohistochemistry to examine tau pathology in the neurosensory retina of the rTg(tauP301L)4510 mouse model of frontotemporal dementia.
Mon Jan 07 00:00:00 UTC 2019
REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease.
Cell reports
Meyer K,Feldman HM,Lu T,Drake D,Lim ET,Ling KH,Bishop NA,Pan Y,Seo J,Lin YT,Su SC,Church GM,Tsai LH,Yankner BA
MN1020 was used in Western Blotting to propose that dysregulation of neural gene networks may set in motion the pathologic cascade that leads to AD.
Tue Jan 29 00:00:00 UTC 2019
Encephalopathy induced by Alzheimer brain inoculation in a non-human primate.
Acta neuropathologica communications
Gary C,Lam S,Hérard AS,Koch JE,Petit F,Gipchtein P,Sawiak SJ,Caillierez R,Eddarkaoui S,Colin M,Aujard F,Deslys JP,Brouillet E,Buée L,Comoy EE,Pifferi F,Picq JL,Dhenain M
MN1020 was used in Immunohistochemistry to demonstrate long term memory and learning impairments in a non-human primate following intracerebral injections with Alzheimer human brain extracts.
Wed Sep 04 00:00:00 UTC 2019
Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.
Cell reports
Wu T,Dejanovic B,Gandham VD,Gogineni A,Edmonds R,Schauer S,Srinivasan K,Huntley MA,Wang Y,Wang TM,Hedehus M,Barck KH,Stark M,Ngu H,Foreman O,Meilandt WJ,Elstrott J,Chang MC,Hansen DV,Carano RAD,Sheng M,Hanson JE
MN1020 was used in Immunohistochemistry to demonstrate that complement activation contributes to neurodegeneration caused by tau pathology and suggest that blocking C3 function might be protective in AD and other tauopathies.
Tue Aug 20 00:00:00 UTC 2019
Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology.
Acta neuropathologica communications
Mendsaikhan A,Tooyama I,Bellier JP,Serrano GE,Sue LI,Lue LF,Beach TG,Walker DG
MN1020 was used in Immunohistochemistry to show the role and interactions of lysosomal proteins Progranulin and Prosaposin in the brains of aged patients and those with Alzheimer's.
Sat Dec 21 00:00:00 UTC 2019
Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways.
Acta neuropathologica communications
Christensen KR,Beach TG,Serrano GE,Kanaan NM
MN1020 was used in Immunohistochemistry to study the importance of targeting tau deposition in Alzheimer's disease, ideally in the initial phases of its deposition in axons.
Thu Feb 28 00:00:00 UTC 2019
Mixed Borrelia burgdorferi and Helicobacter pylori Biofilms in Morgellons Disease Dermatological Specimens.
Healthcare (Basel, Switzerland)
Middelveen MJ,Filush KR,Bandoski C,Kasliwala RS,Melillo A,Stricker RB,Sapi E
MN1020 was used in Immunohistochemistry to study the coexistance of of Borriella burgdorferi and Heliobacter pylori in skin specimens from Morgellons disease patients.
Fri May 17 00:00:00 UTC 2019
Extracellular Vesicles Isolated from Familial Alzheimer's Disease Neuronal Cultures Induce Aberrant Tau Phosphorylation in the Wild-Type Mouse Brain.
Journal of Alzheimer's disease : JAD
Aulston B,Liu Q,Mante M,Florio J,Rissman RA,Yuan SH
MN1020 was used in Western Blotting to identify EVs as a potential mediator of fAD-associated tau dysregulation and warrant future studies to investigate the therapeutic potential of EV-targeted treatments for fAD.
Tue Nov 17 00:00:00 UTC 2020
Arterial Stiffness Due to Carotid Calcification Disrupts Cerebral Blood Flow Regulation and Leads to Cognitive Deficits.
Journal of the American Heart Association
Muhire G,Iulita MF,Vallerand D,Youwakim J,Gratuze M,Petry FR,Planel E,Ferland G,Girouard H
MN1020 was used in Western Blotting to study the mechanisms by which arterial stiffness can contribute to cerebral dysfucntion.
Tue May 07 00:00:00 UTC 2019
Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice.
Scientific reports
Zhang Y,Wu F,Iqbal K,Gong CX,Hu W,Liu F
MN1020 was used in Western Blotting to characterise Alzheimer-like alterations behaviourally, biochemically and immunohistochemically 6 weeks and 7 months after unilateral mild-to-moderate controlled cortical impact in human tau transgenic mice.
Thu Mar 07 00:00:00 UTC 2019
Preventive Effect of Quercetin in a Triple Transgenic Alzheimer's Disease Mice Model.
Molecules (Basel, Switzerland)
Paula PC,Angelica Maria SG,Luis CH,Gloria Patricia CG
MN1020 was used in Immunohistochemistry to study the effect of chronic oral quercetin administration on neurodegeneration markers and cognitive and emotional deficits in Alzheimer's disease.
Thu Jun 20 00:00:00 UTC 2019
Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy.
NPJ vaccines
Maphis NM,Peabody J,Crossey E,Jiang S,Jamaleddin Ahmad FA,Alvarez M,Mansoor SK,Yaney A,Yang Y,Sillerud LO,Wilson CM,Selwyn R,Brigman JL,Cannon JL,Peabody DS,Chackerian B,Bhaskar K
MN1020 was used in Western Blotting to provide a valid scientific premise for the development of VLP-based immunotherapy to target pTau and potentially prevent Alzheimer's diseases and related tauopathies.
Wed Feb 03 00:00:00 UTC 2021
Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease.
Acta neuropathologica communications
Henderson MX,Sengupta M,Trojanowski JQ,Lee VMY
MN1020 was used in Immunohistochemistry to show there is a prevalence of Alzheimer's disease-type tau pathology in leucine-rich repeat kinase 2 familial Parkinson's disease.
Sat Nov 16 00:00:00 UTC 2019
Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes.
Scientific reports
Andersson CR,Falsig J,Stavenhagen JB,Christensen S,Kartberg F,Rosenqvist N,Finsen B,Pedersen JT
MN1020 was used in Immunocytochemistry to study the role of antibody effector functions in the induction of microglial clearance of tau.
Fri Mar 15 00:00:00 UTC 2019
Alzheimer's disease neuropathological change and loss of matrix/neuropil in patients with idiopathic Normal Pressure Hydrocephalus, a model of Alzheimer's disease.
Acta neuropathologica communications
Libard S,Alafuzoff I
MN1020 was used in Immunohistochemistry to assess unique brain tissue samples, obtained from living subjects with idiopathic Normal Pressure Hydrocephalus.
Wed May 29 00:00:00 UTC 2019
Developmental expression of human tau in Drosophila melanogaster glial cells induces motor deficits and disrupts maintenance of PNS axonal integrity, without affecting synapse formation.
PloS one
Scarpelli EM,Trinh VY,Tashnim Z,Krans JL,Keller LC,Colodner KJ
MN1020 was used in Immunohistochemistry-immunofluorescence to determine human tau expression in Drosophila glial cells is deleterious to the maintenance of of glial-axonal interactions in the PNS but does not affect synapse formation.
Wed Apr 01 00:00:00 UTC 2020
Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease.
Cell reports
Wang ZH,Xiang J,Liu X,Yu SP,Manfredsson FP,Sandoval IM,Wu S,Wang JZ,Ye K
MN1020 was used in Immunohistochemistry to show that deprivation of BDNF/TrkB increases inflammatory cytokines and activates the JAK2/STAT3 pathway, resulting in the upregulation of transcription factor C/EBPβ in Alzheimer''s Disease.
Tue Jul 16 00:00:00 UTC 2019
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
Nature
Bussian TJ,Aziz A,Meyer CF,Swenson BL,van Deursen JM,Baker DJ
MN1020 was used in Western Blotting to study the role of senescent cells in the aetiology of tau-dependent pathologies.
Mon Oct 01 00:00:00 UTC 2018
Structures of filaments from Pick's disease reveal a novel tau protein fold.
Nature
Falcon B,Zhang W,Murzin AG,Murshudov G,Garringer HJ,Vidal R,Crowther RA,Ghetti B,Scheres SHW,Goedert M
MN1020 was used in Western Blotting to show how tau can adopt distinct folds in the human brain in different diseases, an essential step for understanding the formation and propagation of molecular conformers.
Sat Sep 01 00:00:00 UTC 2018
A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease.
Nature neuroscience
Park J,Wetzel I,Marriott I,Dréau D,D'Avanzo C,Kim DY,Tanzi RE,Cho H
MN1020 was used in Immunocytochemistry-immunoflourescence to show that the model will serve to facilitate the development of more precise human brain models for basic mechanistic studies in neural-glial interactions and drug discovery.
Sun Jul 01 00:00:00 UTC 2018
A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease.
Nature neuroscience
Park J,Wetzel I,Marriott I,Dréau D,D'Avanzo C,Kim DY,Tanzi RE,Cho H
MN1020 was used in Immunocytochemistry-immunoflourescence to show that the model will serve to facilitate the development of more precise human brain models for basic mechanistic studies in neural-glial interactions and drug discovery.
Sun Jul 01 00:00:00 UTC 2018
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.
Nature neuroscience
Apicco DJ,Ash PEA,Maziuk B,LeBlang C,Medalla M,Al Abdullatif A,Ferragud A,Botelho E,Ballance HI,Dhawan U,Boudeau S,Cruz AL,Kashy D,Wong A,Goldberg LR,Yazdani N,Zhang C,Ung CY,Tripodis Y,Kanaan NM,Ikezu T,Cottone P,Leszyk J,Li H,Luebke J,Bryant CD,Wolozin B
MN1020 was used in Immunohistochemistry to show that reducing the RNA binding protein T-cell intracellular antigen 1 in vivo protects against tau-mediated neurodegeneration.
Mon Jan 01 00:00:00 UTC 2018
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
Neuron
Lin YT,Seo J,Gao F,Feldman HM,Wen HL,Penney J,Cam HP,Gjoneska E,Raja WK,Cheng J,Rueda R,Kritskiy O,Abdurrob F,Peng Z,Milo B,Yu CJ,Elmsaouri S,Dey D,Ko T,Yankner BA,Tsai LH
MN1020 was used in Western Blotting to establish a reference for human cell-type-specific changes associated with the APOE4 variant.
Wed Jun 27 00:00:00 UTC 2018
The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Paspalas CD,Carlyle BC,Leslie S,Preuss TM,Crimins JL,Huttner AJ,van Dyck CH,Rosene DL,Nairn AC,Arnsten AFT
MN1020 was used in Immunocytochemistry to study the progression of tau and amyloid cortical pathology in the ageing rhesus macaque.
Tue May 01 00:00:00 UTC 2018
Estimation of amyloid distribution by [18F]flutemetamol PET predicts the neuropathological phase of amyloid β-protein deposition.
Acta neuropathologica
Thal DR,Beach TG,Zanette M,Lilja J,Heurling K,Chakrabarty A,Ismail A,Farrar G,Buckley C,Smith APL
MN1020 was used in Immunohistochemistry-immunofluorescence to investigate whether it is possible to distinguish the neuropathological amyloid Β-protein-phases with amyloid positron emission tomography imaging.
Mon Oct 01 00:00:00 UTC 2018
Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis.
Acta neuropathologica
Henstridge CM,Sideris DI,Carroll E,Rotariu S,Salomonsson S,Tzioras M,McKenzie CA,Smith C,von Arnim CAF,Ludolph AC,Lulé D,Leighton D,Warner J,Cleary E,Newton J,Swingler R,Chandran S,Gillingwater TH,Abrahams S,Spires-Jones TL
MN1020 was used in Immunohistochemistry to assess the synaptic integrity in the amyotrophic lateral sclerosis brain.
Thu Feb 01 00:00:00 UTC 2018
Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery.
Acta neuropathologica
Jaunmuktane Z,Quaegebeur A,Taipa R,Viana-Baptista M,Barbosa R,Koriath C,Sciot R,Mead S,Brandner S
MN1020 was used in Immunohistochemistry to suggest that amyloid-Β pathology may be transmissible, as prion disease is, through neurosurgical procedures.
Tue May 01 00:00:00 UTC 2018
NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Proceedings of the National Academy of Sciences of the United States of America
Hou Y,Lautrup S,Cordonnier S,Wang Y,Croteau DL,Zavala E,Zhang Y,Moritoh K,O'Connell JF,Baptiste BA,Stevnsner TV,Mattson MP,Bohr VA
MN1020 was used in Western Blotting to examine the role of compromised cellular bioenergetics and DNA repair in the pathogenesis of Alzheimer's disease.
Tue Feb 20 00:00:00 UTC 2018
Pedunculopontine Nucleus Cholinergic Deficiency in Cervical Dystonia.
Movement disorders : official journal of the Movement Disorder Society
Mente K,Edwards NA,Urbano D,Ray-Chaudhury A,Iacono D,Alho ATDL,Alho EJL,Amaro E,Horovitz SG,Hallett M
MN1020 was used in Immunohistochemistry-immunofluorescence to suggest that pedunculopontine nucleus choline acetyltransferase deficiency represents a functional cholinergic deficit in cervical dystonia.
Tue May 01 00:00:00 UTC 2018
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.
Neurobiology of disease
Schapansky J,Khasnavis S,DeAndrade MP,Nardozzi JD,Falkson SR,Boyd JD,Sanderson JB,Bartels T,Melrose HL,LaVoie MJ
MN1020 was used in Western Blotting to study the role of neuronal LRRK2 kinase activity in lysosome function and α-synuclein homeostasis.
Thu Mar 01 00:00:00 UTC 2018
Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chalermpalanupap T,Schroeder JP,Rorabaugh JM,Liles LC,Lah JJ,Levey AI,Weinshenker D
MN1020 was used in Immunohistochemistry-immunofluorescence to investigate the impact of locus coeruleus degeneration in a mouse model of tauopathy.
Wed Jan 03 00:00:00 UTC 2018
Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhu Y,Zhan G,Fenik P,Brandes M,Bell P,Francois N,Shulman K,Veasey S
MN1020 was used in Immunohistochemistry to study whether chronic short sleep influences locus ceruleus neurons tau and the biochemical, neuroanatomical, and/or behavioural progression of tauopathy in male and female P301S mice.
Wed Nov 28 00:00:00 UTC 2018
Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhu Y,Zhan G,Fenik P,Brandes M,Bell P,Francois N,Shulman K,Veasey S
MN1020 was used in Immunohistochemistry to study whether chronic short sleep influences locus ceruleus neurons tau and the biochemical, neuroanatomical, and/or behavioural progression of tauopathy in male and female P301S mice.
Wed Nov 28 00:00:00 UTC 2018
A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bardai FH,Wang L,Mutreja Y,Yenjerla M,Gamblin TC,Feany MB
MN1020 was used in Western Blotting to determine the mechanism by whichFTDP-17 mutations promote disease in vivo.
Wed Jan 03 00:00:00 UTC 2018
Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons.
Frontiers in molecular neuroscience
Rodriguez L,Mdzomba JB,Joly S,Boudreau-Laprise M,Planel E,Pernet V
MN1020 was used in Immunohistochemistry-immunofluorescence to show visual physiology may be positively influenced by human Tau expression in retinal cells.
Mon Sep 28 00:00:00 UTC 2020
A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology.
Frontiers in aging neuroscience
Lippi SLP,Smith ML,Flinn JM
MN1020 was used in Western Blotting to characterise the offspring from the cross of the J20 and rTg4510 mouse strains.
Wed Sep 30 00:00:00 UTC 2020
Bilateral Implantation of Shear Stress Modifier in ApoE Knockout Mouse Induces Cognitive Impairment and Tau Abnormalities.
Frontiers in aging neuroscience
Nie S,Tan Y,Zhang Z,Chen G,Xiong J,Hu D,Ye K,Zhang Y,Cao X,Chen L,Zhang Z
MN1020 was used in Immunohistochemistry to investigate the mechanism underlying vascular cognitive impairment in an Apolipoprotein E knockout mouse model fed with western style food with implantation of bilateral shear stress modifiers.
Tue Sep 29 00:00:00 UTC 2020
Associations between Use of Specific Analgesics and Concentrations of Amyloid-β 42 or Phospho-Tau in Regions of Human Cerebral Cortex.
Journal of Alzheimer's disease : JAD
Flanagan ME,Larson EB,Walker RL,Keene CD,Postupna N,Cholerton B,Sonnen JA,Dublin S,Crane PK,Montine TJ
MN1020 was used in an ELISA assay to show that high levels of non-aspirin nonsteroidal anti-inflammatory drug use in older individuals may promote Amyloid-Β 42 accumulation in cerebral cortex.
Tue Jan 15 00:00:00 UTC 2019
A Study of Amyloid-β and Phosphotau in Plaques and Neurons in the Hippocampus of Alzheimer's Disease Patients.
Journal of Alzheimer's disease : JAD
Furcila D,DeFelipe J,Alonso-Nanclares L
MN1020 was used in Immunohistochemistry-immunofluorescence to study the possible relationship between the presence and distribution of different neurochemical types of amyloid-Β plaques and hyperphosphorylated-Tau immunoreactive neurons.
Mon Jul 15 00:00:00 UTC 2019
Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau.
Journal of Alzheimer's disease : JAD
Arner A,Rockenstein E,Mante M,Florio J,Masliah D,Salehi B,Adame A,Overk C,Masliah E,Rissman RA
MN1020 was used in an ELISA assay to demonstrate that this bigenic model closely parallels the pathological course of AD and may serve as a valuable model for testing new pharmacological interventions.
Thu Jan 17 00:00:00 UTC 2019
Phytochemicals from Achillea fragrantissima are Modulators of AβPP Metabolism.
Journal of Alzheimer's disease : JAD
Bartolotti N,Disouky A,Kalinski A,Elmann A,Lazarov O
MN1020 was used in Western Blotting to examine the effect of two Achillea fragrantissima-derived phytochemicals on learning and memory, amyloid-Β protein precursor metabolism, and tau phosphorylation in an Alzheimer's disease model.
Mon Nov 25 00:00:00 UTC 2019
Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease.
Journal of Alzheimer's disease : JAD
Yan T,Wang L,Gao J,Siedlak SL,Huntley ML,Termsarasab P,Perry G,Chen SG,Wang X
MN1020 was used in Immunocytochemistry to indicate that Rab10 phosphorylation could be responsible for aberrations in the vesicle trafficking observed in Alzheimer's disease leading to neurodegeneration.
Mon Aug 26 00:00:00 UTC 2019
Effects of a Dehydroevodiamine-Derivative on Synaptic Destabilization and Memory Impairment in the 5xFAD, Alzheimer's Disease Mouse Model.
Frontiers in behavioral neuroscience
Kang S,Ha S,Park H,Nam E,Suh WH,Suh YH,Chang KA
MN1020 was used in Immunohistochemistry to investigate the therapeutic effects of carboxy-dehydroevodiamine-HCl and the underlying mechanism in a transgenic mouse model of Alzheimer's disease.
Wed Sep 30 00:00:00 UTC 2020
Effects of a Dehydroevodiamine-Derivative on Synaptic Destabilization and Memory Impairment in the 5xFAD, Alzheimer's Disease Mouse Model.
Frontiers in behavioral neuroscience
Kang S,Ha S,Park H,Nam E,Suh WH,Suh YH,Chang KA
MN1020 was used in Immunohistochemistry to investigate the therapeutic effects of carboxy-dehydroevodiamine-HCl and the underlying mechanism in a transgenic mouse model of Alzheimer's disease.
Wed Sep 30 00:00:00 UTC 2020
Association of antiretroviral therapy with brain aging changes among HIV-infected adults.
AIDS (London, England)
Soontornniyomkij V,Umlauf A,Soontornniyomkij B,Gouaux B,Ellis RJ,Levine AJ,Moore DJ,Letendre SL
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate antiretroviral therapy effects on age-related brain changes in persons living with HIV.
Mon Sep 10 00:00:00 UTC 2018
A transcriptomic atlas of aged human microglia.
Nature communications
Olah M,Patrick E,Villani AC,Xu J,White CC,Ryan KJ,Piehowski P,Kapasi A,Nejad P,Cimpean M,Connor S,Yung CJ,Frangieh M,McHenry A,Elyaman W,Petyuk V,Schneider JA,Bennett DA,De Jager PL,Bradshaw EM
MN1020 was used in Immunohistochemistry to demonstrate the existence of an ageing-related microglial phenotype in the human brain and its involvement in ageing pathology.
Wed Feb 07 00:00:00 UTC 2018
Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer's disease in the 3xTg-AD mouse model.
Cell death & disease
Grimaldi A,Brighi C,Peruzzi G,Ragozzino D,Bonanni V,Limatola C,Ruocco G,Di Angelantonio S
MN1020 was used in Immunohistochemistry-immunofluorescence to investigate novel retinal biomarkers that could anticipate the Alzheimer's disease diagnosis, and help the beginning and the follow-up of possible future treatments.
Thu Jun 07 00:00:00 UTC 2018
APOE ε2 is associated with increased tau pathology in primary tauopathy.
Nature communications
Zhao N,Liu CC,Van Ingelgom AJ,Linares C,Kurti A,Knight JA,Heckman MG,Diehl NN,Shinohara M,Martens YA,Attrebi ON,Petrucelli L,Fryer JD,Wszolek ZK,Graff-Radford NR,Caselli RJ,Sanchez-Contreras MY,Rademakers R,Murray ME,Koga S,Dickson DW,Ross OA,Bu G
MN1020 was used in Immunohistochemistry to evaluate the association of Apolipoprotein E genotype with the presence and severity of tau pathology.
Mon Oct 22 00:00:00 UTC 2018
iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling.
Molecular neurodegeneration
Moreno CL,Della Guardia L,Shnyder V,Ortiz-Virumbrales M,Kruglikov I,Zhang B,Schadt EE,Tanzi RE,Noggle S,Buettner C,Gandy S
MN1020 was used in Western Blotting to investigate whether neuronal insulin resistance is a cell autonomous phenomenon in a familial form of Alzheimer's disease.
Tue Jun 26 00:00:00 UTC 2018
Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.
The Journal of biological chemistry
Tuerde D,Kimura T,Miyasaka T,Furusawa K,Shimozawa A,Hasegawa M,Ando K,Hisanaga SI
MN1020 was used in Immunohistochemistry to study how the transition of the microtubule-associated protein tau isoforms and phosphorylation are regulated.
Fri Feb 02 00:00:00 UTC 2018
Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model.
Journal of neuroinflammation
Huang C,Irwin MG,Wong GTC,Chang RCC
MN1020 was used in Western Blotting to characterise the neuroinflammation and cellular changes induced by systemic inflammation, and their responses to anti-inflammatory treatment.
Thu May 17 00:00:00 UTC 2018
Microglial activation occurs late during preclinical Alzheimer's disease.
Glia
Streit WJ,Braak H,Del Tredici K,Leyh J,Lier J,Khoshbouei H,Eisenlöffel C,Müller W,Bechmann I
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that the role of microglia in AD pathogenesis entails primarily the attempted removal of potentially toxic, extracellular material.
Sat Dec 01 00:00:00 UTC 2018
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
Nature communications
Lee JY,Han SH,Park MH,Baek B,Song IS,Choi MK,Takuwa Y,Ryu H,Kim SH,He X,Schuchman EH,Bae JS,Jin HK
MN1020 was used in Immunohistochemistry to uncover a novel mechanism of SphK1 pathogenesis in Alzheimer's disease, in which impaired specialized proresolving mediators secretion leads to defective microglial phagocytosis.
Mon Apr 16 00:00:00 UTC 2018
Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.
Redox biology
Cuadrado A,Kügler S,Lastres-Becker I
MN1020 was used in Immunohistochemistry to investigate whether dimethyl fumarat, an inducer of the transcription factor NRF2, could mitigate tauopathy in a mouse model.
Sun Apr 01 00:00:00 UTC 2018
Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues.
Nature communications
Lai HM,Liu AKL,Ng HHM,Goldfinger MH,Chau TW,DeFelice J,Tilley BS,Wong WM,Wu W,Gentleman SM
MN1020 was used in Immunohistochemistry to develop a tissue clearing solution, OPTIClear, optimised for fresh and archival human brain tissue, including formalin-fixed paraffin-embedded material.
Wed Mar 14 00:00:00 UTC 2018
Toxoplasma gondii alters NMDAR signaling and induces signs of Alzheimer's disease in wild-type, C57BL/6 mice.
Journal of neuroinflammation
Torres L,Robinson SA,Kim DG,Yan A,Cleland TA,Bynoe MS
MN1020 was used in Immunohistochemistry on frozen tissues to study the induction of advanced signs of Alzheimer's disease in wild type mice following Toxoplasma gondii infection.
Fri Feb 23 00:00:00 UTC 2018
Multiple neuronal pathologies are common in young patients with pathologically proven Frontotemporal lobar degeneration.
Neuropathology and applied neurobiology
Tan RH,Yang Y,Halliday GM
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to examine concomitant pathological neuronal inclusions of TDP-43, hyperphosphorylated tau and a-synuclein protein in the anterior cingulate, hippocampus and entorhinal cortex in young (=65 years at death) vs. elderly (=80 years at death) cases with pathologically confirmed FTLD (n = 52) or Alzheimer's disease (AD) (n = 47).
Wed Aug 01 00:00:00 UTC 2018
Phosphorylation of different tau sites during progression of Alzheimer's disease.
Acta neuropathologica communications
Neddens J,Temmel M,Flunkert S,Kerschbaumer B,Hoeller C,Loeffler T,Niederkofler V,Daum G,Attems J,Hutter-Paier B
MN1020 was used in Immunohistochemistry to investigate total tau and phosphorylated tau as well as amyloid-Β plaques in human brain tissue of Alzheimer's disease patients and controls.
Fri Jun 29 00:00:00 UTC 2018
Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer's disease patients.
Acta neuropathologica communications
Domínguez-Álvaro M,Montero-Crespo M,Blazquez-Llorca L,Insausti R,DeFelipe J,Alonso-Nanclares L
MN1020 was used in Immunohistochemistry to perform a detailed three-dimensional ultrastructural analysis to investigate possible synaptic alterations in the transentorhinal cortex of patients with Alzheimer's disease.
Fri Mar 02 00:00:00 UTC 2018
Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau.
Acta neuropathologica communications
van Ameijde J,Crespo R,Janson R,Juraszek J,Siregar B,Verveen H,Sprengers I,Nahar T,Hoozemans JJ,Steinbacher S,Willems R,Delbroek L,Borgers M,Dockx K,Van Kolen K,Mercken M,Pascual G,Koudstaal W,Apetri A
MN1020 was used in Immunohistochemistry to indicate that in addition to being able to inhibit the spreading of pathological tau aggregates, the matured antibody can potentially also interfere with the nucleation of tau which is believed to be the first step of the pathogenic process.
Thu Jul 12 00:00:00 UTC 2018
Lysosomal LAMP1 immunoreactivity exists in both diffuse and neuritic amyloid plaques in the human hippocampus.
The European journal of neuroscience
Hassiotis S,Manavis J,Blumbergs PC,Hattersley KJ,Carosi JM,Kamei M,Sargeant TJ
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that diffuse plaques, as well as neuritic plaques, contain LAMP1 immunoreactivity in the human hippocampus.
Tue May 01 00:00:00 UTC 2018
Neuropathological Assessment as an Endpoint in Clinical Trial Design.
Methods in molecular biology (Clifton, N.J.)
Gentleman S,Liu AKL
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to present a simple protocol for pathological assessment of neurodegenerative changes.
Wed Feb 06 00:00:00 UTC 2019
Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer's disease.
Scientific reports
Youssef P,Chami B,Lim J,Middleton T,Sutherland GT,Witting PK
MN1020 was used in Western Blotting to evaluate the expression profiles and activity of endogenous anti-oxidants, oxidative damage and caspase activity in the superior temporal gyrus of Alzheimer's disease patients.
Wed Aug 01 00:00:00 UTC 2018
Different tau species lead to heterogeneous tau pathology propagation and misfolding.
Acta neuropathologica communications
Dujardin S,Bégard S,Caillierez R,Lachaud C,Carrier S,Lieger S,Gonzalez JA,Deramecourt V,Déglon N,Maurage CA,Frosch MP,Hyman BT,Colin M,Buée L
MN1020 was used in Immunohistochemistry to show that the existence of specific folding properties of tau depending on isoforms or mutations impacting the behavior of pathological tau species.
Thu Nov 29 00:00:00 UTC 2018
The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome.
Neuropathology and applied neurobiology
Milenkovic I,Jarc J,Dassler E,Aronica E,Iyer A,Adle-Biassette H,Scharrer A,Reischer T,Hainfellner JA,Kovacs GG
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest functional tau disturbance in DS brains during development, rather than axonal loss.
Sun Apr 01 00:00:00 UTC 2018
Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.
Neuron
McInnes J,Wierda K,Snellinx A,Bounti L,Wang YC,Stancu IC,Apóstolo N,Gevaert K,Dewachter I,Spires-Jones TL,De Strooper B,De Wit J,Zhou L,Verstreken P
MN1020 was used in Western Blot to identify Synaptogyrin-3 as the binding partner of Tau on synaptic vesicles, revealing a new presynapse-specific Tau interactor, which may contribute to early synaptic dysfunction in neurodegenerative diseases associated with Tau.
Wed Feb 21 00:00:00 UTC 2018
Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age.
Scientific reports
Brekk OR,Moskites A,Isacson O,Hallett PJ
MN1020 was used in Immunohistochemistry to identify early protein-lipid interactions that coincide with loss of lipid homeostasis.
Fri Oct 12 00:00:00 UTC 2018
Proteomic differences between focal and diffuse traumatic brain injury in human brain tissue.
Scientific reports
Abu Hamdeh S,Shevchenko G,Mi J,Musunuri S,Bergquist J,Marklund N
MN1020 was used in Immunohistochemistry to evaluate the early molecular response to severe traumatic brain injury.
Tue May 01 00:00:00 UTC 2018
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.
Frontiers in cellular neuroscience
Romero-Molina C,Navarro V,Sanchez-Varo R,Jimenez S,Fernandez-Valenzuela JJ,Sanchez-Mico MV,Muñoz-Castro C,Gutierrez A,Vitorica J,Vizuete M
MN1020 was used in Western Blotting to compare the microglial response in two different transgenic tau mouse models: ThyTau22 and P301S.
Wed Sep 30 00:00:00 UTC 2020
Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration.
Brain, behavior, and immunity
Hennessy E,Gormley S,Lopez-Rodriguez AB,Murray C,Murray C,Cunningham C
MN1020 was used in Immunohistochemistry to indicate that acutely elevated TNF-α has robust acute effects on brain function, selectively in the degenerating brain.
Sun Jan 01 00:00:00 UTC 2017
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
Neuron
Espuny-Camacho I,Arranz AM,Fiers M,Snellinx A,Ando K,Munck S,Bonnefont J,Lambot L,Corthout N,Omodho L,Vanden Eynden E,Radaelli E,Tesseur I,Wray S,Ebneth A,Hardy J,Leroy K,Brion JP,Vanderhaeghen P,De Strooper B
MN1020 was used in Immunohistochemistry to develop a novel chimeric model for Alzheimer's disease, displaying human-specific pathological features and allowing the analysis of different genetic backgrounds and mutations during the course of disease.
Wed Mar 08 00:00:00 UTC 2017
Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
Neuron
Espuny-Camacho I,Arranz AM,Fiers M,Snellinx A,Ando K,Munck S,Bonnefont J,Lambot L,Corthout N,Omodho L,Vanden Eynden E,Radaelli E,Tesseur I,Wray S,Ebneth A,Hardy J,Leroy K,Brion JP,Vanderhaeghen P,De Strooper B
MN1020 was used in Immunohistochemistry to develop a novel chimeric model for Alzheimer's disease, displaying human-specific pathological features and allowing the analysis of different genetic backgrounds and mutations during the course of disease.
Wed Mar 08 00:00:00 UTC 2017
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.
Neuron
Fu H,Rodriguez GA,Herman M,Emrani S,Nahmani E,Barrett G,Figueroa HY,Goldberg E,Hussaini SA,Duff KE
MN1020 was used in immunohistochemistry - free floating to report the formation of mature tangles in Alzheimer's diseases is associated with excitatory cell loss and deficits in grid cell function
Wed Feb 08 00:00:00 UTC 2017
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
Acta neuropathologica
Takahashi H,Klein ZA,Bhagat SM,Kaufman AC,Kostylev MA,Ikezu T,Strittmatter SM
MN1020 was used in immunohistochemistry to see that the granulin Alzheimer's disease risk variant has no significant effects on florbetapir positron emission tomographic amyloid imaging and cerebrospinal fluid Abeta levels
Mon May 01 00:00:00 UTC 2017
Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players.
Acta neuropathologica
Ling H,Morris HR,Neal JW,Lees AJ,Hardy J,Holton JL,Revesz T,Williams DD
MN1020 was used in Immunohistochemistry to describe the clinical and pathological features of a group of retired professional footballers who developed dementia in later life.
Wed Mar 01 00:00:00 UTC 2017
Localized cortical chronic traumatic encephalopathy pathology after single, severe axonal injury in human brain.
Acta neuropathologica
Shively SB,Edgerton SL,Iacono D,Purohit DP,Qu BX,Haroutunian V,Davis KL,Diaz-Arrastia R,Perl DP
MN1020 was used in western blot to examine postmortem brain tissues from five institutionalized patients with schizophrenia and history of surgical leucotomy with subsequent survival of at least another 40 years
Wed Mar 01 00:00:00 UTC 2017
Incipient progressive supranuclear palsy is more common than expected and may comprise clinicopathological subtypes: a forensic autopsy series.
Acta neuropathologica
Yoshida K,Hata Y,Kinoshita K,Takashima S,Tanaka K,Nishida N
MN1020 was used in immunohistochemistry to analyze autopsied corpses and reveal that progressive supranuclear palsy may be more common than previously thought
Mon May 01 00:00:00 UTC 2017
Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis.
Acta neuropathologica
Braak H,Ludolph AC,Neumann M,Ravits J,Del Tredici K
MN1020 was used in Immunohistochemistry-floating tissue to discuss some implications of this phenomenon of nuclear clearing in the absence of cytoplasmic inclusions, namely, abnormal but soluble cytoplasmic TDP-43 could enter the axoplasm of Betz cells.
Sun Jan 01 00:00:00 UTC 2017
Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease.
Brain : a journal of neurology
Cisbani G,Maxan A,Kordower JH,Planel E,Freeman TB,Cicchetti F
MN1020 was used in Immunohistochemistry to study whether tau pathology can be seen in patients with Huntington's and Parkinson's disease who had received foetal neural allografts.
Wed Nov 01 00:00:00 UTC 2017
Effects of propofol and surgery on neuropathology and cognition in the 3xTgAD Alzheimer transgenic mouse model.
British journal of anaesthesia
Mardini F,Tang JX,Li JC,Arroliga MJ,Eckenhoff RG,Eckenhoff MF
MN1020 was used in Immunohistochemistry to study the cognitive and neuroinflammatory sequelae induced by surgery under propofol anaesthesia in a vulnerable mouse transgenic model.
Fri Sep 01 00:00:00 UTC 2017
Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model.
Aging cell
Bodea LG,Evans HT,Van der Jeugd A,Ittner LM,Delerue F,Kril J,Halliday G,Hodges J,Kiernan MC,Götz J
MN1020 was used in immunohistochemistry - paraffin section and western blot to generate and characterize a new mouse model of Alzheimer's disease
Sat Apr 01 00:00:00 UTC 2017
Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ogino H,Hisanaga A,Kohno T,Kondo Y,Okumura K,Kamei T,Sato T,Asahara H,Tsuiji H,Fukata M,Hattori M
MN1020 was used in Western Blotting to identify the secreted metallomatrix proteinase, ADAMTS-3, as the protein responsible for the cleavage of Reelin in the cerebral cortex and hippocampus.
Wed Mar 22 00:00:00 UTC 2017
The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells.
Frontiers in molecular neuroscience
Di Primio C,Quercioli V,Siano G,Rovere M,Kovacech B,Novak M,Cattaneo A
MN1020 was used in Western Blotting to find that soluble Tau molecules, detached from MTs, display an unfolded structure.
Thu Oct 01 00:00:00 UTC 2020
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.
The American journal of pathology
Nobuhara CK,DeVos SL,Commins C,Wegmann S,Moore BD,Roe AD,Costantino I,Frosch MP,Pitstick R,Carlson GA,Hock C,Nitsch RM,Montrasio F,Grimm J,Cheung AE,Dunah AW,Wittmann M,Bussiere T,Weinreb PH,Hyman BT,Takeda S
MN1020 was used in an ELISA assay to discover that not all antibodies/epitopes are equally robust in terms of blocking tau uptake of human AD-derived tau species.
Thu Jun 01 00:00:00 UTC 2017
Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE ε4.
The American journal of pathology
Postupna N,Latimer CS,Larson EB,Sherfield E,Paladin J,Shively CA,Jorgensen MJ,Andrews RN,Kaplan JR,Crane PK,Montine KS,Craft S,Keene CD,Montine TJ
MN1020 was used in Flow cytometry/Cell sorting to characterise the molecular composition of human synaptic particles in the striatum and prefrontal cortex.
Sat Apr 01 00:00:00 UTC 2017
Ventricular and Periventricular Anomalies in the Aging and Cognitively Impaired Brain.
Frontiers in aging neuroscience
Todd KL,Brighton T,Norton ES,Schick S,Elkins W,Pletnikova O,Fortinsky RH,Troncoso JC,Molfese PJ,Resnick SM,Conover JC
MN1020 was used in Immunohistochemistry-immunofluorescence to explore the interplay between various ventricular and periventricular anomalies in the ageing and cognitively impaired brain.
Wed Sep 30 00:00:00 UTC 2020
Negative Impact of Female Sex on Outcomes from Repetitive Mild Traumatic Brain Injury in hTau Mice Is Age Dependent: A Chronic Effects of Neurotrauma Consortium Study.
Frontiers in aging neuroscience
Ferguson SA,Mouzon BC,Lynch C,Lungmus C,Morin A,Crynen G,Carper B,Bieler G,Mufson EJ,Stewart W,Mullan M,Crawford F
MN1020 was used in Immunohistochemistry to elucidate the neurobehavioural and neuropathological effects of repetitive mild traumatic brain injury in mice transgenic for human tau.
Wed Sep 30 00:00:00 UTC 2020
Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation.
Molecular neurobiology
Chanu SI,Sarkar S
MN1020 was used in immunohistochemistry - paraffin section and western blot to study suppression of pathogenesis of human neuronal tauopathies in drosophila by limiting tau hyperphosphorylation and heterochromatin relaxation by targeted downregulation of
Mon May 01 00:00:00 UTC 2017
Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model.
International journal of molecular medicine
Park TS,Ryu YK,Park HY,Kim JY,Go J,Noh JR,Kim YH,Hwang JH,Choi DH,Oh WK,Lee CH,Kim KS
MN1020 was used in Immunohistochemistry to investigate whether Humulus japonicus has a beneficial effect on the progression of Alzheimer's disease in APP/PS1 transgenic mice.
Sun Jan 01 00:00:00 UTC 2017
Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease.
Neuropharmacology
Zhu H,Xue X,Wang E,Wallack M,Na H,Hooker JM,Kowall N,Tao Q,Stein TD,Wolozin B,Qiu WQ
MN1020 was used in Immunohistochemistry to study the effect of amylin on the the Alheimer's disease pathological cascade.
Thu Jun 01 00:00:00 UTC 2017
Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.
Neurobiology of aging
Krivinko JM,Erickson SL,Abrahamson EE,Wills ZP,Ikonomovic MD,Penzes P,Sweet RA
MN1020 was used in Western Blotting to determine the molecular and behavioural consequences of kalirin reduction in APPswe/PSEN1dE9 mice.
Thu Jun 01 00:00:00 UTC 2017
Elevated Intraocular Pressure Induces Amyloid-β Deposition and Tauopathy in the Lateral Geniculate Nucleus in a Monkey Model of Glaucoma.
Investigative ophthalmology & visual science
Yan Z,Liao H,Chen H,Deng S,Jia Y,Deng C,Lin J,Ge J,Zhuo Y
MN1020 was used in Immunohistochemistry to establish the existence of hallmark Alzheimer's disease-like pathologies in the glaucomatous lateral geniculate nucleus.
Sun Oct 01 00:00:00 UTC 2017
TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
Human mutation
van der Zee J,Gijselinck I,Van Mossevelde S,Perrone F,Dillen L,Heeman B,Bäumer V,Engelborghs S,De Bleecker J,Baets J,Gelpi E,Rojas-García R,Clarimón J,Lleó A,Diehl-Schmid J,Alexopoulos P,Perneczky R,Synofzik M,Just J,Schöls L,Graff C,Thonberg H,Borroni B,Padovani A,Jordanova A,Sarafov S,Tournev I,de Mendonça A,Miltenberger-Miltényi G,Simões do Couto F,Ramirez A,Jessen F,Heneka MT,Gómez-Tortosa E,Danek A,Cras P,Vandenberghe R,De Jonghe P,De Deyn PP,Sleegers K,Cruts M,Van Broeckhoven C,Goeman J,Nuytten D,Smets K,Robberecht W,Damme PV,Bleecker J,Santens P,Dermaut B,Versijpt J,Michotte A,Ivanoiu A,Deryck O,Bergmans B,Delbeck J,Bruyland M,Willems C,Salmon E,Pastor P,Ortega-Cubero S,Benussi L,Ghidoni R,Binetti G,Hernández I,Boada M,Ruiz A,Sorbi S,Nacmias B,Bagnoli S,Sorbi S,Sanchez-Valle R,Llado A,Santana I,Rosário Almeida M,Frisoni GB,Maetzler W,Matej R,Fraidakis MJ,Kovacs GG,Fabrizi GM,Testi S
MN1020 was used in immunohistochemistry - paraffin section to examine the mutation spectrum of the TANK-Binding Kinase 1 gene and its associated phenotypic spectrum in patients with FTD, ALS or FTD plus ALS
Wed Mar 01 00:00:00 UTC 2017
Transactive DNA Binding Protein 43 Rather Than Other Misfolded Proteins in the Brain is Associated with Islet Amyloid Polypeptide in Pancreas in Aged Subjects with Diabetes Mellitus.
Journal of Alzheimer's disease : JAD
Leino M,Popova SN,Alafuzoff I
MN1020 was used in Immunohistochemistry to assess ageing-related neurodegenerative lesions associated with dementia such as hyperphosphorylated τ, Aβ, α-synuclein, and phosphorylated transactive DNA binding protein 43 seen in the brain and IAPP seen in the pancreas in subjects with and without diabetes mellitus.
Fri Apr 06 00:00:00 UTC 2018
A Novel Ataxic Mutant Mouse Line Having Sensory Neuropathy Shows Heavy Iron Deposition in Kidney.
Neuro-degenerative diseases
Hashimoto H,Kawabe T,Fukuda T,Kusakabe M
MN1020 was used in Immunohistochemistry to suggest that the hak mouse has a tissue-specific impairment in the expression of a type of Bdnf transcripts.
Wed Apr 25 00:00:00 UTC 2018
Proposal Guidelines for Standardized Operating Procedures of Brain Autopsy: Brain Bank in South Korea.
Yonsei medical journal
Lee KH,Seo SW,Lim TS,Kim EJ,Kim BC,Kim Y,Lee HW,Jeon JP,Shim SM,Na DL,Huh GY,Lee MC,Suh YL
MN1020 was used in Immunohistochemistry to develop provisional guidelines for brain autopsy for hospitals and institutes that have not accumulated sufficient expertise.
Fri Sep 01 00:00:00 UTC 2017
Development of [11C]/[3H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand.
Nuclear medicine and biology
Stepanov V,Svedberg M,Jia Z,Krasikova R,Lemoine L,Okamura N,Furumoto S,Mitsios N,Mulder J,Långström B,Nordberg A,Halldin C
MN1020 was used in immunohistochemistry - frozen section to design a [11C]THK-5351 structure for selectively imaging tau protein aggregates
Wed Mar 01 00:00:00 UTC 2017
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies.
Journal of neuroinflammation
Querol-Vilaseca M,Colom-Cadena M,Pegueroles J,San Martín-Paniello C,Clarimon J,Belbin O,Fortea J,Lleó A
MN1020 was used in Immunohistochemistry to demonstrate that that YKL-40 is expressed by an astrocyte subset in tauopathies such as Alzheimer's disease.
Fri Jun 09 00:00:00 UTC 2017
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Nature communications
Zhang Z,Obianyo O,Dall E,Du Y,Fu H,Liu X,Kang SS,Song M,Yu SP,Cabrele C,Schubert M,Li X,Wang JZ,Brandstetter H,Ye K
MN1020 was used in immunohistochemistry to evaluate the efficacy of an orally bioactive and brain permeable gamma-secretase inhibitor in a mouse model of Alzheimer's disease
Mon Mar 27 00:00:00 UTC 2017
A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer's Disease and Its Target Molecule.
Frontiers in pharmacology
Yang Z,Kuboyama T,Tohda C
MN1020 was used in Immunohistochemistry to report a systematic strategy for evaluating the bioactive candidates in natural medicines used for Alzheimer's disease.
Tue Aug 22 00:00:00 UTC 2023
Intranasal insulin reverts central pathology and cognitive impairment in diabetic mother offspring.
Molecular neurodegeneration
Ramos-Rodriguez JJ,Sanchez-Sotano D,Doblas-Marquez A,Infante-Garcia C,Lubian-Lopez S,Garcia-Alloza M
MN1020 was used in Western Blotting to analyse the central long-term complications in the offspring from CD1 diabetic mothers treated with streptozotozin.
Wed Aug 02 00:00:00 UTC 2017
Tau association with synaptic vesicles causes presynaptic dysfunction.
Nature communications
Zhou L,McInnes J,Wierda K,Holt M,Herrmann AG,Jackson RJ,Wang YC,Swerts J,Beyens J,Miskiewicz K,Vilain S,Dewachter I,Moechars D,De Strooper B,Spires-Jones TL,De Wit J,Verstreken P
MN1020 was used in Western Blotting to demonstrate that pathogenic Tau binds to synaptic vesicles via its N-terminal domain and interferes with presynaptic functions.
Thu May 11 00:00:00 UTC 2017
A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy.
Scientific reports
Trzeciakiewicz H,Tseng JH,Wander CM,Madden V,Tripathy A,Yuan CX,Cohen TJ
MN1020 was used in immunocytochemistry and western blot to study the mechanisms of pathogenesis via tau acetylation in Alzheimer's disease
Mon Mar 13 00:00:00 UTC 2017
Oxidative Stress Modifies the Levels and Phosphorylation State of Tau Protein in Human Fibroblasts.
Frontiers in neuroscience
Ibáñez-Salazar A,Bañuelos-Hernández B,Rodríguez-Leyva I,Chi-Ahumada E,Monreal-Escalante E,Jiménez-Capdeville ME,Rosales-Mendoza S
MN1020 was used in Immunohistochemistry to represent a useful model for studying the physiopathology of AD at the cellular level in terms of tau protein implications.
Mon Jun 03 00:00:00 UTC 2024
Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers.
eLife
Wang H,Muiznieks LD,Ghosh P,Williams D,Solarski M,Fang A,Ruiz-Riquelme A,Pomès R,Watts JC,Chakrabartty A,Wille H,Sharpe S,Schmitt-Ulms G
MN1020 was used in Western Blotting to identify proteins in human brain extract that bind to oligomeric Aβ1-42 (oAβ1-42) and/or monomeric Aβ1-42 (mAβ1-42) baits.
Mon Jun 26 00:00:00 UTC 2017
Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer's Disease.
Journal of Alzheimer's disease : JAD
Hares K,Miners JS,Cook AJ,Rice C,Scolding N,Love S,Wilkins A
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to conclude that upregulation of KIFs may be an adaptive response to impaired axonal transport in Alzheimer's disease (AD).
Mon Jul 23 00:00:00 UTC 2018
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Scientific reports
Lathuilière A,Valdés P,Papin S,Cacquevel M,Maclachlan C,Knott GW,Muhs A,Paganetti P,Schneider BL
MN1020 was used in Immunohistochemistry to demonstrate that motifs that are critical for tau conformation determine interaction with microtubules and subsequent pathological modifications.
Thu Oct 19 00:00:00 UTC 2017
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Scientific reports
Lathuilière A,Valdés P,Papin S,Cacquevel M,Maclachlan C,Knott GW,Muhs A,Paganetti P,Schneider BL
MN1020 was used in Immunohistochemistry to demonstrate that motifs that are critical for tau conformation determine interaction with microtubules and subsequent pathological modifications.
Thu Oct 19 00:00:00 UTC 2017
Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI.
NeuroImage. Clinical
Blanken AE,Hurtz S,Zarow C,Biado K,Honarpisheh H,Somme J,Brook J,Tung S,Kraft E,Lo D,Ng DW,Vinters HV,Apostolova LG
MN1020 was used in Immunohistochemistry to evaluate the efficacy of hippocampal neuroimaging as a means of assessing Alzheimer's disease.
Fri Mar 02 00:00:00 UTC 2018
Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation.
EBioMedicine
Kobayashi S,Tanaka T,Soeda Y,Almeida OFX,Takashima A
MN1020 was used in Immunocytochemistry to demonstrate that alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and N-methyl-d-aspartate stimulation redistributes tau to the somato-dendritic region of neurons where it may trigger neurodegeneration.
Thu Jun 01 00:00:00 UTC 2017
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Scientific reports
Li JG,Barrero C,Merali S,Praticò D
MN1020 was used in immunohistochemistry and western blot to show that ALOX5 upregulation results in homocysteine-dependent worsening of the Alzheimer's disease phenotype
Thu Apr 06 00:00:00 UTC 2017
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
The Journal of biological chemistry
Boselli M,Lee BH,Robert J,Prado MA,Min SW,Cheng C,Silva MC,Seong C,Elsasser S,Hatle KM,Gahman TC,Gygi SP,Haggarty SJ,Gan L,King RW,Finley D
MN1020 was used in Western Blotting to identify a potent USP14 inhibitor that retains specificity for USP14.
Fri Nov 24 00:00:00 UTC 2017
Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series.
The Lancet. Neurology
Shively SB,Horkayne-Szakaly I,Jones RV,Kelly JP,Armstrong RC,Perl DP
MN1020 was used in immunohistochemistry - paraffin section to study the human brain after blast exposure in post-mortem cases to characterize the interface astroglial scarring
Mon Aug 01 00:00:00 UTC 2016
Neuronal activity enhances tau propagation and tau pathology in vivo.
Nature neuroscience
Wu JW,Hussaini SA,Bastille IM,Rodriguez GA,Mrejeru A,Rilett K,Sanders DW,Cook C,Fu H,Boonen RA,Herman M,Nahmani E,Emrani S,Figueroa YH,Diamond MI,Clelland CL,Wray S,Duff KE
MN1020 was used in Immunofluorescence to demonstrate that increased neuronal activity stimulates the release of tau in vitro and enhances tau pathology in vivo.
Mon Aug 01 00:00:00 UTC 2016
Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Montine TJ,Monsell SE,Beach TG,Bigio EH,Bu Y,Cairns NJ,Frosch M,Henriksen J,Kofler J,Kukull WA,Lee EB,Nelson PT,Schantz AM,Schneider JA,Sonnen JA,Trojanowski JQ,Vinters HV,Zhou XH,Hyman BT
MN1020 was used in immunohistochemistry to characterize the neuropathologic evaluation of Alzheimer's disease by multisite assessment of NIA-AA guidelines
Mon Feb 01 00:00:00 UTC 2016
Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Herring A,Münster Y,Akkaya T,Moghaddam S,Deinsberger K,Meyer J,Zahel J,Sanchez-Mendoza E,Wang Y,Hermann DM,Arzberger T,Teuber-Hanselmann S,Keyvani K
MN1020 was used in western blot to study the attenuation of Alzheimer's pathology in mice due to kallikrein-8 inhibition
Thu Dec 01 00:00:00 UTC 2016
Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.
Acta neuropathologica
Vasconcelos B,Stancu IC,Buist A,Bird M,Wang P,Vanoosthuyse A,Van Kolen K,Verheyen A,Kienlen-Campard P,Octave JN,Baatsen P,Moechars D,Dewachter I
MN1020 was used in Western Blotting to demonstrate that pre-aggregated beta-amyloid can induce Tau fibrillisation by cross-seeding.
Fri Apr 01 00:00:00 UTC 2016
Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity.
Brain : a journal of neurology
Müller-Schiffmann A,Herring A,Abdel-Hafiz L,Chepkova AN,Schäble S,Wedel D,Horn AH,Sticht H,de Souza Silva MA,Gottmann K,Sergeeva OA,Huston JP,Keyvani K,Korth C
MN1020 was used in western blot to assess the impairment in synaptic plasticity and learning due to amyloid-beta dimers in the absence of plaque pathology
Mon Feb 01 00:00:00 UTC 2016
Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse.
Brain : a journal of neurology
Peng Y,Kim MJ,Hullinger R,O'Riordan KJ,Burger C,Pehar M,Puglielli L
MN1020 was used in immunohistochemistry and western blot to assess rescue of Alzheimer's disease in the mouse by improved proteostasis in the secretory pathway
Tue Mar 01 00:00:00 UTC 2016
Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
EMBO molecular medicine
Kretner B,Trambauer J,Fukumori A,Mielke J,Kuhn PH,Kremmer E,Giese A,Lichtenthaler SF,Haass C,Arzberger T,Steiner H
MN1020 was used in Immunohistochemistry to study the generation and deposition of AΒ43 by the virtually inactive presenilin-1 L435F mutant in familial Alzheimer's Disease.
Sun May 01 00:00:00 UTC 2016
Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice.
Molecular psychiatry
Di Meco A,Joshi YB,Lauretti E,Praticò D
MN1020 was used in western blot to study amelioration of tau pathology and cognition in the offspring of triple transgenic AD mice by maternal dexamethasone exposure
Tue Mar 01 00:00:00 UTC 2016
Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.
Autophagy
Pajares M,Jiménez-Moreno N,García-Yagüe ÁJ,Escoll M,de Ceballos ML,Van Leuven F,Rábano A,Yamamoto M,Rojo AI,Cuadrado A
MN1020 was used in immunohistochemistry - free floating to identify NFE2L2/NRF2 as a regulator of autophagy gene expression and study its role in Alzheimer disease
Sun Oct 02 00:00:00 UTC 2016
Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.
Aging cell
Manassero G,Guglielmotto M,Zamfir R,Borghi R,Colombo L,Salmona M,Perry G,Odetti P,Arancio O,Tamagno E,Tabaton M
MN1020 was used in immunohistochemistry - paraffin section elucidate the mechanistic relationship between amyloid beta1-42 and Tau
Sat Oct 01 00:00:00 UTC 2016
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease.
Brain pathology (Zurich, Switzerland)
Tapia-Rojas C,Aranguiz F,Varela-Nallar L,Inestrosa NC
MN1020 was used in immunohistochemistry to assess the effect of voluntary running on several aspects of Alzheimer's disease
Fri Jan 01 00:00:00 UTC 2016
Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.
Neurobiology of disease
El Khoury NB,Gratuze M,Petry F,Papon MA,Julien C,Marcouiller F,Morin F,Nicholls SB,Calon F,Hébert SS,Marette A,Planel E
MN1020 was used in western blot to examine the impact of type 2 diabetes on tau phosphorylation in diabetic mouse model
Fri Apr 01 00:00:00 UTC 2016
Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease.
Neurobiology of disease
Ando K,Tomimura K,Sazdovitch V,Suain V,Yilmaz Z,Authelet M,Ndjim M,Vergara C,Belkouch M,Potier MC,Duyckaerts C,Brion JP
MN1020 was used in immunohistochemistry - paraffin section to assess the correlation with levels of phosphotau and autophagy-related proteins and tau inclusions in PSP, Pick, and AD disease and levels of a key component of clathrin-mediated endocytosis,
Sat Oct 01 00:00:00 UTC 2016
Late running is not too late against Alzheimer's pathology.
Neurobiology of disease
Herring A,Münster Y,Metzdorf J,Bolczek B,Krüssel S,Krieter D,Yavuz I,Karim F,Roggendorf C,Stang A,Wang Y,Hermann DM,Teuber-Hanselmann S,Keyvani K
MN1020 was used in immunohistochemistry and western blot to It is never too late to start late running regarding Alzheimer's pathology
Sat Oct 01 00:00:00 UTC 2016
(I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains.
Neuropharmacology
Garcia-Ratés S,Morrill P,Tu H,Pottiez G,Badin AS,Tormo-Garcia C,Heffner C,Coen CW,Greenfield SA
MN1020 was used in western blot to research blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer's brains by pharmacological profiling of the novel modulator of the alpha7 nicotinic receptor
Wed Jun 01 00:00:00 UTC 2016
TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.
Neuropharmacology
Jiang T,Zhang YD,Chen Q,Gao Q,Zhu XC,Zhou JS,Shi JQ,Lu H,Tan L,Yu JT
MN1020 was used in immunohistochemistry and western blot to elucidate modification microglial phenotype and neuroprotection in P301S tau transgenic mice via TREM2
Wed Jun 01 00:00:00 UTC 2016
Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice.
Neuropharmacology
Sabogal-Guáqueta AM,Osorio E,Cardona-Gómez GP
MN1020 was used in immunohistochemistry to characterize linalool that reverses behavioral and neuropathological impairments in old triple transgenic Alzheimer's mice
Tue Mar 01 00:00:00 UTC 2016
Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei).
Neurobiology of aging
Perez SE,Sherwood CC,Cranfield MR,Erwin JM,Mudakikwa A,Hof PR,Mufson EJ
MN1020 was used in immunohistochemistry - free floating to characterize the frontal cortex of wild mountain gorillas (Gorilla beringei beringei) for early Alzheimer's disease-type pathology
Tue Mar 01 00:00:00 UTC 2016
Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease.
Journal of Alzheimer's disease : JAD
Guillot F,Kemppainen S,Levasseur G,Miettinen PO,Laroche S,Tanila H,Davis S
MN1020 was used in western blot to study novelty-induced and brain-specific basal alternations in PI3K-Akt and MAPK/ERK signaling in a middle-aged A-betaPP/PS1 mouse model of Alzheimer's disease
Thu Dec 29 00:00:00 UTC 2016
Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease.
Neuroscience
Platt TL,Beckett TL,Kohler K,Niedowicz DM,Murphy MP
MN1020 was used in western blot to characterize tau pathology mouse models via obesity, diabetes, and leptin resistance
Fri Feb 19 00:00:00 UTC 2016
Locus ceruleus neurons in people with autism contain no histochemically-detectable mercury.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Pamphlett R,Kum Jew S
MN1020 was used in immunohistochemistry to discover why mercury is found in locus ceruleus neurons in people with autism
Mon Feb 01 00:00:00 UTC 2016
Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology.
Journal of neuropathology and experimental neurology
Adams SL,Tilton K,Kozubek JA,Seshadri S,Delalle I
MN1020 was used in immunohistochemistry - paraffin section to characterize the cerebral cortex during the progression of Alzheimer disease pathology by visualizing subcellular changes in bridging integrator 1 protein expression
Mon Aug 01 00:00:00 UTC 2016
Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.
Neurobiology of learning and memory
Van der Jeugd A,Vermaercke B,Halliday GM,Staufenbiel M,Götz J
MN1020 was used in immunohistochemistry - paraffin section to elucidate a mouse model of frontotemporal dementia by decreased social exploration, impulsivity, and executive dysfunction
Fri Apr 01 00:00:00 UTC 2016
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
The Journal of comparative neurology
Smolek T,Madari A,Farbakova J,Kandrac O,Jadhav S,Cente M,Brezovakova V,Novak M,Zilka N
MN1020 was used in immunohistochemistry - paraffin section to study canine cognitive impairment syndrome.
Tue Mar 01 00:00:00 UTC 2016
Hypersialylation is a common feature of neurofibrillary tangles and granulovacuolar degenerations in Alzheimer's disease and tauopathy brains.
Neuropathology : official journal of the Japanese Society of Neuropathology
Nagamine S,Yamazaki T,Makioka K,Fujita Y,Ikeda M,Takatama M,Okamoto K,Yokoo H,Ikeda Y
MN1020 was used in immunohistochemistry - paraffin section to analysis of neurofibrillary tangles and granulovacuolar degeneration in Alzheimer's disease and tauopathy brains and the common feature of hypersialylation
Mon Aug 01 00:00:00 UTC 2016
Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mizukami K,Akatsu H,Abrahamson EE,Mi Z,Ikonomovic MD
MN1020 was used in Immunohistochemistry-immunofluorescence to demonstrate that in Alzheimer's disease hippocampus, BChE accumulates in neurons and plaque-associated neuritic clusters, but only in a small proportion of neurofibrillary tangles.
Fri Apr 01 00:00:00 UTC 2016
Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier.
Scientific reports
Villaseñor R,Ozmen L,Messaddeq N,Grüninger F,Loetscher H,Keller A,Betsholtz C,Freskgård PO,Collin L
MN1020 was used in Immunofluorescence in immunohistochemistry on frozen tissues to suggest that immunoglobulin (IgG) lysosomal degradation may be a downstream mechanism by which brain endothelial cells further restrict IgG access to the brain.
Fri May 06 00:00:00 UTC 2016
High Resolution Dissection of Reactive Glial Nets in Alzheimer's Disease.
Scientific reports
Bouvier DS,Jones EV,Quesseveur G,Davoli MA,A Ferreira T,Quirion R,Mechawar N,Murai KK
MN1020 was used in immunohistochemistry - free floating to analyze reactive glial nets in Alzheimer's disease by high resolution dissection
Tue Apr 19 00:00:00 UTC 2016
Increased tauopathy drives microglia-mediated clearance of beta-amyloid.
Acta neuropathologica communications
Chen W,Abud EA,Yeung ST,Lakatos A,Nassi T,Wang J,Blum D,Buée L,Poon WW,Blurton-Jones M
MN1020 was used in Immunohistochemistry-immunofluorescence to study the interplay between AΒ deposition, tau pathology and microgliosis in Alzheimer's disease.
Thu Jun 23 00:00:00 UTC 2016
Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin.
Scientific reports
Mansuroglu Z,Benhelli-Mokrani H,Marcato V,Sultan A,Violet M,Chauderlier A,Delattre L,Loyens A,Talahari S,Bégard S,Nesslany F,Colin M,Souès S,Lefebvre B,Buée L,Galas MC,Bonnefoy E
MN1020 was used in immunohistochemistry to suggest that Tau regulates neuronal pericentromeric heterochromatin integrity
Thu Sep 08 00:00:00 UTC 2016
Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer's disease pathology.
Journal of neuroinflammation
Rosenberger AF,Morrema TH,Gerritsen WH,van Haastert ES,Snkhchyan H,Hilhorst R,Rozemuller AJ,Scheltens P,van der Vies SM,Hoozemans JJ
MN1020 was used in immunohistochemistry to analyze astrocytes in Alzheimer's disease pathology by an increased occurrence of protein kinase CK2
Wed Jan 06 00:00:00 UTC 2016
NPT088 reduces both amyloid-β and tau pathologies in transgenic mice.
Alzheimer's & dementia (New York, N. Y.)
Levenson JM,Schroeter S,Carroll JC,Cullen V,Asp E,Proschitsky M,Chung CH,Gilead S,Nadeem M,Dodiya HB,Shoaga S,Mufson EJ,Tsubery H,Krishnan R,Wright J,Solomon B,Fisher R,Gannon KS
MN1020 was used in Immunohistochemistry to establish NPT088 as a novel therapeutic approach and potential drug class that targets both Aβ and tau.
Thu Sep 01 00:00:00 UTC 2016
TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits.
eNeuro
Wang H,Wang R,Carrera I,Xu S,Lakshmana MK
MN1020 was used in western blot to analyze the mitigation that increases PHF1 levels and lipofuscin puncta and rescues memory deficits by TFEB overexpression in the P301S model of tauopathy
Fri Oct 20 00:00:00 UTC 2017
Protocols for Monitoring the Development of Tau Pathology in Alzheimer's Disease.
Methods in molecular biology (Clifton, N.J.)
Rábano A,Cuadros R,Merino-Serráis P,Rodal I,Benavides-Piccione R,Gómez E,Medina M,DeFelipe J,Avila J
MN1020 was used in immunohistochemistry - paraffin section and western blot to discuss protocols that monitor tau pathology development in Alzheimer's disease
Fri Apr 29 00:00:00 UTC 2016
Diminishing evidence for torsinA-positive neuronal inclusions in DYT1 dystonia.
Acta neuropathologica communications
Pratt D,Mente K,Rahimpour S,Edwards NA,Tinaz S,Berman BD,Hallett M,Ray-Chaudhury A
MN1020 was used in Immunohistochemistry to add to the growing body of evidence that there are no consistent torsinA immunoreactive protein inclusions associated with, or specific to, DYT1 dystonia in humans.
Wed Aug 17 00:00:00 UTC 2016
Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Hostetler ED,Walji AM,Zeng Z,Miller P,Bennacef I,Salinas C,Connolly B,Gantert L,Haley H,Holahan M,Purcell M,Riffel K,Lohith TG,Coleman P,Soriano A,Ogawa A,Xu S,Zhang X,Joshi E,Della Rocca J,Hesk D,Schenk DJ,Evelhoch JL
MN1020 was used in Immunohistochemistry to describe the preclinical characterization of the NFT PET tracer 18F-MK-6240.
Sat Oct 01 00:00:00 UTC 2016
Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.
Cell reports
Lee SH,Le Pichon CE,Adolfsson O,Gafner V,Pihlgren M,Lin H,Solanoy H,Brendza R,Ngu H,Foreman O,Chan R,Ernst JA,DiCara D,Hotzel I,Srinivasan K,Hansen DV,Atwal J,Lu Y,Bumbaca D,Pfeifer A,Watts RJ,Muhs A,Scearce-Levie K,Ayalon G
MN1020 was used in Western Blot to investigate whether antibody effector function is required for targeting tau.
Tue Aug 09 00:00:00 UTC 2016
Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration.
Acta neuropathologica communications
Kawakami I,Kobayashi Z,Arai T,Yokota O,Nonaka T,Aoki N,Niizato K,Oshima K,Higashi S,Katsuse O,Hosokawa M,Hasegawa M,Akiyama H
MN1020 was used in immunohistochemistry - paraffin section to suggest that the clinical feature of choreoathetosis in behavioral variant of frontotemporal dementia might be associated with the basophilic inclusion body disease subtype of frontotemporal lobar degeneration
Mon Apr 04 00:00:00 UTC 2016
Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models.
Cell death & disease
Lipton SA,Rezaie T,Nutter A,Lopez KM,Parker J,Kosaka K,Satoh T,McKercher SR,Masliah E,Nakanishi N
MN1020 was used in immunohistochemistry to examine the effects of carnosic acid in models of Alzheimer's disease
Thu Dec 01 00:00:00 UTC 2016
Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.
Scientific reports
Gorsky MK,Burnouf S,Dols J,Mandelkow E,Partridge L
MN1020 was used in western blot to elucidate the exacerbation of human Tau neurotoxicity in vivo by acetylation mimic of lysine 280
Fri Mar 04 00:00:00 UTC 2016
Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection.
Acta neuropathologica communications
Ikonomovic MD,Buckley CJ,Heurling K,Sherwin P,Jones PA,Zanette M,Mathis CA,Klunk WE,Chakrabarty A,Ironside J,Ismail A,Smith C,Thal DR,Beach TG,Farrar G,Smith AP
MN1020 was used in Immunohistochemistry to support that amyloid in neuritic plaque burden is the primary form of Β-amyloid pathology detectable with [18F]flutemetamol PET imaging.
Mon Dec 12 00:00:00 UTC 2016
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
Molecular neurodegeneration
Sohn PD,Tracy TE,Son HI,Zhou Y,Leite RE,Miller BL,Seeley WW,Grinberg LT,Gan L
MN1020 was used in western blot to investigate the axon initial segment in neurological disorders
Wed Jun 29 00:00:00 UTC 2016
Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation.
PloS one
Blair JA,Wang C,Hernandez D,Siedlak SL,Rodgers MS,Achar RK,Fahmy LM,Torres SL,Petersen RB,Zhu X,Casadesus G,Lee HG
MN1020 was used in Immunohistochemistry-immunofluorescence and Western Blotting to assess the impact of postmortem interval time on brain tissue preservation.
Mon Jul 25 00:00:00 UTC 2016
Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation.
PloS one
Blair JA,Wang C,Hernandez D,Siedlak SL,Rodgers MS,Achar RK,Fahmy LM,Torres SL,Petersen RB,Zhu X,Casadesus G,Lee HG
MN1020 was used in Immunohistochemistry-immunofluorescence and Western Blotting to assess the impact of postmortem interval time on brain tissue preservation.
Mon Jul 25 00:00:00 UTC 2016
Unfolded protein response is activated in Lewy body dementias.
Neuropathology and applied neurobiology
Baek JH,Whitfield D,Howlett D,Francis P,Bereczki E,Ballard C,Hortobágyi T,Attems J,Aarsland D
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to give emphasis to the role of UPR in Lewy body dementias, and suggest that Lewy body degeneration, in combination with AD-type pathologies, is associated with increased UPR activation to a greater extent than AD alone, possibly as a consequence of the increasing load of ER proteins.
Wed Jun 01 00:00:00 UTC 2016
Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model.
Science translational medicine
Leinenga G,Götz J
MN1020 was used in western blot to explore a nonpharmacological approach, repeated scanning ultrasound treatments, for removing Abeta and restoring memory function in a mouse model of Alzheimer's disease
Wed Mar 11 00:00:00 UTC 2015
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
The Journal of experimental medicine
Jay TR,Miller CM,Cheng PJ,Graham LC,Bemiller S,Broihier ML,Xu G,Margevicius D,Karlo JC,Sousa GL,Cotleur AC,Butovsky O,Bekris L,Staugaitis SM,Leverenz JB,Pimplikar SW,Landreth GE,Howell GR,Ransohoff RM,Lamb BT
MN1020 was used in immunohistochemistry - free floating to elucidate the cell types and mechanisms underlying TREM2's contribution to neurodegeneration.
Mon Mar 09 00:00:00 UTC 2015
A 3D human neural cell culture system for modeling Alzheimer's disease.
Nature protocols
Kim YH,Choi SH,D'Avanzo C,Hebisch M,Sliwinski C,Bylykbashi E,Washicosky KJ,Klee JB,Brüstle O,Tanzi RE,Kim DY
MN1020 was used in Immunohistochemistry to provide instructions for the generation and analysis of 3D human neural cell cultures.
Wed Jul 01 00:00:00 UTC 2015
[(18)F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: specific detection of advanced phases of amyloid-β pathology.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Thal DR,Beach TG,Zanette M,Heurling K,Chakrabarty A,Ismail A,Smith AP,Buckley C
MN1020 was used in Immunohistochemistry to evaluate the diagnostic value of the amyloid positron emission tomography tracer, [(18)F]flutemetamol, in relation to AΒ pathology at autopsy.
Sat Aug 01 00:00:00 UTC 2015
Relationship between hippocampal atrophy and neuropathology markers: a 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Apostolova LG,Zarow C,Biado K,Hurtz S,Boccardi M,Somme J,Honarpisheh H,Blanken AE,Brook J,Tung S,Lo D,Ng D,Alger JR,Vinters HV,Bocchetta M,Duvernoy H,Jack CR,Frisoni GB
MN1020 was used in immunohistochemistry - paraffin section to validate the European Alzheimer's Disease Consortium Alzheimer's Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP).
Sun Feb 01 00:00:00 UTC 2015
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Acta neuropathologica
Wagner J,Krauss S,Shi S,Ryazanov S,Steffen J,Miklitz C,Leonov A,Kleinknecht A,Göricke B,Weishaupt JH,Weckbecker D,Reiner AM,Zinth W,Levin J,Ehninger D,Remy S,Kretzschmar HA,Griesinger C,Giese A,Fuhrmann M
MN1020 was used in immunohistochemistry and western blot to report that the di-phenyl-pyrazole anle138b binds to and inhibits tau aggregation in vitro and in vivo
Sun Nov 01 00:00:00 UTC 2015
Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain.
Brain : a journal of neurology
Maphis N,Xu G,Kokiko-Cochran ON,Jiang S,Cardona A,Ransohoff RM,Lamb BT,Bhaskar K
MN1020 was used in western blot to demonstrate that microglia promote tau pathology in a cell-autonomous manner.
Mon Jun 01 00:00:00 UTC 2015
HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.
Brain : a journal of neurology
Sepulveda-Diaz JE,Alavi Naini SM,Huynh MB,Ouidja MO,Yanicostas C,Chantepie S,Villares J,Lamari F,Jospin E,van Kuppevelt TH,Mensah-Nyagan AG,Raisman-Vozari R,Soussi-Yanicostas N,Papy-Garcia D
MN1020 was used in western blot to characterize Alzheimer's disease-related tau pathology by HS3ST2 expression in critical for the abonormal phosphorylation of tau
Fri May 01 00:00:00 UTC 2015
Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias.
Brain pathology (Zurich, Switzerland)
Howlett DR,Whitfield D,Johnson M,Attems J,O'Brien JT,Aarsland D,Lai MK,Lee JH,Chen C,Ballard C,Hortobágyi T,Francis PT
MN1020 was used in Immunohistochemistry to show that cognitive decline in Lewy body dementias is due to a combination of α-synuclein-induced neurodegeneration, senile plaque and phosphorylated tau pathology.
Wed Jul 01 00:00:00 UTC 2015
Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo.
Neurobiology of disease
Violet M,Chauderlier A,Delattre L,Tardivel M,Chouala MS,Sultan A,Marciniak E,Humez S,Binder L,Kayed R,Lefebvre B,Bonnefoy E,Buée L,Galas MC
MN1020 was used in immunohistochemistry - paraffin section to determine the therapeutic window to prevent the formation of Tau aggregates
Thu Oct 01 00:00:00 UTC 2015
The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Spilsbury A,Miwa S,Attems J,Saretzki G
MN1020 was used in immunocytochemistry and immunohistochemistry - paraffin section to investigate the role of TERT in the adult human brain
Wed Jan 28 00:00:00 UTC 2015
Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hunt JB,Nash KR,Placides D,Moran P,Selenica ML,Abuqalbeen F,Ratnasamy K,Slouha N,Rodriguez-Ospina S,Savlia M,Ranaweera Y,Reid P,Dickey CA,Uricia R,Yang CG,Sandusky LA,Gordon MN,Morgan D,Lee DC
MN1020 was used in Immunohistochemistry to study the effects of Arginase 1 overexperssion in the central nervous system of rTg4510 tau transgenic mice.
Wed Nov 04 00:00:00 UTC 2015
At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei.
Neuropathology and applied neurobiology
Reis R,Hennessy E,Murray C,Griffin ÉW,Cunningham C
MN1020 was used in immunohistochemistry - paraffin section to investigate the spread of neuronal pathology.
Thu Oct 01 00:00:00 UTC 2015
The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease.
Experimental neurology
Collins JM,King AE,Woodhouse A,Kirkcaldie MT,Vickers JC
MN1020 was used in immunohistochemistry - free floating to use the APP/PS1 (APPSWE, PSEN1dE9) transgenic model of Alzheimer's disease to study the role of localized damage on disease progression
Fri May 01 00:00:00 UTC 2015
Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.
Journal of neurochemistry
Ittner A,Bertz J,Suh LS,Stevens CH,Götz J,Ittner LM
MN1020 was used in immunohistochemistry - paraffin section and western blot to determine the pathology in tau transgenic mice due to tau-targeting passive immunization
Thu Jan 01 00:00:00 UTC 2015
Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA-195 down-regulation.
Journal of neurochemistry
Sun LH,Ban T,Liu CD,Chen QX,Wang X,Yan ML,Hu XL,Su XL,Bao YN,Sun LL,Zhao LJ,Pei SC,Jiang XM,Zong DK,Ai J
MN1020 was used in western blot to investigate the involvement of microRNA-195 in the effect of chronic brain hypoperfusion on rodent Cdk5/p25 and tau phosphorylation
Tue Sep 01 00:00:00 UTC 2015
The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice.
Neuropharmacology
Sabogal-Guáqueta AM,Muñoz-Manco JI,Ramírez-Pineda JR,Lamprea-Rodriguez M,Osorio E,Cardona-Gómez GP
MN1020 was used in immunohistochemistry and western blot to assess the neuroprotective effect of quercetin administration in the triple transgenic Alzheimer's disease model mice
Mon Jun 01 00:00:00 UTC 2015
Aneuploidy in Lewy body diseases.
Neurobiology of aging
Yang Y,Shepherd C,Halliday G
MN1020 was used in immunohistochemistry - paraffin section to evaluate the role of DNA content in Lewy body diseases
Sun Mar 01 00:00:00 UTC 2015
Isolation and characterization of antibody fragments selective for toxic oligomeric tau.
Neurobiology of aging
Tian H,Davidowitz E,Lopez P,He P,Schulz P,Moe J,Sierks MR
MN1020 was used in ELISA to generate reagents that selectively recognize toxic oligomeric tau
Sun Mar 01 00:00:00 UTC 2015
Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor.
Neurobiology of aging
Lauretti E,Di Meco A,Chu J,Praticò D
MN1020 was used in immunohistochemistry - paraffin section and western blot to characterize the behavioral, biochemical, and neuropathologic effects of 8ISO in the triple transgenic mouse model of Alzheimer's disease
Sun Feb 01 00:00:00 UTC 2015
miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.
Human molecular genetics
Smith PY,Hernandez-Rapp J,Jolivette F,Lecours C,Bisht K,Goupil C,Dorval V,Parsi S,Morin F,Planel E,Bennett DA,Fernandez-Gomez FJ,Sergeant N,Buée L,Tremblay MÈ,Calon F,Hébert SS
MN1020 was used in western blot to investigate the role of miR-132/212 in tauopathies
Tue Dec 01 00:00:00 UTC 2015
Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2.
Journal of neuroscience research
Hamm M,Bailey R,Shaw G,Yen SH,Lewis J,Giasson BI
MN1020 was used in western blot to study how microtubules and cations impact LRRK2-tau interactions.
Thu Oct 01 00:00:00 UTC 2015
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Journal of Alzheimer's disease : JAD
Dunn HC,Ager RR,Baglietto-Vargas D,Cheng D,Kitazawa M,Cribbs DH,Medeiros R
MN1020 was used in western blot to assess the effect of aging on brain lipoxin A4 levels using non-transgenic and 3xTg-AD mice.
Fri Aug 21 00:00:00 UTC 2015
Dexmedetomidine directly increases tau phosphorylation.
Journal of Alzheimer's disease : JAD
Huang C,Ho YS,Ng OT,Irwin MG,Chang RC,Wong GT
MN1020 was used in immunohistochemistry - paraffin section and western blot to study tau phosphorylation and its direct increase by dexmedetomidine
Mon Oct 26 00:00:00 UTC 2015
Different Populations of Human Locus Ceruleus Neurons Contain Heavy Metals or Hyperphosphorylated Tau: Implications for Amyloid-β and Tau Pathology in Alzheimer's Disease.
Journal of Alzheimer's disease : JAD
Pamphlett R,Kum Jew S
MN1020 was used in Immunofluorescence in immunohistochemistry on frozen tissues to describe a model that proposes that the locus ceruleus plays a part in both the amyloid-Β and tau pathologies of Alzheimer's disease.
Thu Jan 14 00:00:00 UTC 2016
Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons.
Neuroscience
Li R,Xu DE,Ma T
MN1020 was used in western blot to elucidate the neuroprotective mechanism of statins
Thu May 21 00:00:00 UTC 2015
Clinico-Pathological Correlations of the Frontal Lobe Syndrome: Results of a Large Brain Bank Study.
Dementia and geriatric cognitive disorders
Krudop WA,Bosman S,Geurts JJ,Sikkes SA,Verwey NA,Stek ML,Scheltens P,Rozemuller AJ,Pijnenburg YA
MN1020 was used in Immunohistochemistry to show that the distribution of pathological changes in subjects with FLS was shown to be frontal-subcortical for the first time.
Thu Jan 14 00:00:00 UTC 2016
Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product.
Journal of neuroimmunology
Hromadkova L,Kolarova M,Jankovicova B,Bartos A,Ricny J,Bilkova Z,Ripova D
MN1020 was used in western blot to investigate the reactivity of isolated natural antibodies against tau protein
Tue Dec 15 00:00:00 UTC 2015
Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology.
Journal of neuropathology and experimental neurology
Perez SE,He B,Nadeem M,Wuu J,Ginsberg SD,Ikonomovic MD,Mufson EJ
MN1020 was used in Western Blotting to indicate that alterations in hippocampal endosomal-lysosomal proteins in mild cognitive impairment are independent of tau or Aβ pathology.
Wed Apr 01 00:00:00 UTC 2015
Correlations between mini-mental state examination score, cerebrospinal fluid biomarkers, and pathology observed in brain biopsies of patients with normal-pressure hydrocephalus.
Journal of neuropathology and experimental neurology
Elobeid A,Laurell K,Cesarini KG,Alafuzoff I
MN1020 was used in Immunohistochemistry to assess Alzheimer disease-related pathology in cortical biopsy samples of 111 patients with idiopathic normal-pressure hydrocephalus.
Fri May 01 00:00:00 UTC 2015
Cerebral cortical Aβ42 and PHF-τ in 325 consecutive brain autopsies stratified by diagnosis, location, and APOE.
Journal of neuropathology and experimental neurology
Postupna N,Keene CD,Crane PK,Gonzalez-Cuyar LF,Sonnen JA,Hewitt J,Rice S,Howard K,Montine KS,Larson EB,Montine TJ
MN1020 was used in immunohistochemistry - paraffin section to quantify amyloid beta 42 and paired helical filament-tau in the frontal, temporal, and parietal cortices
Sun Feb 01 00:00:00 UTC 2015
Array tomography for the detection of non-dilated, injured axons in traumatic brain injury.
Journal of neuroscience methods
Bennett RE,Brody DL
MN1020 was used in immunohistochemistry to discuss the limitations assessing axonal injury by microscopy
Thu Apr 30 00:00:00 UTC 2015
Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice.
Neuroreport
Kim JM,Kim SS,Lee YD
MN1020 was used in immunohistochemistry - paraffin section to investigate the relationship between neurofibrillary changes and degeneration of septal cholinergic neurons in P301L tau transgenic mice
Wed Sep 09 00:00:00 UTC 2015
Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets.
PloS one
Eggers SD,Horn AK,Roeber S,Härtig W,Nair G,Reich DS,Leigh RJ
MN1020 was used in Immunohistochemistry to support current models and experimental studies of the brainstem saccade-generating neurons and indicate that damage to PN may permanently impair the function of these neurons that the PN ensheathe.
Tue May 03 00:00:00 UTC 2016
The domestic cat as a natural animal model of Alzheimer's disease.
Acta neuropathologica communications
Chambers JK,Tokuda T,Uchida K,Ishii R,Tatebe H,Takahashi E,Tomiyama T,Une Y,Nakayama H
MN1020 was used in immunohistochemistry - paraffin section to study Alzheimer's disease by use of a domestic cat animal model
Thu Dec 10 00:00:00 UTC 2015
Role of Liver X Receptor in AD Pathophysiology.
PloS one
Sandoval-Hernández AG,Buitrago L,Moreno H,Cardona-Gómez GP,Arboleda G
MN1020 was used in immunohistochemistry to test if a LXR agonist affects cognitive impairment in amyloid and Tau Alzheimer's disease mouse models
Sun Jun 26 00:00:00 UTC 2016
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Molecular neurodegeneration
Song L,Lu SX,Ouyang X,Melchor J,Lee J,Terracina G,Wang X,Hyde L,Hess JF,Parker EM,Zhang L
MN1020 was used in western blot to use rTg4510 mice to elucidate pathogenesis of tau-induced disease.
Thu Mar 26 00:00:00 UTC 2015
β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.
Frontiers in cellular neuroscience
Piedrahita D,Castro-Alvarez JF,Boudreau RL,Villegas-Lanau A,Kosik KS,Gallego-Gomez JC,Cardona-Gómez GP
MN1020 was used in western blot to study reduction of hyperphosphorilated Tau by beta-secretase 1's targeting implying autophagy actors in 3xTg-AD mice
Mon Jan 18 00:00:00 UTC 2016
Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses.
Tremor and other hyperkinetic movements (New York, N.Y.)
Iacono D,Geraci-Erck M,Peng H,Rabin ML,Kurlan R
MN1020 was used in immunohistochemistry to characterize the neuropathological features of dystonias
Sat Jun 13 00:00:00 UTC 2015
Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential.
Nature communications
Chauhan S,Ahmed Z,Bradfute SB,Arko-Mensah J,Mandell MA,Won Choi S,Kimura T,Blanchet F,Waller A,Mudd MH,Jiang S,Sklar L,Timmins GS,Maphis N,Bhaskar K,Piguet V,Deretic V
MN1020 was used in western blot to use a pharmaceutical screen to discover new mechanisms of autophagy activation
Tue Oct 27 00:00:00 UTC 2015
Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.
Stem cell reports
Schwab AJ,Ebert AD
MN1020 was used in western blot to study the effect of G2019S on neuronal subtypes
Tue Dec 08 00:00:00 UTC 2015
The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.
Molecular brain
Watanabe K,Uemura K,Asada M,Maesako M,Akiyama H,Shimohama S,Takahashi R,Kinoshita A
MN1020 was used in western blot to characterize the release of insulin-like growth factor-binding protein 3 from astrocytes in the pathology of Alzheimer's disease
Fri Dec 04 00:00:00 UTC 2015
Human neural stem cells alleviate Alzheimer-like pathology in a mouse model.
Molecular neurodegeneration
Lee IS,Jung K,Kim IS,Lee H,Kim M,Yun S,Hwang K,Shin JE,Park KI
MN1020 was used in western blot to analyze a mouse model where human neural stem cells alleviate Alzheimer-like pathology
Fri Aug 21 00:00:00 UTC 2015
Identification of age- and disease-related alterations in circulating miRNAs in a mouse model of Alzheimer's disease.
Frontiers in cellular neuroscience
Garza-Manero S,Arias C,Bermúdez-Rattoni F,Vaca L,Zepeda A
MN1020 was used in immunohistochemistry - free floating to investigate if circulating miRNA levels can be used as biomarkers for Alzheimer's disease
Fri Mar 06 00:00:00 UTC 2015
Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse.
Acta neuropathologica communications
Henstridge CM,Jackson RJ,Kim JM,Herrmann AG,Wright AK,Harris SE,Bastin ME,Starr JM,Wardlaw J,Gillingwater TH,Smith C,McKenzie CA,Cox SR,Deary IJ,Spires-Jones TL
MN1020 was used in immunohistochemistry (paraffin) to present data from the first donated Lothian Birth Cohort of 1936 and compare it with other aged and diseased samples.
Fri Sep 04 00:00:00 UTC 2015
Analysis of in vivo turnover of tau in a mouse model of tauopathy.
Molecular neurodegeneration
Yamada K,Patel TK,Hochgräfe K,Mahan TE,Jiang H,Stewart FR,Mandelkow EM,Holtzman DM
MN1020 was used in ELISA to study in vivo turnover of tau by use of a mouse model of tauopathy
Mon Oct 26 00:00:00 UTC 2015
Conformation determines the seeding potencies of native and recombinant Tau aggregates.
The Journal of biological chemistry
Falcon B,Cavallini A,Angers R,Glover S,Murray TK,Barnham L,Jackson S,O'Neill MJ,Isaacs AM,Hutton ML,Szekeres PG,Goedert M,Bose S
MN1020 was used in western blot to determine seeding potencies of recombinant and native Tau aggregates due to conformation
Fri Jan 09 00:00:00 UTC 2015
Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes.
Biochimica et biophysica acta
Filipcik P,Cente M,Zilka N,Smolek T,Hanes J,Kucerak J,Opattova A,Kovacech B,Novak M
MN1020 was used in immunohistochemistry - free floating to study the involvement of heat shock protein 27 (Hsp27) in a transgenic rat model of Alzheimer's disease
Wed Jul 01 00:00:00 UTC 2015
Huntington's disease is a four-repeat tauopathy with tau nuclear rods.
Nature medicine
Fernández-Nogales M,Cabrera JR,Santos-Galindo M,Hoozemans JJ,Ferrer I,Rozemuller AJ,Hernández F,Avila J,Lucas JJ
MN1020 was used in western blot to investigate the role of tau missplicing in the pathogenesis of Huntington disease
Fri Aug 01 00:00:00 UTC 2014
REST and stress resistance in ageing and Alzheimer's disease.
Nature
Lu T,Aron L,Zullo J,Pan Y,Kim H,Chen Y,Yang TH,Kim HM,Drake D,Liu XS,Bennett DA,Colaiácovo MP,Yankner BA
MN1020 was used in western blot to investigate the role of repressor element 1-silencing transcription factor in neurodegeneration during ageing.
Thu Mar 27 00:00:00 UTC 2014
Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration.
Acta neuropathologica
van der Zee J,Van Langenhove T,Kovacs GG,Dillen L,Deschamps W,Engelborghs S,Matěj R,Vandenbulcke M,Sieben A,Dermaut B,Smets K,Van Damme P,Merlin C,Laureys A,Van Den Broeck M,Mattheijssens M,Peeters K,Benussi L,Binetti G,Ghidoni R,Borroni B,Padovani A,Archetti S,Pastor P,Razquin C,Ortega-Cubero S,Hernández I,Boada M,Ruiz A,de Mendonça A,Miltenberger-Miltényi G,do Couto FS,Sorbi S,Nacmias B,Bagnoli S,Graff C,Chiang HH,Thonberg H,Perneczky R,Diehl-Schmid J,Alexopoulos P,Frisoni GB,Bonvicini C,Synofzik M,Maetzler W,vom Hagen JM,Schöls L,Haack TB,Strom TM,Prokisch H,Dols-Icardo O,Clarimón J,Lleó A,Santana I,Almeida MR,Santiago B,Heneka MT,Jessen F,Ramirez A,Sanchez-Valle R,Llado A,Gelpi E,Sarafov S,Tournev I,Jordanova A,Parobkova E,Fabrizi GM,Testi S,Salmon E,Ströbel T,Santens P,Robberecht W,De Jonghe P,Martin JJ,Cras P,Vandenberghe R,De Deyn PP,Cruts M,Sleegers K,Van Broeckhoven C
MN1020 was used in Immunohistochemistry to provide evidence for a putative role of rare mutations in Sequestosome 1 in the genetic etiology of frontotemporal lobar degeneration.
Mon Sep 01 00:00:00 UTC 2014
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies.
Acta neuropathologica
Yarchoan M,Toledo JB,Lee EB,Arvanitakis Z,Kazi H,Han LY,Louneva N,Lee VM,Kim SF,Trojanowski JQ,Arnold SE
MN1020 was used in immunohistochemistry - paraffin section to determine the expression of abnormal serine phosphorylation of insulin receptor substrate 1 in healthy and diseased human brains
Sat Nov 01 00:00:00 UTC 2014
Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease.
Brain : a journal of neurology
Collin L,Bohrmann B,Göpfert U,Oroszlan-Szovik K,Ozmen L,Grüninger F
MN1020 was used in immunohistochemistry - free floating to investigate the mechanisms by which anti-Tau antibodies alleviate Alzheimer's disease in mice
Wed Oct 01 00:00:00 UTC 2014
Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB.
EMBO molecular medicine
Polito VA,Li H,Martini-Stoica H,Wang B,Yang L,Xu Y,Swartzlander DB,Palmieri M,di Ronza A,Lee VM,Sardiello M,Ballabio A,Zheng H
MN1020 was used in immunocytochemistry and western blot to assess transcription factor ED activity in Alzheimer's disease mouse models
Mon Sep 01 00:00:00 UTC 2014
Loss of the m-AAA protease subunit AFG₃L₂ causes mitochondrial transport defects and tau hyperphosphorylation.
The EMBO journal
Kondadi AK,Wang S,Montagner S,Kladt N,Korwitz A,Martinelli P,Herholz D,Baker MJ,Schauss AC,Langer T,Rugarli EI
MN1020 was used in immunohistochemistry and western blot to study the mitochondrial import defects and hyperphosphorylation of tau that result from depletion of the AFG(3)L(2) subunit of the m-AAA proteinase in neurons
Fri May 02 00:00:00 UTC 2014
New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications.
Journal of neurology, neurosurgery, and psychiatry
Chare L,Hodges JR,Leyton CE,McGinley C,Tan RH,Kril JJ,Halliday GM
MN1020 was used in immunohistochemistry to study the clinical implications of new diagnostic criteria for frontotemporal dementia syndromes
Fri Aug 01 00:00:00 UTC 2014
Tau reduction prevents disease in a mouse model of Dravet syndrome.
Annals of neurology
Gheyara AL,Ponnusamy R,Djukic B,Craft RJ,Ho K,Guo W,Finucane MM,Sanchez PE,Mucke L
MN1020 was used in immunohistochemistry to assess if tau reduction benefits intractable genetic epilepsies
Mon Sep 01 00:00:00 UTC 2014
P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion.
Aging cell
Pehar M,Ko MH,Li M,Scrable H,Puglielli L
MN1020 was used in western blot to study the role of the short p44 isoform of p53 in driving the expression of tau-phosphorylating protein kinases and the age-dependent increase in nuclear p44
Sun Jun 01 00:00:00 UTC 2014
Visualizing the microtubule-associated protein tau in the nucleus.
Science China. Life sciences
Lu J,Li T,He R,Bartlett PF,Götz J
MN1020 was used in western blot to perform a comparative study of methods for the detection of nuclear tau protein
Tue Apr 01 00:00:00 UTC 2014
Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis.
Neurobiology of disease
Köhler C,Dinekov M,Götz J
MN1020 was used in immunocytochemistry to assess the presence of granulovacuolar degeneration and the activated unfolded protein response in two mouse models of Alzheimer's disease
Sat Nov 01 00:00:00 UTC 2014
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Neurobiology of disease
Baglietto-Vargas D,Kitazawa M,Le EJ,Estrada-Hernandez T,Rodriguez-Ortiz CJ,Medeiros R,Green KN,LaFerla FM
MN1020 was used in western blot to study the effect of endogenous murine tau on cognition and neurofibrillary tangles in a murine Alzheimer's disease model transgenically expressing human tau
Sat Feb 01 00:00:00 UTC 2014
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Castillo-Carranza DL,Sengupta U,Guerrero-Muñoz MJ,Lasagna-Reeves CA,Gerson JE,Singh G,Estes DM,Barrett AD,Dineley KT,Jackson GR,Kayed R
MN1020 was used in ELISA, immunohistochemistry, and western blot to study the ability of an anti-oligomeric tau monoclonal antibody to specifically reduce oligomeric tau and improve memory and locomotion in a murine Alzheimer's disease model
Wed Mar 19 00:00:00 UTC 2014
Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Forny-Germano L,Lyra e Silva NM,Batista AF,Brito-Moreira J,Gralle M,Boehnke SE,Coe BC,Lablans A,Marques SA,Martinez AM,Klein WL,Houzel JC,Ferreira ST,Munoz DP,De Felice FG
MN1020 was used in immunohistochemistry - free floating to study the impact of amyloid-beta oligomers in the brains of rats and adult cynomolgus macaques
Wed Oct 08 00:00:00 UTC 2014
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shilling D,Müller M,Takano H,Mak DO,Abel T,Coulter DA,Foskett JK
MN1020 was used in immunohistochemistry and western blot to study the role of exagerated Ca(2+) signaling mediated by InsP3 receptor1 in the pathogenesis of mutant presenilin-linked Alzheimer's disease
Wed May 14 00:00:00 UTC 2014
Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lee S,Xu G,Jay TR,Bhatta S,Kim KW,Jung S,Landreth GE,Ransohoff RM,Lamb BT
MN1020 was used in immunohistochemistry - free floating and western blot to investigate the role of membrane-anchored versus soluble CX3CL1 in regulating the microglia-mediated amelioration of Abeta pathology
Wed Sep 10 00:00:00 UTC 2014
Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Stancu IC,Ris L,Vasconcelos B,Marinangeli C,Goeminne L,Laporte V,Haylani LE,Couturier J,Schakman O,Gailly P,Pierrot N,Kienlen-Campard P,Octave JN,Dewachter I
MN1020 was used in immunohistochemistry (free floating) to present data that suggests that pathological Aβ species induce changes in Tau that contribute to cognitive deficits correlating with synaptic deficits and hippocampal atrophy in an Alzheimer's disease model.
Sun Jun 01 00:00:00 UTC 2014
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.
The American journal of pathology
Abbondante S,Baglietto-Vargas D,Rodriguez-Ortiz CJ,Estrada-Hernandez T,Medeiros R,Laferla FM
MN1020 was used in western blot to study the cognitive defects observed in type 1 diabetes and the role of tau in mediating these effects
Sat Mar 01 00:00:00 UTC 2014
α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.
The American journal of pathology
Medeiros R,Castello NA,Cheng D,Kitazawa M,Baglietto-Vargas D,Green KN,Esbenshade TA,Bitner RS,Decker MW,LaFerla FM
MN1020 was used in Western Blotting to determine the effect of long-term treatment with the selective α7 nAChR agonist A-582941 in aged 3xTg-AD mice with robust Alzheimer's disease-like pathology.
Sat Feb 01 00:00:00 UTC 2014
Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.
Frontiers in aging neuroscience
Castro-Alvarez JF,Uribe-Arias SA,Kosik KS,Cardona-Gómez GP
MN1020 was used in western blot to use triple transgenic Alzhemier's mice to study short- and long-term CDK5 knockdown and prevention of spatial memory dysfunction and tau pathology
Mon Oct 13 00:00:00 UTC 2014
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Experimental neurology
Yamada ES,Respondek G,Müssner S,de Andrade A,Höllerhage M,Depienne C,Rastetter A,Tarze A,Friguet B,Salama M,Champy P,Oertel WH,Höglinger GU
MN1020 was used in immunohistochemistry and western blot to study the increased tau phosphorylation following treatment with a mitochondrial complex I inhibitor in a tau transgenic mouse model
Sat Mar 01 00:00:00 UTC 2014
Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice.
Journal of neurochemistry
Palm R,Chang J,Blair J,Garcia-Mesa Y,Lee HG,Castellani RJ,Smith MA,Zhu X,Casadesus G
MN1020 was used in immunohistochemistry to study the improvement in neuronal plasticity and cognition in ovariectomized Alzheimer's disease mice following serum gonadotropin down regulation
Tue Jul 01 00:00:00 UTC 2014
Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance.
Journal of neurochemistry
Bonda DJ,Stone JG,Torres SL,Siedlak SL,Perry G,Kryscio R,Jicha G,Casadesus G,Smith MA,Zhu X,Lee HG
MN1020 was used in immunohistochemistry to study the involvement of neuronal leptin resistance in Alzheimer's disease
Wed Jan 01 00:00:00 UTC 2014
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.
Neuropharmacology
Jiang T,Yu JT,Zhu XC,Zhang QQ,Cao L,Wang HF,Tan MS,Gao Q,Qin H,Zhang YD,Tan L
MN1020 was used in immunohistochemistry and western blot to study the ability of the rapamycin analog temsirolimus to promote autophagic clearance of hyperphosphorylated tau and improve memory deficits in animal models
Wed Oct 01 00:00:00 UTC 2014
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.
Neuropharmacology
Graham DL,Gray AJ,Joyce JA,Yu D,O'Moore J,Carlson GA,Shearman MS,Dellovade TL,Hering H
MN1020 was used in immunohistochemistry and western blot to study the mechanism by which O-GlcNAcylation prevents pathological agregation of tau in a murine tauopathy model
Tue Apr 01 00:00:00 UTC 2014
Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease.
Neurobiology of aging
Huang XT,Qian ZM,He X,Gong Q,Wu KC,Jiang LR,Lu LN,Zhu ZJ,Zhang HY,Yung WH,Ke Y
MN1020 was used in immunohistochemistry to study the role of reduced brain iron levels in the neuroprotective effects of huperzine A in a murine model of Alzheimer's disease
Thu May 01 00:00:00 UTC 2014
Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.
Neurobiology of aging
Orr ME,Salinas A,Buffenstein R,Oddo S
MN1020 was used in western blot to study the role of mTOR hyperactivation in the mechanism by which a high-sucrose diet promotes beta-amyloid pathology in Alzheimer's disease
Sun Jun 01 00:00:00 UTC 2014
Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms.
Psychoneuroendocrinology
García-Mesa Y,Pareja-Galeano H,Bonet-Costa V,Revilla S,Gómez-Cabrera MC,Gambini J,Giménez-Llort L,Cristòfol R,Viña J,Sanfeliu C
MN1020 was used in western blot to study the role of BDNF in the neuropretoective effects of aerobic physical exercise in a murine model of Alzheimer's disease
Tue Jul 01 00:00:00 UTC 2014
Alzheimer's-related changes in non-demented essential tremor patients vs. controls: links between tau and tremor?
Parkinsonism & related disorders
Pan JJ,Lee M,Honig LS,Vonsattel JP,Faust PL,Louis ED
MN1020 was used in immunohistochemistry to study the relationships between essential tremor, tau pathology and Alzheimer's disease
Sun Jun 01 00:00:00 UTC 2014
Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis.
Journal of Alzheimer's disease : JAD
Murray PS,Kirkwood CM,Gray MC,Fish KN,Ikonomovic MD,Hamilton RL,Kofler JK,Klunk WE,Lopez OL,Sweet RA
MN1020 was used in immunohistochemistry to study the relationship between Alzheimer's disease displaying psychosis and tau hyperphosphorylation
Thu Oct 30 00:00:00 UTC 2014
Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.
Journal of Alzheimer's disease : JAD
Yanagisawa D,Taguchi H,Ibrahim NF,Morikawa S,Shiino A,Inubushi T,Hirao K,Shirai N,Sogabe T,Tooyama I
MN1020 was used in immunohistochemistry to study the probe structural requirements for [19F] MRI detection of brain amyloid
Mon Oct 06 00:00:00 UTC 2014
Altered function of hippocampal CA1 pyramidal neurons in the rTg4510 mouse model of tauopathy.
Journal of Alzheimer's disease : JAD
Dalby NO,Volbracht C,Helboe L,Larsen PH,Jensen HS,Egebjerg J,Elvang AB
MN1020 was used in immunohistochemistry to study hippocampal CA1 pyramidal neuron function in a murine tauopathy model
Thu Jan 15 00:00:00 UTC 2015
Region-specific expression of tau, amyloid-β protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats.
Journal of Alzheimer's disease : JAD
Lin L,Yang SS,Chu J,Wang L,Ning LN,Zhang T,Jiang Q,Tian Q,Wang JZ
MN1020 was used in western blot to study the regional expression of proteins involved in Alzheimer's disease pathology and the effect of indicung ER stress
Mon Mar 30 00:00:00 UTC 2015
Distribution of pathology in frontal variant Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Blennerhassett R,Lillo P,Halliday GM,Hodges JR,Kril JJ
MN1020 was used in immunohistochemistry to study the spacial distribution of neurodegeneration in the brains of patients with frontal variant Alzheimer's disease
Wed Sep 03 00:00:00 UTC 2014
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.
FEBS letters
Inoue H,Hiradate Y,Shirakata Y,Kanai K,Kosaka K,Gotoh A,Fukuda Y,Nakai Y,Uchida T,Sato E,Tanemura K
MN1020 was used in immunohistochemistry and western blot to study the role of Tau phosphorylation in murine spermatogenesis during meiosis
Thu May 29 00:00:00 UTC 2014
A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases.
Journal of neuropathology and experimental neurology
Bit-Ivan EN,Suh E,Shim HS,Weintraub S,Hyman BT,Arnold SE,McCarty-Wood E,Van Deerlin VM,Schneider JA,Trojanowski JQ,Frosch MP,Baker MC,Rademakers R,Mesulam M,Bigio EH
MN1020 was used in immunohistochemistry to report on six cases of frontotemporal lobar degeneration with TDP-43-positive inclusions bearing a novel GRN mutation
Thu May 01 00:00:00 UTC 2014
Distribution of the hematopoietic growth factor G-CSF and its receptor in the adult human brain with specific reference to Alzheimer's disease.
Journal of anatomy
Ridwan S,Bauer H,Frauenknecht K,Hefti K,von Pein H,Sommer CJ
MN1020 was used in immunohistochemistry to investigate the protein expression of G-CSF and its receptor in the adult human brain
Tue Apr 01 00:00:00 UTC 2014
Neuropathologic analysis of hematomas evacuated from patients with spontaneous intracerebral hemorrhage.
Neuropathology : official journal of the Japanese Society of Neuropathology
Dye JA,Rees G,Yang I,Vespa PM,Martin NA,Vinters HV
MN1020 was used in immunohistochemistry to perform a detailed analysis of hematomas resected from patients suffering spontaneous intracerebral hemorrhage
Sun Jun 01 00:00:00 UTC 2014
Immunohistochemical analysis of ubiquilin-1 in the human hippocampus: association with neurofibrillary tangle pathology.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mizukami K,Abrahamson EE,Mi Z,Ishikawa M,Watanabe K,Kinoshita S,Asada T,Ikonomovic MD
MN1020 was used in immunohistochemistry to study the relationship between human hippocampal ubiquilin-1 and neurofibrilliary tangles in Alzheimer's disease brain
Sat Feb 01 00:00:00 UTC 2014
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
Molecular neurodegeneration
Ohia-Nwoko O,Montazari S,Lau YS,Eriksen JL
MN1020 was used in immunohistochemistry - paraffin section and western blot to evaluate motor function and tau pathology of P301S tau transgenic mice
Fri Nov 28 00:00:00 UTC 2014
Two cases of multinodular and vacuolating neuronal tumour.
Acta neuropathologica communications
Bodi I,Curran O,Selway R,Elwes R,Burrone J,Laxton R,Al-Sarraj S,Honavar M
MN1020 was used in immunohistochemistry (paraffin) to characterize two patients with multinodular and vacuolating neuronal tumors.
Mon Jan 20 00:00:00 UTC 2014
The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes.
Acta neuropathologica communications
Lasagna-Reeves CA,Sengupta U,Castillo-Carranza D,Gerson JE,Guerrero-Munoz M,Troncoso JC,Jackson GR,Kayed R
MN1020 was used in immunohistochemistry to study the formation of tau annular protofibrils and the significance for different neurodegenerative tauopathic diseases
Thu May 29 00:00:00 UTC 2014
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.
Acta neuropathologica communications
Dujardin S,Lécolle K,Caillierez R,Bégard S,Zommer N,Lachaud C,Carrier S,Dufour N,Aurégan G,Winderickx J,Hantraye P,Déglon N,Colin M,Buée L
MN1020 was used in immunohistochemistry to discuss the molecular and cellular mechanisms that contribute to disease progression in sporadic tauopathies such as argyrophilic grain disorder and progressive supranuclear palsy
Thu Jan 30 00:00:00 UTC 2014
Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease.
Biochimica et biophysica acta
Torres M,Price SL,Fiol-Deroque MA,Marcilla-Etxenike A,Ahyayauch H,Barceló-Coblijn G,Terés S,Katsouri L,Ordinas M,López DJ,Ibarguren M,Goñi FM,Busquets X,Vitorica J,Sastre M,Escribá PV
MN1020 was used in western blot to study the role of changes in membrane lipid composition in the therapeutic effects of 2-hydroxydocosahexaenoic acid in a murine model of Alzheimer's disease
Sun Jun 01 00:00:00 UTC 2014
Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation.
Vaccines
Richter M,Mewes A,Fritsch M,Krügel U,Hoffmann R,Singer D
MN1020 was used in immunohistochemistry and western blot to study protection of transgenic P301S mice against tau aggregation in Alzheimer's disease by doubly phosphorylated peptied vaccines
Tue Jul 29 00:00:00 UTC 2014
The problem of axonal injury in the brains of veterans with histories of blast exposure.
Acta neuropathologica communications
Ryu J,Horkayne-Szakaly I,Xu L,Pletnikova O,Leri F,Eberhart C,Troncoso JC,Koliatsos VE
MN1020 was used in immunohistochemistry - paraffin section to characterize the neuropathology of blast injury
Tue Nov 25 00:00:00 UTC 2014
S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model.
PloS one
Kim HJ,Chang KA,Ha TY,Kim J,Ha S,Shin KY,Moon C,Nacken W,Kim HS,Suh YH
MN1020 was used in immunohistochemistry to study the beneficial effects of S100A9 deletion on memory and beta-amyloid pathology in a murine model of Alzheimer's disease
Mon Dec 22 00:00:00 UTC 2014
Brainstem aminergic nuclei and late-life depressive symptoms.
JAMA psychiatry
Wilson RS,Nag S,Boyle PA,Hizel LP,Yu L,Buchman AS,Shah RC,Schneider JA,Arnold SE,Bennett DA
MN1020 was used in immunohistochemistry to investigate the neurobiologic basis of late-life depressive symptoms
Sun Dec 01 00:00:00 UTC 2013
Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau.
Acta neuropathologica
Wu TH,Lu YN,Chuang CL,Wu CL,Chiang AS,Krantz DE,Chang HY
MN1020 was used in immunocytochemistry to report that expression of human wild-type tau is sufficient to disrupt the survival of dopaminergic neurons in a Drosophila model
Wed May 01 00:00:00 UTC 2013
Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.
Acta neuropathologica
Clippinger AK,D'Alton S,Lin WL,Gendron TF,Howard J,Borchelt DR,Cannon A,Carlomagno Y,Chakrabarty P,Cook C,Golde TE,Levites Y,Ranum L,Schultheis PJ,Xu G,Petrucelli L,Sahara N,Dickson DW,Giasson B,Lewis J
MN1020 was used in immunohistochemistry - paraffin section to test if a primary proteinopathy might secondarily drive TDP-43 proteinopathy
Mon Jul 01 00:00:00 UTC 2013
Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins.
Brain : a journal of neurology
Hurley MJ,Brandon B,Gentleman SM,Dexter DT
MN1020 was used in Immunohistochemistry to examine the expression of Ca(V)1 subtypes and various Calcium-binding proteins in areas vulnerable and resistant to neurodegeneration in Parkinson's disease.
Mon Jul 01 00:00:00 UTC 2013
Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.
Molecular therapy : the journal of the American Society of Gene Therapy
Caillierez R,Bégard S,Lécolle K,Deramecourt V,Zommer N,Dujardin S,Loyens A,Dufour N,Aurégan G,Winderickx J,Hantraye P,Déglon N,Buée L,Colin M
MN1020 was used in immunohistochemistry to study the slow and progressive neurodegeneration induced in rat brain by lentiviral-mediated transduction with wild-type human tau
Mon Jul 01 00:00:00 UTC 2013
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Biological psychiatry
Baglietto-Vargas D,Medeiros R,Martinez-Coria H,LaFerla FM,Green KN
MN1020 was used in western blot to study the reduced alpha- and beta-cleavage of APP and reduced phosporylated tau accumulation in transgenic mice treated with mifepristone
Sun Sep 01 00:00:00 UTC 2013
Clinical correlates in an experimental model of repetitive mild brain injury.
Annals of neurology
Mannix R,Meehan WP,Mandeville J,Grant PE,Gray T,Berglass J,Zhang J,Bryant J,Rezaie S,Chung JY,Peters NV,Lee C,Tien LW,Kaplan DL,Feany M,Whalen M
MN1020 was used in immunohistochemistry to use a murine model of repetetive mild brain injury to study whether the observed congnitive deficits are associated with beta-amyloid/tau pathology or ApoE allele
Mon Jul 01 00:00:00 UTC 2013
Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.
Aging cell
Parrella E,Maxim T,Maialetti F,Zhang L,Wan J,Wei M,Cohen P,Fontana L,Longo VD
MN1020 was used in immunohistochemistry to study the effect of periodic protein restriction cycles on levels of IGF-1, phosphorylated tau, and cognitive performance in a murine model of Alzheimer's disease
Mon Apr 01 00:00:00 UTC 2013
Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.
Diabetes
Leboucher A,Laurent C,Fernandez-Gomez FJ,Burnouf S,Troquier L,Eddarkaoui S,Demeyer D,Caillierez R,Zommer N,Vallez E,Bantubungi K,Breton C,Pigny P,Buée-Scherrer V,Staels B,Hamdane M,Tailleux A,Buée L,Blum D
MN1020 was used in immunohistochemistry - free floating to study the effects of diet-induced obesity on tau pathology
Wed May 01 00:00:00 UTC 2013
Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ₁ receptor agonist, in a nontransgenic mouse model of Alzheimer's disease.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Lahmy V,Meunier J,Malmström S,Naert G,Givalois L,Kim SH,Villard V,Vamvakides A,Maurice T
MN1020 was used in Western Blotting to establish whether the mixed σ1/muscarinic ligand ANAVEX2-73 could have the ability to reduce the appearance of hyperphosphorylated Tau and amyloid-β1-42.
Thu Aug 01 00:00:00 UTC 2013
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Barron AM,Garcia-Segura LM,Caruso D,Jayaraman A,Lee JW,Melcangi RC,Pike CJ
MN1020 was used in immunohistochemistry to study the ability of the Ro5-4864 translocator protein ligand to protect against disease pathology and behaviour deficit in a murine model of Alzheimer's disease
Wed May 15 00:00:00 UTC 2013
Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sundaram JR,Poore CP,Sulaimee NH,Pareek T,Asad AB,Rajkumar R,Cheong WF,Wenk MR,Dawe GS,Chuang KH,Pant HC,Kesavapany S
MN1020 was used in Immunohistochemistry-immunofluorescence to study the effects of selective inhibition of p25/Cdk5 hyperactivation in vivo on neurodegenerative pathologies.
Wed Jan 02 00:00:00 UTC 2013
Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sundaram JR,Poore CP,Sulaimee NH,Pareek T,Asad AB,Rajkumar R,Cheong WF,Wenk MR,Dawe GS,Chuang KH,Pant HC,Kesavapany S
MN1020 was used in Immunohistochemistry-immunofluorescence to study the effects of selective inhibition of p25/Cdk5 hyperactivation in vivo on neurodegenerative pathologies.
Wed Jan 02 00:00:00 UTC 2013
Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease.
The Journal of nutritional biochemistry
Vepsäläinen S,Koivisto H,Pekkarinen E,Mäkinen P,Dobson G,McDougall GJ,Stewart D,Haapasalo A,Karjalainen RO,Tanila H,Hiltunen M
MN1020 was used in western blot to study the beneficial effects of anthacyanin-rich bilberry and blackberry extracts on APP processing and behavioural deficits in a murine model of Alzheimer's disease
Tue Jan 01 00:00:00 UTC 2013
Alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway.
ACS chemical neuroscience
Chen RJ,Chang WW,Lin YC,Cheng PL,Chen YR
MN1020 was used in western blot to study the role of the Fyn pathway in the mechanism by which beta-amyloid oligomers modulate the down regulation of tau by cellular prion protein
Wed Sep 18 00:00:00 UTC 2013
Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.
ACS chemical neuroscience
Alonso E,Vale C,Vieytes MR,Botana LM
MN1020 was used in western blot to study the role of PKC activation in the mechanism underyling the beneficial effects of yessotoxin on tau and Abeta pathology in a cellular model of Alzheimer's disease
Wed Jul 17 00:00:00 UTC 2013
Making the diagnosis of frontotemporal lobar degeneration.
Archives of pathology & laboratory medicine
Bigio EH
MN1020 was used in immunohistochemistry to review the diagnosis of frontotemporal lobar degeneration
Fri Mar 01 00:00:00 UTC 2013
PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins.
Neurobiology of aging
Magnaudeix A,Wilson CM,Page G,Bauvy C,Codogno P,Lévêque P,Labrousse F,Corre-Delage M,Yardin C,Terro F
MN1020 was used in western blot to study the effect of protein phosphatase 2A modulation on neuronal autophagy.
Fri Mar 01 00:00:00 UTC 2013
Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.
Neurobiology of aging
Geekiyanage H,Upadhye A,Chan C
MN1020 was used in western blot to study the reduction in beta-amyloid levels and tau hyperphosphorylation in response to inhibition of serine palmitoyltransferase in a mouse model of Alzheimer's disease
Thu Aug 01 00:00:00 UTC 2013
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Neurobiology of aging
Nash KR,Lee DC,Hunt JB,Morganti JM,Selenica ML,Moran P,Reid P,Brownlow M,Guang-Yu Yang C,Savalia M,Gemma C,Bickford PC,Gordon MN,Morgan D
MN1020 was used in western blot to study the beneficial effects on tau pathology in a murine transgenic tauopathy model of the virally-mediated overexpression of soluble fractalkine
Sat Jun 01 00:00:00 UTC 2013
MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.
Neurobiology of aging
Colom-Cadena M,Gelpi E,Martí MJ,Charif S,Dols-Icardo O,Blesa R,Clarimón J,Lleó A
MN1020 was used in immunohistochemistry to study the relationship between MAPT haplotype and enhanced alpha-synuclein deposition in dementia with Lewy bodies
Fri Mar 01 00:00:00 UTC 2013
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice.
Neurobiology of aging
Köhler C,Dinekov M,Götz J
MN1020 was used in immunohistochemistry to study the association of GSK3 activity with tau phosphorylation and neuronal tyrosine phosphorylation in a murine model expressing human P301L tau
Wed May 01 00:00:00 UTC 2013
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.
Neurobiology of aging
Cancino GI,Miller FD,Kaplan DR
MN1020 was used in western blot to study the effects of p73 haploinsufficiency on tau phosphorylation status and the activity of GSK3-beta, c-Abl and Cdk5 in murine models of ageing and Alzheimer's disease
Fri Feb 01 00:00:00 UTC 2013
Age-related appearance of dendritic inclusions in catecholaminergic brainstem neurons.
Neurobiology of aging
Braak H,Thal DR,Matschke J,Ghebremedhin E,Del Tredici K
MN1020 was used in immunohistochemistry to study the presence of dendritic inclusions in catecholaminergic brainstem neurons and their increased prevalence with advancing age
Tue Jan 01 00:00:00 UTC 2013
Dopamine D2 receptor SPECT in corticobasal syndrome and autopsy-confirmed corticobasal degeneration.
Parkinsonism & related disorders
Pirker S,Perju-Dumbrava L,Kovacs GG,Traub-Weidinger T,Asenbaum S,Pirker W
MN1020 was used in immunohistochemistry to study striatal dopamine D2 receptor binding in corticobasal syndrome
Fri Feb 01 00:00:00 UTC 2013
Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Natunen T,Parrado AR,Helisalmi S,Pursiheimo JP,Sarajärvi T,Mäkinen P,Kurkinen KM,Mullin K,Alafuzoff I,Haapasalo A,Bertram L,Soininen H,Tanzi RE,Hiltunen M
MN1020 was used in western blot to study whether the BACE1-modulator GGA3 contributes to Alzheimer's disease pathology
Tue Apr 08 00:00:00 UTC 2014
Of rodents and men: the mysterious interneuronal pilgrimage of misfolded protein tau in Alzheimer’s disease.
Journal of Alzheimer's disease : JAD
Levarska L,Zilka N,Jadhav S,Neradil P,Novak M
MN1020 was used in immunohistochemistry to study the infectivity and spreading propensity of tau complexes containing the 3R or 4R human tau misfolded truncates
Fri Jun 27 00:00:00 UTC 2014
Abnormal interaction of oligomeric amyloid-β with phosphorylated tau: implications to synaptic dysfunction and neuronal damage.
Journal of Alzheimer's disease : JAD
Manczak M,Reddy PH
MN1020 was used in immunohistochemistry to study the interaction of monomeric and oligomeric beta-amyloid with phosphorylated tau in the brains of Alzheimer's disease patients
Mon Jan 27 00:00:00 UTC 2014
SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Capsoni S,Carlo AS,Vignone D,Amato G,Criscuolo C,Willnow TE,Cattaneo A
MN1020 was used in immunohistochemistry to study the effect of SorLA-deficiency to dissociate amyloid and tau neurodegeneration in a novel murine model of Alzheimer's disease
Tue May 28 00:00:00 UTC 2013
Distribution of SLC10A4, a synaptic vesicle protein in the human brain, and the association of this protein with Alzheimer's disease-related neuronal degeneration.
Journal of Alzheimer's disease : JAD
Popova SN,Alafuzoff I
MN1020 was used in immunohistochemistry to study the distribution in human brain of the synaptic protein SLC10A4 and its potential association with Alzheimer's disease neurodegeneration
Fri Jun 27 00:00:00 UTC 2014
Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice.
Brain research bulletin
Zufferey V,Vallet PG,Moeri M,Moulin-Sallanon M,Piotton F,Marin P,Savioz A
MN1020 was used in immunohistochemistry to study the neuropatholgy and behavioural abnormalities of a murine Alzheimer's disease model transgenically expressing P117L mutant presenilin-1
Wed May 01 00:00:00 UTC 2013
Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice.
Brain research
Morcinek K,Köhler C,Götz J,Schröder H
MN1020 was used in immunohistochemistry to study whether the expression of mutant human tau in tau filament-forming mice recapitulates the pathological chages observed in Alzheimer's disease brainstem
Mon Feb 25 00:00:00 UTC 2013
Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.
ChemMedChem
Gu J,Anumala UR,Heyny-von Haußen R,Hölzer J,Goetschy-Meyer V,Mall G,Hilger I,Czech C,Schmidt B
MN1020 was used in immunohistochemistry to study the use of fluorescent trimethine cyanine dyes for the detection of tau fibrils in postmortem Alzheimer's disease brain
Sat Jun 01 00:00:00 UTC 2013
Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.
Bioorganic & medicinal chemistry
Anumala UR,Gu J,Lo Monte F,Kramer T,Heyny-von Haußen R,Hölzer J,Goetschy-Meyer V,Schön C,Mall G,Hilger I,Czech C,Herms J,Schmidt B
MN1020 was used in immunohistochemistry to study the detection of neurofibrilliary tangles in Alzheimer's disease brains using fluorescent rhodamine-3-acetic acid-based imaging probes
Sun Sep 01 00:00:00 UTC 2013
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Neuro-degenerative diseases
Flunkert S,Hierzer M,Löffler T,Rabl R,Neddens J,Duller S,Schofield EL,Ward MA,Posch M,Jungwirth H,Windisch M,Hutter-Paier B
MN1020 was used in western blot to study the role of soluble total and hyperphosphorylated tau in brain pathology and behaviour in a transgenic mouse model
Wed Nov 13 00:00:00 UTC 2013
A derivative of the brain metabolite lanthionine ketimine improves cognition and diminishes pathology in the 3 × Tg-AD mouse model of Alzheimer disease.
Journal of neuropathology and experimental neurology
Hensley K,Gabbita SP,Venkova K,Hristov A,Johnson MF,Eslami P,Harris-White ME
MN1020 was used in immunohistochemistry to study the beneficial effects of a bioavailable ester of lanthione ketimine in respect of cognition and pathology in a murine model of Alzheimer's disease
Tue Oct 01 00:00:00 UTC 2013
Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes.
Journal of neuropathology and experimental neurology
Hales CM,Rees H,Seyfried NT,Dammer EB,Duong DM,Gearing M,Montine TJ,Troncoso JC,Thambisetty M,Levey AI,Lah JJ,Wingo TS
MN1020 was used in immunohistochemistry to study the role of gephyrin accumulation in the pathology of Alzheimer's disease
Fri Nov 01 00:00:00 UTC 2013
Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla).
The Journal of comparative neurology
Perez SE,Raghanti MA,Hof PR,Kramer L,Ikonomovic MD,Lacor PN,Erwin JM,Sherwood CC,Mufson EJ
MN1020 was used in immunohistochemistry to study the pathology of Alzheimer's disease in the western lowland Gorilla
Sun Dec 15 00:00:00 UTC 2013
Paraffin sections of 70-100 μm: a novel technique and its benefits for studying the nervous system.
Journal of neuroscience methods
Feldengut S,Del Tredici K,Braak H
MN1020 was used in immunohistochemistry to report on the use of 70-100 micrometer paraffin sections for studying the nervous system
Wed May 15 00:00:00 UTC 2013
Quantitative neurofibrillary tangle density and brain volumetric MRI analyses in Alzheimer's disease presenting as logopenic progressive aphasia.
Brain and language
Josephs KA,Dickson DW,Murray ME,Senjem ML,Parisi JE,Petersen RC,Jack CR,Whitwell JL
MN1020 was used in immunohistochemistry to study grey matter volume and neurofibrilliary tangle density in Alzheimer's disease patients including those presenting with logopenic progressive aphasia
Fri Nov 01 00:00:00 UTC 2013
Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.
PloS one
Ozcelik S,Fraser G,Castets P,Schaeffer V,Skachokova Z,Breu K,Clavaguera F,Sinnreich M,Kappos L,Goedert M,Tolnay M,Winkler DT
MN1020 was used in immunohistochemistry and western blot to study the protective effects of rapamycin against tau pathology in a murine transgenic model
Mon Dec 09 00:00:00 UTC 2013
Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies.
The Journal of biological chemistry
Hawkins BE,Krishnamurthy S,Castillo-Carranza DL,Sengupta U,Prough DS,Jackson GR,DeWitt DS,Kayed R
MN1020 was used in ELISA, immunohistochemistry, and western blot to study the generation of oligomeric and phosphorylated forms of tau in a rat model of traumatic brain injury
Fri Jun 07 00:00:00 UTC 2013
The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.
PloS one
Rantamäki T,Kemppainen S,Autio H,Stavén S,Koivisto H,Kojima M,Antila H,Miettinen PO,Kärkkäinen E,Karpova N,Vesa L,Lindemann L,Hoener MC,Tanila H,Castrén E
MN1020 was used in immunohistochemistry to study the effects of Bdnf gene deficiency on memory, behaviour and disease pathology in a murine Alzheimer's disease model
Fri Feb 07 00:00:00 UTC 2014
Clusterin associates specifically with Aβ40 in Alzheimer's disease brain tissue.
Brain pathology (Zurich, Switzerland)
Howlett DR,Hortobágyi T,Francis PT
MN1020 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that in AD, but not aged control brain, clusterin was associated specifically with the Aß40 form of Aß in the brain.
Fri Nov 01 00:00:00 UTC 2013
NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss.
Cell death & disease
Tackenberg C,Grinschgl S,Trutzel A,Santuccione AC,Frey MC,Konietzko U,Grimm J,Brandt R,Nitsch RM
MN1020 was used in western blot to study the effect of the subunit composition of NMDA receptors on neurodegeneration and synaptic loss induced by beta-amyloid
Thu Apr 25 00:00:00 UTC 2013
PINCH in the cellular stress response to tau-hyperphosphorylation.
PloS one
Ozdemir AY,Rom I,Kovalevich J,Yen W,Adiga R,Dave RS,Langford D
MN1020 was used in western blot to study the ability of PINCH in bind and stabilize hyperphoshorylated tau
Mon Sep 30 00:00:00 UTC 2013
Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate.
Biochimica et biophysica acta
Barros-Miñones L,Martín-de-Saavedra D,Perez-Alvarez S,Orejana L,Suquía V,Goñi-Allo B,Hervias I,López MG,Jordan J,Aguirre N,Puerta E
MN1020 was used in western blot to study the role of calpain-regulated p35/cdk5 in the mechanism by which the PDE5 inhibitor sildenafil protects against malonate-induced chemical hypoxia
Sat Jun 01 00:00:00 UTC 2013
Specific serotonergic denervation affects tau pathology and cognition without altering senile plaques deposition in APP/PS1 mice.
PloS one
Ramos-Rodriguez JJ,Molina-Gil S,Rey-Brea R,Berrocoso E,Garcia-Alloza M
MN1020 was used in Western Blotting to study the role of serotonergic denervation in some of the pathological aspects observed in Alzheimer's disease.
Tue Sep 23 00:00:00 UTC 2014
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.
Acta neuropathologica communications
Trujillo-Estrada L,Jimenez S,De Castro V,Torres M,Baglietto-Vargas D,Moreno-Gonzalez I,Navarro V,Sanchez-Varo R,Sanchez-Mejias E,Davila JC,Vizuete M,Gutierrez A,Vitorica J
MN1020 was used in western blot to study the beneficial effects of lithium treatment on beta-amyloid neuropathology in a murine model of Alzheimer's disease
Tue Nov 12 00:00:00 UTC 2013
Ubiquilin 2 is not associated with tau pathology.
PloS one
Nölle A,van Haastert ES,Zwart R,Hoozemans JJ,Scheper W
MN1020 was used in immunohistochemistry to study the lack of association of ubiquilin-2 with tau pathology in Alzheimer's disease
Mon Jun 16 00:00:00 UTC 2014
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Acta neuropathologica communications
Hoffmann NA,Dorostkar MM,Blumenstock S,Goedert M,Herms J
MN1020 was used in immunohistochemistry to study the potential involvement of pre-fibrilliary tau in the defective plasticity of cortical dendritic spines observed in transgenic mice bearing the P301S tau mutation
Tue Dec 17 00:00:00 UTC 2013
Age-related loss of noradrenergic neurons in the brains of triple transgenic mice.
Age (Dordrecht, Netherlands)
Manaye KF,Mouton PR,Xu G,Drew A,Lei DL,Sharma Y,Rebeck GW,Turner S
MN1020 was used in immunocytochemistry to investigate the changes of TH+ neurons in an Alzheimer disease mouse model
Fri Feb 01 00:00:00 UTC 2013
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.
The Journal of clinical investigation
Talbot K,Wang HY,Kazi H,Han LY,Bakshi KP,Stucky A,Fuino RL,Kawaguchi KR,Samoyedny AJ,Wilson RS,Arvanitakis Z,Schneider JA,Wolf BA,Bennett DA,Trojanowski JQ,Arnold SE
MN1020 was used in immunohistochemistry to study the role of IGF-1 and IRS-1 in brain insulin resistance and cognitive decline in Alzheimer's disease
Sun Apr 01 00:00:00 UTC 2012
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease.
The Journal of experimental medicine
Yao J,Ho D,Calingasan NY,Pipalia NH,Lin MT,Beal MF
MN1020 was used in immunohistochemistry to study the beneficial effects of hydroxy-beta-cyclodextrin on neuropathology and beta-amyloid levels in Alzheimer's disease models
Mon Dec 17 00:00:00 UTC 2012
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts.
Acta neuropathologica
Okamoto Y,Yamamoto T,Kalaria RN,Senzaki H,Maki T,Hase Y,Kitamura A,Washida K,Yamada M,Ito H,Tomimoto H,Takahashi R,Ihara M
MN1020 was used in immunohistochemistry to investigate the effect of low cerebral perfusion on cerebral amyloid angiopathy
Thu Mar 01 00:00:00 UTC 2012
Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia.
Acta neuropathologica
Woehrer A,Laszlo L,Finsterer J,Stöllberger C,Furtner J,Rinner W,Molnar K,Budka H,Kovacs GG
MN1020 was used in immunohistochemistry to study crystalloid oligodendrogliopathy in hereditary spastic paraplegia
Mon Oct 01 00:00:00 UTC 2012
Asymmetry of neurodegenerative disease-related pathologies: a cautionary note.
Acta neuropathologica
Stefanits H,Budka H,Kovacs GG
MN1020 was used in immunohistochemistry to characterize Alzheimer disease associated pathology
Thu Mar 01 00:00:00 UTC 2012
Hyperphosphorylated tau in young and middle-aged subjects.
Acta neuropathologica
Elobeid A,Soininen H,Alafuzoff I
MN1020 was used in immunohistochemistry - paraffin section to examine the brains of cognitively unimpaired subjects for neurodegenerative changes
Sun Jan 01 00:00:00 UTC 2012
Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation.
Brain : a journal of neurology
Petratos S,Ozturk E,Azari MF,Kenny R,Lee JY,Magee KA,Harvey AR,McDonald C,Taghian K,Moussa L,Mun Aui P,Siatskas C,Litwak S,Fehlings MG,Strittmatter SM,Bernard CC
MN1020 was used in immunohistochemistry to study the effect of blocking the Nogo receptor and CRMP-2 phosphorylation on multiple sclerosis-related axonopathy
Fri Jun 01 00:00:00 UTC 2012
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.
The Journal of pathology
Nijholt DA,van Haastert ES,Rozemuller AJ,Scheper W,Hoozemans JJ
MN1020 was used in immunohistochemistry to investigate the unfolded protein response in the hippocampus of tauopathies.
Sun Apr 01 00:00:00 UTC 2012
Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models.
Journal of medicinal chemistry
Boländer A,Kieser D,Voss C,Bauer S,Schön C,Burgold S,Bittner T,Hölzer J,Heyny-von Haußen R,Mall G,Goetschy V,Czech C,Knust H,Berger R,Herms J,Hilger I,Schmidt B
MN1020 was used in immunohistochemistry to investigate the potential of fluorescent pyrazine, pyrimidine, and pyridazine derivatives for tau-based diagnosis of Alzhemer's disease
Thu Nov 08 00:00:00 UTC 2012
Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology.
Brain pathology (Zurich, Switzerland)
Morawski M,Brückner G,Jäger C,Seeger G,Matthews RT,Arendt T
MN1020 was used in immunocytochemistry to investigate aggrecan-based perineuronal nets and brevican-based perisynaptic axonal coats in brains with amyloid plaques and neurofibrillary tangles
Sun Jul 01 00:00:00 UTC 2012
Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults.
Brain pathology (Zurich, Switzerland)
Postupna N,Rose SE,Bird TD,Gonzalez-Cuyar LF,Sonnen JA,Larson EB,Keene CD,Montine TJ
MN1020 was used in Immunohistochemistry to obtain quantitative data from population-based studies and quantitative insights into latent AD that may guide expectations from neuroimaging and prevention studies.
Sun Jul 01 00:00:00 UTC 2012
Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sundaram JR,Chan ES,Poore CP,Pareek TK,Cheong WF,Shui G,Tang N,Low CM,Wenk MR,Kesavapany S
MN1020 was used in immunohistochemistry to investigate the important roles of p25/Cdk5 in neuroinflammation and neurodegeneration
Wed Jan 18 00:00:00 UTC 2012
SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hong Y,Chan CB,Kwon IS,Li X,Song M,Lee HP,Liu X,Sompol P,Jin P,Lee HG,Yu SP,Ye K
MN1020 was used in immunohistochemistry to study the ability of the cell cycle-regulated kinase SRPK2 to phosphorylate tau and the significance for Alzheimer's disease cognitive decline
Wed Nov 28 00:00:00 UTC 2012
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wang HY,Bakshi K,Frankfurt M,Stucky A,Goberdhan M,Shah SM,Burns LH
MN1020 was used in western blot to study the ability of a small molecule that binds filamin A with high affinity to reduce beta-amyloid-associated Alzheimer's disease pathology
Wed Jul 18 00:00:00 UTC 2012
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Barten DM,Fanara P,Andorfer C,Hoque N,Wong PY,Husted KH,Cadelina GW,Decarr LB,Yang L,Liu V,Fessler C,Protassio J,Riff T,Turner H,Janus CG,Sankaranarayanan S,Polson C,Meredith JE,Gray G,Hanna A,Olson RE,Kim SH,Vite GD,Lee FY,Albright CF
MN1020 was used in immunohistochemistry to study the effects of a small molecule microtubule-stabilizer on microtubule hyperdynamics, cognitive performance and pathology in tau transgenic mice
Wed May 23 00:00:00 UTC 2012
Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.
Neuropathology and applied neurobiology
Satoh J,Tabunoki H,Ishida T,Saito Y,Arima K
MN1020 was used in immunohistochemistry to investigate the changes of GSAP expression in Alzheimer disease patients
Sun Apr 01 00:00:00 UTC 2012
Hirano body-rich subtypes of Creutzfeldt-Jakob disease.
Neuropathology and applied neurobiology
Martinez-Saez E,Gelpi E,Rey MJ,Ferrer I,Ribalta T,Botta-Orfila T,Nos C,Yagüe J,Sanchez-Valle R
MN1020 was used in immunohistochemistry to detect Hirano bodies in neurons of Creutzfeldt-Jakob disease
Sun Apr 01 00:00:00 UTC 2012
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lasagna-Reeves CA,Castillo-Carranza DL,Sengupta U,Sarmiento J,Troncoso J,Jackson GR,Kayed R
MN1020 was used in immunohistochemistry to investigate the important role of tau oligomers in Alzheimer disease brains
Tue May 01 00:00:00 UTC 2012
Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.
The American journal of pathology
Perez SE,Getova DP,He B,Counts SE,Geula C,Desire L,Coutadeur S,Peillon H,Ginsberg SD,Mufson EJ
MN1020 was used in immunohistochemistry to study the expression of Raclb in cholinergic nucleus basalis neurones and the correlation with tau pathology and Alzheimer's disease progression
Wed Feb 01 00:00:00 UTC 2012
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
The American journal of pathology
Medeiros R,Kitazawa M,Chabrier MA,Cheng D,Baglietto-Vargas D,Kling A,Moeller A,Green KN,LaFerla FM
MN1020 was used in western blot to study the beneficial effects of a novel calpain inhibitor on Alzheimers's disease pathology and cognitive decline in transgenic mouse model
Wed Aug 01 00:00:00 UTC 2012
(Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains.
European journal of pharmacology
Li L,Zhang ZF,Holscher C,Gao C,Jiang YH,Liu YZ
MN1020 was used in western blot to investigate the effect of glucagon-like peptide-1 on the Alzheimer disease phenotype induced by streptozotocin
Sun Jan 15 00:00:00 UTC 2012
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
Neurobiology of aging
Krüger U,Wang Y,Kumar S,Mandelkow EM
MN1020 was used in western blot to investigate the effect of trehalose on tau accumulation in AD patients
Mon Oct 01 00:00:00 UTC 2012
Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.
Neurobiology of aging
Sheppard O,Plattner F,Rubin A,Slender A,Linehan JM,Brandner S,Tybulewicz VL,Fisher EM,Wiseman FK
MN1020 was used in western blot to investigate the regulation of tau phosphorylation in Tc1 mice
Sun Apr 01 00:00:00 UTC 2012
Lack of detectable diffuse or neuritic plaques and neurofibrillary tangles in the brains of aged hamsters.
Neurobiology of aging
Gerhauser I,Wohlsein P,Ernst H,Germann PG,Baumgärtner W
MN1020 was used in immunohistochemistry to evaluate Syrian hamsters as a useful animal model for Alzheimer disease
Wed Aug 01 00:00:00 UTC 2012
Antemortem amyloid imaging and β-amyloid pathology in a case with dementia with Lewy bodies.
Neurobiology of aging
Kantarci K,Yang C,Schneider JA,Senjem ML,Reyes DA,Lowe VJ,Barnes LL,Aggarwal NT,Bennett DA,Smith GE,Petersen RC,Jack CR,Boeve BF
MN1020 was used in immunohistochemistry to study the association of beta-amyloid and lewy body in a clinical case of dementia
Tue May 01 00:00:00 UTC 2012
Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse.
Neurobiology of aging
García-Mesa Y,Giménez-Llort L,López LC,Venegas C,Cristòfol R,Escames G,Acuña-Castroviejo D,Sanfeliu C
MN1020 was used in western blot to investigate the efficacy of exercise and melatonin in AD therapy
Fri Jun 01 00:00:00 UTC 2012
Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model.
Neurobiology of aging
Orejana L,Barros-Miñones L,Jordán J,Puerta E,Aguirre N
MN1020 was used in western blot to determine effect of sildenafil on age-related neurodeneration
Thu Mar 01 00:00:00 UTC 2012
Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation.
Neurobiology of aging
Lee HJ,Lee JK,Lee H,Carter JE,Chang JW,Oh W,Yang YS,Suh JG,Lee BH,Jin HK,Bae JS
MN1020 was used in immunohistochemistry to investigate the efficiency of human umbilical cord blood-derived mesenchymal stem cell transplantation in mouse model
Thu Mar 01 00:00:00 UTC 2012
Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice.
Human molecular genetics
Dumont M,Stack C,Elipenahli C,Jainuddin S,Gerges M,Starkova N,Calingasan NY,Yang L,Tampellini D,Starkov AA,Chan RB,Di Paolo G,Pujol A,Beal MF
MN1020 was used in immunohistochemistry to study the effects of the pan-PPAR agonist bezafibrate on inflammation, behaviour and tau pathology in a murine model
Sat Dec 01 00:00:00 UTC 2012
Frontal cortex neuropathology in dementia pugilistica.
Journal of neurotrauma
Saing T,Dick M,Nelson PT,Kim RC,Cribbs DH,Head E
MN1020 was used in immunohistochemistry to investigate the neuropathological changes in dementia pugilistica patients
Tue Apr 10 00:00:00 UTC 2012
RETRACTED: Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.
Molecular and cellular neurosciences
Khandelwal PJ,Dumanis SB,Herman AM,Rebeck GW,Moussa CE
MN1020 was used in western blot to investigate the effects of wild type and P301L mutant tau on neuro-inflammation and alpha-synuclein accumulation in a rat model
Sun Jan 01 00:00:00 UTC 2012
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Neurotoxicology
Rahman A,Khan KM,Al-Khaledi G,Khan I,Al-Shemary T
MN1020 was used in western blot to study the role of hippocampal PP1 and PP2A activation in the deleterious effects of lead on learning and memory in a rat model
Fri Jun 01 00:00:00 UTC 2012
Tau protein phosphorylation in diverse brain areas of normal and CRH deficient mice: up-regulation by stress.
Cellular and molecular neurobiology
Filipcik P,Novak P,Mravec B,Ondicova K,Krajciova G,Novak M,Kvetnansky R
MN1020 was used in western blot to characterize the role of tau protein phosphorylation in tau protein misfolding
Sun Jul 01 00:00:00 UTC 2012
Decrease of the immunophilin FKBP52 accumulation in human brains of Alzheimer's disease and FTDP-17.
Journal of Alzheimer's disease : JAD
Giustiniani J,Sineus M,Sardin E,Dounane O,Panchal M,Sazdovitch V,Duyckaerts C,Chambraud B,Baulieu EE
MN1020 was used in immunohistochemistry to investigate the change of the immunophilin FKBP52 in human brains of neurodegenerative diseases
Thu Jul 26 00:00:00 UTC 2012
Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline.
Journal of Alzheimer's disease : JAD
Clausen A,Xu X,Bi X,Baudry M
MN1020 was used in immunohistochemistry to study the role of oxidative stress in Alzheimer's disease pathogenesis and progression
Mon Sep 10 00:00:00 UTC 2012
Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates.
Journal of Alzheimer's disease : JAD
Venkataramani V,Wirths O,Budka H,Härtig W,Kovacs GG,Bayer TA
MN1020 was used in immunohistochemistry to characterize a conformation-dependent amyloid beta monoclonal antibody
Thu Jul 26 00:00:00 UTC 2012
Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice.
Journal of Alzheimer's disease : JAD
Elipenahli C,Stack C,Jainuddin S,Gerges M,Yang L,Starkov A,Beal MF,Dumont M
MN1020 was used in immunohistochemistry to study the behavioral benefit of coenzyme Q10 in P301S transgenic mice
Wed Sep 12 00:00:00 UTC 2012
Breakpoint sequence analysis of an AβPP locus duplication associated with autosomal dominant Alzheimer's disease and severe cerebral amyloid angiopathy.
Journal of Alzheimer's disease : JAD
Antonell A,Gelpi E,Sánchez-Valle R,Martínez R,Molinuevo JL,Lladó A
MN1020 was used in immunohistochemistry to analyze the breakpoint sequence of an APP locus duplication associated with autosomal dominant Alzheimer disease
Thu May 24 00:00:00 UTC 2012
Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice.
Journal of Alzheimer's disease : JAD
Cuadrado-Tejedor M,Ricobaraza A,Frechilla D,Franco R,Pérez-Mediavilla A,Garcia-Osta A
MN1020 was used in immunohistochemistry to investigate the role of chronic mild stress in the pathogenesis of Alzheimer disease
Fri Jun 15 00:00:00 UTC 2012
Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain.
FEBS letters
Yokota T,Akatsu H,Miyauchi T,Heese K
MN1020 was used in western blot to study the potential involvement of the novel P9TLDR protein in Alzheimer's disease
Fri Dec 14 00:00:00 UTC 2012
Nigral Tau pathology and striatal amyloid-β deposition does not correlate with striatal dopamine deficit in Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996)
Schauer TH,Lochner M,Kovacs GG
MN1020 was used in immunohistochemistry to study the lack of association between striatal dopamine deficit and nigral tau pathology and striatal amyloid-beta deposition
Sat Dec 01 00:00:00 UTC 2012
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease.
Metabolic brain disease
Kapas I,Majtenyi K,Törö K,Keller E,Voigtländer T,Kovacs GG
MN1020 was used in immunohistochemistry to study pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease
Fri Jun 01 00:00:00 UTC 2012
Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.
Behavioural brain research
Mustroph ML,King MA,Klein RL,Ramirez JJ
MN1020 was used in immunohistochemistry to study the role of tauopathy on spatial working memory in a rat model
Sun Jul 15 00:00:00 UTC 2012
STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease.
Neuroscience letters
van Abel D,Abdulhamid O,Scheper W,van Dijk M,Oudejans CB
MN1020 was used in western blot to study the induction of tau phosphorylation at sites hyperphosphorylated in Alzheimer's disease by over expression of the STOX1A transcription factor
Wed Oct 24 00:00:00 UTC 2012
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Current Alzheimer research
Troquier L,Caillierez R,Burnouf S,Fernandez-Gomez FJ,Grosjean ME,Zommer N,Sergeant N,Schraen-Maschke S,Blum D,Buee L
MN1020 was used in immunohistochemistry to study the therapeutic efficacy of active immunization with a phospho-serine 422 Tau peptide in a murine transgenic Tau model
Tue May 01 00:00:00 UTC 2012
Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
Journal of molecular neuroscience : MN
Löffler T,Flunkert S,Taub N,Schofield EL,Ward MA,Windisch M,Hutter-Paier B
MN1020 was used in western blot to develop a cell line stably expressing mutant tau441 for screening Alzheimer's disease drug candidates
Tue May 01 00:00:00 UTC 2012
"Preclinical" MSA in definite Creutzfeldt-Jakob disease.
Neuropathology : official journal of the Japanese Society of Neuropathology
Rodriguez-Diehl R,Rey MJ,Gironell A,Martinez-Saez E,Ferrer I,Sánchez-Valle R,Jagüe J,Nos C,Gelpi E
MN1020 was used in immunohistochemistry to report on a case of co-existing multiple system atrophy and Creutzfeldt-Jakob disease
Sun Apr 01 00:00:00 UTC 2012
Unusual clinical presentation and neuropathology in two subjects with fused-in sarcoma (FUS) positive inclusions.
Neuropathology : official journal of the Japanese Society of Neuropathology
Hartikainen PH,Pikkarainen M,Hänninen T,Soininen H,Alafuzoff I
MN1020 was used in immunohistochemistry to describe atypical clinical symptoms in two patients with frontotemporal lobar degeneration
Wed Feb 01 00:00:00 UTC 2012
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice.
Experimental brain research
Fine JM,Baillargeon AM,Renner DB,Hoerster NS,Tokarev J,Colton S,Pelleg A,Andrews A,Sparley KA,Krogh KM,Frey WH,Hanson LR
MN1020 was used in western blot to study the molecular and behavioural effects of deferoxamine in tau transgenic mice
Fri Jun 01 00:00:00 UTC 2012
Squirrel monkeys (Saimiri sciureus) infected with the agent of bovine spongiform encephalopathy develop tau pathology.
Journal of comparative pathology
Piccardo P,Cervenak J,Yakovleva O,Gregori L,Pomeroy K,Cook A,Muhammad FS,Seuberlich T,Cervenakova L,Asher DM
MN1020 was used in immunohistochemistry to study the tau pathology in squirrel monkeys after infection with the agent of bovine spongiform encephalopathy
Sun Jul 01 00:00:00 UTC 2012
Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
PloS one
Castello NA,Green KN,LaFerla FM
MN1020 was used in western blot to study the lack of effect of BDNF knockdown on Abeta or tau pathology in a model of Alzheimer's disease
Tue Feb 19 00:00:00 UTC 2013
Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.
Acta biologica Hungarica
Rahman A,Khan KM,Al-Khaledi G,Khan I,Attur S
MN1020 was used in western blot to study tau phosphorylation in response to early post-natal exposure to lead
Sat Dec 01 00:00:00 UTC 2012
Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice.
PloS one
Capsoni S,Marinelli S,Ceci M,Vignone D,Amato G,Malerba F,Paoletti F,Meli G,Viegi A,Pavone F,Cattaneo A
MN1020 was used in immunohistochemistry to study the therapeutic effect of intranasal delivery of nerve growth factor in a modelof Alzheimer's disease
Mon Oct 29 00:00:00 UTC 2012
Hemimegalencephaly: foetal tauopathy with mTOR hyperactivation and neuronal lipidosis.
Folia neuropathologica
Sarnat H,Flores-Sarnat L,Crino P,Hader W,Bello-Espinosa L
MN1020 was used in immunohistochemistry to report on three cases of hemimegalencephaly
Wed Nov 13 00:00:00 UTC 2013
Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.
PloS one
Caesar I,Jonson M,Nilsson KP,Thor S,Hammarström P
MN1020 was used in immunohistochemistry to study the effect of curcumin on A-beta fibrillation and neurotoxicity in transgenic Drosophila
Tue Jul 31 00:00:00 UTC 2012
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Molecular neurodegeneration
Inoue K,Rispoli J,Kaphzan H,Klann E,Chen EI,Kim J,Komatsu M,Abeliovich A
MN1020 was used in immunohistochemistry to study the role of the phospho-Tau pathway in the mechanism by which deficient macroautophagy promotes age-related neurodegeneration
Fri Sep 21 00:00:00 UTC 2012
Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.
Scientific reports
Bretteville A,Marcouiller F,Julien C,El Khoury NB,Petry FR,Poitras I,Mouginot D,Lévesque G,Hébert SS,Planel E
MN1020 was used in western blot to test if hypothermia could be used to assess tau kinase inhibitors efficacy
Sun Mar 17 00:00:00 UTC 2013
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.
The Journal of biological chemistry
Matsushima T,Saito Y,Elliott JI,Iijima-Ando K,Nishimura M,Kimura N,Hata S,Yamamoto T,Nakaya T,Suzuki T
MN1020 was used in western blot to study the role of phosphorylation in the membrane-microdomain localization of amyloid ?-precursor protein C-terminal fragments
Fri Jun 01 00:00:00 UTC 2012
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
PloS one
Kawakami F,Yabata T,Ohta E,Maekawa T,Shimada N,Suzuki M,Maruyama H,Ichikawa T,Obata F
MN1020 was used in western blot to investigate the important roles of LRRK2 in phosphorylation-mediated dissociation of tau from microtubules
Mon Jun 11 00:00:00 UTC 2012
Neurofibrillary tangles and the deposition of a beta amyloid peptide with a novel N-terminal epitope in the brains of wild Tsushima leopard cats.
PloS one
Chambers JK,Uchida K,Harada T,Tsuboi M,Sato M,Kubo M,Kawaguchi H,Miyoshi N,Tsujimoto H,Nakayama H
MN1020 was used in immunohistochemistry - paraffin section to identify and characterize Abeta deposits in the brains of Japanese Tsushima leopard cats
Tue Jun 11 00:00:00 UTC 2013
Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.
PLoS genetics
Merkwirth C,Martinelli P,Korwitz A,Morbin M,Brönneke HS,Jordan SD,Rugarli EI,Langer T
MN1020 was used in immunohistochemistry to study tau hyperphosphorylation and neurodegeneration induced by loss of murine neuronal PHB2
Mon May 13 00:00:00 UTC 2013
Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.
The Journal of biological chemistry
Mondragón-Rodríguez S,Trillaud-Doppia E,Dudilot A,Bourgeois C,Lauzon M,Leclerc N,Boehm J
MN1020 was used in immunocytochemistry to study the role of NMDA receptor-dependent tau phosphorylation in modulating the interaction of endogenous tau with synaptic proteins
Fri Sep 14 00:00:00 UTC 2012
Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype.
PloS one
Sudduth TL,Wilson JG,Everhart A,Colton CA,Wilcock DM
MN1020 was used in immunohistochemistry and western blot to study the effect of lithium treatment on tau hyperphosphorylation and amyloid deposition in a model of Alzheimer's disease
Tue Jul 31 00:00:00 UTC 2012
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.
Journal of neuroinflammation
Britschgi M,Takeda-Uchimura Y,Rockenstein E,Johns H,Masliah E,Wyss-Coray T
MN1020 was used in immunohistochemistry to study the potential role of the central and terminal complement pathways in tau neuropathology
Tue Sep 18 00:00:00 UTC 2012
Organotypic brain slice cultures of adult transgenic P301S mice--a model for tauopathy studies.
PloS one
Mewes A,Franke H,Singer D
MN1020 was used in Immunohistochemistry to study the benefits and limitations of organotypic brain slice cultures made of mature adult transgenic mice as a potential model system for the multifactorial phenotype of Alzheimer's disease.
Tue Mar 05 00:00:00 UTC 2013
Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.
PloS one
Harris JA,Koyama A,Maeda S,Ho K,Devidze N,Dubal DB,Yu GQ,Masliah E,Mucke L
MN1020 was used in immunohistochemistry to study whether tau pathology caused by overexpression of mutant P301L tau in the murine entorhinal-hippocampal network leads to cognitive defects
Thu Feb 28 00:00:00 UTC 2013
Transient focal cerebral ischemia/reperfusion induces early and chronic axonal changes in rats: its importance for the risk of Alzheimer's disease.
PloS one
Zhang Q,Gao T,Luo Y,Chen X,Gao G,Gao X,Zhou Y,Dai J
MN1020 was used in immunohistochemistry to study the early and chronic axonal changes caused by transient focal cerebral ischemia-reperfusion and the significance for Alzheimer's disease pathogenesis
Fri Aug 03 00:00:00 UTC 2012
Microglial pathology in Down syndrome.
Acta neuropathologica
Xue QS,Streit WJ
MN1020 was used in immunohistochemistry to investigate the changes of microglial cells in Down syndrome patients
Sat Oct 01 00:00:00 UTC 2011
The pathological process underlying Alzheimer's disease in individuals under thirty.
Acta neuropathologica
Braak H,Del Tredici K
MN1020 was used in immunocytochemistry to investigate the changes of gene expression in young Alzheimer disease patients
Tue Feb 01 00:00:00 UTC 2011
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.
The EMBO journal
Li X,Kumar Y,Zempel H,Mandelkow EM,Biernat J,Mandelkow E
MN1020 was used in western blot to investigate the mechanism for the tau missorting in Alzheimer disease
Tue Oct 18 00:00:00 UTC 2011
Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease.
Biological psychiatry
Engmann O,Hortobágyi T,Thompson AJ,Guadagno J,Troakes C,Soriano S,Al-Sarraj S,Kim Y,Giese KP
MN1020 was used in immunohistochemistry to study the generation of the p25 Cdk5 activator during spatial memory formation and its reduction in early stage Alzheimer's disease
Fri Jul 15 00:00:00 UTC 2011
ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo.
Annals of neurology
Green KN,Khashwji H,Estrada T,Laferla FM
MN1020 was used in western blot to investigate the effect of ZSET 1446 on APP digestion in vivo
Sun May 01 00:00:00 UTC 2011
Rapidly progressive diffuse Lewy body disease.
Movement disorders : official journal of the Movement Disorder Society
Gaig C,Valldeoriola F,Gelpi E,Ezquerra M,Llufriu S,Buongiorno M,Rey MJ,Martí MJ,Graus F,Tolosa E
MN1020 was used in immunohistochemistry to evaluate clinical and neuropathological features of patients with a rapidly progressive diffuse Lewy body disease
Wed Jun 01 00:00:00 UTC 2011
Clinical correlates of similar pathologies in parkinsonian syndromes.
Movement disorders : official journal of the Movement Disorder Society
Song YJ,Huang Y,Halliday GM
MN1020 was used in immunohistochemistry to conduct the pathological analysis in parkinsonian syndromes
Tue Feb 15 00:00:00 UTC 2011
Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.
British journal of pharmacology
Cuadrado-Tejedor M,Hervias I,Ricobaraza A,Puerta E,Pérez-Roldán JM,García-Barroso C,Franco R,Aguirre N,García-Osta A
MN1020 was used in western blot to study the effect of sildenafil on neuroplasticity related to Alzheimer
Thu Dec 01 00:00:00 UTC 2011
WNT signaling in activated microglia is proinflammatory.
Glia
Halleskog C,Mulder J,Dahlström J,Mackie K,Hortobágyi T,Tanila H,Kumar Puli L,Färber K,Harkany T,Schulte G
MN1020 was used in immunohistochemistry to study the involvement of WNT signaling in inflammatory response in microglia
Sat Jan 01 00:00:00 UTC 2011
Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease.
Brain pathology (Zurich, Switzerland)
Sepulveda-Falla D,Matschke J,Bernreuther C,Hagel C,Puig B,Villegas A,Garcia G,Zea J,Gomez-Mancilla B,Ferrer I,Lopera F,Glatzel M
MN1020 was used in immunohistochemistry to investigate the distribution of phosphorylated tau in Alzheimer disease patients
Fri Jul 01 00:00:00 UTC 2011
Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain.
Brain pathology (Zurich, Switzerland)
Wilhelmus MM,Verhaar R,Andringa G,Bol JG,Cras P,Shan L,Hoozemans JJ,Drukarch B
MN1020 was used in immunohistochemistry to study the presence of tissue transglutaminase in melanized neurons in Parkinson's disease brain
Tue Mar 01 00:00:00 UTC 2011
Encephalopathy with neuroserpin inclusion bodies presenting as progressive myoclonus epilepsy and associated with a novel mutation in the Proteinase Inhibitor 12 gene.
Brain pathology (Zurich, Switzerland)
Hagen MC,Murrell JR,Delisle MB,Andermann E,Andermann F,Guiot MC,Ghetti B
MN1020 was used in immunohistochemistry to investigate the role of PI12 mutation on neuronal pathologenesis
Thu Sep 01 00:00:00 UTC 2011
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
Neurobiology of disease
Belarbi K,Burnouf S,Fernandez-Gomez FJ,Laurent C,Lestavel S,Figeac M,Sultan A,Troquier L,Leboucher A,Caillierez R,Grosjean ME,Demeyer D,Obriot H,Brion I,Barbot B,Galas MC,Staels B,Humez S,Sergeant N,Schraen-Maschke S,Muhr-Tailleux A,Hamdane M,Buée L,Blum D
MN1020 was used in immunohistochemistry to investigate the influence of long-term voluntary exercise on a transgenic mouse model of Tau pathology
Mon Aug 01 00:00:00 UTC 2011
Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis.
Neurobiology of disease
Nunes A,Pressey SN,Cooper JD,Soriano S
MN1020 was used in western blot to study the status of amyloid precursor protein in a Niemann-Pick type C disease mouse model and its effect on tau homeostasis
Wed Jun 01 00:00:00 UTC 2011
Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice.
Neurobiology of disease
Perez SE,He B,Muhammad N,Oh KJ,Fahnestock M,Ikonomovic MD,Mufson EJ
MN1020 was used in immunohistochemistry to investigate the changes of cholinotrophic system in Alzheimer disease mouse model
Tue Feb 01 00:00:00 UTC 2011
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sydow A,Van der Jeugd A,Zheng F,Ahmed T,Balschun D,Petrova O,Drexler D,Zhou L,Rune G,Mandelkow E,D'Hooge R,Alzheimer C,Mandelkow EM
MN1020 was used in immunohistochemistry to investigate the effect of Tau mutations on the behavior and electrophysiology of mice
Wed Feb 16 00:00:00 UTC 2011
A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dusonchet J,Kochubey O,Stafa K,Young SM,Zufferey R,Moore DJ,Schneider BL,Aebischer P
MN1020 was used in immunohistochemistry to generate a rat model using the mutant G2019S of LRRK2 to study Parkinson's disease.
Wed Jan 19 00:00:00 UTC 2011
Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shipton OA,Leitz JR,Dworzak J,Acton CE,Tunbridge EM,Denk F,Dawson HN,Vitek MP,Wade-Martins R,Paulsen O,Vargas-Caballero M
MN1020 was used in western blot to study the role of Abeta in Tau phosphorylation and its mechanism
Wed Feb 02 00:00:00 UTC 2011
Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies.
Molecular medicine (Cambridge, Mass.)
Ferreira A,Bigio EH
MN1020 was used in western blot to investigate tau cleavage mediated by calpain and its relationship with tau aggregation in tauopathies
Tue Dec 27 00:00:00 UTC 2011
Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dumont M,Stack C,Elipenahli C,Jainuddin S,Gerges M,Starkova NN,Yang L,Starkov AA,Beal F
MN1020 was used in western blot to determine the role of oxidative stress in neurodegenerative disease progression
Tue Nov 01 00:00:00 UTC 2011
Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis.
The American journal of pathology
Wilhelmus MM,Bol JG,Van Haastert ES,Rozemuller AJ,Bu G,Drukarch B,Hoozemans JJ
MN1020 was used in immunohistochemistry to study the potential roles of ApoE1 and LRP1 in the pathogenesis of Parkinson's disease
Tue Nov 01 00:00:00 UTC 2011
A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.
Disease models & mechanisms
Copenhaver PF,Anekonda TS,Musashe D,Robinson KM,Ramaker JM,Swanson TL,Wadsworth TL,Kretzschmar D,Woltjer RL,Quinn JF
MN1020 was used in western blot to study the role of calcium homeostasis in Alzheimer disease using four model systems
Thu Sep 01 00:00:00 UTC 2011
A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.
Laboratory investigation; a journal of technical methods and pathology
Castellani RJ,Gupta Y,Sheng B,Siedlak SL,Harris PL,Coller JM,Perry G,Lee HG,Tabaton M,Smith MA,Wang X,Zhu X
MN1020 was used in immunohistochemistry to study the phosphorylated ribosomal protein S6 in aging and Alzheimer disease
Thu Dec 01 00:00:00 UTC 2011
Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues.
Neurobiology of aging
Hall EC,Lee SY,Mairuae N,Simmons Z,Connor JR
MN1020 was used in western blot to test if HFE polymorphisms are associated with alterations in tau phosphorylation in a human neuroblastoma cell line
Mon Aug 01 00:00:00 UTC 2011
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.
Human molecular genetics
Ambegaokar SS,Jackson GR
MN1020 was used in western blot to identify modifiers of tau toxicity and their relationships with tau phosphorylation state
Thu Dec 15 00:00:00 UTC 2011
Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertension.
Journal of hypertension
Goodwin JE,Zhang J,Gonzalez D,Albinsson S,Geller DS
MN1020 was used in immunocytochemistry to investigate the role of the vasculature in the generation and maintenance of glucocorticoid-mediated hypertension
Fri Jul 01 00:00:00 UTC 2011
13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.
Neurochemistry international
Alonso E,Vale C,Vieytes MR,Laferla FM,Giménez-Llort L,Botana LM
MN1020 was used in western blot to investigate the effect of 13-desmethyl spirolide-C on both tau and beta-amyloid peptide
Thu Dec 01 00:00:00 UTC 2011
Amyloid-β-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway.
Journal of Alzheimer's disease : JAD
Silva DF,Esteves AR,Arduino DM,Oliveira CR,Cardoso SM
MN1020 was used in western blot to investigate the impairment of autophagic lysosomal pathway caused by amyloid-beta-induced mitochondrial dysfunction
Wed Jan 11 00:00:00 UTC 2012
JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models.
Journal of Alzheimer's disease : JAD
Ploia C,Antoniou X,Sclip A,Grande V,Cardinetti D,Colombo A,Canu N,Benussi L,Ghidoni R,Forloni G,Borsello T
MN1020 was used in immunocytochemistry and western blot to study the contribution of JNK in tau hyperphosphorylation.
Tue Jan 17 00:00:00 UTC 2012
JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models.
Journal of Alzheimer's disease : JAD
Ploia C,Antoniou X,Sclip A,Grande V,Cardinetti D,Colombo A,Canu N,Benussi L,Ghidoni R,Forloni G,Borsello T
MN1020 was used in immunocytochemistry and western blot to study the contribution of JNK in tau hyperphosphorylation.
Tue Jan 17 00:00:00 UTC 2012
Fronto-temporal lobar degeneration: neuropathology in 60 cases.
Journal of neural transmission (Vienna, Austria : 1996)
Seilhean D,Le Ber I,Sarazin M,Lacomblez L,Millecamps S,Salachas F,Pradat PF,Le Forestier N,LeGuern E,Dubois B,Meininger V,Brice A,Hauw JJ,Duyckaerts C
MN1020 was used in immunohistochemistry to investigate the neuropathology of fronto-temporal lobar degeneration patients
Sun May 01 00:00:00 UTC 2011
Nerve cells immunoreactive for p62 in select hypothalamic and brainstem nuclei of controls and Parkinson's disease cases.
Journal of neural transmission (Vienna, Austria : 1996)
Braak H,Thal DR,Del Tredici K
MN1020 was used in immunohistochemistry to investigate the localization of p62 in specific brain regions of Parkinson disease patients
Sun May 01 00:00:00 UTC 2011
Protein aggregation in the aging retina.
Journal of neuropathology and experimental neurology
Leger F,Fernagut PO,Canron MH,Léoni S,Vital C,Tison F,Bezard E,Vital A
MN1020 was used in immunohistochemistry to study the age-related protein aggregation in retina
Sat Jan 01 00:00:00 UTC 2011
Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice.
Journal of neuropathology and experimental neurology
Glöckner F,Meske V,Lütjohann D,Ohm TG
MN1020 was used in immunohistochemistry to investigate the effect of dietary cholesterol on phosphorylation and aggregation of tau protein
Fri Apr 01 00:00:00 UTC 2011
Truncation of tau at E391 promotes early pathologic changes in transgenic mice.
Journal of neuropathology and experimental neurology
McMillan PJ,Kraemer BC,Robinson L,Leverenz JB,Raskind M,Schellenberg G
MN1020 was used in immunohistochemistry to investigate the role of a truncated tau in Alzheimer disease pathogenesis in mice
Tue Nov 01 00:00:00 UTC 2011
Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years.
Journal of neuropathology and experimental neurology
Braak H,Thal DR,Ghebremedhin E,Del Tredici K
MN1020 was used in immunohistochemistry to investigate the progression of Alzheimer disease and the association between tauopathy and Alzheimer disease
Tue Nov 01 00:00:00 UTC 2011
Peripheral neuropathy is linked to a severe form of myotonic dystrophy in transgenic mice.
Journal of neuropathology and experimental neurology
Panaite PA,Kielar M,Kraftsik R,Gourdon G,Kuntzer T,Barakat-Walter I
MN1020 was used in immunohistochemistry to investigate the role of peripheral neuropathy in myotonic dystrophy
Mon Aug 01 00:00:00 UTC 2011
Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons.
Journal of molecular neuroscience : MN
Currais A,Kato K,Canuet L,Ishii R,Tanaka T,Takeda M,Soriano S
MN1020 was used in western blot to investigate the effect of caffeine on tau phosphorylation and Akt signaling
Tue Mar 01 00:00:00 UTC 2011
αB-crystallin negative astrocytic inclusions.
Brain & development
Barnett BP,Bressler J,Chen T,Hutchins GM,Crain BJ,Kaufmann WE
MN1020 was used in immunohistochemistry to describe the pathology of astrocyte inclusions.
Fri Apr 01 00:00:00 UTC 2011
Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location.
PloS one
Talbot K,Louneva N,Cohen JW,Kazi H,Blake DJ,Arnold SE
MN1020 was used in immunohistochemistry to investigate the changes of dysbindin-1 in schizophrenia patients
Tue Mar 01 00:00:00 UTC 2011
FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical phenotype of TDP-43 proteinopathies. A report of three cases.
BMC neurology
Rusina R,Kovacs GG,Fiala J,Hort J,Ridzoň P,Holmerová I,Ströbel T,Matěj R
MN1020 was used in immunohistochemistry to investigate the different phenotypes of TDP-43 proteinopathies
Tue May 10 00:00:00 UTC 2011
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.
The Journal of biological chemistry
Cho SH,Sun B,Zhou Y,Kauppinen TM,Halabisky B,Wes P,Ransohoff RM,Gan L
MN1020 was used in western blot to study the role of CX3CR1 protein in microglial activation and cognitive deficits in Alzheimer disease mouse model
Fri Sep 16 00:00:00 UTC 2011
Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.
PloS one
Maarouf CL,Daugs ID,Kokjohn TA,Walker DG,Hunter JM,Kruchowsky JC,Woltjer R,Kaye J,Castaño EM,Sabbagh MN,Beach TG,Roher AE
MN1020 was used in western blot to examine the brains of non-demented high pathology controls individuals for mechanisms that protect against Alzheimer's disease
Fri May 18 00:00:00 UTC 2012
Propofol directly increases tau phosphorylation.
PloS one
Whittington RA,Virág L,Marcouiller F,Papon MA,El Khoury NB,Julien C,Morin F,Emala CW,Planel E
MN1020 was used in immunocytochemistry to study the effect of propofol on tau phosphorylation
Mon Jan 31 00:00:00 UTC 2011
Influence of water quality on cholesterol-induced tau pathology: preliminary data.
International journal of Alzheimer's disease
Sparks DL,Ziolkowski C,Lawmaster T,Martin T
MN1020 was used in immunohistochemistry to investigate the effect of water quality on tau pathology induced by cholesterol in a rabbit model
Sun Apr 17 00:00:00 UTC 2011
The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation.
PloS one
Stieler JT,Bullmann T,Kohl F,Tøien Ø,Brückner MK,Härtig W,Barnes BM,Arendt T
MN1020 was used in immunohistochemistry and western blot to study the physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation
Tue Jan 18 00:00:00 UTC 2011
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease.
Journal of neuroinflammation
Fonseca MI,Chu SH,Berci AM,Benoit ME,Peters DG,Kimura Y,Tenner AJ
MN1020 was used in immunohistochemistry to investigate the role of complement activation pathways in Alzheimer disease
Sat Jan 15 00:00:00 UTC 2011
The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice.
PloS one
To AW,Ribe EM,Chuang TT,Schroeder JE,Lovestone S
MN1020 was used in western blot to study the amyloid beta and tau pathology in APOE knockout mice, carrying human APOEepsilon3 or epsilon4 transgenes, after diet-induced insulin resistance with and without pioglitazone treatment
Thu Feb 10 00:00:00 UTC 2011
Caspase activation precedes and leads to tangles.
Nature
de Calignon A,Fox LM,Pitstick R,Carlson GA,Bacskai BJ,Spires-Jones TL,Hyman BT
MN1020 was used in immunohistochemistry to investigate the effect of caspase activation on tangle formation
Thu Apr 22 00:00:00 UTC 2010
Acetylation of tau inhibits its degradation and contributes to tauopathy.
Neuron
Min SW,Cho SH,Zhou Y,Schroeder S,Haroutunian V,Seeley WW,Huang EJ,Shen Y,Masliah E,Mukherjee C,Meyers D,Cole PA,Ott M,Gan L
MN1020 was used in western blot to investigate the effect of tau modification on its stability and function in neurons
Thu Sep 23 00:00:00 UTC 2010
Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice.
Acta neuropathologica
Blanchard J,Wanka L,Tung YC,Cárdenas-Aguayo Mdel C,LaFerla FM,Iqbal K,Grundke-Iqbal I
MN1020 was used in immunohistochemistry to study the therapeutic enhancement of neuronal generation and plasticity in a model of Alzheimer's disease.
Mon Nov 01 00:00:00 UTC 2010
Amyotrophic lateral sclerosis: dash-like accumulation of phosphorylated TDP-43 in somatodendritic and axonal compartments of somatomotor neurons of the lower brainstem and spinal cord.
Acta neuropathologica
Braak H,Ludolph A,Thal DR,Del Tredici K
MN1020 was used in immunohistochemistry to study the phosphorylation and accumulation of TDP-43 in brainstem and spinal cord in amyotrophic lateral sclerosis
Thu Jul 01 00:00:00 UTC 2010
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease.
Acta neuropathologica
Del Tredici K,Hawkes CH,Ghebremedhin E,Braak H
MN1020 was used in immunohistochemistry to investigate the submandibular gland of patients with Parkinson disease, incidental Lewy body disease, and multiple system atrophy
Tue Jun 01 00:00:00 UTC 2010
Very early-onset frontotemporal dementia with no family history predicts underlying fused in sarcoma pathology.
Brain : a journal of neurology
Loy CT,McCusker E,Kril JJ,Kwok JB,Brooks WS,McCann H,Isaacs AM,Halliday GM
MN1020 was used in immunohistochemistry to study the pathological manifestation of very early-onset frontotemporal dementia
Wed Dec 01 00:00:00 UTC 2010
Isolated bulbar paralysis in a patient with medullar tau pathology: a case report.
Journal of neurology, neurosurgery, and psychiatry
Pretnar-Oblak J,Zaletel M,Hajnsek TM,Meglic B,Hocevar-Boltezar I,Popovic M
MN1020 was used in immunohistochemistry to report a clinical case of medullar tau pathology with isolated bulbar paralysis
Sun Aug 01 00:00:00 UTC 2010
Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.
Proceedings of the National Academy of Sciences of the United States of America
van Eersel J,Ke YD,Liu X,Delerue F,Kril JJ,Götz J,Ittner LM
MN1020 was used in western blot to investigate the effect of sodium selenate on tau pathology
Tue Aug 03 00:00:00 UTC 2010
Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice.
Experimental & molecular medicine
Lee JH,Won SM,Suh J,Son SJ,Moon GJ,Park UJ,Gwag BJ
MN1020 was used in immunohistochemistry to examine the correlation between induction of the unfolded protein response and neurofibrillary tangle
Mon May 31 00:00:00 UTC 2010
Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2.
Stroke
Van Nostrand WE,Xu F,Rozemuller AJ,Colton CA
MN1020 was used in immunohistochemistry to study cerebral amyloid angiopathy in mice lacking nitric oxide synthase-2.
Fri Oct 01 00:00:00 UTC 2010
Hyposmia in progressive supranuclear palsy.
Movement disorders : official journal of the Movement Disorder Society
Silveira-Moriyama L,Hughes G,Church A,Ayling H,Williams DR,Petrie A,Holton J,Revesz T,Kingsbury A,Morris HR,Burn DJ,Lees AJ
MN1020 was used in immunohistochemistry to investigate the changes of smell capability in progressive supranuclear palsy
Thu Apr 15 00:00:00 UTC 2010
Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Escribano L,Simón AM,Gimeno E,Cuadrado-Tejedor M,López de Maturana R,García-Osta A,Ricobaraza A,Pérez-Mediavilla A,Del Río J,Frechilla D
MN1020 was used in immunohistochemistry to investigate the effect of rosiglitazone on memory rescue in Alzheimer disease patients and its mechanism
Tue Jun 01 00:00:00 UTC 2010
Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis.
Glia
Höftberger R,Fink S,Aboul-Enein F,Botond G,Olah J,Berki T,Ovadi J,Lassmann H,Budka H,Kovacs GG
MN1020 was used in immunohistochemistry to investigate the expression tubulin polymerization promoting protein in oligodendrocytes in multiple sclerosis
Mon Nov 15 00:00:00 UTC 2010
Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish.
Neurobiology of disease
van Bebber F,Paquet D,Hruscha A,Schmid B,Haass C
MN1020 was used in immunohistochemistry to investigate the non-effectiveness of methylene blue on tau function and polyglutamine toxicity in zebrafish
Wed Sep 01 00:00:00 UTC 2010
Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Boutajangout A,Quartermain D,Sigurdsson EM
MN1020 was used in immunohistochemistry to investigate the effect of immunotherapy on cognitive decline in mouse
Wed Dec 08 00:00:00 UTC 2010
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tamayev R,Giliberto L,Li W,d'Abramo C,Arancio O,Vidal R,D'Adamio L
MN1020 was used in immunohistochemistry to investigate the influence of BRI2 mutation on learning and memory in mice
Wed Nov 03 00:00:00 UTC 2010
Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease.
Neuropathology and applied neurobiology
Ma JF,Huang Y,Chen SD,Halliday G
MN1020 was used in immunohistochemistry to study the pathological structures associated with macroautophagy in neurons and endothelial cells in Alzheimer disease
Tue Jun 01 00:00:00 UTC 2010
Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy.
Neuropathology and applied neurobiology
Bhaskar K,Hobbs GA,Yen SH,Lee G
MN1020 was used in immunohistochemistry to compare the temporal and spatial distribution of Tyr18-phosphorylated tau with that of Ser202/Thr205-phosphorylated tau in the JNPL3 mouse model
Fri Oct 01 00:00:00 UTC 2010
Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses.
Stem cells (Dayton, Ohio)
Lee JK,Jin HK,Endo S,Schuchman EH,Carter JE,Bae JS
MN1020 was used in immunohistochemistry to evaluate bone marrow-derived mesenchymal stem cells as potential cellular therapy for Alzheimer disease
Mon Feb 01 00:00:00 UTC 2010
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
The American journal of pathology
Lee S,Varvel NH,Konerth ME,Xu G,Cardona AE,Ransohoff RM,Lamb BT
MN1020 was used in immunohistochemistry to investigate the influence of CX3CR1 deletion on A-beta accumulation in Alzheimer disease models
Mon Nov 01 00:00:00 UTC 2010
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
The American journal of pathology
Martinez-Coria H,Green KN,Billings LM,Kitazawa M,Albrecht M,Rammes G,Parsons CG,Gupta S,Banerjee P,LaFerla FM
MN1020 was used in western blot to investigate the effect of memantine on Alzheimer disease treatment in mice
Mon Feb 01 00:00:00 UTC 2010
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
The American journal of pathology
Koike MA,Green KN,Blurton-Jones M,Laferla FM
MN1020 was used in western blot to investigate the effect of oligemic hypoperfusion on tau and amyloid-beta in 3xTg-Alzheimer disease mice
Thu Jul 01 00:00:00 UTC 2010
Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer's disease peripheral biomarker.
Neurobiology of aging
Khan TK,Alkon DL
MN1020 was used in immunohistochemistry to evaluate an approach for the early diagnostic of Alzheimer disease
Tue Jun 01 00:00:00 UTC 2010
Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice.
Endocrinology
Carroll JC,Rosario ER,Villamagna A,Pike CJ
MN1020 was used in immunohistochemistry to determine the effects of continuous and cyclic P4 treatments on levels of tau hyperphosphorylation
Tue Jun 01 00:00:00 UTC 2010
Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster.
Genetics
Ambegaokar SS,Jackson GR
MN1020 was used in western blot to study the interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila
Wed Sep 01 00:00:00 UTC 2010
Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Greco SJ,Bryan KJ,Sarkar S,Zhu X,Smith MA,Ashford JW,Johnston JM,Tezapsidis N,Casadesus G
MN1020 was used in western blot to investigate the effect of leptin treatment on histopathology and memory capability in Alzheimer disease model
Thu Jul 22 00:00:00 UTC 2010
Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet.
Journal of Alzheimer's disease : JAD
Chen X,Wagener JF,Morgan DH,Hui L,Ghribi O,Geiger JD
MN1020 was used in immunohistochemistry to study the role of elevated cholesterol ingestion on the pathology of Alzheimer's disease.
Wed May 25 00:00:00 UTC 2011
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
Journal of Alzheimer's disease : JAD
Parachikova A,Vasilevko V,Cribbs DH,LaFerla FM,Green KN
MN1020 was used in western blot to investigate the effect of minocycline on endogenous neuroinflammation and tau modification in Alzheimer disease mouse model
Mon Dec 20 00:00:00 UTC 2010
Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2.
Journal of Alzheimer's disease : JAD
Liu XA,Liao K,Liu R,Wang HH,Zhang Y,Zhang Q,Wang Q,Li HL,Tian Q,Wang JZ
MN1020 was used in western blot to study the mechanism by which tau dephosphorylation facilitates apoptosis
Wed May 05 00:00:00 UTC 2010
Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau.
Brain structure & function
Dickstein DL,Brautigam H,Stockton SD,Schmeidler J,Hof PR
MN1020 was used in immunocytochemistry to investigate the alterations in dendrites and spines in the transgenic mice with human wild-type tau
Mon Mar 01 00:00:00 UTC 2010
Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease.
Neuroscience
Lecanu L,Rammouz G,McCourty A,Sidahmed EK,Greeson J,Papadopoulos V
MN1020 was used in immunohistochemistry to study the effect of caprospinol on amyloid deposits and cognitive function in a rodent Alzheimer disease model
Wed Jan 20 00:00:00 UTC 2010
The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons.
Neuroscience
Bertrand J,Plouffe V,Sénéchal P,Leclerc N
MN1020 was used in western blot to study the relationship between Tau phosphorylation pattern and neurodegenerative diseases
Wed Jun 30 00:00:00 UTC 2010
Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease.
Neuroscience
Morawski M,Brückner G,Jäger C,Seeger G,Arendt T
MN1020 was used in immunohistochemistry to investigate the effect of aggrecan-based extracellular matrix on neuroprotection in Alzheimer disease
Wed Sep 01 00:00:00 UTC 2010
In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles.
The European journal of neuroscience
Härtig W,Kacza J,Paulke BR,Grosche J,Bauer U,Hoffmann A,Elsinghorst PW,Gütschow M
MN1020 was used in immunohistochemistry to evaluate nanoparticles as carriers of AChE inhibitors for the treatment of Alzheimer disease
Fri Jan 01 00:00:00 UTC 2010
Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains.
Brain research
Feuillette S,Deramecourt V,Laquerriere A,Duyckaerts C,Delisle MB,Maurage CA,Blum D,Buée L,Frébourg T,Campion D,Lecourtois M
MN1020 was used in immunohistochemistry to study the colocalization of filamin-A and myosin VI with fibrillary tau protein in neurodegenerative diseases
Fri Jul 23 00:00:00 UTC 2010
Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models.
Brain research
Nicholson RM,Kusne Y,Nowak LA,LaFerla FM,Reiman EM,Valla J
MN1020 was used in immunohistochemistry to study areas of common vulnerability in different mouse models of Alzheimer's disease
Fri Aug 06 00:00:00 UTC 2010
Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways.
Brain research
Rosario ER,Carroll J,Pike CJ
MN1020 was used in immunohistochemistry to investigate the mechanism for the testosterone effect on Alzheimer disease-related pathology
Thu Nov 04 00:00:00 UTC 2010
Acute hypoxia promote the phosphorylation of tau via ERK pathway.
Neuroscience letters
Fang H,Zhang LF,Meng FT,Du X,Zhou JN
MN1020 was used in western blot to study the role of the ERK pathway in hypoxia induced phosphorylation of tau
Mon May 03 00:00:00 UTC 2010
Widespread distribution of reticulon-3 in various neurodegenerative diseases.
Neuropathology : official journal of the Japanese Society of Neuropathology
Heath JE,Siedlak SL,Zhu X,Lee HG,Thakur A,Yan R,Perry G,Smith MA,Castellani RJ
MN1020 was used in immunohistochemistry to investigate the distribution of membrane bound Reticulon proteins in neurodegenerative diseases
Wed Dec 01 00:00:00 UTC 2010
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
PloS one
Bittner T,Fuhrmann M,Burgold S,Ochs SM,Hoffmann N,Mitteregger G,Kretzschmar H,LaFerla FM,Herms J
MN1020 was used in immunohistochemistry to investigate the dendritic spine loss during the progression of Alzheimer disease in a mouse model
Tue Nov 16 00:00:00 UTC 2010
Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses.
Nature protocols
Berg I,Nilsson KP,Thor S,Hammarström P
MN1020 was used in immunohistochemistry to describe a way to image amyloid deposits in the Drosophila brain
Sat May 01 00:00:00 UTC 2010
Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.
Frontiers in neuroanatomy
Blazquez-Llorca L,Garcia-Marin V,Defelipe J
MN1020 was used in Immunohistochemistry to observe the distribution of PHF-tau protein filaments and study its effect on synaptic connectivity in Alzheimer's patients.
Thu Jul 14 00:00:00 UTC 2011
A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases.
PloS one
Sharma A,Callahan LM,Sul JY,Kim TK,Barrett L,Kim M,Powers JM,Federoff H,Eberwine J
MN1020 was used in immunohistochemistry to characterize Elk-1 as a link between symptoms of neurodegenerative diseases
Tue Feb 02 00:00:00 UTC 2010
A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.
The Journal of biological chemistry
Zheng YL,Amin ND,Hu YF,Rudrabhatla P,Shukla V,Kanungo J,Kesavapany S,Grant P,Albers W,Pant HC
MN1020 was used in western blot to investigate the effect of a p35 fragment on Cdk5-p25 activity and tau hyperphosphorylation
Fri Oct 29 00:00:00 UTC 2010
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
PLoS genetics
Khurana V,Elson-Schwab I,Fulga TA,Sharp KA,Loewen CA,Mulkearns E,Tyynelä J,Scherzer CR,Feany MB
MN1020 was used in western blot to investigate the role of lysosomal dysfunction in tau cleavage and neurotoxicity in vivo
Thu Jul 15 00:00:00 UTC 2010
Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.
The Journal of biological chemistry
Liang B,Duan BY,Zhou XP,Gong JX,Luo ZG
MN1020 was used in western blot to elucidate the mechanism of calpain during Alzheimer's disease progression
Fri Sep 03 00:00:00 UTC 2010
Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease.
Journal of neuroinflammation
Minami SS,Sidahmed E,Aid S,Shimoji M,Niikura T,Mocchetti I,Rebeck GW,Prendergast JS,Dealwis C,Wetzel R,Bosetti F,Matsuoka Y,Hoe HS,Turner RS
MN1020 was used in western blot to investigate the benefit vs. adverse effect of passive immunization in an Alzheimer disease model
Tue Sep 28 00:00:00 UTC 2010
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities.
PloS one
Kakefuda K,Oyagi A,Ishisaka M,Tsuruma K,Shimazawa M,Yokota K,Shirai Y,Horie K,Saito N,Takeda J,Hara H
MN1020 was used in western blot to investigate the role of diacylglycerol kinase beta in behavioral changes
Mon Oct 18 00:00:00 UTC 2010
Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice.
PloS one
Pan-Montojo F,Anichtchik O,Dening Y,Knels L,Pursche S,Jung R,Jackson S,Gille G,Spillantini MG,Reichmann H,Funk RH
MN1020 was used in immunohistochemistry to study the ability of the pesticide and mitochondrial respiratory chain inhibitor rotenone to reproduce Parkinson's disease pathology in the mouse
Tue Jan 19 00:00:00 UTC 2010
TDP-43 pathology in familial British dementia.
Acta neuropathologica
Schwab C,Arai T,Hasegawa M,Akiyama H,Yu S,McGeer PL
MN1020 was used in immunohistochemistry to study the TDP-43 pathological inclusions in familial British dementia
Sat Aug 01 00:00:00 UTC 2009
p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis.
Acta neuropathologica
Nogalska A,Terracciano C,D'Agostino C,King Engel W,Askanas V
MN1020 was used in immunocytochemistry to investigate the distribution of p62 in sporadic inclusion-body myositis muscle fibers and its application as a biomarker
Tue Sep 01 00:00:00 UTC 2009
Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study.
Brain : a journal of neurology
Lace G,Savva GM,Forster G,de Silva R,Brayne C,Matthews FE,Barclay JJ,Dakin L,Ince PG,Wharton SB
MN1020 was used in immunohistochemistry to investigate the role of hippocampal tau stages in the diagnosis of cognitive impairment
Fri May 01 00:00:00 UTC 2009
Parkinsonism in Gaucher's disease type 1: ten new cases and a review of the literature.
Movement disorders : official journal of the Movement Disorder Society
Kraoua I,Stirnemann J,Ribeiro MJ,Rouaud T,Verin M,Annic A,Rose C,Defebvre L,Réménieras L,Schüpbach M,Belmatoug N,Vidailhet M,Sedel F
MN1020 was used in Immunohistochemistry to examine the prevalence of Parkinsonism in patients with Gaucher's disease.
Thu Jul 30 00:00:00 UTC 2009
TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea.
Movement disorders : official journal of the Movement Disorder Society
Kovacs GG,Murrell JR,Horvath S,Haraszti L,Majtenyi K,Molnar MJ,Budka H,Ghetti B,Spina S
MN1020 was used in immunohistochemistry to report on a case of TARDBP variation associated with non-ALS neurodegeneration
Tue Sep 15 00:00:00 UTC 2009
Tremor on smiling.
Movement disorders : official journal of the Movement Disorder Society
Schwingenschuh P,Cordivari C,Czerny J,Esposito M,Bhatia KP
MN1020 was used in Immunohistochemistry to describe two patients with bilateral facial tremors, with a high frequency of 9 Hz, which occurred on smiling and other activation of therisorii muscles.
Thu Jul 30 00:00:00 UTC 2009
No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism.
Movement disorders : official journal of the Movement Disorder Society
Halliday G,Herrero MT,Murphy K,McCann H,Ros-Bernal F,Barcia C,Mori H,Blesa FJ,Obeso JA
MN1020 was used in immunohistochemistry to examine the effect of MPTP-induced oxidative stress and inflammation per se on Lewy body formation
Thu Jul 30 00:00:00 UTC 2009
Bell's palsy preceding Parkinson's disease: a case-control study.
Movement disorders : official journal of the Movement Disorder Society
Savica R,Bower JH,Maraganore DM,Grossardt BR,Rocca WA
MN1020 was used in immunohistochemistry to study the Bell palsy in Parkinson disease
Thu Jul 30 00:00:00 UTC 2009
Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Ricobaraza A,Cuadrado-Tejedor M,Pérez-Mediavilla A,Frechilla D,Del Río J,García-Osta A
MN1020 was used in western blot to investigate the effect of phenylbutyrate on neurocognitive function and taupathy in Alzheimer disease murine model
Mon Jun 01 00:00:00 UTC 2009
Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2.
Brain pathology (Zurich, Switzerland)
Vidal R,Barbeito AG,Miravalle L,Ghetti B
MN1020 was used in immunohistochemistry to investigate the neuropathological features in a transgenic mouse model of familial Danish dementia
Thu Jan 01 00:00:00 UTC 2009
Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain.
Brain pathology (Zurich, Switzerland)
Wilhelmus MM,Grunberg SC,Bol JG,van Dam AM,Hoozemans JJ,Rozemuller AJ,Drukarch B
MN1020 was used in immunohistochemistry to study the role of transglutaminases and transglutaminase-catalyzed cross-links in Alzheimer's disease pathology
Thu Oct 01 00:00:00 UTC 2009
Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation.
Life sciences
Sul D,Kim HS,Lee D,Joo SS,Hwang KW,Park SY
MN1020 was used in western blot to investigate the potential neuroprotective effects of caffeic acid against Abeta-induced toxicity
Fri Feb 27 00:00:00 UTC 2009
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Planel E,Bretteville A,Liu L,Virag L,Du AL,Yu WH,Dickson DW,Whittington RA,Duff KE
MN1020 was used in western blot to investigate the neurofibrillary pathology in a mouse model of tauopathy
Sat Aug 01 00:00:00 UTC 2009
Brain-specific deletion of extracellular signal-regulated kinase 2 mitogen-activated protein kinase leads to aberrant cortical collagen deposition.
The American journal of pathology
Heffron DS,Landreth GE,Samuels IS,Mandell JW
MN1020 was used in Immunohistochemistry to investigate neural-specific functions of extracellular signal-regulated kinase 2 in the murine brain.
Tue Dec 01 00:00:00 UTC 2009
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
Journal of neurochemistry
Kasher PR,De Vos KJ,Wharton SB,Manser C,Bennett EJ,Bingley M,Wood JD,Milner R,McDermott CJ,Miller CC,Shaw PJ,Grierson AJ
MN1020 was used in immunocytochemistry to investigate the effect of spastin mutation on the defective axonal transport in the pathogenesis of hereditary spastic paraplegia
Wed Jul 01 00:00:00 UTC 2009
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
Human molecular genetics
Chatterjee S,Sang TK,Lawless GM,Jackson GR
MN1020 was used in Western Blot to suggest that, in addition to tau phosphorylation, microtubule binding plays a crucial role in the regulation of tau toxicity when misexpressed.
Thu Jan 01 00:00:00 UTC 2009
Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression.
Human molecular genetics
Tang J,LeGros RP,Louneva N,Yeh L,Cohen JW,Hahn CG,Blake DJ,Arnold SE,Talbot K
MN1020 was used in immunohistochemistry to study isoform-specific Dysbindin-1 decreases in the dorsolateral prefrontal cortex in schizophrenia
Thu Oct 15 00:00:00 UTC 2009
2,3,7,8-TCDD neurotoxicity in neuroblastoma cells is caused by increased oxidative stress, intracellular calcium levels, and tau phosphorylation.
Toxicology
Sul D,Kim HS,Cho EK,Lee M,Kim HS,Jung WW,Hwang KW,Park SY
MN1020 was used in western blot to investigate the neurotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin
Thu Jan 08 00:00:00 UTC 2009
Pathological-like assembly of tau induced by a paired helical filament core expressed at the plasma membrane.
Journal of Alzheimer's disease : JAD
Campos-Peña V,Tapia-Ramírez J,Sánchez-Torres C,Meraz-Rios MA
MN1020 was used in immunocytochemistry to study the generation of pathological-like tau assemblies at the plasma membrane
Thu Sep 16 00:00:00 UTC 2010
Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains.
FEBS letters
Sasaki K,Shimura H,Itaya M,Tanaka R,Mori H,Mizuno Y,Kosik KS,Tanaka S,Hattori N
MN1020 was used in immunohistochemistry to show the association of excitatory amino acid transporter 2 with phosphorylated tau and its localization in neurofibrillary tangles
Tue Jul 07 00:00:00 UTC 2009
Phospholipids block nuclear factor-kappa B and tau phosphorylation and inhibit amyloid-beta secretion in human neuroblastoma cells.
Neuroscience
Pandey NR,Sultan K,Twomey E,Sparks DL
MN1020 was used in western blot to study the effect of phospholipids on NF-kappa-B and Tau phosphorylation in human neuroblastoma cells
Tue Dec 29 00:00:00 UTC 2009
The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.
Brain research
Lee HG,Zhu X,Casadesus G,Pallàs M,Camins A,O'Neill MJ,Nakanishi S,Perry G,Smith MA
MN1020 was used in western blot to study the role of mGluR2 in the activation of ERK pathways and neuronal cell survival
Fri Jan 16 00:00:00 UTC 2009
Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells.
Biochemical and biophysical research communications
Greco SJ,Sarkar S,Johnston JM,Tezapsidis N
MN1020 was used in western blot to study the regulation of tau phosphorylation and amyloid by leptin in neuronal cells.
Fri Feb 27 00:00:00 UTC 2009
Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.
Neuroscience letters
Greco SJ,Sarkar S,Casadesus G,Zhu X,Smith MA,Ashford JW,Johnston JM,Tezapsidis N
MN1020 was used in western blot to study the role of GSK-3beta in mediating the effectsof leptin on tau phosphorylation in neuronal cells
Fri May 22 00:00:00 UTC 2009
Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation.
Bioscience, biotechnology, and biochemistry
Kim HS,Sul D,Lim JY,Lee D,Joo SS,Hwang KW,Park SY
MN1020 was used in western blot to assess the neuroprotective effects of delphinidin against Abeta-induced toxicity
Wed Jul 01 00:00:00 UTC 2009
Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration.
Journal of neural engineering
McConnell GC,Rees HD,Levey AI,Gutekunst CA,Gross RE,Bellamkonda RV
MN1020 was used in immunohistochemistry to study the inflammatory and neurodegenerative effects caused by implanted neural electrodes
Thu Oct 01 00:00:00 UTC 2009
Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.
Aging
Bonda DJ,Evans TA,Santocanale C,Llosá JC,Viña J,Bajic V,Castellani RJ,Siedlak SL,Perry G,Smith MA,Lee HG
MN1020 was used in immunohistochemistry to study aberrant cell cycle progression and abnormal subcellular localization of phosphorylated Mcm2 in Alzheimer's disease and the significance for neronal degeneration
Wed Apr 01 00:00:00 UTC 2009
LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.
Acta neuropathologica
Huang Y,Song YJ,Murphy K,Holton JL,Lashley T,Revesz T,Gai WP,Halliday GM
MN1020 was used in immunohistochemistry to determine whether LRRK2 and parkin associate with glial cytoplasmic inclusions
Mon Dec 01 00:00:00 UTC 2008
MAPT S305I mutation: implications for argyrophilic grain disease.
Acta neuropathologica
Kovacs GG,Pittman A,Revesz T,Luk C,Lees A,Kiss E,Tariska P,Laszlo L,Molnár K,Molnar MJ,Tolnay M,de Silva R
MN1020 was used in immunohistochemistry to study the role of MAPT mutation in argyrophilic grain disease.
Tue Jul 01 00:00:00 UTC 2008
Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu Y,Yoo MJ,Savonenko A,Stirling W,Price DL,Borchelt DR,Mamounas L,Lyons WE,Blue ME,Lee MK
MN1020 was used in immunocytochemistry to investigate the pathology of MAergic neurons in an Alzheimer disease mouse model
Wed Dec 17 00:00:00 UTC 2008
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Planel E,Krishnamurthy P,Miyasaka T,Liu L,Herman M,Kumar A,Bretteville A,Figueroa HY,Yu WH,Whittington RA,Davies P,Takashima A,Nixon RA,Duff KE
MN1020 was used in western blot to investigate the effect of anesthesia-induced hyperphosphorylation on the detachment of 3-repeat Tau and Tau stability
Wed Nov 26 00:00:00 UTC 2008
Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Park SY,Kim HS,Cho EK,Kwon BY,Phark S,Hwang KW,Sul D
MN1020 was used in western blot to elucidate the neuroprotective mechanisms by which curcumin protects against Abeta-induced toxicity
Fri Aug 01 00:00:00 UTC 2008
The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins.
Journal of neurochemistry
Kanungo J,Zheng YL,Amin ND,Pant HC
MN1020 was used in immunocytochemistry and western blot to elucidate the relationship between Notch and cdk5 signaling.
Mon Sep 01 00:00:00 UTC 2008
Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells.
Journal of neurochemistry
Hu M,Waring JF,Gopalakrishnan M,Li J
MN1020 was used in western blot to investigate the role of tau phosphorylation in PC12 cells
Fri Aug 01 00:00:00 UTC 2008
Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels.
Hippocampus
Schrag M,Sharma S,Brown-Borg H,Ghribi O
MN1020 was used in immunohistochemistry to examine the resistance of Ames dwarf mice towards the beta-amyloid-induced neurotoxicities
Thu Mar 27 00:00:00 UTC 2008
CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.
Brain research
Laporte V,Ait-Ghezala G,Volmar CH,Ganey C,Ganey N,Wood M,Mullan M
MN1020 was used in immunohistochemistry to study the role of CD40 ligation in plaque-associated tau phosphorylation in beta-amyloid overproducing mice
Mon Sep 22 00:00:00 UTC 2008
Brain region-specificity of palmitic acid-induced abnormalities associated with Alzheimer's disease.
BMC research notes
Patil S,Balu D,Melrose J,Chan C
MN1020 was used in western blot to investigate the relationship between brain region-specific free fatty acid metabolism and region-specific brain damage observed in Alzheimer disease
Wed Jun 04 00:00:00 UTC 2008
A new function of microtubule-associated protein tau: involvement in chromosome stability.
Cell cycle (Georgetown, Tex.)
Rossi G,Dalprà L,Crosti F,Lissoni S,Sciacca FL,Catania M,Di Fede G,Mangieri M,Giaccone G,Croci D,Tagliavini F
MN1020 was used in immunocytochemistry to study a potential role of tau in chromosome stability via its interaction with chromatin and microtubules
Sun Jun 15 00:00:00 UTC 2008
Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9.
BMC neurology
Luty AA,Kwok JB,Thompson EM,Blumbergs P,Brooks WS,Loy CT,Dobson-Stone C,Panegyres PK,Hecker J,Nicholson GA,Halliday GM,Schofield PR
MN1020 was used in immunohistochemistry to identify the gene loci for the frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology
Fri Aug 29 00:00:00 UTC 2008
Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Carroll JC,Rosario ER,Chang L,Stanczyk FZ,Oddo S,LaFerla FM,Pike CJ
MN1020 was used in immunohistochemistry to examine the individual and combined effects of estrogen and progesterone on beta-amyloid accumulation, tau hyperphosphorylation, and hippocampal-dependent behavioral impairments
Wed Nov 28 00:00:00 UTC 2007
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Green KN,Martinez-Coria H,Khashwji H,Hall EB,Yurko-Mauro KA,Ellis L,LaFerla FM
MN1020 was used in western blot to show steady-state levels of phospho-tau epitopes from 9 month PUFA-treated transgenic mouse model that exhibits both A Beta^A and tau pathologies.
Wed Apr 18 00:00:00 UTC 2007
Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Rissman RA,Lee KF,Vale W,Sawchenko PE
MN1020 was used in western blot to investigate the influence of CRFR on tau modification under stress conditions
Wed Jun 13 00:00:00 UTC 2007
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Planel E,Richter KE,Nolan CE,Finley JE,Liu L,Wen Y,Krishnamurthy P,Herman M,Wang L,Schachter JB,Nelson RB,Lau LF,Duff KE
MN1020 was used in immunohistochemistry to examine the effect of anesthesia on tau hyperphosphorylation
Wed Mar 21 00:00:00 UTC 2007
Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies.
Neuropathology and applied neurobiology
Sikorska B,Papierz W,Preusser M,Liberski PP,Budka H
MN1020 was used in immunohistochemistry to characterize a unique case of synucleinopathy with multiple system atrophy and dementia
Thu Feb 01 00:00:00 UTC 2007
Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death.
Journal of neurochemistry
Leschik J,Welzel A,Weissmann C,Eckert A,Brandt R
MN1020 was used in western blot to investigate the regulatory effect of presenilin 1 and amyloid-beta on tau-dependent neurodegeneration
Fri Jun 01 00:00:00 UTC 2007
Insular pathology in Parkinson's disease patients with orthostatic hypotension.
Parkinsonism & related disorders
Papapetropoulos S,Mash DC
MN1020 was used in immunohistochemistry to study the association between the severity of insular cortex pathology in Parkinson's disease and the occurrence orthostatic hypotension
Sun Jul 01 00:00:00 UTC 2007
Motor fluctuations and dyskinesias in advanced/end stage Parkinson's disease: a study from a population of brain donors.
Journal of neural transmission (Vienna, Austria : 1996)
Papapetropoulos S,Mash DC
MN1020 was used in immunohistochemistry to investigate the prevalence of motor fluctuations and dyskinesias in end stage patients with Parkinson disease
Thu Mar 01 00:00:00 UTC 2007
Increased expression of the Nogo receptor in the hippocampus and its relation to the neuropathology in Alzheimer's disease.
Human pathology
Zhu HY,Guo HF,Hou HL,Liu YJ,Sheng SL,Zhou JN
MN1020 was used in immunohistochemistry to study the increased expression of NgR in hippocampus and its role in Alzheimer Disease neuropathology
Thu Mar 01 00:00:00 UTC 2007
Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias.
Neuroscience letters
Magaki S,Raghavan R,Mueller C,Oberg KC,Vinters HV,Kirsch WM
MN1020 was used in immunohistochemistry to study the role of iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias
Fri May 11 00:00:00 UTC 2007
Autophagocytosis of mitochondria is prominent in Alzheimer disease.
Journal of neuropathology and experimental neurology
Moreira PI,Siedlak SL,Wang X,Santos MS,Oliveira CR,Tabaton M,Nunomura A,Szweda LI,Aliev G,Smith MA,Zhu X,Perry G
MN1020 was used in immunohistochemistry to investigate the autophagocytosis of mitochondria in Alzheimer disease
Fri Jun 01 00:00:00 UTC 2007
Autopsy at 2 months after death: brain is satisfactorily preserved for neuropathology.
Forensic science international
Gelpi E,Preusser M,Bauer G,Budka H
MN1020 was used in immunohistochemistry to study neuropathological features of a brain fixed 2 months after death
Thu May 24 00:00:00 UTC 2007
Expression of serine/threonine protein-kinases and related factors in normal monkey and human retinas: the mechanistic understanding of a CDK2 inhibitor induced retinal toxicity.
Toxicologic pathology
Saturno G,Pesenti M,Cavazzoli C,Rossi A,Giusti AM,Gierke B,Pawlak M,Venturi M
MN1020 was used in Immunohistochemistry to demonstrate how complementary gene expression and protein-based technologies can be used to understand the molecular mechanism of a cyclin dependent protein-kinase 2 inhibitor induced toxicity.
Sat Dec 01 00:00:00 UTC 2007
A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice.
Neurobiology of disease
Blain JF,Sullivan PM,Poirier J
MN1020 was used in western blot to investigate the effect of apoE4 on astroglial repair process and synaptic remodeling
Wed Mar 01 00:00:00 UTC 2006
Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?
Journal of neuroscience research
Lee HG,Ueda M,Zhu X,Perry G,Smith MA
MN1020 was used in immunocytochemistry to investigate the alteration of transforming growth factor-beta pathway in Alzheimer disease
Fri Dec 01 00:00:00 UTC 2006
Formation of phospho-SAPK/JNK granules in the hippocampus is an early event in Alzheimer disease.
Journal of neuropathology and experimental neurology
Lagalwar S,Guillozet-Bongaarts AL,Berry RW,Binder LI
MN1020 was used in immunohistochemistry to study the formation of p-SAPK/JNK in hippocampus during the early stages of Alzheimer disease
Mon May 01 00:00:00 UTC 2006
X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease.
Methods in enzymology
Ikonomovic MD,Abrahamson EE,Isanski BA,Debnath ML,Mathis CA,Dekosky ST,Klunk WE
MN1020 was used in immunohistochemistry to describe methods for the fluorescent labeling of abnormal protein aggregates in Alzheimer's disease
Tue Nov 14 00:00:00 UTC 2006
A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy.
Annals of neurology
Obici L,Demarchi A,de Rosa G,Bellotti V,Marciano S,Donadei S,Arbustini E,Palladini G,Diegoli M,Genovese E,Ferrari G,Coverlizza S,Merlini G
MN1020 was used in immunohistochemistry to investigate the association between a APP mutation and cerebral amyloid angiopathy.
Sat Oct 01 00:00:00 UTC 2005
Alpha-synuclein immunohistochemistry in two cases of co-occurring idiopathic Parkinson's disease and motor neuron disease.
Movement disorders : official journal of the Movement Disorder Society
Klos KJ,Josephs KA,Parisi JE,Dickson DW
MN1020 was used in immunohistochemistry to study the clinicopathological features of co-occurring idiopathic Parkinson disease and motor neuron disease
Tue Nov 01 00:00:00 UTC 2005
The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology.
Brain research
Wang YJ,Chen GH,Hu XY,Lu YP,Zhou JN,Liu RY
MN1020 was used in immunohistochemistry to study the expression of CaMKII-alpha in hippocampus and its role in Alzheimer disease neuropathology
Fri Jan 07 00:00:00 UTC 2005
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
Journal of neuropathology and experimental neurology
Hung KS,Hwang SL,Liang CL,Chen YJ,Lee TH,Liu JK,Howng SL,Wang CH
MN1020 was used in immunohistochemistry to investigate the influence of calpain inhibition on spinal cord hemisection treatment
Sat Jan 01 00:00:00 UTC 2005
Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease.
Acta neuropathologica
Lee HG,Ogawa O,Zhu X,O'Neill MJ,Petersen RB,Castellani RJ,Ghanbari H,Perry G,Smith MA
MN1020 was used in immunocytochemistry to study the involvement of metabotropic glutamate receptor 2 in the pathogenesis of Alzheimer disease
Thu Apr 01 00:00:00 UTC 2004
Astrocytic degeneration relates to the severity of disease in frontotemporal dementia.
Brain : a journal of neurology
Broe M,Kril J,Halliday GM
MN1020 was used in immunohistochemistry to investigate the relationship between astrocytic degeneration and frontotemporal dementia
Fri Oct 01 00:00:00 UTC 2004
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.
Annals of neurology
Mesulam M,Shaw P,Mash D,Weintraub S
MN1020 was used in immunohistochemistry to study cholinergic nucleus basalis tauopathy at the early stage of neurodegeneration
Tue Jun 01 00:00:00 UTC 2004
Mutant superoxide dismutase 1 causes motor neuron degeneration independent of cyclin-dependent kinase 5 activation by p35 or p25.
Journal of neurochemistry
Takahashi S,Kulkarni AB
MN1020 was used in western blot to report that the pathogenesis of motor neuron disease is independent of the Cdk5 activation by p35 or p25.
Mon Mar 01 00:00:00 UTC 2004
Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene.
Journal of neuropathology and experimental neurology
Vidal R,Ghetti B,Takao M,Brefel-Courbon C,Uro-Coste E,Glazier BS,Siani V,Benson MD,Calvas P,Miravalle L,Rascol O,Delisle MB
MN1020 was used in immunohistochemistry to investigate ferritin accumulation in neurodegenerative diseases
Thu Apr 01 00:00:00 UTC 2004
Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival.
The Journal of biological chemistry
Shimura H,Miura-Shimura Y,Kosik KS
MN1020 was used in western blot to investigate the influence of heat shock protein 27 interaction with tau on tau phosphorylation and cell survival
Fri Apr 23 00:00:00 UTC 2004
Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders.
Brain : a journal of neurology
Schofield E,Kersaitis C,Shepherd CE,Kril JJ,Halliday GM
MN1020 was used in immunocytochemistry to characterize the tau protein in Pick disease and frontotemporal lobar degeneration
Tue Apr 01 00:00:00 UTC 2003
14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex.
The Journal of biological chemistry
Agarwal-Mawal A,Qureshi HY,Cafferty PW,Yuan Z,Han D,Lin R,Paudel HK
MN1020 was used in western blot to investigate the role of 14-3-3 in tau function in brain
Fri Apr 11 00:00:00 UTC 2003
Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules.
The Journal of biological chemistry
Takahashi S,Saito T,Hisanaga S,Pant HC,Kulkarni AB
MN1020 was used in western blot to report that tau is phosphorylated by Cdk5/p39 during brain development.
Fri Mar 21 00:00:00 UTC 2003
Ubiquitin-positive neuronal and tau 2-positive glial inclusions in frontotemporal dementia of motor neuron type.
Acta neuropathologica
Forno LS,Langston JW,Herrick MK,Wilson JD,Murayama S
MN1020 was used in immunohistochemistry (paraffin) to discuss classification of fronto-temporal dementias.
Sat Jun 01 00:00:00 UTC 2002
The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease.
Neuropathology and applied neurobiology
Cottrell DA,Borthwick GM,Johnson MA,Ince PG,Turnbull DM
MN1020 was used in immunohistochemistry to study the effect of cytochrome c oxidase deficiency in Alzheimer hippocampal neurons
Tue Oct 01 00:00:00 UTC 2002
Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age.
Neurobiology of aging
Cottrell DA,Blakely EL,Johnson MA,Ince PG,Borthwick GM,Turnbull DM
MN1020 was used in immunocytochemistry to study the role of age in cytochrome c oxidase deficient cells in the hippocampus and choroid plexus
Thu May 03 00:00:00 UTC 2001
PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons.
Journal of neurochemistry
Rapoport M,Ferreira A
MN1020 was used in western blot to investigate the signal transduction pathway activated by fibrillar Abeta.
Sat Jan 01 00:00:00 UTC 2000
