Invitrogen

Phospho-TrkC (Tyr705) Polyclonal Antibody

View all (46) TrkC antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-99562

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NTRK3(Accession Q16288), corresponding to amino acid residues around phosphorylated Tyr705.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818495

Product Specific Information

Antibody detects endogenous levels of TrkC only when phosphorylated at Tyr705.

Target Information

NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; neural receptor protein-tyrosine kinase (trkC); Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin-3; NT-3 growth factor receptor; Trk-C; TrkC tyrosine kinase; tyrosine kinase receptor C

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Gene Aliases: AW125844; gp145(trkC); GP145-TrkC; NTRK3; Ntrk3_tv3; TRKC

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UniProt ID: (Human) Q16288, (Mouse) Q6VNS1, (Rat) Q03351

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Entrez Gene ID: (Human) 4916, (Mouse) 18213, (Rat) 29613

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Function(s)
p53 binding GPI-linked ephrin receptor activity neurotrophin receptor activity protein binding ATP binding neurotrophin binding nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups ephrin receptor binding
Process(es)
activation of MAPK activity neuron migration negative regulation of protein phosphorylation protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development positive regulation of cell proliferation positive regulation of gene expression phosphorylation cell differentiation positive regulation of cell migration activation of protein kinase B activity positive regulation of peptidyl-serine phosphorylation neurotrophin signaling pathway mechanoreceptor differentiation positive regulation of apoptotic process protein autophosphorylation neuron fate specification positive regulation of axon extension involved in regeneration negative regulation of astrocyte differentiation positive regulation of positive chemotaxis positive regulation of synapse assembly negative regulation of cell death lens fiber cell differentiation activation of GTPase activity positive regulation of actin cytoskeleton reorganization positive regulation of protein phosphorylation heart development circadian rhythm peptidyl-tyrosine phosphorylation modulation by virus of host transcription response to ethanol ephrin receptor signaling pathway response to axon injury response to corticosterone cellular response to retinoic acid cochlea development
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