Invitrogen

Phospho-VANGL2 (Thr78, Ser79, Ser82) Recombinant Rabbit Monoclonal Antibody (7H7C2)

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View all (12) VANGL2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-38241

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 1 publication 1 publication

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

7H7C2

Immunogen

A phospho specific peptide corresponding to residues surrounding T78/S79/S82 of human VANGL2
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898157

Product Specific Information

Positive Samples: HeLa, NIH/3T3, C6

Immunogen sequence: TSEHS

Target Information

Van Gogh is an alternate name for the Drosophila strabismus protein. Van Gogh like-2 (VANGL2) is a 521 amino acidprotein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-disheveled tissue polarity pathway. It interacts through it's C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3 and is a potent tumor suppressor. It ispredominantly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process. It is expressed in a wide range of tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: loop tail associated protein; Loop-tail protein 1; Loop-tail protein 1 homolog; Loop-tail-associated protein; MGC119403; MGC119404; Strabismus 1; Van Gogh-like protein 2; vang; vang (van gogh)-like 2; vang-like 2 (van gogh, Drosophila); Vang-like protein 2; vangl2 {ECO:0000312|RGD:1309442}

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Gene Aliases: C530001F03Rik; KIAA1215; loop-tail; Lp; LPP1; LTAP; ska17; ska; STB1; STBM; STBM1; strabismus; Vang1l2; VANGL2

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UniProt ID: (Human) Q9ULK5, (Rat) P84889, (Mouse) Q91ZD4

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Entrez Gene ID: (Human) 57216, (Rat) 289229, (Mouse) 93840

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Function(s)
protein binding molecular_function
Process(es)
establishment of planar polarity neural tube closure hair follicle development heart looping membranous septum morphogenesis muscular septum morphogenesis planar cell polarity pathway involved in axis elongation Rho protein signal transduction anterior/posterior pattern specification heparan sulfate proteoglycan biosynthetic process convergent extension involved in neural plate elongation regulation of Wnt signaling pathway glomerulus development regulation of actin cytoskeleton organization somatic stem cell population maintenance nonmotile primary cilium assembly cell migration involved in kidney development post-anal tail morphogenesis dopaminergic neuron axon guidance serotonergic neuron axon guidance wound healing positive regulation of JUN kinase activity apical protein localization establishment or maintenance of epithelial cell apical/basal polarity somatic stem cell division establishment of body hair planar orientation digestive tract morphogenesis convergent extension involved in axis elongation inner ear receptor stereocilium organization orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis planar dichotomous subdivision of terminal units involved in lung branching morphogenesis lateral sprouting involved in lung morphogenesis kidney morphogenesis planar cell polarity pathway involved in heart morphogenesis cochlea morphogenesis establishment of planar polarity involved in neural tube closure planar cell polarity pathway involved in neural tube closure biological_process non-canonical Wnt signaling pathway convergent extension involved in organogenesis Wnt signaling pathway, planar cell polarity pathway inner ear receptor cell development cochlea development regulation of establishment of planar polarity patterning of blood vessels outflow tract septum morphogenesis epicardial cell to mesenchymal cell transition multicellular organism development cardiac vascular smooth muscle cell differentiation establishment of epithelial cell polarity
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