Invitrogen

Phospho-beta-2 Adrenergic Receptor (Ser346) Polyclonal Antibody

View all (42) beta-2 Adrenergic Receptor antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-104767

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ADRB2(Accession P07550), corresponding to amino acid residues around phosphorylated Ser346.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816240

Product Specific Information

Antibody detects endogenous levels of ADRB2 only when phosphorylated at Serine 346.

Target Information

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Adrenergic beta 2- receptor surface; adrenergic receptor, beta 2; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; adrenoceptor beta 2, surface; AR beta2; beta 2-AR; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; beta2-Adrenoreceptor; catecholamine receptor; HGNC:286

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Gene Aliases: Adrb-2; ADRB2; ADRB2R; ADRBR; B2AR; Badm; BAR; BETA2AR; Gpcr7

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UniProt ID: (Human) P07550, (Mouse) P18762

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Entrez Gene ID: (Human) 154, (Mouse) 11555, (Rat) 24176

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Function(s)
G-protein alpha-subunit binding beta2-adrenergic receptor activity protein binding drug binding adenylate cyclase binding potassium channel regulator activity B2 bradykinin receptor binding protein complex binding dopamine binding ionotropic glutamate receptor binding protein homodimerization activity epinephrine binding norepinephrine binding signal transducer activity G-protein coupled receptor activity adrenergic receptor activity enzyme binding PDZ domain binding
Process(es)
diet induced thermogenesis vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure desensitization of G-protein coupled receptor protein signaling pathway by arrestin diaphragm contraction positive regulation of the force of heart contraction by epinephrine receptor-mediated endocytosis cell surface receptor signaling pathway activation of transmembrane receptor protein tyrosine kinase activity adenylate cyclase-modulating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity cell-cell signaling female pregnancy aging positive regulation of cell proliferation associative learning endosome to lysosome transport response to cold positive regulation of sodium ion transport negative regulation of angiogenesis negative regulation of ossification positive regulation of bone mineralization positive regulation of protein ubiquitination heat generation response to progesterone positive regulation of ATPase activity response to testosterone synaptic transmission, glutamatergic negative regulation of urine volume negative regulation of multicellular organism growth wound healing positive regulation of apoptotic process positive regulation of potassium ion transport positive regulation of MAPK cascade response to estrogen estrous cycle bone resorption positive regulation of vasodilation positive regulation of transcription from RNA polymerase II promoter negative regulation of smooth muscle contraction positive regulation of skeletal muscle tissue growth negative regulation of inflammatory response brown fat cell differentiation regulation of calcium ion transport regulation of sensory perception of pain excitatory postsynaptic potential cellular response to hypoxia response to dexamethasone response to monoamine adenylate cyclase-activating adrenergic receptor signaling pathway negative regulation of platelet aggregation liver regeneration positive regulation of autophagosome maturation positive regulation of lipophagy positive regulation of mitophagy in response to mitochondrial depolarization regulation of systemic arterial blood pressure by norepinephrine-epinephrine regulation of sodium ion transport regulation of smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway regulation of vasodilation positive regulation of heart contraction adrenergic receptor signaling pathway mitophagy in response to mitochondrial depolarization response to hypoxia liver development
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