Invitrogen

Phospho-c-Abl (Tyr393) Recombinant Rabbit Monoclonal Antibody (19H22L15)

View all (54) c-Abl antibodies

Promotion

View available promotion(s)

Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

702334

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

19H22L15

Immunogen

Peptide corresponding to Human ABL1 (aa 390-397)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2632966

Product Specific Information

This antibody is predicted to react with Monkey, Horse, Dog and Bat

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns c-Abl into an oncogene. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for c-Abl. In chronic myelogenous leukemia and a subset of acute lymphoblastic leukemias, the c-Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The c-Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-ABL potentially regulates DNA repair by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Abelson murine leukemia oncogene; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Abl 1 antib; ABL2; ABLL; ARG; B30; bcr/c-abl oncogene protein; c-abl oncogene 1, receptor tyrosine kinase; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; RP11-83J21.1; Tyrosine kinase ARG; Tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene homolog 1

View more View less

Gene Aliases: ABL; ABL1; AI325092; bcr/abl; c-ABL; c-ABL1; E430008G22Rik; JTK7; p150; v-abl

View more View less

UniProt ID: (Human) P00519, (Mouse) P00520

View more View less

Entrez Gene ID: (Human) 25, (Mouse) 11350

View more View less

Function(s)
magnesium ion binding DNA binding actin monomer binding nicotinate-nucleotide adenylyltransferase activity protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein kinase C binding receptor binding protein binding ATP binding protein C-terminus binding SH3 domain binding syntaxin binding manganese ion binding actin filament binding mitogen-activated protein kinase binding proline-rich region binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein kinase binding protein domain specific binding metal ion binding delta-catenin binding
Process(es)
B-1 B cell homeostasis positive regulation of protein phosphorylation B cell proliferation involved in immune response transitional one stage B cell differentiation mismatch repair regulation of transcription, DNA-templated cellular protein modification process autophagy cellular response to DNA damage stimulus DNA damage induced protein phosphorylation response to oxidative stress cell cycle arrest mitotic nuclear division epidermal growth factor receptor signaling pathway positive regulation of cytosolic calcium ion concentration intrinsic apoptotic signaling pathway in response to DNA damage regulation of autophagy peptidyl-tyrosine phosphorylation cerebellum morphogenesis negative regulation of cell-cell adhesion microspike assembly actin cytoskeleton organization regulation of endocytosis regulation of cell adhesion negative regulation of BMP signaling pathway regulation of axon extension regulation of microtubule polymerization regulation of actin cytoskeleton organization positive regulation of osteoblast proliferation substrate adhesion-dependent cell spreading cellular response to oxidative stress platelet-derived growth factor receptor-beta signaling pathway peptidyl-tyrosine autophosphorylation Fc-gamma receptor signaling pathway involved in phagocytosis regulation of cell proliferation signal transduction in response to DNA damage positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling innate immune response establishment of protein localization negative regulation of mitotic cell cycle positive regulation of mitotic cell cycle alpha-beta T cell differentiation protein autophosphorylation spleen development thymus development collateral sprouting positive regulation of peptidyl-tyrosine phosphorylation activated T cell proliferation B cell receptor signaling pathway neuromuscular process controlling balance positive regulation of muscle cell differentiation positive regulation of release of sequestered calcium ion into cytosol positive regulation of oxidoreductase activity negative regulation of ubiquitin-protein transferase activity mitochondrial depolarization Bergmann glial cell differentiation cellular response to hydrogen peroxide negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide negative regulation of protein serine/threonine kinase activity actin filament branching positive regulation of interleukin-2 secretion negative regulation of phospholipase C activity positive regulation of neuron death positive regulation of interferon-gamma secretion regulation of extracellular matrix organization cellular response to dopamine positive regulation of microtubule binding positive regulation of actin filament binding activation of protein kinase C activity positive regulation of Wnt signaling pathway, planar cell polarity pathway regulation of cell motility regulation of actin cytoskeleton reorganization negative regulation of endothelial cell apoptotic process negative regulation of cellular senescence regulation of response to DNA damage stimulus DNA repair protein phosphorylation endocytosis phagocytosis apoptotic process cell adhesion phosphorylation cell migration B cell proliferation platelet-derived growth factor receptor signaling pathway regulation of cell cycle regulation of cellular senescence
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support