Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Phospho-p57 Kip2 (Thr310) Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 2
Phospho-p57 Kip2 (Thr310) Antibody (PA5-114613) in IHC (P)
Immunohistochemistry analysis of Phospho-p57 Kip2 (Thr310) in human mammary cancer and adjacent normal tissues. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-114613) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-114613
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human p57 Kip2 around the phosphorylation site of Thr310.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899249
Product Specific Information
Antibody detects endogenous levels of p57 Kip2 only when phosphorylated at Thr310.
Target Information
This gene is part of a gene cluster on chromosome Xp11.23. The encoded protein contains a zinc finger motif often found in transcriptional regulators, however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Beckwith Wiedemann syndrome (WBS); Cyclin dependent kinase inhibitor 1C (CDKN1C); Cyclin-dependent kinase inhibitor 1C; cyclin-dependent kinase inhibitor 1C (p57, Kip2); Cyclin-dependent kinase inhibitor p57; IMAGE; p57 Kip2; p57Kip2
Gene Aliases: BWCR; BWS; CDKN1C; KIP2; p57; p57Kip2; WBS
UniProt ID: (Human) P49918
Entrez Gene ID: (Human) 1028
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
kidney development
cell cycle arrest
regulation of mitotic cell cycle
aging
myeloid cell differentiation
adrenal gland development
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of kinase activity
multicellular organism growth
negative regulation of phosphorylation
neuron maturation
camera-type eye development
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of epithelial cell proliferation
digestive system development
uterus development
embryonic placenta morphogenesis
genetic imprinting
negative regulation of protein serine/threonine kinase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support