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Invitrogen
Phospho-p70 S6 Kinase (Thr421) Recombinant Rabbit Monoclonal Antibody (0Y3C7)
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Product Details
MA5-38224
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
0Y3C7
Immunogen
A synthesized peptide derived from human Phospho-S6K1 (T421 + S424)
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898140
Product Specific Information
Positive Samples: NIH/3T3, C6
Immunogen sequence: TPVSP
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with 2 non-identical kinase catalytic domains which phosphorylates several residues of the S6 ribosomal protein. p70 S6 kinase is predominantly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 70 kDa ribosomal protein S6 kinase 1; EC 2.7.11.1; kinase p70S6K; KS6B1; p70 p70-S6K; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6 kinase, alpha; p70 S6K-alpha; p70 S6KA; p70(S6K)-alpha; p70-S6K 1; P70S6K; p70S6K-alpha; P70S6K1; p80-S6K 1; p85 p85S6K; Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kD, polypeptide 1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; S6 kinase; S6K; S6K-beta-1; S6K1; serine/threonine kinase 14 alpha; Serine/threonine-protein kinase 14A
Gene Aliases: 2610318I15Rik; 4732464A07Rik; 70kDa; AA959758; AI256796; AI314060; p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; p70/85s6k; p70s6k; PS6K; RPS6KB1; S6K; S6K-beta-1; S6K1; STK14A
UniProt ID: (Human) P23443, (Mouse) Q8BSK8, (Rat) P67999
Entrez Gene ID: (Human) 6198, (Mouse) 72508, (Rat) 83840
protein kinase activity
ribosomal protein S6 kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
kinase activity
PDZ domain binding
peptide binding
identical protein binding
protein phosphatase 2A binding
nucleotide binding
protein serine/threonine kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
G1/S transition of mitotic cell cycle
behavioral fear response
regulation of translation
protein phosphorylation
apoptotic process
cell cycle
signal transduction
germ cell development
positive regulation of smooth muscle cell migration
phosphorylation
TOR signaling
response to insulin
cellular response to insulin stimulus
response to tumor necrosis factor
negative regulation of apoptotic process
protein kinase B signaling
positive regulation of translation
positive regulation of mitotic cell cycle
positive regulation of translational initiation
regulation of glucose import
negative regulation of insulin receptor signaling pathway
positive regulation of skeletal muscle tissue growth
positive regulation of smooth muscle cell proliferation
cellular response to growth factor stimulus
cellular response to organic cyclic compound
negative regulation of extrinsic apoptotic signaling pathway
skeletal muscle contraction
aging
response to nutrient
long-term memory
response to heat
response to wounding
response to mechanical stimulus
response to toxic substance
response to glucose
skeletal muscle atrophy
response to electrical stimulus involved in regulation of muscle adaptation
cell migration
response to lipopolysaccharide
cellular response to hormone stimulus
response to testosterone
response to glucagon
response to drug
response to leucine
response to ethanol
phosphatidylinositol-mediated signaling
response to glucocorticoid
response to organic substance
response to organonitrogen compound
response to organic cyclic compound
response to amino acid
response to peptide hormone
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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