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Invitrogen
Phospho-p73 (Thr86) Polyclonal Antibody
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Product Details
PA5-64698
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human p73 (Phospho-Thr86)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2662075
Product Specific Information
Phospho-p73 (Thr86) Polyclonal Antibody detects endogenous levels of p73 only when phosphorylated at Thr86.
Target Information
P73 (TP73) participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; RP23-254N4.10; Tumor protein p73
Gene Aliases: P73; TP73
UniProt ID: (Human) O15350
Entrez Gene ID: (Human) 7161
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
p53 binding
chromatin binding
damaged DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein kinase binding
identical protein binding
transcription regulatory region DNA binding
metal ion binding
negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
kidney development
mismatch repair
transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
cell cycle arrest
regulation of mitotic cell cycle
intrinsic apoptotic signaling pathway in response to DNA damage
response to X-ray
response to organonitrogen compound
response to gamma radiation
regulation of gene expression
viral process
mitotic G1 DNA damage checkpoint
cellular response to UV
response to drug
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
negative regulation of JUN kinase activity
negative regulation of neuron apoptotic process
negative regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of oligodendrocyte differentiation
protein tetramerization
negative regulation of cardiac muscle cell proliferation
positive regulation of cell cycle arrest
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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