Product References
RANKL Inhibition Reduces Cardiac Hypertrophy in mdx Mice and Possibly in Children with Duchenne Muscular Dystrophy.
Cells
Marcadet L,Juracic ES,Khan N,Bouredji Z,Yagita H,Ward LM,Tupling AR,Argaw A,Frenette J
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Sat Jun 03 00:00:00 UTC 2023
Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca2+ mishandling and atrial fibrosis in active immunization rabbit models.
Clinical science (London, England : 1979)
Sun H,Song J,Li K,Li Y,Shang L,Zhou Q,Lu Y,Zong Y,He X,Kari M,Yang H,Zhou X,Zhang L,Tang B
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Tue Jan 31 00:00:00 UTC 2023
CaMKII and reactive oxygen species contribute to early reperfusion arrhythmias, but oxidation of CaMKIIδ at methionines 281/282 is not a determining factor.
Journal of molecular and cellular cardiology
Haugsten Hansen M,Sadredini M,Hasic A,Anderson ME,Sjaastad I,Korseberg Stokke M
MA3-922 was used in Western Blotting to investigate the role of oxidized-CaMKIIδ (Ox-CaMKIIδ) in early ischemia-reperfusion arrhythmias (IRA).
Wed Feb 01 00:00:00 UTC 2023
Ketogenic Diet Regulates Cardiac Remodeling and Calcium Homeostasis in Diabetic Rat Cardiomyopathy.
International journal of molecular sciences
Lee TI,Trang NN,Lee TW,Higa S,Kao YH,Chen YC,Chen YJ
MA3-922 was used in Western Blot to investigate the effects of a KD on Ca2+ homeostasis and electrophysiology in diabetic cardiomyopathy.
Thu Nov 09 00:00:00 UTC 2023
Skeletal muscle overexpression of sAnk1.5 in transgenic mice does not predispose to type 2 diabetes.
Scientific reports
Pierantozzi E,Raucci L,Buonocore S,Rubino EM,Ding Q,Laurino A,Fiore F,Soldaini M,Chen J,Rossi D,Vangheluwe P,Chen H,Sorrentino V
MA3-922 was used in Western Blotting to indicate that sAnk1.5 overexpression in skeletal muscle does not predispose mice to T2D susceptibility.
Sat May 20 00:00:00 UTC 2023
Physiological calcium combined with electrical pacing accelerates maturation of human engineered heart tissue.
Stem cell reports
Shen S,Sewanan LR,Shao S,Halder SS,Stankey P,Li X,Campbell SG
MA3-922 was used in Western Blotting to present a method whereby maturation of hiPSC-CMs can be accelerated by simultaneous application of physiological Ca2+ and frequency-ramped electrical pacing in culture.
Tue Sep 13 00:00:00 UTC 2022
Physiological calcium combined with electrical pacing accelerates maturation of human engineered heart tissue.
Stem cell reports
Shen S,Sewanan LR,Shao S,Halder SS,Stankey P,Li X,Campbell SG
MA3-922 was used in Western Blotting to present a method whereby maturation of hiPSC-CMs can be accelerated by simultaneous application of physiological Ca2+ and frequency-ramped electrical pacing in culture.
Tue Sep 13 00:00:00 UTC 2022
The activin receptor ligand trap ActRIIB:ALK4-Fc ameliorates cardiomyopathy induced by neuromuscular disease and diabetes.
FEBS letters
Li J,Fredericks M,Tang M,Cannell M,Joshi S,Kumar R,Andre P,Suragani RNVS
MA3-922 was used in Western Blot to explore the effects of activin ligand inhibition using ActRIIB:ALK4-Fc, a heterodimeric receptor fusion protein, in two mechanistically distinct murine models of cardiomyopathy.
Thu Dec 01 00:00:00 UTC 2022
Heterozygous SOD2 deletion selectively impairs SERCA function in the soleus of female mice.
Physiological reports
Braun JL,Messner HN,Cleverdon REG,Baranowski RW,Hamstra SI,Geromella MS,Stuart JA,Fajardo VA
MA3-922 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to study the heterozygous SOD2 deletion in female mice.
Sun May 01 00:00:00 UTC 2022
Characterizing SERCA Function in Murine Skeletal Muscles after 35-37 Days of Spaceflight.
International journal of molecular sciences
Braun JL,Geromella MS,Hamstra SI,Messner HN,Fajardo VA
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Fri Oct 29 00:00:00 UTC 2021
Breast Cancer Promotes Cardiac Dysfunction Through Deregulation of Cardiomyocyte Ca2+-Handling Protein Expression That is Not Reversed by Exercise Training.
Journal of the American Heart Association
da Costa TSR,Urias U,Negrao MV,Jordão CP,Passos CS,Gomes-Santos IL,Salemi VMC,Camargo AA,Brum PC,Oliveira EM,Hajjar LA,Chammas R,Filho RK,Negrao CE
MA3-922 was used in Western Blot to conclude that breast cancer is associated with decreased exercise capacity and subclinical left ventricular dysfunction in MMTV-PyMT+, which is at least partly associated with dysregulation of cardiomyocyte Ca2+ handling.
Mon Feb 01 00:00:00 UTC 2021
Breast Cancer Promotes Cardiac Dysfunction Through Deregulation of Cardiomyocyte Ca2+-Handling Protein Expression That is Not Reversed by Exercise Training.
Journal of the American Heart Association
da Costa TSR,Urias U,Negrao MV,Jordão CP,Passos CS,Gomes-Santos IL,Salemi VMC,Camargo AA,Brum PC,Oliveira EM,Hajjar LA,Chammas R,Filho RK,Negrao CE
MA3-922 was used in Western Blot to conclude that breast cancer is associated with decreased exercise capacity and subclinical left ventricular dysfunction in MMTV-PyMT+, which is at least partly associated with dysregulation of cardiomyocyte Ca2+ handling.
Mon Feb 01 00:00:00 UTC 2021
Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel.
Nature communications
Liu D,Song AT,Qi X,van Vliet PP,Xiao J,Xiong F,Andelfinger G,Nattel S
MA3-922 was used in Immunoprecipitation to reveal a critical non-canonical, cohesin-independent role for Shugoshin-1 in maintaining cardiac automaticity, offering a potential therapeutic avenue for cardiac pacemaking disorders.
Wed May 05 00:00:00 UTC 2021
Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel.
Nature communications
Liu D,Song AT,Qi X,van Vliet PP,Xiao J,Xiong F,Andelfinger G,Nattel S
MA3-922 was used in Immunoprecipitation to reveal a critical non-canonical, cohesin-independent role for Shugoshin-1 in maintaining cardiac automaticity, offering a potential therapeutic avenue for cardiac pacemaking disorders.
Wed May 05 00:00:00 UTC 2021
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy.
Nature communications
Grote Beverborg N,Später D,Knöll R,Hidalgo A,Yeh ST,Elbeck Z,Silljé HHW,Eijgenraam TR,Siga H,Zurek M,Palmér M,Pehrsson S,Albery T,Bomer N,Hoes MF,Boogerd CJ,Frisk M,van Rooij E,Damle S,Louch WE,Wang QD,Fritsche-Danielson R,Chien KR,Hansson KM,Mullick AE,de Boer RA,van der Meer P
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Immunocytochemistry
Mon Aug 30 00:00:00 UTC 2021
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy.
Nature communications
Grote Beverborg N,Später D,Knöll R,Hidalgo A,Yeh ST,Elbeck Z,Silljé HHW,Eijgenraam TR,Siga H,Zurek M,Palmér M,Pehrsson S,Albery T,Bomer N,Hoes MF,Boogerd CJ,Frisk M,van Rooij E,Damle S,Louch WE,Wang QD,Fritsche-Danielson R,Chien KR,Hansson KM,Mullick AE,de Boer RA,van der Meer P
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Immunocytochemistry
Mon Aug 30 00:00:00 UTC 2021
Interleukin-6-Mediated-Ca2+ Handling Abnormalities Contributes to Atrial Fibrillation in Sterile Pericarditis Rats.
Frontiers in immunology
Liao J,Zhang S,Yang S,Lu Y,Lu K,Wu Y,Wu Q,Zhao N,Dong Q,Chen L,Du Y
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Mon Feb 14 00:00:00 UTC 2022
Interleukin-6-Mediated-Ca2+ Handling Abnormalities Contributes to Atrial Fibrillation in Sterile Pericarditis Rats.
Frontiers in immunology
Liao J,Zhang S,Yang S,Lu Y,Lu K,Wu Y,Wu Q,Zhao N,Dong Q,Chen L,Du Y
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Mon Feb 14 00:00:00 UTC 2022
The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1.
Physiological reports
Sadredini M,Manotheepan R,Lehnart SE,Anderson ME,Sjaastad I,Stokke MK
MA3-922 was used in Western Blotting to test whether an oxidation-resistant form of CaMKII protects mice carrying the CPVT1-causative mutation RyR2-R2474S (RyR2-RS) against arrhythmias.
Wed Sep 01 00:00:00 UTC 2021
PDE1 Inhibition Modulates Cav1.2 Channel to Stimulate Cardiomyocyte Contraction.
Circulation research
Muller GK,Song J,Jani V,Wu Y,Liu T,Jeffreys WPD,O'Rourke B,Anderson ME,Kass DA
MA3-922 was used in Western Blot to determine signaling mecchanisms between b-ARs, PDE1, and cAMP.
Fri Oct 15 00:00:00 UTC 2021
Changes in Thyroid Hormone Signaling Mediate Cardiac Dysfunction in the Tg197 Mouse Model of Arthritis: Potential Therapeutic Implications.
Journal of clinical medicine
Ntari L,Mantzouratou P,Katsaouni A,Pantos C,Kollias G,Mourouzis I
MA3-922 was used in Immunohistochemistry-immunofluorescence to investigate possible causes of cardiac dysfunction related to thyroid hormone (TH) signaling in a Rheumatoid Arthritis mouse model.
Thu Nov 25 00:00:00 UTC 2021
Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase.
Circulation research
Xie D,Geng L,Xiong K,Zhao T,Wang S,Xue J,Wang C,Wang G,Feng Z,Zhou H,Li Y,Li L,Liu Y,Xue Z,Yang J,Ma H,Liang D,Chen YH
MA3-922 was used in Western Blot to indicate that cold-inducible RNA-binding protein acts as an mRNA stabilizer involved in the regulation of the heart rate stress response.
Fri Jun 05 00:00:00 UTC 2020
Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase.
Circulation research
Xie D,Geng L,Xiong K,Zhao T,Wang S,Xue J,Wang C,Wang G,Feng Z,Zhou H,Li Y,Li L,Liu Y,Xue Z,Yang J,Ma H,Liang D,Chen YH
MA3-922 was used in Western Blot to indicate that cold-inducible RNA-binding protein acts as an mRNA stabilizer involved in the regulation of the heart rate stress response.
Fri Jun 05 00:00:00 UTC 2020
Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells.
Stem cells (Dayton, Ohio)
Liang W,Han P,Kim EH,Mak J,Zhang R,Torrente AG,Goldhaber JI,Marbán E,Cho HC
MA3-922 was used in Western Blot to investigate the mechanisms for nodal pacemaker cell commitment.
Sun Mar 01 00:00:00 UTC 2020
Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes.
Journal of molecular medicine (Berlin, Germany)
Pabel S,Reetz F,Dybkova N,Shomroni O,Salinas G,Mustroph J,Hammer KP,Hasenfuss G,Hamdani N,Maier LS,Streckfuss-Bömeke K,Sossalla S
MA3-922 was used in Western Blotting to investigate the long-term effects (up to 2 months) of empagliflozin on excitation-contraction (EC)-coupling in human cardiomyocytes derived from induced pluripotent stem cells (iPSC-CM) in a blinded manner.
Tue Dec 01 00:00:00 UTC 2020
Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes.
Journal of molecular medicine (Berlin, Germany)
Pabel S,Reetz F,Dybkova N,Shomroni O,Salinas G,Mustroph J,Hammer KP,Hasenfuss G,Hamdani N,Maier LS,Streckfuss-Bömeke K,Sossalla S
MA3-922 was used in Western Blotting to investigate the long-term effects (up to 2 months) of empagliflozin on excitation-contraction (EC)-coupling in human cardiomyocytes derived from induced pluripotent stem cells (iPSC-CM) in a blinded manner.
Tue Dec 01 00:00:00 UTC 2020
The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy.
Scientific reports
Eijgenraam TR,Boukens BJ,Boogerd CJ,Schouten EM,van de Kolk CWA,Stege NM,Te Rijdt WP,Hoorntje ET,van der Zwaag PA,van Rooij E,van Tintelen JP,van den Berg MP,van der Meer P,van der Velden J,Silljé HHW,de Boer RA
MA3-922 was used in Immunohistochemistry to generate a novel mouse model with the PLN-R14del pathogenic variant, performe detailed phenotyping, and test the efficacy of established heart failure therapies eplerenone or metoprolol.
Wed Jun 17 00:00:00 UTC 2020
The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy.
Scientific reports
Eijgenraam TR,Boukens BJ,Boogerd CJ,Schouten EM,van de Kolk CWA,Stege NM,Te Rijdt WP,Hoorntje ET,van der Zwaag PA,van Rooij E,van Tintelen JP,van den Berg MP,van der Meer P,van der Velden J,Silljé HHW,de Boer RA
MA3-922 was used in Immunohistochemistry to generate a novel mouse model with the PLN-R14del pathogenic variant, performe detailed phenotyping, and test the efficacy of established heart failure therapies eplerenone or metoprolol.
Wed Jun 17 00:00:00 UTC 2020
Low-dose lithium feeding increases the SERCA2a-to-phospholamban ratio, improving SERCA function in murine left ventricles.
Experimental physiology
Hamstra SI,Kurgan N,Baranowski RW,Qiu L,Watson CJF,Messner HN,MacPherson REK,MacNeil AJ,Roy BD,Fajardo VA
MA3-922 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to suggest that low-dose lithium supplementation can improve SERCA function by increasing the SERCA2a:PLN ratio.
Wed Apr 01 00:00:00 UTC 2020
Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation-remodeled hearts.
JCI insight
Liu T,Xiong F,Qi XY,Xiao J,Villeneuve L,Abu-Taha I,Dobrev D,Huang C,Nattel S
MA3-922 was used in Western Blotting to show reduced expression of total and phosphorylated ryanodine receptors and calsequestrin in AF and unchanged phospholamban/SERCA expression.
Tue Apr 07 00:00:00 UTC 2020
Phosphorylation of cardiac myosin-binding protein-C contributes to calcium homeostasis.
The Journal of biological chemistry
Kumar M,Haghighi K,Kranias EG,Sadayappan S
MA3-922 was used in Western Blotting to conclude that improvement of contractile deficits alone without improving calcium handling may be insufficient for effective management of heart failure.
Fri Aug 07 00:00:00 UTC 2020
Differential localizations of protein phosphatase 1 isoforms determine their physiological function in the heart.
Acta biochimica et biophysica Sinica
Liu R,Miller C,D'Annibale C,Vo K,Jacobs A
MA3-922 was used in Western Blotting to investigate the isoform-specific roles of protein phosphatase 1 in the heart.
Fri Mar 01 00:00:00 UTC 2019
Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload.
Scientific reports
Miranda-Silva D,Gonçalves-Rodrigues P,Almeida-Coelho J,Hamdani N,Lima T,Conceição G,Sousa-Mendes C,González A,Díez J,Linke WA,Leite-Moreira A,Falcão-Pires I
MA3-922 was used in Western Blotting to study the mechanism underlying the process of left ventricle reverse remodelling regarding myocardial structural, functional and molecular changes before the onset of heart failure symptoms.
Wed Feb 27 00:00:00 UTC 2019
Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload.
Scientific reports
Miranda-Silva D,Gonçalves-Rodrigues P,Almeida-Coelho J,Hamdani N,Lima T,Conceição G,Sousa-Mendes C,González A,Díez J,Linke WA,Leite-Moreira A,Falcão-Pires I
MA3-922 was used in Western Blotting to study the mechanism underlying the process of left ventricle reverse remodelling regarding myocardial structural, functional and molecular changes before the onset of heart failure symptoms.
Wed Feb 27 00:00:00 UTC 2019
Nanoscale reorganization of sarcoplasmic reticulum in pressure-overload cardiac hypertrophy visualized by dSTORM.
Scientific reports
Hadipour-Lakmehsari S,Driouchi A,Lee SH,Kuzmanov U,Callaghan NI,Heximer SP,Simmons CA,Yip CM,Gramolini AO
MA3-922 was used in Western Blotting to investigate the changes in the nanoscale organisation of sarcoplasmic reticulum proteins in pathological cardiac hypertrophy.
Mon May 27 00:00:00 UTC 2019
Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors.
Cardiovascular research
Valverde CA,Mazzocchi G,Di Carlo MN,Ciocci Pardo A,Salas N,Ragone MI,Felice JI,Cely-Ortiz A,Consolini AE,Portiansky E,Mosca S,Kranias EG,Wehrens XHT,Mattiazzi A
MA3-922 was used in Western Blotting to test the hypothesis that an increase in SR Ca2+ uptake is able to attenuate reperfusion arrhythmias and cardiac injury elicited by increased RyR2-Ser2814 phosphorylation.
Fri Mar 01 00:00:00 UTC 2019
Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure.
Circulation
Kushnir A,Santulli G,Reiken SR,Coromilas E,Godfrey SJ,Brunjes DL,Colombo PC,Yuzefpolskaya M,Sokol SI,Kitsis RN,Marks AR
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Tue Sep 11 00:00:00 UTC 2018
Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant.
Autophagy
Liu GS,Zhu H,Cai WF,Wang X,Jiang M,Essandoh K,Vafiadaki E,Haghighi K,Lam CK,Gardner G,Adly G,Nicolaou P,Sanoudou D,Liang Q,Rubinstein J,Fan GC,Kranias EG
MA3-922 was used in Western Blotting to reveal a novel regulatory mechanism of heat shock protein family B [small] member 6 in cell survival through its interaction with BECN1.
Tue Feb 26 00:00:00 UTC 2019
Three-dimensional imaging reveals endo(sarco)plasmic reticulum-containing invaginations within the nucleoplasm of muscle.
American journal of physiology. Cell physiology
Lee SH,Hadipour-Lakmehsari S,Miyake T,Gramolini AO
MA3-922 was used in Immunocytochemistry-immunoflourescence to characterise the molecular constituents of nuclear invaginations in the nucleoplasm in HEK293 cells, murine C2C12 muscle cells, and cardiac myocytes.
Thu Mar 01 00:00:00 UTC 2018
Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes.
Scientific reports
Ng KM,Lau YM,Dhandhania V,Cai ZJ,Lee YK,Lai WH,Tse HF,Siu CW
MA3-922 was used in Western Blotting to investigate whether empagliflozin exerts direct effects on cardiomyocytes that attenuate diabetic cardiomyopathy.
Fri Oct 05 00:00:00 UTC 2018
The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy.
eLife
Makarewich CA,Munir AZ,Schiattarella GG,Bezprozvannaya S,Raguimova ON,Cho EE,Vidal AH,Robia SL,Bassel-Duby R,Olson EN
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Tue Oct 09 00:00:00 UTC 2018
Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice.
Physiological reports
Rouet-Benzineb P,Merval R,Polidano E
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Thu Nov 01 00:00:00 UTC 2018
Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes.
Frontiers in physiology
Koyani CN,Trummer C,Shrestha N,Scheruebel S,Bourgeois B,Plastira I,Kickmaier S,Sourij H,Rainer PP,Madl T,Sattler W,Pelzmann B,Malle E,von Lewinski D
MA3-922 was used in Western Blotting to investigate whether dipeptidyl peptidase 8/9 contribute to saxagliptin-mediated inhibition of calmodulin-dependent protein kinase II and protein kinase C activity.
Wed Feb 14 00:00:00 UTC 2024
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy.
Cardiovascular research
Røe ÅT,Aronsen JM,Skårdal K,Hamdani N,Linke WA,Danielsen HE,Sejersted OM,Sjaastad I,Louch WE
MA3-922 was used in Western Blotting to dissect the contributions of passive and active mechanisms to diastolic dysfunction in the concentrically hypertrophied heart following pressure-overload.
Tue Aug 01 00:00:00 UTC 2017
Up-regulation of Intracellular Calcium Handling Underlies the Recovery of Endotoxemic Cardiomyopathy in Mice.
Anesthesiology
Morse JC,Huang J,Khona N,Miller EJ,Siwik DA,Colucci WS,Hobai IA
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Thu Jun 01 00:00:00 UTC 2017
High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts.
The Journal of physiology
Fu Q,Hu Y,Wang Q,Liu Y,Li N,Xu B,Kim S,Chiamvimonvat N,Xiang YK
MA3922 was used in western blot to evaluate the impacts of high fat diet on the insulin-adrenergic receptor signal network in hearts
Wed Mar 15 00:00:00 UTC 2017
Misregulation of calcium-handling proteins promotes hyperactivation of calcineurin-NFAT signaling in skeletal muscle of DM1 mice.
Human molecular genetics
Ravel-Chapuis A,Bélanger G,Côté J,Michel RN,Jasmin BJ
MA3-922 was used in Western Blotting to show that calcium-CnA signaling is hyperactivated in DM1 muscle and that such hyperactivation represents a beneficial compensatory adaptation to the disease.
Thu Jun 15 00:00:00 UTC 2017
Heart failure modulates electropharmacological characteristics of sinoatrial nodes.
Experimental and therapeutic medicine
Chang SL,Chuang HL,Chen YC,Kao YH,Lin YK,Yeh YH,Chen SA,Chen YJ
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Wed Feb 01 00:00:00 UTC 2017
Cardiac, Metabolic and Molecular Profiles of Sedentary Rats in the Initial Moment of Obesity.
Arquivos brasileiros de cardiologia
Jacobsen BB,Leopoldo APL,Cordeiro JP,Campos DHS,Nascimento AFD,Sugizaki MM,Cicogna AC,Padovani CR,Leopoldo AS
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Wed Nov 01 00:00:00 UTC 2017
Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction.
Scientific reports
Li Y,Baldwin TA,Wang Y,Subramaniam J,Carbajal AG,Brand CS,Cunha SR,Dessauer CW
MA3-922 was used in Western Blotting to determine the physiological role of adenylyl cyclase type 9 in the heart.
Mon Jul 17 00:00:00 UTC 2017
Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice.
PloS one
Fajardo VA,Gamu D,Mitchell A,Bloemberg D,Bombardier E,Chambers PJ,Bellissimo C,Quadrilatero J,Tupling AR
MA3922 was used in western blot to report the physiological role of sarcolipin upregulation in muscle myopathy
Wed Sep 06 00:00:00 UTC 2017
Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure.
Circulation research
Barbagallo F,Xu B,Reddy GR,West T,Wang Q,Fu Q,Li M,Shi Q,Ginsburg KS,Ferrier W,Isidori AM,Naro F,Patel HH,Bossuyt J,Bers D,Xiang YK
MA3-922 was used in Western Blotting to show that PKA activity is shifted from the sarcolemma to the myofilaments in hypertrophic failing rabbit myocytes.
Fri Sep 30 00:00:00 UTC 2016
TRPC4α and TRPC4β Similarly Affect Neonatal Cardiomyocyte Survival during Chronic GPCR Stimulation.
PloS one
Kirschmer N,Bandleon S,von Ehrlich-Treuenstätt V,Hartmann S,Schaaf A,Lamprecht AK,Miranda-Laferte E,Langsenlehner T,Ritter O,Eder P
MA3922 was used in western blot to analyze cardiomyocyte function in dependence of TRPC4 splice variant expression.
Mon Jul 10 00:00:00 UTC 2017
Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure.
PloS one
Sadredini M,Danielsen TK,Aronsen JM,Manotheepan R,Hougen K,Sjaastad I,Stokke MK
MA3-922 was used in western blot to investigate left ventricular cardiomyocytes from post-infaction rats with and without heart failure after beta-adrenoceptor stimulation to revela Ca2+ waves and sarcoplasmic reticulum Ca2+ depletion
Fri Sep 09 00:00:00 UTC 2016
Diaphragm assessment in mice overexpressing phospholamban in slow-twitch type I muscle fibers.
Brain and behavior
Fajardo VA,Smith IC,Bombardier E,Chambers PJ,Quadrilatero J,Tupling AR
MA3-922 was used in western blot to study slow-twitch type 1 muscle fibers and diaphragm assessment in mice overexpressing phospholamban
Wed Jun 01 00:00:00 UTC 2016
Interplay between the E2F pathway and β-adrenergic signaling in the pathological hypertrophic response of myocardium.
Journal of molecular and cellular cardiology
Major JL,Salih M,Tuana BS
MA3-922 was used in western blot to study the relationship between the E2F pathway, beta2-adrenergic/PKA/PDE4D, and ERK/c-Src axis during the pathological hypertrophic growth response
Wed Jul 01 00:00:00 UTC 2015
Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype.
Disease models & mechanisms
Fajardo VA,Bombardier E,McMillan E,Tran K,Wadsworth BJ,Gamu D,Hopf A,Vigna C,Smith IC,Bellissimo C,Michel RN,Tarnopolsky MA,Quadrilatero J,Tupling AR
MA3-922 was used in western blot to study SERCA dysfunction in mice overexpressing phospholamban
Sat Aug 01 00:00:00 UTC 2015
Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging.
American journal of physiology. Heart and circulatory physiology
Manning JR,Withers CN,Levitan B,Smith JD,Andres DA,Satin J
MA3-922 was used in Western Blotting to test the hypothesis that Rad deletion drives a stable non-failing hypercontractile phenotype in adult hearts.
Thu Oct 01 00:00:00 UTC 2015
Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats.
PloS one
Dalpiaz PL,Lamas AZ,Caliman IF,Ribeiro RF,Abreu GR,Moyses MR,Andrade TU,Gouvea SA,Alves MF,Carmona AK,Bissoli NS
MA3-922 was used in western blot to determine the relationship between ACE and ACE2 activity, left ventricular function, and gender in spontaneously hypertensive rats.
Mon Apr 18 00:00:00 UTC 2016
Atrial fibrillation complicated by heart failure induces distinct remodeling of calcium cycling proteins.
PloS one
Lugenbiel P,Wenz F,Govorov K,Schweizer PA,Katus HA,Thomas D
MA3-922 was used in Western Blotting to conclude that AF produced distinct arrhythmogenic remodeling of Ca2+ handling in the presence of tachycardia-induced mild HF that is different from AF without structural alterations.
Wed Jan 27 00:00:00 UTC 2016
Sex-specific cardiovascular responses to control or high fat diet feeding in C57bl/6 mice chronically exposed to bisphenol A.
Toxicology reports
Patel BB,Raad M,Sebag IA,Chalifour LE
MA3-922 was used in Western Blotting to show that chronic bisphenol A exposure alters cardiac contraction and relaxation and alters coordination of this contraction by the cardiac conduction system in mice.
Wed Sep 30 00:00:00 UTC 2020
Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model.
Circulation
Li N,Chiang DY,Wang S,Wang Q,Sun L,Voigt N,Respress JL,Ather S,Skapura DG,Jordan VK,Horrigan FT,Schmitz W,Müller FU,Valderrabano M,Nattel S,Dobrev D,Wehrens XHT
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Tue Mar 25 00:00:00 UTC 2014
Progesterone modulates SERCA2a expression and function in rabbit cardiomyocytes.
American journal of physiology. Cell physiology
Moshal KS,Zhang Z,Roder K,Kim TY,Cooper L,Patedakis Litvinov B,Lu Y,Reddy V,Terentyev D,Choi BR,Koren G
MA3-922 was used in western blot to study the effect of progesterone on SERCA2a regulation in isolated cardiomyocytes
Mon Dec 01 00:00:00 UTC 2014
The beneficial effects of ranolazine on cardiac function after myocardial infarction are greater in diabetic than in nondiabetic rats.
Journal of cardiovascular pharmacology and therapeutics
Mourouzis I,Mantzouratou P,Galanopoulos G,Kostakou E,Dhalla AK,Belardinelli L,Pantos C
MA3-922 was used in western blot to study the mechanisms underlying the greater therapeutic effect of ranolazine in diabetic than in non-diabetic infarcted rat heart
Mon Sep 01 00:00:00 UTC 2014
Obesity does not lead to imbalance between myocardial phospholamban phosphorylation and dephosphorylation.
Arquivos brasileiros de cardiologia
Freire PP,Alves CA,Deus AF,Leopoldo AP,Leopoldo AS,Silva DC,Tomasi LC,Campos DH,Cicogna AC
MA3-922 was used in western blot to learn that imbalance between myocardial phospholamban dephosphorylation and phosphorylation is not caused by obesity
Tue Jul 01 00:00:00 UTC 2014
Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts.
PloS one
Sivagangabalan G,Nazzari H,Bignolais O,Maguy A,Naud P,Farid T,Massé S,Gaborit N,Varro A,Nair K,Backx P,Vigmond E,Nattel S,Demolombe S,Nanthakumar K
MA3-922 was used in western blot to study the relationship between ventricular fibrillation and the regional expression of ion channels in the myopathic heart
Fri Oct 17 00:00:00 UTC 2014
Chronic exposure to low doses of HgCl2 avoids calcium handling impairment in the right ventricle after myocardial infarction in rats.
PloS one
Faria Tde O,Costa GP,Almenara CC,Angeli JK,Vassallo DV,Stefanon I,Vassallo PF
MA3-922 was used in western blot to study the normalization of right ventricular sarcolemmal calcium fluxes by chronic low-dose mercury chloride treatment following myocardial infarction in a rat model
Fri May 29 00:00:00 UTC 2015
Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a/PLN function.
Nature communications
Traister A,Li M,Aafaqi S,Lu M,Arab S,Radisic M,Gross G,Guido F,Sherret J,Verma S,Slorach C,Mertens L,Hui W,Roy A,Delgado-Olguín P,Hannigan G,Maynes JT,Coles JG
MA3-922 was used in Immunohistochemistry to show that integrin-linked kinase (ILK) mediates cardiomyocyte force transduction through regulation of sarcoplasmic/endoplasmic reticulum Ca(2+)ATPase isoform 2a (SERCA-2a) and phosphorylation of phospholamban (PLN) in the human heart.
Thu Sep 11 00:00:00 UTC 2014
Chronic lead exposure increases blood pressure and myocardial contractility in rats.
PloS one
Fioresi M,Simões MR,Furieri LB,Broseghini-Filho GB,Vescovi MV,Stefanon I,Vassallo DV
MA3-922 was used in western blot to study the elevated blood pressure and myocardial contractility of rats following chronic oral lead exposure
Wed Dec 31 00:00:00 UTC 2014
Measuring Ca2+-dependent Ca2+-uptake activity in the mouse heart.
Cold Spring Harbor protocols
Holemans T,Vandecaetsbeek I,Wuytack F,Vangheluwe P
MA3-922 was used in western blot to describe a protocol to determine the affinity of Ca(2+) to the Ca(2+) pump in crude homogenates of mouse heart.
Fri Aug 01 00:00:00 UTC 2014
Right ventricular pacing with mechanical dyssynchrony causes apoptosis interruptus and calcium mishandling.
The Canadian journal of cardiology
Klug D,Boule S,Wissocque L,Montaigne D,Marechal X,Hassoun SM,Neviere R
MA3-922 was used in western blot to study the effects on left ventricular apoptosis and calcium metabolism of right ventricular pacing with mechanical dyssynchrony
Mon Apr 01 00:00:00 UTC 2013
SERCA Cys674 sulphonylation and inhibition of L-type Ca2+ influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis.
American journal of physiology. Heart and circulatory physiology
Hobai IA,Buys ES,Morse JC,Edgecomb J,Weiss EH,Armoundas AA,Hou X,Khandelwal AR,Siwik DA,Brouckaert P,Cohen RA,Colucci WS
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Tue Oct 15 00:00:00 UTC 2013
Identifying cellular mechanisms of zinc-induced relaxation in isolated cardiomyocytes.
American journal of physiology. Heart and circulatory physiology
Yi T,Vick JS,Vecchio MJ,Begin KJ,Bell SP,Delay RJ,Palmer BM
MA3-922 was used in western blot to study the mechanisms underlying the effects of zinc on cardiomyocyte contraction-relaxation
Sun Sep 01 00:00:00 UTC 2013
Inhibition of thyroid hormone receptor α1 impairs post-ischemic cardiac performance after myocardial infarction in mice.
Molecular and cellular biochemistry
Mourouzis I,Kostakou E,Galanopoulos G,Mantzouratou P,Pantos C
MA3-922 was used in western blot to study the deleterious effect of pharmacological inhibition of thyroid hormone receptor alpha1 on post-ischemic cardiac function in a murine model of myocardial infarction
Mon Jul 01 00:00:00 UTC 2013
Cardiac structure/function, protein expression, and DNA methylation are changed in adult female mice exposed to diethylstilbestrol in utero.
Canadian journal of physiology and pharmacology
Haddad R,Kasneci A,Sebag IA,Chalifour LE
MA3-922 was used in western blot to study the effects of in utero exposure to diethylstilbestrol on adult mouse cardiac biology
Sun Sep 01 00:00:00 UTC 2013
Carvedilol prevents ovariectomy-induced myocardial contractile dysfunction in female rat.
PloS one
Ribeiro RF,Potratz FF,Pavan BM,Forechi L,Lima FL,Fiorim J,Fernandes AA,Vassallo DV,Stefanon I
MA3-922 was used in western blot to study the mechanism underlying the ability of carvedilol to protect against dysfunctional cardiac contractile function in rats following ovariectomy
Mon Jul 01 00:00:00 UTC 2013
Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers.
PloS one
Fajardo VA,Bombardier E,Vigna C,Devji T,Bloemberg D,Gamu D,Gramolini AO,Quadrilatero J,Tupling AR
MA3-922 was used in immunohistochemistry - frozen section, immunoprecipitation, and western blot to determine if sarcolipin and phospholamban regulate SERCA1a, SERCA2a, or both in skeletal muscle
Tue Sep 16 00:00:00 UTC 2014
Aldosterone blockade reduces mortality without changing cardiac remodeling in spontaneously hypertensive rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Cezar MD,Damatto RL,Martinez PF,Lima AR,Campos DH,Rosa CM,Guizoni DM,Bonomo C,Cicogna AC,Gimenes R,Pagan LU,Okoshi MP,Okoshi K
MA3-922 was used in Western Blotting to evaluate the effects of the early administration of spironolactone on cardiac remodelling, myocardial function, and mortality in spontaneously hypertensive rats.
Thu Aug 14 00:00:00 UTC 2014
Lifelong exposure to bisphenol a alters cardiac structure/function, protein expression, and DNA methylation in adult mice.
Toxicological sciences : an official journal of the Society of Toxicology
Patel BB,Raad M,Sebag IA,Chalifour LE
MA3-922 was used in western blot to study the effects on murine heart structure, function and molecular biology of lifelong exposure to polyphenol A
Wed May 01 00:00:00 UTC 2013
Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction.
Circulation
Gurha P,Abreu-Goodger C,Wang T,Ramirez MO,Drumond AL,van Dongen S,Chen Y,Bartonicek N,Enright AJ,Lee B,Kelm RJ,Reddy AK,Taffet GE,Bradley A,Wehrens XH,Entman ML,Rodriguez A
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Tue Jun 05 00:00:00 UTC 2012
Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart.
Circulation
Cutler MJ,Wan X,Plummer BN,Liu H,Deschenes I,Laurita KR,Hajjar RJ,Rosenbaum DS
MA3-922 was used in western blot to study the restoration of electrical stability and contractile function of the failing heart by gene transfer of SERCA2a in a guinea pig model
Tue Oct 23 00:00:00 UTC 2012
Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension.
Hypertension (Dallas, Tex. : 1979)
Xie YP,Chen B,Sanders P,Guo A,Li Y,Zimmerman K,Wang LC,Weiss RM,Grumbach IM,Anderson ME,Song LS
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Wed Feb 01 00:00:00 UTC 2012
Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective.
Heart rhythm
Odening KE,Choi BR,Liu GX,Hartmann K,Ziv O,Chaves L,Schofield L,Centracchio J,Zehender M,Peng X,Brunner M,Koren G
MA3-922 was used in western blot to study the ability of estradiol to promote and progesterone to protect against sudden cardiac death in a rabbit model of long QT type 2
Tue May 01 00:00:00 UTC 2012
Abnormalities of calcium handling proteins in skeletal muscle mirror those of the heart in humans with heart failure: a shared mechanism?
Journal of cardiac failure
Middlekauff HR,Vigna C,Verity MA,Fonarow GC,Horwich TB,Hamilton MA,Shieh P,Tupling AR
MA3-922 was used in western blot to investigate the abnormalities of calcium handling proteins in skeletal and heart muscle during heart failure
Sat Sep 01 00:00:00 UTC 2012
Functional scaffold-free 3-D cardiac microtissues: a novel model for the investigation of heart cells.
American journal of physiology. Heart and circulatory physiology
Desroches BR,Zhang P,Choi BR,King ME,Maldonado AE,Li W,Rago A,Liu G,Nath N,Hartmann KM,Yang B,Koren G,Morgan JR,Mende U
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Tue May 15 00:00:00 UTC 2012
Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training.
American journal of physiology. Heart and circulatory physiology
Calvé A,Haddad R,Barama SN,Meilleur M,Sebag IA,Chalifour LE
MA3-922 was used in Western Blotting to characterise doxorubicin cardiac damage, and determine the ability of dexrazoxane to reduce this damage.
Tue May 15 00:00:00 UTC 2012
Fosinopril attenuates the doxorubicin-induced cardiomyopathy by restoring the function of sarcoplasmic reticulum.
Cell biochemistry and biophysics
Zhang YC,Tang Y,Zhang M,Chen J,Zhou Q,Sun YG,Chen MT,Xu WP
MA3-922 was used in western blot to study the mechanism by which fosinapril protects against cardiomyopathy induced by treatment with doxorubicin
Sat Dec 01 00:00:00 UTC 2012
cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes.
Circulation research
Stangherlin A,Gesellchen F,Zoccarato A,Terrin A,Fields LA,Berrera M,Surdo NC,Craig MA,Smith G,Hamilton G,Zaccolo M
MA3-922 was used in Western Blotting to study the effect of cGMP signals on the local cAMP response to catecholamines in specific subcellular compartments.
Fri Apr 15 00:00:00 UTC 2011
cAMP- and Ca²(+) /calmodulin-dependent protein kinases mediate inotropic, lusitropic and arrhythmogenic effects of urocortin 2 in mouse ventricular myocytes.
British journal of pharmacology
Yang LZ,Kockskämper J,Khan S,Suarez J,Walther S,Doleschal B,Unterer G,Khafaga M,Mächler H,Heinzel FR,Dillmann WH,Pieske B,Spiess J
MA3-922 was used in western blot to study the signal transduction pathway of urocortin 2 in mouse ventricular myocytes
Sat Jan 01 00:00:00 UTC 2011
Angiotensin receptor blockade improves the net balance of cardiac Ca(2+) handling-related proteins in sympathetic hyperactivity-induced heart failure.
Life sciences
Ferreira JC,Moreira JB,Campos JC,Pereira MG,Mattos KC,Coelho MA,Brum PC
MA3-922 was used in western blot to study the effects on Ca(2+) metabolism of therapeutic blockade of angiotensin II type 1 receptors.
Mon Mar 28 00:00:00 UTC 2011
Baroreflex sensitivity impairment is associated with cardiac diastolic dysfunction in rats.
Journal of cardiac failure
Mostarda C,Moraes-Silva IC,Moreira ED,Medeiros A,Piratello AC,Consolim-Colombo FM,Caldini EG,Brum PC,Krieger EM,Irigoyen MC
MA3-922 was used in western blot to investigate the relationship between baroreflex dysfunction and heart diastolic function in rodents
Wed Jun 01 00:00:00 UTC 2011
Slowed relaxation and preserved maximal force in soleus muscles of mice with targeted disruption of the Serca2 gene in skeletal muscle.
The Journal of physiology
Sjåland C,Lunde PK,Swift F,Munkvik M,Ericsson M,Lunde M,Boye S,Christensen G,Ellingsen Ø,Sejersted OM,Andersson KB
MA3-922 was used in western blot to investigate the role of SERCAs in muscle contractile function
Thu Dec 15 00:00:00 UTC 2011
Silencing calcineurin A subunit reduces SERCA2 expression in cardiac myocytes.
American journal of physiology. Heart and circulatory physiology
Prasad AM,Inesi G
MA3-922 was used in immunocytochemistry and western blot to investigate the effect of calcineurin A subunit on SERCA2 expression in myocytes
Sat Jan 01 00:00:00 UTC 2011
Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes.
American journal of physiology. Heart and circulatory physiology
Horiuchi-Hirose M,Kashihara T,Nakada T,Kurebayashi N,Shimojo H,Shibazaki T,Sheng X,Yano S,Hirose M,Hongo M,Sakurai T,Moriizumi T,Ueda H,Yamada M
MA3-922 was used in western blot to investigate the mechanism for the decrease of the TT LTCC current density in failing ventricular myocytes
Tue Mar 01 00:00:00 UTC 2011
Prevention of ventricular arrhythmia and calcium dysregulation in a catecholaminergic polymorphic ventricular tachycardia mouse model carrying calsequestrin-2 mutation.
Journal of cardiovascular electrophysiology
Alcalai R,Wakimoto H,Arad M,Planer D,Konno T,Wang L,Seidman JG,Seidman CE,Berul CI
MA3-922 was used in western blot to identify therapeutic targets in ventricular arrhythmia and calcium dysregulation
Tue Mar 01 00:00:00 UTC 2011
Myocardial contractility is preserved early but reduced late after ovariectomy in young female rats.
Reproductive biology and endocrinology : RB&E
Paigel AS,Ribeiro RF,Fernandes AA,Targueta GP,Vassallo DV,Stefanon I
MA3-922 was used in western blot to investigate the effect of deficiency of ovarian sex hormones on myocardial contractility in rats after ovariectomy
Sat Apr 23 00:00:00 UTC 2011
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.
Circulation
van Oort RJ,McCauley MD,Dixit SS,Pereira L,Yang Y,Respress JL,Wang Q,De Almeida AC,Skapura DG,Anderson ME,Bers DM,Wehrens XH
MA3-922 was used in western blot to investigate the involvement of ryanodine receptor phosphorylation in ventricular arrhythmias
Tue Dec 21 00:00:00 UTC 2010
Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure.
Proceedings of the National Academy of Sciences of the United States of America
Kushnir A,Shan J,Betzenhauser MJ,Reiken S,Marks AR
Tue Jun 01 00:00:00 UTC 2010
Caspase-dependent protein phosphatase 2A activation contributes to endotoxin-induced cardiomyocyte contractile dysfunction.
Critical care medicine
Neviere R,Hassoun SM,Decoster B,Bouazza Y,Montaigne D,Maréchal X,Marciniak C,Marchetti P,Lancel S
MA3-922 was used in western blot to investigate the mechanism of intracellular calcium dysregulation caused by endotoxin
Fri Oct 01 00:00:00 UTC 2010
Succinate modulates Ca(2+) transient and cardiomyocyte viability through PKA-dependent pathway.
Cell calcium
Aguiar CJ,Andrade VL,Gomes ER,Alves MN,Ladeira MS,Pinheiro AC,Gomes DA,Almeida AP,Goes AM,Resende RR,Guatimosim S,Leite MF
MA3-922 was used in western blot to study the role of succinate in calcium homeostasis and cardiomyocyte viability
Fri Jan 01 00:00:00 UTC 2010
Thyroid hormone can favorably remodel the diabetic myocardium after acute myocardial infarction.
Molecular and cellular biochemistry
Kalofoutis C,Mourouzis I,Galanopoulos G,Dimopoulos A,Perimenis P,Spanou D,Cokkinos DV,Singh J,Pantos C
MA3-922 was used in western blot to investigate the effect of thyroid hormone on remodelling the diabetic myocardium
Wed Dec 01 00:00:00 UTC 2010
NADPH oxidase inhibition ameliorates cardiac dysfunction in rabbits with heart failure.
Molecular and cellular biochemistry
Liu Y,Huang H,Xia W,Tang Y,Li H,Huang C
MA3-922 was used in western blot to investigate the therapeutic effectiveness of NADPH oxidase inhibitor apocynin against heart failure in rabbits
Fri Oct 01 00:00:00 UTC 2010
Superior calcium homeostasis of extraocular muscles.
Experimental eye research
Zeiger U,Mitchell CH,Khurana TS
MA3-922 was used in western blot to investigate the effect of calcium buffering on extraocular muscles
Mon Nov 01 00:00:00 UTC 2010
Calsequestrin and junctin immunoreactivity in hexagonally cross-linked tubular arrays myopathy.
Neuromuscular disorders : NMD
Di Blasi C,Blasevich F,Bellafiore E,Mottarelli E,Gibertini S,Zanotti S,Saredi S,Mantegazza R,Morandi L,Mora M
MA3-922 was used in immunohistochemistry to investigate the immunohistochemical features of hexagonally cross-linked tubular arrays myopathy
Sat May 01 00:00:00 UTC 2010
More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease.
Journal of muscle research and cell motility
Hamdani N,Borbély A,Veenstra SP,Kooij V,Vrydag W,Zaremba R,Dos Remedios C,Niessen HW,Michel MC,Paulus WJ,Stienen GJ,van der Velden J
MA3-922 was used in western blot to investigate the different phenotypes between idiopathic dilated cardiomyopathy and ischemic heart disease
Wed Dec 01 00:00:00 UTC 2010
Cerebral ischemia elicits aberration in myocardium contractile function and intracellular calcium handling.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Sun L,Ai J,Wang N,Zhang R,Li J,Zhang T,Wu W,Hang P,Lu Y,Yang B
MA3-922 was used in western blot to investigate the effect of cerebral ischemia on myocardial dysfunction and calcium homeostasis
Wed Dec 08 00:00:00 UTC 2010
Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy.
Circulation
Aiba T,Hesketh GG,Barth AS,Liu T,Daya S,Chakir K,Dimaano VL,Abraham TP,O'Rourke B,Akar FG,Kass DA,Tomaselli GF
MA3-922 was used in Western Blotting to study how CRT partially restores DHF-induced ion channel remodeling and abnormal Ca(2+) homeostasis and attenuates the regional heterogeneity of action potential duration.
Tue Mar 10 00:00:00 UTC 2009
Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia.
Circulation research
Fernández-Velasco M,Rueda A,Rizzi N,Benitah JP,Colombi B,Napolitano C,Priori SG,Richard S,Gómez AM
MA3-922 was used in Western Blotting to analyze the underlying Ca(2+) release defect that leads to arrhythmia in cardiomyocytes isolated from heterozygous knock-in mice carrying the RyR2(R4496C) mutation.
Fri Jan 30 00:00:00 UTC 2009
Effects of thapsigargin and phenylephrine on calcineurin and protein kinase C signaling functions in cardiac myocytes.
American journal of physiology. Cell physiology
Prasad AM,Inesi G
MA3-922 was used in western blot and immunohistochemistry to study the alteration of calcineurin and protein kinase C signaling functions by thapsigargin and phenylephrine in cardiac myocytes.
Fri May 01 00:00:00 UTC 2009
Induced overexpression of Na+/Ca2+ exchanger transgene: altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents, and action potential duration.
American journal of physiology. Heart and circulatory physiology
Wang J,Chan TO,Zhang XQ,Gao E,Song J,Koch WJ,Feldman AM,Cheung JY
MA3-922 was used in western blot to study the phenotype of transgenic rats overexpressing sodium/calcium exchanger .
Sat Aug 01 00:00:00 UTC 2009
Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation.
Journal of applied physiology (Bethesda, Md. : 1985)
Shao CH,Wehrens XH,Wyatt TA,Parbhu S,Rozanski GJ,Patel KP,Bidasee KR
MA3-922 was used in Western Blotting to show that ExT during diabetes normalizes RyR2 function and Ca(2+) release from the sarcoplasmic reticulum, providing insights into mechanisms by which ExT during diabetes improves cardiac function.
Wed Apr 01 00:00:00 UTC 2009
Unexpected structural and functional consequences of the R33Q homozygous mutation in cardiac calsequestrin: a complex arrhythmogenic cascade in a knock in mouse model.
Circulation research
Rizzi N,Liu N,Napolitano C,Nori A,Turcato F,Colombi B,Bicciato S,Arcelli D,Spedito A,Scelsi M,Villani L,Esposito G,Boncompagni S,Protasi F,Volpe P,Priori SG
MA3-922 was used in western blot to investigate the structural and functional consequences of the R33Q homozygous mutation in cardiac calsequestrin in a homozygous CASQ2 (R33Q/R33Q) knock in mouse model
Fri Aug 01 00:00:00 UTC 2008
Nonionic detergent phase extraction for the proteomic analysis of heart membrane proteins using label-free LC-MS.
Proteomics
Donoghue PM,Hughes C,Vissers JP,Langridge JI,Dunn MJ
MA3-922 was used in western blot to evaluate a proteomic method for heart membrane proteins
Mon Sep 01 00:00:00 UTC 2008
Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.
American journal of physiology. Heart and circulatory physiology
Zhu M,Gach AA,Liu G,Xu X,Lim CC,Zhang JX,Mao L,Chuprun K,Koch WJ,Liao R,Koren G,Blaxall BC,Mende U
MA3-922 was used in western blot to investigate the role of G alpha o on calcium cycling and contractile function in heart
Sat Mar 01 00:00:00 UTC 2008
Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.
The Journal of biological chemistry
Prasad V,Bodi I,Meyer JW,Wang Y,Ashraf M,Engle SJ,Doetschman T,Sisco K,Nieman ML,Miller ML,Lorenz JN,Shull GE
MA3-922 was used in western blot to study the role of AE3 and NKCC1 in the expression and localization of cardiac phosphatases.
Fri Nov 14 00:00:00 UTC 2008
Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.
The Journal of biological chemistry
Prasad V,Bodi I,Meyer JW,Wang Y,Ashraf M,Engle SJ,Doetschman T,Sisco K,Nieman ML,Miller ML,Lorenz JN,Shull GE
MA3-922 was used in western blot to study the role of AE3 and NKCC1 in the expression and localization of cardiac phosphatases.
Fri Nov 14 00:00:00 UTC 2008
Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.
The Journal of biological chemistry
Prasad V,Bodi I,Meyer JW,Wang Y,Ashraf M,Engle SJ,Doetschman T,Sisco K,Nieman ML,Miller ML,Lorenz JN,Shull GE
MA3-922 was used in western blot to study the role of AE3 and NKCC1 in the expression and localization of cardiac phosphatases.
Fri Nov 14 00:00:00 UTC 2008
Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Szczesna-Cordary D,Jones M,Moore JR,Watt J,Kerrick WG,Xu Y,Wang Y,Wagg C,Lopaschuk GD
MA3-922 was used in western blot to study how the myosin regulatory light chain E22K mutation affects its functions
Sat Dec 01 00:00:00 UTC 2007
Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms.
American journal of physiology. Heart and circulatory physiology
Armoundas AA,Rose J,Aggarwal R,Stuyvers BD,O'rourke B,Kass DA,Marbán E,Shorofsky SR,Tomaselli GF,William Balke C
MA3-922 was used in western blot to investigate the molecular basis of the aberrant calcium handling during heart failure.
Thu Mar 01 00:00:00 UTC 2007
Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes.
American journal of physiology. Heart and circulatory physiology
Birkeland JA,Swift F,Tovsrud N,Enger U,Lunde PK,Qvigstad E,Levy FO,Sejersted OM,Sjaastad I
MA3-922 was used in western blot to study how 5-HT affects intracellular calcium handling
Mon Oct 01 00:00:00 UTC 2007
Thyroid hormone attenuates cardiac remodeling and improves hemodynamics early after acute myocardial infarction in rats.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Pantos C,Mourouzis I,Markakis K,Dimopoulos A,Xinaris C,Kokkinos AD,Panagiotou M,Cokkinos DV
MA3-922 was used in western blot to investigate the role of thyroid hormone on cardiac remodeling and myocardial performance in rat
Wed Aug 01 00:00:00 UTC 2007
Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction.
Circulation
Takahashi T,Tang T,Lai NC,Roth DM,Rebolledo B,Saito M,Lew WY,Clopton P,Hammond HK
MA3-922 was used in western blot to investigate the relationship between left ventricular adenylyl cyclase type VI content and mortality after myocardial infarction
Tue Aug 01 00:00:00 UTC 2006
Functional properties of human embryonic stem cell-derived cardiomyocytes: intracellular Ca2+ handling and the role of sarcoplasmic reticulum in the contraction.
Stem cells (Dayton, Ohio)
Dolnikov K,Shilkrut M,Zeevi-Levin N,Gerecht-Nir S,Amit M,Danon A,Itskovitz-Eldor J,Binah O
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Wed Feb 01 00:00:00 UTC 2006
UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-/- mice.
The Journal of biological chemistry
Ukropec J,Anunciado RP,Ravussin Y,Hulver MW,Kozak LP
MA3-922 was used in western blot to investigate the thermogenic mechanism of the white adipose tissue in cold-acclimated Ucp1-/- mice.
Fri Oct 20 00:00:00 UTC 2006
Identification of a novel phosphorylation site in protein phosphatase inhibitor-1 as a negative regulator of cardiac function.
The Journal of biological chemistry
Rodriguez P,Mitton B,Waggoner JR,Kranias EG
MA3-922 was used in western blot to study the mechanism for cardiac contractility regulation
Fri Dec 15 00:00:00 UTC 2006
Impaired Ca2+ handling and contraction in cardiomyocytes from mice with a dominant negative thyroid hormone receptor alpha1.
Journal of molecular and cellular cardiology
Tavi P,Sjögren M,Lunde PK,Zhang SJ,Abbate F,Vennström B,Westerblad H
MA3-922 was used in western blot to study the role of thyroid hormone receptor alpha1 in calcium homeostasis and cardiomyocyte function
Fri Apr 01 00:00:00 UTC 2005
Chronic ventricular myocyte-specific overexpression of angiotensin II type 2 receptor results in intrinsic myocyte contractile dysfunction.
American journal of physiology. Heart and circulatory physiology
Nakayama M,Yan X,Price RL,Borg TK,Ito K,Sanbe A,Robbins J,Lorell BH
MA3-922 was used in western blot to investigate the effect of chronic ventricular myocyte-specific overexpression of angiotensin II type 2 receptor on myocyte contractile function
Sat Jan 01 00:00:00 UTC 2005
Protein kinase C and preconditioning: role of the sarcoplasmic reticulum.
American journal of physiology. Heart and circulatory physiology
Yamamura K,Steenbergen C,Murphy E
MA3-922 was used in western blot to study the mechanism for the cardioprotective effect of protein kinase C
Thu Dec 01 00:00:00 UTC 2005
Genetic manipulation of calcium-handling proteins in cardiac myocytes. I. Experimental studies.
American journal of physiology. Heart and circulatory physiology
Coutu P,Metzger JM
MA3-922 was used in western blot to investigate the effects of parvalbumin (Parv) expression and sarco (endo) plasmic reticulum calcium-ATPase (SERCA2a) overexpression in the presence of beta-adrenergic stimulation
Tue Feb 01 00:00:00 UTC 2005
Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure.
Physiological genomics
Rothermel BA,Berenji K,Tannous P,Kutschke W,Dey A,Nolan B,Yoo KD,Demetroulis E,Gimbel M,Cabuay B,Karimi M,Hill JA
MA3-922 was used in western blot to investigate the activation of intracellular signaling pathways by graded degrees of hemodynamic stress
Wed Sep 21 00:00:00 UTC 2005
Mechanical unloading improves intracellular Ca2+ regulation in rats with doxorubicin-induced cardiomyopathy.
Journal of the American College of Cardiology
Takaseya T,Ishimatsu M,Tayama E,Nishi A,Akasu T,Aoyagi S
MA3-922 was used in western blot to investigate the effects of mechanical unloading on cardiomyocytes from doxorubicin-induced cardiomyopathy
Tue Dec 07 00:00:00 UTC 2004
Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction.
Circulation research
van der Velden J,Merkus D,Klarenbeek BR,James AT,Boontje NM,Dekkers DH,Stienen GJ,Lamers JM,Duncker DJ
MA3-922 was used in western blot to study the mechanism underlying the early impairment of LV beta-adrenergic responsiveness after myocardial infarction in vivo
Fri Nov 26 00:00:00 UTC 2004
Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites.
Circulation research
Takimoto E,Soergel DG,Janssen PM,Stull LB,Kass DA,Murphy AM
MA3-922 was used in western blot to elucidate the functional role of PKA-mediated phosphorylation of cTnI both in vivo and in vitro
Fri Mar 05 00:00:00 UTC 2004
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor.
Circulation research
Wehrens XH,Lehnart SE,Reiken SR,Marks AR
MA3-922 was used in western blot to demonstrate that CaMKII phosphorylation could regulate the cardiac ryanodine receptor and increase RyR2 calcium sensitivity
Fri Apr 02 00:00:00 UTC 2004
Phosphorylation-status of phospholamban and calsequestrin modifies their affinity towards commonly used antibodies.
Journal of molecular and cellular cardiology
Huke S,Periasamy M
MA3-922 was used in western blot to investigate the influence of phosphorylation on specific protein interaction with their cognate antibodies
Wed Sep 01 00:00:00 UTC 2004
The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm.
American journal of physiology. Cell physiology
Radzyukevich TL,Moseley AE,Shelly DA,Redden GA,Behbehani MM,Lingrel JB,Paul RJ,Heiny JA
MA3-922 was used in western blot to study the role of the sodium/potassium-ATPase alpha2-subunit isoform during muscle contraction
Mon Nov 01 00:00:00 UTC 2004
Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart.
American journal of physiology. Heart and circulatory physiology
Zheng M,Dilly K,Dos Santos Cruz J,Li M,Gu Y,Ursitti JA,Chen J,Ross J,Chien KR,Lederer JW,Wang Y
MA3-922 was used in western blot to characterize the alterations in sarcoplasmic reticulum calcium homostasis in Ras-induced hypertrophic cardiomyopathy heart
Thu Jan 01 00:00:00 UTC 2004
Doxycycline inducible expression of SERCA2a improves calcium handling and reverts cardiac dysfunction in pressure overload-induced cardiac hypertrophy.
American journal of physiology. Heart and circulatory physiology
Suarez J,Gloss B,Belke DD,Hu Y,Scott B,Dieterle T,Kim YK,Valencik ML,McDonald JA,Dillmann WH
MA3-922 was used in western blot to investigate the effects of overexpression of SERCA2a on cardiac function and calcium handling in mice
Mon Nov 01 00:00:00 UTC 2004
Insights into cardioprotection obtained from study of cellular Ca2+ handling in myocardium of true hibernating mammals.
American journal of physiology. Heart and circulatory physiology
Yatani A,Kim SJ,Kudej RK,Wang Q,Depre C,Irie K,Kranias EG,Vatner SF,Vatner DE
MA3-922 was used in western blot to study mammalian hibernators' inborn cardioprotective functions during hibernation
Tue Jun 01 00:00:00 UTC 2004
Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity.
American journal of physiology. Heart and circulatory physiology
Schultz Jel J,Glascock BJ,Witt SA,Nieman ML,Nattamai KJ,Liu LH,Lorenz JN,Shull GE,Kimball TR,Periasamy M
MA3-922 was used in western blot to investigate the effect of chronically decreased SERCA2 calcium pump activity on heart failure in mice
Mon Mar 01 00:00:00 UTC 2004
Autologous stem cell transplantation for myocardial repair.
American journal of physiology. Heart and circulatory physiology
Liu J,Hu Q,Wang Z,Xu C,Wang X,Gong G,Mansoor A,Lee J,Hou M,Zeng L,Zhang JR,Jerosch-Herold M,Guo T,Bache RJ,Zhang J
MA3-922 was used in immunocytochemistry to evaluate the effect of a novel patch method for myocardial repair
Sun Aug 01 00:00:00 UTC 2004
S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts.
The journal of gene medicine
Remppis A,Pleger ST,Most P,Lindenkamp J,Ehlermann P,Schweda C,Löffler E,Weichenhan D,Zimmermann W,Eschenhagen T,Koch WJ,Katus HA
MA3-922 was used in western blot to evaluate the S100A1 gene transfer for engineering cardiac grafts
Thu Apr 01 00:00:00 UTC 2004
Improved expression and characterization of Ca2+-ATPase and phospholamban in High-Five cells.
Protein expression and purification
Waggoner JR,Huffman J,Griffith BN,Jones LR,Mahaney JE
MA3-922 was used in immunocytochemistry to investigate the use of the baculovirus/High-Five insect cell system for the recombinant expression of Ca(2+)-ATPase and phospholamban
Mon Mar 01 00:00:00 UTC 2004
Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3.
The Journal of biological chemistry
Gao MH,Tang T,Guo T,Sun SQ,Feramisco JR,Hammond HK
MA3-922 was used in western blot to demonstrate the effect of ACVI on has cAMP-independent gene transcription.
Fri Sep 10 00:00:00 UTC 2004
Regional alterations in protein expression in the dyssynchronous failing heart.
Circulation
Spragg DD,Leclercq C,Loghmani M,Faris OP,Tunin RS,DiSilvestre D,McVeigh ER,Tomaselli GF,Kass DA
MA3-922 was used in western blot to examine the regional changes in protein expression during heart failure
Tue Aug 26 00:00:00 UTC 2003
Effect of tachycardia on myocardial sarcoplasmic reticulum and Ca2+ dynamics: a mechanism for preconditioning?
Journal of molecular and cellular cardiology
Domenech RJ,Sánchez G,Donoso P,Parra V,Macho P
MA3-922 was used in western blot to study the effect of earlier tachycardia on infarct size
Mon Dec 01 00:00:00 UTC 2003
Gender differences in sarcoplasmic reticulum calcium loading after isoproterenol.
American journal of physiology. Heart and circulatory physiology
Chen J,Petranka J,Yamamura K,London RE,Steenbergen C,Murphy E
MA3-922 was used in western blot to study the possible relationship between SR calcium loading after isoproterenol and gender as well as its correlation with gender differences in ischemia-reperfusion injury
Mon Dec 01 00:00:00 UTC 2003
Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II in cardiac longitudinal sarcoplasmic reticulum results in decreased phospholamban phosphorylation at threonine 17.
The Journal of biological chemistry
Ji Y,Li B,Reed TD,Lorenz JN,Kaetzel MA,Dedman JR
MA3-922 was used in western blot to investigate the role of the calcium/calmodulin-dependent kinase II pathway in cardiac disease.
Fri Jul 04 00:00:00 UTC 2003
Nitric oxide protects cardiac sarcolemmal membrane enzyme function and ion active transport against ischemia-induced inactivation.
The Journal of biological chemistry
Xu KY,Kuppusamy SP,Wang JQ,Li H,Cui H,Dawson TM,Huang PL,Burnett AL,Kuppusamy P,Becker LC
MA3-922 was used in western blot to demonstrate the protective effect of nitric oxide on cardiac SL NOSs and sodium/potassium-ATPase against ischemia-induced inactivation.
Fri Oct 24 00:00:00 UTC 2003
Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt.
The Journal of biological chemistry
Kim YK,Kim SJ,Yatani A,Huang Y,Castelli G,Vatner DE,Liu J,Zhang Q,Diaz G,Zieba R,Thaisz J,Drusco A,Croce C,Sadoshima J,Condorelli G,Vatner SF
MA3-922 was used in western blot to investigate the effect of Akt on cardiac morphology and cardiac function.
Fri Nov 28 00:00:00 UTC 2003
Targeting phospholamban by gene transfer in human heart failure.
Circulation
del Monte F,Harding SE,Dec GW,Gwathmey JK,Hajjar RJ
MA3-922 was used in immunocytochemistry to investigate that phospholamban may a good good therapeutic target in human heart failure.
Tue Feb 26 00:00:00 UTC 2002
Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart.
Circulation
Toma C,Pittenger MF,Cahill KS,Byrne BJ,Kessler PD
MA3-922 was used in immunohistochemistry to investigate the myogenic differentiation of human mesenchymal stem cells (hMSCs) in the adult murine heart
Tue Jan 01 00:00:00 UTC 2002
Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel.
Circulation research
Song LS,Guia A,Muth JN,Rubio M,Wang SQ,Xiao RP,Josephson IR,Lakatta EG,Schwartz A,Cheng H
MA3-922 was used in western blot to study the effects of increase in L-type calcium channels (LCC) density on calcium signaling in cardiac myocytes overexpressing the alpha (1) subunit of LCC
Fri Feb 08 00:00:00 UTC 2002
Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy.
Diabetes
Trost SU,Belke DD,Bluhm WF,Meyer M,Swanson E,Dillmann WH
MA3-922 was used in western blot to investigate the effects of overexpression of the SR calcium pump (SERCA2a) on myocardial contractility in diabetic cardiomyopathy
Mon Apr 01 00:00:00 UTC 2002
Developmental changes of Ca(2+) handling in mouse ventricular cells from early embryo to adulthood.
Life sciences
Liu W,Yasui K,Opthof T,Ishiki R,Lee JK,Kamiya K,Yokota M,Kodama I
MA3-922 was used in western blot to investigate the calcium handling in cardiomyocytes throughout murine development
Fri Aug 02 00:00:00 UTC 2002
Cardiac remodeling and atrial fibrillation in transgenic mice overexpressing junctin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hong CS,Cho MC,Kwak YG,Song CH,Lee YH,Lim JS,Kwon YK,Chae SW,Kim DH
MA3-922 was used in western blot to study junctin's functions in heart
Thu Aug 01 00:00:00 UTC 2002
Interaction between increased SERCA2a activity and beta -adrenoceptor stimulation in adult rabbit myocytes.
American journal of physiology. Heart and circulatory physiology
Chaudhri B,Del Monte F,Hajjar RJ,Harding SE
MA3-922 was used in western blot to study the interaction of increased SERCA2a activity with beta-adrenoceptor stimulation in rabbit myocytes
Sun Dec 01 00:00:00 UTC 2002
Altered dose response to beta-agonists in SERCA1a-expressing hearts ex vivo and in vivo.
American journal of physiology. Heart and circulatory physiology
Huke S,Prasad V,Nieman ML,Nattamai KJ,Grupp IL,Lorenz JN,Periasamy M
MA3-922 was used in western blot to investigate the contractility of hearts expressing SERCA1a ex vivo and in vivo as well as their response to beta-adrenergic stimulation
Sun Sep 01 00:00:00 UTC 2002
Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats.
American journal of physiology. Heart and circulatory physiology
Choi KM,Zhong Y,Hoit BD,Grupp IL,Hahn H,Dilly KW,Guatimosim S,Lederer WJ,Matlib MA
MA3-922 was used in western blot to study the possible contribution of defects in intracellular calcium signaling cardiomyopathy in streptozotocin (STZ)-induced diabetic rats
Tue Oct 01 00:00:00 UTC 2002
Type 1 phosphatase, a negative regulator of cardiac function.
Molecular and cellular biology
Carr AN,Schmidt AG,Suzuki Y,del Monte F,Sato Y,Lanner C,Breeden K,Jing SL,Allen PB,Greengard P,Yatani A,Hoit BD,Grupp IL,Hajjar RJ,DePaoli-Roach AA,Kranias EG
MA3-922 was used in western blot to demonstrate the role of type 1 phosphatase in heart function.
Sat Jun 01 00:00:00 UTC 2002
Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality.
Circulation
Dash R,Kadambi V,Schmidt AG,Tepe NM,Biniakiewicz D,Gerst MJ,Canning AM,Abraham WT,Hoit BD,Liggett SB,Lorenz JN,Dorn GW,Kranias EG
MA3-922 was used in western blot to investigate the role of phospholamban (PLB) in the development of cardiomyopathy and early mortality
Tue Feb 13 00:00:00 UTC 2001
mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope.
Journal of cell science
Kapiloff MS,Jackson N,Airhart N
MA3-922 was used in western blot to study the role of mAKAP and ryanodine receptor in cardiomyocyte nuclear envelope signalling.
Sat Sep 01 00:00:00 UTC 2001
Altered SR protein expression associated with contractile dysfunction in diabetic rat hearts.
American journal of physiology. Heart and circulatory physiology
Zhong Y,Ahmed S,Grupp IL,Matlib MA
MA3-922 was used in western blot to investigate the relationship of altered sarcoplasmic reticulum (SR) protein expression with late-onset dysfunction in diabetic rats
Sat Sep 01 00:00:00 UTC 2001
Impaired sarcoplasmic reticulum function leads to contractile dysfunction and cardiac hypertrophy.
American journal of physiology. Heart and circulatory physiology
Meyer M,Trost SU,Bluhm WF,Knot HJ,Swanson E,Dillmann WH
MA3-922 was used in western blot to detect the expression changes of phospholamban in mices treated with ryanodine
Tue May 01 00:00:00 UTC 2001
Exogenous Ca2+-ATPase isoform effects on Ca2+ transients of embryonic chicken and neonatal rat cardiac myocytes.
The Journal of physiology
Cavagna M,O'Donnell JM,Sumbilla C,Inesi G,Klein MG
Published figure using Phospholamban monoclonal antibody (Product # MA3-922) in Western Blot
Sun Oct 01 00:00:00 UTC 2000
Sprint training normalizes Ca(2+) transients and SR function in postinfarction rat myocytes.
Journal of applied physiology (Bethesda, Md. : 1985)
Zhang LQ,Zhang XQ,Ng YC,Rothblum LI,Musch TI,Moore RL,Cheung JY
MA3-922 was used in western blot to investigate the effect of sprint training on calcium regulation and sarcoplasmic reticulum (SR) function in postinfarction rat myocytes
Sat Jul 01 00:00:00 UTC 2000
Cardiac-specific overexpression of a superinhibitory pentameric phospholamban mutant enhances inhibition of cardiac function in vivo.
The Journal of biological chemistry
Zhai J,Schmidt AG,Hoit BD,Kimura Y,MacLennan DH,Kranias EG
MA3-922 was used in western blot to investigate the inhibitory activity of N27A mutant form by using transgenic mice with cardiac-specific overexpression of mutant phospholamban.
Fri Apr 07 00:00:00 UTC 2000
Cardiac-specific overexpression of a superinhibitory pentameric phospholamban mutant enhances inhibition of cardiac function in vivo.
The Journal of biological chemistry
Zhai J,Schmidt AG,Hoit BD,Kimura Y,MacLennan DH,Kranias EG
MA3-922 was used in western blot to investigate the inhibitory activity of N27A mutant form by using transgenic mice with cardiac-specific overexpression of mutant phospholamban.
Fri Apr 07 00:00:00 UTC 2000
Comparative analysis of the isoform expression pattern of Ca(2+)-regulatory membrane proteins in fast-twitch, slow-twitch, cardiac, neonatal and chronic low-frequency stimulated muscle fibers.
Biochimica et biophysica acta
Froemming GR,Murray BE,Harmon S,Pette D,Ohlendieck K
MA3-922 was used in western blot to study the expression of Ca(2+) regulatory membrane protein isoforms in skeletal, cardiac and neonatal muscle fibres
Thu Jun 01 00:00:00 UTC 2000
Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies.
Circulation research
O'Rourke B,Kass DA,Tomaselli GF,Kääb S,Tunin R,Marbán E
MA3-922 was used in western blot to demonstrate that the mechanisms of altered excitation-contraction coupling in canine are similar to those reported in human heart failure
Fri Mar 19 00:00:00 UTC 1999
Nitric oxide synthase in cardiac sarcoplasmic reticulum.
Proceedings of the National Academy of Sciences of the United States of America
Xu KY,Huso DL,Dawson TM,Bredt DS,Becker LC
MA3-922 was used in immunohistochemistry to study the localization and function of the nitric oxide synthase in heart.
Tue Jan 19 00:00:00 UTC 1999
In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.
The Journal of clinical investigation
Takeishi Y,Chu G,Kirkpatrick DM,Li Z,Wakasaki H,Kranias EG,King GL,Walsh RA
MA3-922 was used in western blot to investigate the mechanism underlying depressed cardiac function caused by PKC beta 2-mediated phosphorylation
Wed Jul 01 00:00:00 UTC 1998
Regulation of Ca2+ handling by phosphorylation status in mouse fast- and slow-twitch skeletal muscle fibers.
The American journal of physiology
Liu Y,Kranias EG,Schneider MF
MA3-922 was used in western blot to study the regulatory role of phosphorylation status on calcium handling in mouse fast- and slow-twitch skeletal muscle fibers
Mon Dec 01 00:00:00 UTC 1997
Transcriptional regulation of phospholamban gene and translational regulation of SERCA2 gene produces coordinate expression of these two sarcoplasmic reticulum proteins during skeletal muscle phenotype switching.
The Journal of biological chemistry
Hu P,Yin C,Zhang KM,Wright LD,Nixon TE,Wechsler AS,Spratt JA,Briggs FN
MA3-922 was used in western blot to investigate how coordinated expression of SERCA2a and phospholamban is achieved during skeletal muscle phenotype switching
Fri May 12 00:00:00 UTC 1995
Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium.
Circulation
Movsesian MA,Karimi M,Green K,Jones LR
MA3-922 was used in western blot to investigate the expression of SERCA2 ATPase, calsequestrin and phospholamban in nonfailing and failing human left ventricular myocardium
Mon Aug 01 00:00:00 UTC 1994
The Ca2+-release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle.
The Journal of cell biology
Jorgensen AO,Shen AC,Arnold W,McPherson PS,Campbell KP
MA3-922 was used in immunohistochemistry to check the existence of ryanodine receptor in junctional SR and corbular SR
Mon Feb 01 00:00:00 UTC 1993
Phospholamban expressed in slow-twitch and chronically stimulated fast-twitch muscles minimally affects calcium affinity of sarcoplasmic reticulum Ca(2+)-ATPase.
The Journal of biological chemistry
Briggs FN,Lee KF,Wechsler AW,Jones LR
MA3-922 was used in western blot to study the expression of the phospholamban protein in stimulated muscles and the corresponding functions
Fri Dec 25 00:00:00 UTC 1992
Phospholamban mediates the beta-adrenergic-enhanced Ca2+ uptake in mammalian ventricular myocytes.
The American journal of physiology
Sham JS,Jones LR,Morad M
MA3-922 was used in blocking/activating experiment to investigate the effect of phospholamban on the regulation of calcium uptake in myocytes of mammals with beta-adrenergic stimulation
Tue Oct 01 00:00:00 UTC 1991
