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Pinin Polyclonal Antibody

Pinin Antibody in Immunocytochemistry (ICC/IF)

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Pinin Antibody (18266-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using Pinin antibody (Product # 18266-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Pinin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Pinin Antibody in Immunoprecipitation (IP)

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Product Details

18266-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Pinin Fusion Protein Ag6643 (376-717 aa encoded by BC062602)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EKQQDSQPE EVMDVLEMVE NVKHVIADQE VMETNRVESV EPSENEASKE LEPEMEFEIE PDKECKSLSP GKENVSALDM EKESEEKEEK ESEPQPEPVA QPQPQSQPQL QLQSQSQPVL QSQPPSQPED LSLAVLQPTP QVTQEQGHLL PERKDFPVES VKLTEVPVEP VLTVHPESKS KTKTRSRSRG RARNKTSKSR SRSSSSSSSS SSSTSSSSGS SSSSGSSSSR SSSSSSSSTS GSSSRDSSSS TSSSSESRSR SRGRGHNRDR KHRRSVDRKR RDTSGLERSH KSSKGGSSRD TKGSKDKNSR SDRKRSISES SRSGKRSSRS ERDRKSDRKD KRR (376-717 aa encoded by BC062602)

Target Information

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Methyltransferase like 3 enhances pinin mRNA stability through N⁶ -methyladenosine modification to augment tumourigenesis of colon adenocarcinoma.

Experimental physiology

He M,Jiang D,Xun A,Yang J,Luo Q,Wu H

Tue Nov 01 00:00:00 UTC 2022

Methyltransferase like 3 enhances pinin mRNA stability through N⁶ -methyladenosine modification to augment tumourigenesis of colon adenocarcinoma.

Experimental physiology

He M,Jiang D,Xun A,Yang J,Luo Q,Wu H

Tue Nov 01 00:00:00 UTC 2022

Methyltransferase like 3 enhances pinin mRNA stability through N⁶ -methyladenosine modification to augment tumourigenesis of colon adenocarcinoma.

Experimental physiology

He M,Jiang D,Xun A,Yang J,Luo Q,Wu H

Tue Nov 01 00:00:00 UTC 2022

Methyltransferase like 3 enhances pinin mRNA stability through N⁶ -methyladenosine modification to augment tumourigenesis of colon adenocarcinoma.

Experimental physiology

He M,Jiang D,Xun A,Yang J,Luo Q,Wu H

Tue Nov 01 00:00:00 UTC 2022

NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.

Cell metabolism

Park MK,Zhang L,Min KW,Cho JH,Yeh CC,Moon H,Hormaechea-Agulla D,Mun H,Ko S,Lee JW,Jathar S,Smith AS,Yao Y,Giang NT,Vu HH,Yan VC,Bridges MC,Kourtidis A,Muller F,Chang JH,Song SJ,Nakagawa S,Hirose T,Yoon JH,Song MS

Tue Dec 07 00:00:00 UTC 2021

NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.

Cell metabolism

Tue Dec 07 00:00:00 UTC 2021

LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma.

Molecular oncology

Tang T,Yang L,Cao Y,Wang M,Zhang S,Gong Z,Xiong F,He Y,Zhou Y,Liao Q,Xiang B,Zhou M,Guo C,Li X,Li Y,Xiong W,Li G,Zeng Z

Tue Sep 01 00:00:00 UTC 2020

LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma.

Molecular oncology

Tang T,Yang L,Cao Y,Wang M,Zhang S,Gong Z,Xiong F,He Y,Zhou Y,Liao Q,Xiang B,Zhou M,Guo C,Li X,Li Y,Xiong W,Li G,Zeng Z

Tue Sep 01 00:00:00 UTC 2020

LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma.

Molecular oncology

Tang T,Yang L,Cao Y,Wang M,Zhang S,Gong Z,Xiong F,He Y,Zhou Y,Liao Q,Xiang B,Zhou M,Guo C,Li X,Li Y,Xiong W,Li G,Zeng Z

Tue Sep 01 00:00:00 UTC 2020

Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer.

Oncotarget

Zhang L,Yu Z,Wang Y,Wang X,Zhang L,Wang C,Yue Q,Wang X,Deng S,Huo X,Tian X,Huang S,Zhang B,Ma X

Tue Nov 22 00:00:00 UTC 2016

Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer.

Oncotarget

Zhang L,Yu Z,Wang Y,Wang X,Zhang L,Wang C,Yue Q,Wang X,Deng S,Huo X,Tian X,Huang S,Zhang B,Ma X

Tue Nov 22 00:00:00 UTC 2016

Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis.

Oncotarget

Yang X,Sun D,Dong C,Tian Y,Gao Z,Wang L

Tue Jun 28 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: 140 kDa nuclear and cell adhesion-related phosphoprotein; Desmosome-associated protein; Domain-rich serine protein; DRS protein; Melanoma metastasis clone A protein; neutrophil protein; Nuclear protein SDK3; Pinin; SR-like protein

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Gene Aliases: DRS; DRSP; MEMA; PNN; SDK3

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UniProt ID: (Human) Q9H307

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Entrez Gene ID: (Human) 5411

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Function(s)

DNA binding structural molecule activity poly(A) RNA binding

Process(es)

mRNA splicing, via spliceosome transcription, DNA-templated regulation of transcription, DNA-templated cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Pinin Polyclonal Antibody

Pinin Antibody (18266-1-AP) in ICC/IF

Product Details

18266-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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