Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
MA5-15596
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1H10
Immunogen
Purified recombinant fragment of human Pirh2 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10985612
Product Specific Information
MA5-15596 targets Pirh2 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human and Rat samples.
The MA5-15596 immunogen is purified recombinant fragment of human Pirh2 expressed in E. Coli.
MA5-15596 detects Pirh2 which has a predicted molecular weight of approximately 30kDa; 60kDa (homodimer).
Target Information
The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Androgen receptor N-terminal-interacting protein; androgen-receptor N-terminal-interacting protein; CH-rich interacting match with PLAG1; CH-rich-interacting match with PLAG1; DKFZp586C1620; E3 ubiquitin-protein ligase Pirh2; h PRO1996; hPirh2; p53-induced protein with a RING-H2 domain; p53-induced RING-H2 protein; PIRH2E; PIRH2F; ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase; RING finger and CHY zinc finger domain-containing protein 1; RING finger protein 199; RING-type E3 ubiquitin transferase RCHY1; Zinc finger protein 363; zinc finger, CHY-type
Gene Aliases: ARNIP; CHIMP; PIRH2; PRO1996; RCHY1; RNF199; ZCHY; ZNF363
UniProt ID: (Human) Q96PM5
Entrez Gene ID: (Human) 25898, (Rat) 289508
protein ubiquitination
positive regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
error-free translesion synthesis
biological_process
protein autoubiquitination
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support