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Progen
Plakoglobin Monoclonal Antibody (PG 5.1)
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Product Details
61005PROGEN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
PG 5.1
Immunogen
Plakoglobin,
Conjugate
Form
Lyophilized
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute lyophilized product with 1 mL distilled water.
PG 5.1 represents an excellent marker for all forms of intercellular adhering junctions, such as: desmosomes of epithelial and myocardial cells (incl. cultured cells); zonulae and fasciae adherentes of epithelia, endothelia of blood vessels and myocardial cells; adherens-type junctions (e.g. lens tissue, pigmented retinal cells, Sertoli cells of testis). The PG 5.1 epitope maps within the C-terminus at the extreme end of repeat 13 (aa 632-687) of plakoglobin. Polypeptide reacting: MW 83 000 Plakoglobin, "band 5" polypeptide of intercellular adhering junctions (identical to gamma-catenin)Reactivity on cultured cell lines: Cell cultures forming monolayers .
Target Information
JUP is a major cytoplasmic protein which is the only known constituent common to sub membranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; Desmoplakin III; Desmoplakin-3; gama-catenin; Gamma-catenin; gamma-catenin (plakoglobin); Junction plakoglobin; Junction plakoglobin a; OTTHUMP00000164735; Plakoglobin; Plakoglobin-1a
Gene Aliases: ARVD12; BOS_19078; cb80; CTNNG; D930025P04Rik; danPG; DP3; DPIII; fb11b06; JUP; jupa; PDGB; PG; PKGB; wu:fb11b06
UniProt ID: (Bovine) Q8SPJ1, (Human) P14923, (Rat) Q6P0K8, (Mouse) Q02257, (Zebrafish) Q9PVF7
Entrez Gene ID: (Bovine) 445543, (Human) 3728, (Rat) 81679, (Mouse) 16480, (Zebrafish) 30415
transcription coactivator activity
structural molecule activity
protein binding
protein kinase binding
protein phosphatase binding
protein homodimerization activity
alpha-catenin binding
cadherin binding
signal transducer activity
structural constituent of cell wall
cell adhesion molecule binding
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
cadherin binding involved in cell-cell adhesion
nuclear hormone receptor binding
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
desmosome assembly
negative regulation of heart induction by canonical Wnt signaling pathway
atrioventricular valve morphogenesis
negative regulation of Wnt signaling pathway involved in heart development
cytoskeletal anchoring at plasma membrane
gastrulation
ectoderm development
nervous system development
morphogenesis of embryonic epithelium
cell migration
regulation of cell proliferation
positive regulation of protein import into nucleus
regulation of apoptotic process
skin development
oocyte development
detection of mechanical stimulus
positive regulation of sequence-specific DNA binding transcription factor activity
endothelial cell-cell adhesion
cellular response to indole-3-methanol
ventricular cardiac muscle cell action potential
bundle of His cell to Purkinje myocyte communication
regulation of heart rate by cardiac conduction
cell adhesion
heart development
negative regulation of Wnt signaling pathway
positive regulation of transcription from RNA polymerase II promoter
signal transduction
single organismal cell-cell adhesion
adherens junction organization
adherens junction assembly
protein heterooligomerization
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
establishment of protein localization to plasma membrane
positive regulation of canonical Wnt signaling pathway
regulation of ventricular cardiac muscle cell action potential
regulation of cell fate specification
regulation of nucleic acid-templated transcription
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