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Progen
Plakophilin 3 Monoclonal Antibody (PKP3-270.6.2)
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Product Details
651113
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
PKP3-270.6.2
Immunogen
Recombinant Protein (E. Coli) Of Human Plakophilin 3
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Plakophilin 3 is seen in most desmosomes and partly dispersed in cytoplasm under various fixation conditions (FA, MeAc long, MeAc short):Positive tissues and culture cells:stratified squamous epithelia: palmar, epidermis, scalp skinstratified epithelia: tongue, vagina, esophagustransitional epithelia: bladdernon-stratified epithelia: colon, duodenum, pancreas, several glandsnon-epithelial: reticulum cells of lymph node follicleHaCaT, MCF7, HeLa, HT-29, CaCo 2, Caski, BMGE, MDCK and otherNegative tissues and cell lines:liver, heart, skeletal muscle, endothelia (vessels)PLC, RD, SV80, HL60, Raji, Jok1, Glioma, K562, 3T3L1, A6, PtK2.
Target Information
Plakophilin-3 is an Armadillo-like protein present in nuclei and desmosomes of epithelial cells. The expression pattern of this protein seems to be largely restricted to epithelial cell types. Plakophilin-3 can be detected along cell borders in a punctuate staining pattern typical for desmosomal proteins. In addition to the desmosomal immunolocalization, immunostaining was observed as bright nuclear speckles. Thus, like plakophilin-1 and-2, plakophilin-3 displays a dual intracellular localization in the desmosomal plaque and in the cell nucleus, and therefore is probably involved in signal transduction pathways between the plasma membrane and the nucleus. The human protein has a predicted molecular mass of ~87 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: plakophilin 3b; Plakophilin-3
Gene Aliases: 2310056L12Rik; PKP3
UniProt ID: (Human) Q9Y446, (Mouse) Q9QY23
Entrez Gene ID: (Human) 11187, (Mouse) 56460, (Rat) 293619
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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