Invitrogen

Pleiotrophin Polyclonal Antibody

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1 Published Figure
1 Reference
View all (16) Pleiotrophin antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-94984

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Pleiotrophin (150-168aa QAESKKKKKEGKKQEKMLD).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2806790

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: Rat Brain Tissue, Rat Kidney Tissue, MCF-7 Cell, HT1080 Cell, SMMC Cell. IHC: Human Mammary Cancer Tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

Pleiotrophin (PTN) is an 18 kDa secreted heparin and chondroitin-binding protein that is a regulatory cytokine critical to the early development of blood vessels and neurons. High PTN serum levels are associated with a variety of solid tumors. It was shown that patients with multiple myeloma (MM) also have elevated serum levels of this protein. The expression of this protein is very limited in normal adult tissues.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: HB-GAM; HBBM; HBGF-8; HBNF; HBNF-1; heparin affin regulatory peptide; heparin affin regulatory protein; heparin binding factor; Heparin-binding brain mitogen; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; heparin-binding neurite outgrowth promoting factor; Heparin-binding neurite outgrowth-promoting factor; Heparin-binding neurite outgrowth-promoting factor 1; heparin-binding neurite promoting factor; heparin-binding neurotorphic factor; Heparin-binding neutrophic factor; OSF-1; Osteoblast-specific factor 1; osteoblastic cell factor; Pleiotrophin; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1); Pleiotrophin (Heparine binding factor, Hbnf, in the mouse); PTN

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Gene Aliases: HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBGF8; HBNF; HBNF-1; HBNF1; NEGF1; OSF; OSF-1; Osf1; PTN

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UniProt ID: (Human) P21246, (Rat) P63090, (Mouse) P63089

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Entrez Gene ID: (Human) 5764, (Rat) 24924, (Mouse) 19242

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Function(s)
protein phosphatase inhibitor activity growth factor activity heparin binding chondroitin sulfate proteoglycan binding chondroitin sulfate binding vascular endothelial growth factor binding heparan sulfate binding glycosaminoglycan binding
Process(es)
liver development transmembrane receptor protein tyrosine phosphatase signaling pathway nervous system development heart development learning positive regulation of cell proliferation regulation of cell shape positive regulation of cell-substrate adhesion positive regulation of neuron projection development response to activity negative regulation of angiogenesis spinal cord development cerebellum development thalamus development bone mineralization lung development negative regulation of cell migration response to estradiol response to progesterone cellular response to UV cellular response to platelet-derived growth factor stimulus response to drug positive regulation of apoptotic process negative regulation of catalytic activity estrous cycle endothelial cell differentiation negative regulation of membrane potential negative regulation of epithelial cell proliferation positive regulation of cell division retinal rod cell differentiation negative regulation of glial cell proliferation long-term synaptic potentiation cellular response to vitamin D cellular response to hypoxia negative regulation of mesenchymal cell proliferation response to kainic acid rod bipolar cell differentiation response to ciliary neurotrophic factor positive regulation of skeletal muscle acetylcholine-gated channel clustering negative regulation of neuromuscular junction development response to nerve growth factor positive regulation of hepatocyte proliferation ossification neuromuscular junction development skeletal muscle acetylcholine-gated channel clustering
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