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Invitrogen
Plexin-A1 Monoclonal Antibody (M535)
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FIGURE: 1 / 2
Plexin-A1 Antibody (MA5-47679) in ICC/IF
Immunocytochemistry analysis of Plexin-A1 in aldehyde fixed and NP-40 permeabilized human NCI-H1299 lung carcinoma cells. The cells were labeled with mouse Plexin-A1 monoclonal antibody (Product # MA5-47679). The antibody was detected using goat anti-mouse DyLight® 594.
Product Details
MA5-47679
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
M535
Immunogen
Clone M535 was generated from a Plexin-A1 synthetic peptide (coupled to carrier protein) corresponding to a region within the N-terminal half of the semaphorin domain in human Plexin-A1. This sequence is highly conserved in rat and mouse Plexin-A1, and has low homology to other Plexin family members.
Conjugate
Form
Liquid
Concentration
~1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2942660
Product Specific Information
The antibody detects a 220 kDa* protein corresponding to the apparent molecular mass of Plexin-A1 on SDS-PAGE immunoblots of neonatal mouse brain, and detects a recombinant mouse Plexin A1 protein containing the extracellular region.
Target Information
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Plex 1; plexin 1; plexin A1; plexin-1; Plexin-A1; Semaphorin receptor NOV
Gene Aliases: 2600013D04Rik; Kiaa4053; mKIAA4053; NOV; NOVP; PlexA1; PLEXIN-A1; PLXN1; PLXNA1; RGD1560871
UniProt ID: (Human) Q9UIW2, (Mouse) P70206
Entrez Gene ID: (Human) 5361, (Rat) 362398, (Mouse) 18844
multicellular organism development
regulation of smooth muscle cell migration
branchiomotor neuron axon guidance
regulation of cell migration
regulation of axon extension involved in axon guidance
dichotomous subdivision of terminal units involved in salivary gland branching
semaphorin-plexin signaling pathway involved in axon guidance
neuron projection extension
semaphorin-plexin signaling pathway
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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