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Bethyl Laboratories
Plexin-A3 Polyclonal Antibody
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Plexin-A3 Antibody (A304-473A) in WB
Detection of human Plexin-A3 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, and Jurkat cells prepared using RIPA lysis buffer. Antibodies: Affinity purified rabbit anti-Plexin-A3 antibody (Product # A304-473A) (lot A304-473A-1) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 3 minutes.
Product Details
A304-473A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1050 to 1100 of Human Plexin-A3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Plexin-4; Plexin-A3; Semaphorin receptor SEX; Sex chromosome X transmembrane protein of HGF receptor family 3; SEXPLEXIN-A3
Gene Aliases: 6.3; HSSEXGENE; PLXN3; PLXN4; PLXNA3; SEX; XAP-6
UniProt ID: (Human) P51805
Entrez Gene ID: (Human) 55558
multicellular organism development
facial nerve structural organization
trigeminal nerve structural organization
hippocampus development
branchiomotor neuron axon guidance
pyramidal neuron development
regulation of cell migration
regulation of axon extension involved in axon guidance
negative regulation of axon extension involved in axon guidance
negative chemotaxis
positive regulation of cytoskeleton organization
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in axon guidance
neuron projection extension
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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