Invitrogen

Polycystin 1 Polyclonal Antibody

View all (7) Polycystin 1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-115779

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PKD1(Accession P98161), corresponding to amino acid residues Y2444-E2494.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900414

Product Specific Information

Antibody detects endogenous levels of total Polycystin 1.

Target Information

Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Autosomal dominant polycystic kidney disease 1 protein; Autosomal dominant polycystic kidney disease 1 protein homolog; PC1; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease 1 homolog; polycystin-1; polycystic kidney disease-associated protein; polycystin 1; Polycystin-1; transient receptor potential cation channel, subfamily P, member 1

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Gene Aliases: mFLJ00285; PBP; Pc-1; PC1; PKD1; TRPP1

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UniProt ID: (Human) P98161, (Mouse) O08852

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Entrez Gene ID: (Human) 5310, (Rat) 24650, (Mouse) 18763

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Function(s)
calcium channel activity protein binding protein kinase binding protein domain specific binding carbohydrate binding ion channel binding cation channel activity
Process(es)
cartilage condensation in utero embryonic development kidney development liver development embryonic placenta development protein export from nucleus nitrogen compound metabolic process cell cycle arrest homophilic cell adhesion via plasma membrane adhesion molecules cell-matrix adhesion calcium-independent cell-matrix adhesion positive regulation of cytosolic calcium ion concentration JAK-STAT cascade heart development anatomical structure morphogenesis single organismal cell-cell adhesion peptidyl-serine phosphorylation spinal cord development neural tube development establishment of cell polarity regulation of cell adhesion positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle positive regulation of protein binding response to fluid shear stress lymph vessel morphogenesis cytoplasmic sequestering of transcription factor skin development positive regulation of transcription from RNA polymerase II promoter digestive tract development branching morphogenesis of an epithelial tube genitalia development detection of mechanical stimulus cartilage development regulation of mitotic spindle organization lung epithelium development placenta blood vessel development regulation of proteasomal protein catabolic process calcium ion transmembrane transport mesonephric tubule development mesonephric duct development metanephric collecting duct development metanephric ascending thin limb development metanephric proximal tubule development metanephric distal tubule morphogenesis blood vessel development calcium ion transport renal system development cation transmembrane transport patterning of lymph vessels
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