Proteintech

PrP Polyclonal Antibody

PrP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PrP Antibody (12555-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 12555-1-AP ( PrP Antibody) at dilution of 1:200 (under 40x lens).

PrP Antibody in Immunoprecipitation (IP)

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Product Details

12555-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PrP Fusion Protein Ag3257 (17-240 aa encoded by BC022532)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SDLGLCKKR PKPGGWNTGG SRYPGQGSPG GNRYPPQGGG GWGQPHGGGW GQPHGGGWGQ PHGGGWGQPH GGGWGQGGGT HSQWNKPSKP KTNMKHMAGA AAAGAVVGGL GGYVLGSAMS RPIIHFGSDY EDRYYRENMH RYPNQVYYRP MDEYSNQNNF VHDCVNITIK QHTVTTTTKG ENFTETDVKM MERVVEQMCI TQYERESQAY YKRGSSMVLF SSPPV (17-240 aa encoded by B C022532)

Target Information

Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Single-cell transcriptomics uncover the key ferroptosis regulators contribute to cancer progression in head and neck squamous cell carcinoma.

Frontiers in molecular biosciences

Liu F,Tang L,Li Q,Chen L,Pan Y,Yin Z,He J,Tian J

Fri Aug 26 00:00:00 UTC 2022

Integrative genome analysis identified the KANNO blood group antigen as prion protein.

Transfusion

Omae Y,Ito S,Takeuchi M,Isa K,Ogasawara K,Kawabata K,Oda A,Kaito S,Tsuneyama H,Uchikawa M,Wada I,Ohto H,Tokunaga K

Mon Jul 01 00:00:00 UTC 2019

Muskelin Coordinates PrP^C Lysosome versus Exosome Targeting and Impacts Prion Disease Progression.

Neuron

Heisler FF,Pechmann Y,Wieser I,Altmeppen HC,Veenendaal L,Muhia M,Schweizer M,Glatzel M,Krasemann S,Kneussel M

Wed Sep 19 00:00:00 UTC 2018

Muskelin Coordinates PrP^C Lysosome versus Exosome Targeting and Impacts Prion Disease Progression.

Neuron

Heisler FF,Pechmann Y,Wieser I,Altmeppen HC,Veenendaal L,Muhia M,Schweizer M,Glatzel M,Krasemann S,Kneussel M

Wed Sep 19 00:00:00 UTC 2018

Muskelin Coordinates PrP^C Lysosome versus Exosome Targeting and Impacts Prion Disease Progression.

Neuron

Heisler FF,Pechmann Y,Wieser I,Altmeppen HC,Veenendaal L,Muhia M,Schweizer M,Glatzel M,Krasemann S,Kneussel M

Wed Sep 19 00:00:00 UTC 2018

Muskelin Coordinates PrP^C Lysosome versus Exosome Targeting and Impacts Prion Disease Progression.

Neuron

Heisler FF,Pechmann Y,Wieser I,Altmeppen HC,Veenendaal L,Muhia M,Schweizer M,Glatzel M,Krasemann S,Kneussel M

Wed Sep 19 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: Alternative prion protein; AltPrP; ASCR; BSE; CD230; CD230 antigen; Major prion protein; MGC26679; prion protein, PrP; prion protein, structural; prion-related protein; PrP; PrP27-30; PrP33-35C; TSE

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Gene Aliases: AA960666; AI325101; ALTPRP; ASCR; CD230; CJD; GSS; KURU; p27-30; PRIP; Prn; Prn-i; Prn-p; PRNP; PRP; PrP27-30; PrP33-35C; PrP; PrPC; PrPSc; Sinc

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UniProt ID: (Human) P04156, (Mouse) P04925, (Rat) P13852

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Entrez Gene ID: (Human) 5621, (Mouse) 19122, (Rat) 24686

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Function(s)

copper ion binding protein binding lamin binding microtubule binding tubulin binding identical protein binding ATP-dependent protein binding ion channel binding chaperone binding metal ion binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PrP Polyclonal Antibody

PrP Antibody (12555-1-AP) in IHC (P)

Product Details

12555-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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