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Invitrogen
Precerebellin Polyclonal Antibody
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Precerebellin Antibody (PA5-101513) in WB
Western blot analysis of Precerebellin in extracts from various samples. Samples were incubated with Precerebellin polyclonal antibody (Product # PA5-101513). Lane 1: Rat liver, blocked with antigen-specific peptides; Lane 2: Rat liver; Lane 3: Hela cells (heat-shock treatment).
Product Details
PA5-101513
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CBLN1(Accession P23435), corresponding to amino acid residues I139-L189.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2850948
Product Specific Information
Antibody detects endogenous levels of total CBLN1.
Target Information
Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q. Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus. Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin posseses functions other than those already stated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brain protein D3; cerebellin 1 precursor protein; Cerebellin-1; Precerebellin
Gene Aliases: AI323299; CBLN1
UniProt ID: (Human) P23435, (Mouse) Q9R171, (Rat) P63182
Entrez Gene ID: (Human) 869, (Mouse) 12404, (Rat) 498922
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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