Fabgennix

Presenilin 1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PSEN-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Bovine, Cat, Human, Non-human primate, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 1-50 on Presenilin 1 (Alzheimer disease 3) protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Target Information

Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alzheimer Disease 3; Minilin; presenilin 1 (Alzheimer disease 3); Presenilin-1; presenilin1; Protein S182; PS-1; S182 protein; Senilin 1

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Gene Aliases: AD3; BOS_11013; FAD; PS-1; PS1; PSEN1; PSNL1; S182

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UniProt ID: (Bovine) Q9XT97, (Human) P49768

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Entrez Gene ID: (Bovine) 282705, (Pig) 780411, (Human) 5663

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Function(s)
endopeptidase activity aspartic-type endopeptidase activity calcium channel activity beta-catenin binding PDZ domain binding cadherin binding protein binding
Process(es)
autophagosome assembly negative regulation of transcription from RNA polymerase II promoter activation of MAPKK activity blood vessel development cell fate specification somitogenesis neuron migration positive regulation of receptor recycling heart looping hematopoietic progenitor cell differentiation T cell activation involved in immune response myeloid leukocyte differentiation protein glycosylation membrane protein ectodomain proteolysis calcium ion transport mitochondrial transport cellular response to DNA damage stimulus response to oxidative stress negative regulation of epidermal growth factor-activated receptor activity Notch signaling pathway Notch receptor processing memory post-embryonic development protein transport L-glutamate transport choline transport synaptic vesicle targeting single organismal cell-cell adhesion protein processing cerebral cortex cell migration Cajal-Retzius cell differentiation dorsal/ventral neural tube patterning embryonic limb morphogenesis positive regulation of proteasomal ubiquitin-dependent protein catabolic process beta-amyloid formation intracellular signal transduction anagen amyloid precursor protein catabolic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of catalytic activity regulation of protein binding positive regulation of MAP kinase activity skin morphogenesis regulation of synaptic plasticity thymus development neuron development skeletal system morphogenesis brain morphogenesis beta-amyloid metabolic process epithelial cell proliferation negative regulation of axonogenesis positive regulation of coagulation T cell receptor signaling pathway neuron apoptotic process negative regulation of ubiquitin-protein transferase activity smooth endoplasmic reticulum calcium ion homeostasis regulation of synaptic transmission, glutamatergic regulation of resting membrane potential negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process neural retina development endoplasmic reticulum calcium ion homeostasis regulation of phosphorylation myeloid dendritic cell differentiation negative regulation of neuron apoptotic process positive regulation of transcription, DNA-templated canonical Wnt signaling pathway positive regulation of dendritic spine development calcium ion transmembrane transport negative regulation of apoptotic signaling pathway
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