Proteintech

Profilin 1 Polyclonal Antibody

Profilin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Profilin 1 Antibody (11680-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 11680-1-AP (Profilin 1 antibody) at dilution of 1:50 (under 10x lens).

Profilin 1 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

11680-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Profilin 1 Fusion Protein Ag2286 (1-140 aa encoded by BC006768)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAGWNAYID NLMADGTCQD AAIVGYKDSP SVWAAVPGKT FVNITPAEVG VLVGKDRSSF YVNGLTLGGQ KCSVIRDSLL QDGEFSMDLR TKSTGGAPTF NVTVTKTDKT LVLLMGKEGV HGGLINKKCY EMASHLRRSQ Y (1-140 aa encoded by BC006768)

Target Information

Profilin is an ubiquitous small (12-15 kDa) phosphoinositides and poly-L-proline binding protein that plays a role in both signal transduction pathways and actin filament dynamics. There are two mammalian profilins with similar biochemical properties but different expression patterns. Profilin I appears to be highly expressed in most tissues except for skeletal muscle. Profilin II is predominantly expressed in brain and at lower levels in skeletal muscle, uterus and kidney. Profilin is a mainly cytosolic protein with higher concentrations in dynamic membrane areas like the leading edge and ruffling membranes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

LncRNA PEG11as aggravates cerebral ischemia/reperfusion injury after ischemic stroke through miR-342-5p/PFN1 axis.

Life sciences

Yu Z,Zhu M,Shu D,Zhang R,Xiang Z,Jiang A,Liu S,Zhang C,Yuan Q,Hu X

Sun Jan 15 00:00:00 UTC 2023

LncRNA PEG11as aggravates cerebral ischemia/reperfusion injury after ischemic stroke through miR-342-5p/PFN1 axis.

Life sciences

Yu Z,Zhu M,Shu D,Zhang R,Xiang Z,Jiang A,Liu S,Zhang C,Yuan Q,Hu X

Sun Jan 15 00:00:00 UTC 2023

Profilin1 Regulates Trophoblast Invasion and Macrophage Differentiation.

The American journal of pathology

Chen X,Song QL,Wang JY,Ji R,Li ZH,Cao ML,Mu XF,Guo DY,Zhang Y,Yang J

Tue Aug 01 00:00:00 UTC 2023

Profilin1 Regulates Trophoblast Invasion and Macrophage Differentiation.

The American journal of pathology

Chen X,Song QL,Wang JY,Ji R,Li ZH,Cao ML,Mu XF,Guo DY,Zhang Y,Yang J

Tue Aug 01 00:00:00 UTC 2023

Profilin1 Regulates Trophoblast Invasion and Macrophage Differentiation.

The American journal of pathology

Chen X,Song QL,Wang JY,Ji R,Li ZH,Cao ML,Mu XF,Guo DY,Zhang Y,Yang J

Tue Aug 01 00:00:00 UTC 2023

Profilin1 Regulates Trophoblast Invasion and Macrophage Differentiation.

The American journal of pathology

Chen X,Song QL,Wang JY,Ji R,Li ZH,Cao ML,Mu XF,Guo DY,Zhang Y,Yang J

Tue Aug 01 00:00:00 UTC 2023

Profilin 1 Negatively Regulates Osteoclast Migration in Postnatal Skeletal Growth, Remodeling, and Homeostasis in Mice.

JBMR plus

Shirakawa J,Kajikawa S,Böttcher RT,Costell M,Izu Y,Hayata T,Noda M,Ezura Y

Sat Jun 01 00:00:00 UTC 2019

Upregulation and hypomethylation of lncRNA AFAP1‑AS1 predicts a poor prognosis and promotes the migration and invasion of cervical cancer.

Oncology reports

Bo H,Fan L,Gong Z,Liu Z,Shi L,Guo C,Li X,Liao Q,Zhang W,Zhou M,Xiang B,Li X,Li G,Xiong W,Zeng Z,Cao K,Zhang S,Xiong F

Mon Apr 01 00:00:00 UTC 2019

Proteomic analysis of rat serum revealed the effects of chronic sleep deprivation on metabolic, cardiovascular and nervous system.

PloS one

Ma B,Chen J,Mu Y,Xue B,Zhao A,Wang D,Chang D,Pan Y,Liu J

Mon Feb 11 00:00:00 UTC 2019

Proteomic analysis of rat serum revealed the effects of chronic sleep deprivation on metabolic, cardiovascular and nervous system.

PloS one

Ma B,Chen J,Mu Y,Xue B,Zhao A,Wang D,Chang D,Pan Y,Liu J

Mon Feb 11 00:00:00 UTC 2019

Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway.

Journal of experimental & clinical cancer research : CR

Lian Y,Xiong F,Yang L,Bo H,Gong Z,Wang Y,Wei F,Tang Y,Li X,Liao Q,Wang H,Zhou M,Xiang B,Wu X,Li Y,Li X,Chen X,Li G,Guo C,Zeng Z,Xiong W

Tue Oct 16 00:00:00 UTC 2018

Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway.

Journal of experimental & clinical cancer research : CR

Lian Y,Xiong F,Yang L,Bo H,Gong Z,Wang Y,Wei F,Tang Y,Li X,Liao Q,Wang H,Zhou M,Xiang B,Wu X,Li Y,Li X,Chen X,Li G,Guo C,Zeng Z,Xiong W

Tue Oct 16 00:00:00 UTC 2018

AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Zeng Z,Bo H,Gong Z,Lian Y,Li X,Li X,Zhang W,Deng H,Zhou M,Peng S,Li G,Xiong W

Fri Jan 01 00:00:00 UTC 2016

AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Zeng Z,Bo H,Gong Z,Lian Y,Li X,Li X,Zhang W,Deng H,Zhou M,Peng S,Li G,Xiong W

Fri Jan 01 00:00:00 UTC 2016

Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma.

Oncotarget

Bo H,Gong Z,Zhang W,Li X,Zeng Y,Liao Q,Chen P,Shi L,Lian Y,Jing Y,Tang K,Li Z,Zhou Y,Zhou M,Xiang B,Li X,Yang J,Xiong W,Li G,Zeng Z

Fri Aug 21 00:00:00 UTC 2015

Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma.

Oncotarget

Bo H,Gong Z,Zhang W,Li X,Zeng Y,Liao Q,Chen P,Shi L,Lian Y,Jing Y,Tang K,Li Z,Zhou Y,Zhou M,Xiang B,Li X,Yang J,Xiong W,Li G,Zeng Z

Fri Aug 21 00:00:00 UTC 2015

The molecular mechanism for effects of TiN coating on NiTi alloy on endothelial cell function.

Biomaterials

Yang D,Lü X,Hong Y,Xi T,Zhang D

Fri Aug 01 00:00:00 UTC 2014

The molecular mechanism for effects of TiN coating on NiTi alloy on endothelial cell function.

Biomaterials

Yang D,Lü X,Hong Y,Xi T,Zhang D

Fri Aug 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: actin binding protein; Epididymis tissue protein Li 184a; Profilin I; Profilin-1

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Gene Aliases: ALS18; Pfn; PFN1

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UniProt ID: (Human) P07737, (Rat) P62963, (Mouse) P62962

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Entrez Gene ID: (Human) 5216, (Rat) 64303, (Mouse) 18643

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Function(s)

adenyl-nucleotide exchange factor activity actin binding actin monomer binding receptor binding protein binding phosphatidylinositol-4,5-bisphosphate binding Rho GTPase binding poly(A) RNA binding proline-rich region binding cadherin binding involved in cell-cell adhesion

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Profilin 1 Polyclonal Antibody

Profilin 1 Antibody (11680-1-AP) in IHC (P)

Product Details

11680-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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