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Invitrogen
Prolactin Receptor Recombinant Rabbit Monoclonal Antibody (9B10J3)
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FIGURE: 1 / 5
Prolactin Receptor Antibody (MA5-38107) in ICC/IF
Immunofluorescence analysis of Prolactin Receptor was performed using 70% confluent log phase T-47D and MCF 10A cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.01% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Prolactin Receptor Recombinant Rabbit Monoclonal Antibody (ARC2123) (Product # MA5-381... View More
Product Details
MA5-38107
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
9B10J3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Prolactin Receptor (P16471)
Conjugate
Form
Liquid
Concentration
0.55 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898025
Product Specific Information
Positive Samples: HepG2, BT-474, MCF7
Immunogen sequence: MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI
Target Information
Prolactin (PRL) is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor (PRLR), a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. PRLR consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hPRL receptor; Lactogen receptor; Prl R; PRL-R; Prolactin receptor; prolactin receptor related sequence 1; secreted prolactin binding protein
Gene Aliases: AI987712; HPRL; hPRLrI; MFAB; Pr-1; Pr-3; PRLR; Prlr-rs1; RATPRLR
UniProt ID: (Human) P16471, (Rat) P05710, (Mouse) Q08501
Entrez Gene ID: (Human) 5618, (Rat) 24684, (Mouse) 19116
steroid biosynthetic process
cell surface receptor signaling pathway
activation of transmembrane receptor protein tyrosine kinase activity
embryo implantation
lactation
regulation of cell adhesion
regulation of epithelial cell differentiation
prolactin signaling pathway
T cell activation
activation of JAK2 kinase activity
negative regulation of apoptotic process
JAK-STAT cascade involved in growth hormone signaling pathway
mammary gland epithelial cell differentiation
prostate gland growth
mammary gland alveolus development
JAK-STAT cascade
cytokine-mediated signaling pathway
mammary gland epithelium development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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