Invitrogen

Protein APC Monoclonal Antibody (KT45)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA1-72530

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:10,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

KT45

Immunogen

Adenomatous polyposis coli protein fused to GST (aa 2170-2394)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_923265

Target Information

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adenomatous polyposis coli protein; FAP; FPC; multiple intestinal neoplasia

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Gene Aliases: AI047805; AU020952; AW124434; CC1; mAPC; Min

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Entrez Gene ID: (Mouse) 11789

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Function(s)
protease binding protein binding beta-catenin binding microtubule binding protein kinase regulator activity protein kinase binding protein complex binding gamma-catenin binding microtubule plus-end binding
Process(es)
mitotic cytokinesis kidney development hair follicle development protein complex assembly cellular response to DNA damage stimulus negative regulation of microtubule depolymerization cell cycle arrest metaphase/anaphase transition of mitotic cell cycle mitotic spindle assembly checkpoint establishment or maintenance of cell polarity pattern specification process axonogenesis negative regulation of cell proliferation axis specification anterior/posterior pattern specification dorsal/ventral pattern formation proximal/distal pattern formation Wnt signaling pathway cell migration stem cell population maintenance negative regulation of Wnt signaling pathway regulation of cell migration positive regulation of cell migration regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation positive regulation of microtubule polymerization cytoplasmic microtubule organization neuron projection development positive regulation of pseudopodium assembly regulation of microtubule-based process T cell differentiation in thymus somatic stem cell population maintenance negative regulation of odontogenesis positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of MAPK cascade skin development canonical Wnt signaling pathway involved in negative regulation of apoptotic process canonical Wnt signaling pathway involved in positive regulation of apoptotic process regulation of cell differentiation positive regulation of cell differentiation regulation of osteoblast differentiation regulation of osteoclast differentiation positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of cell adhesion muscle cell cellular homeostasis thymus development negative regulation of epithelial cell proliferation regulation of nitrogen compound metabolic process chromosome organization regulation of cell cycle positive regulation of cell division regulation of attachment of spindle microtubules to kinetochore retina development in camera-type eye canonical Wnt signaling pathway negative regulation of epithelial cell proliferation involved in prostate gland development negative regulation of canonical Wnt signaling pathway regulation of glutamate metabolic process
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