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Immunogen sequence: ELHRGFQQL LQELNQPRDG FQLSLGNALF TDLVVDLQDT FVSAMKTLYL ADTFPTNFRD SAGAMKQIND YVAKQTKGKI VDLLKNLDSN AVVIMVNYIF FKAKWETSFN HKGTQEQDFY VTSETVVRVP MMSREDQYHY LLDRNLSCRV VGVPYQGNAT ALFILPSEGK MQQVENGLSE KTLRKWLKMF KKRQLELYLP KFSIEGSYQL EKVLPSLGIS NVFTSHADLS GISNHSNIQV SEMVHKAVVE VDESGTRAAA ATGTIFTFRS ARLNSQRLVF NRPFLMFIVD NNILFLGKVN RP (106-406 aa encoded by BC008915)
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acrosomal serine protease inhibitor; antitr; PAI-3; PCI; Plasma serine protease inhibitor; Plasminogen activator inhibitor 3; plasminogen activator inhibitor III; plasminogen activator inhibitor-3; Protein C inhibitor; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5; Serpin A5; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Gene Aliases: PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI; SERPINA5
UniProt ID: (Human) P05154
Entrez Gene ID: (Human) 5104
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