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Exalpha
Protein Phosphatase 2 B alpha (calcineurin) Polyclonal Antibody
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Product Details
P245P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A purified peptide conjugated to KLH
Conjugate
Form
Liquid
Concentration
0.5-2 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Dilutions may be prepared by adding phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the antiserum. Diluted antiserum should be stored at 4 C, not refrozen, and preferably used the same day.
In immunoelectrophoresis use 2 µL serum or equivalent against 120 µL antiserum. In double radial immunodiffusion (Ouchterlony) use a rosette arrangement with 10 µL antiserum in 3 mm diameter center well and 2 µL serum samples (neat and serially diluted in 2 mm diameter peripheral wells. Different bleedings of the immunized animals are pooled to obtain a broad spectrum balanced against the varying concentrations of the individual serum protein components.
Target Information
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcineurin A alpha; Calcineurin A1; Calcineurin subunit A alpha; CalcineurinA; Calmodulin-dependent calcineurin A subunit alpha isoform; CALNA 1; CAM-PRP catalytic subunit; CCN 1; CNA alpha; PP2B alpha 1; PP2BA alpha; PP2CB; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha); Protein phosphatase 3 catalytic subunit alpha; protein phosphatase 3 catalytic subunit alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme; protein phosphatase-2Ba; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Gene Aliases: 2900074D19Rik; BOS_6444; CALN; CALNA; CALNA1; CCN1; CN; CNA; CNA1; PPP2B; PPP3CA
UniProt ID: (Bovine) P48452, (Human) Q08209, (Mouse) P63328, (Rat) P63329
Entrez Gene ID: (Bovine) 286852, (Human) 5530, (Mouse) 19055, (Rat) 24674
calmodulin binding
drug binding
enzyme binding
calmodulin-dependent protein phosphatase activity
metal ion binding
protein dimerization activity
protein serine/threonine phosphatase activity
calcium ion binding
protein binding
protein heterodimerization activity
phosphoprotein phosphatase activity
calcium-dependent protein serine/threonine phosphatase activity
hydrolase activity
G1/S transition of mitotic cell cycle
protein dephosphorylation
protein import into nucleus
calcium ion transport
transition between fast and slow fiber
cardiac muscle hypertrophy in response to stress
dephosphorylation
calcium-mediated signaling
calcineurin-NFAT signaling cascade
multicellular organismal response to stress
negative regulation of chromatin binding
cellular response to drug
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin secretion
skeletal muscle fiber development
negative regulation of dendrite morphogenesis
modulation of synaptic transmission
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NFAT protein import into nucleus
response to calcium ion
excitatory postsynaptic potential
cellular response to glucose stimulus
positive regulation of cardiac muscle hypertrophy in response to stress
response to amphetamine
negative regulation of calcium ion-dependent exocytosis
response to stress
Wnt signaling pathway, calcium modulating pathway
Fc-epsilon receptor signaling pathway
T cell activation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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