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Invitrogen
Pyruvate Carboxylase Polyclonal Antibody
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Product Details
PA5-120984
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 879-1178 of human Pyruvate carboxylase (Pyruvate carboxylase (PC)) (NP_0010358061)
Conjugate
Form
Liquid
Concentration
1.96 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2914556
Product Specific Information
Positive test controls include: HepG2, HeLa, MCF7, A-549, U-251MG, Mouse liver, Mouse brain, Rat liver, Rat brain. The target is usually found in the following locations: Mitochondrion matrix.
Immunogen sequence: HSMGLGSKFK EVKKAYVEAN QMLGDLIKVT PSSKIVGDLA QFMVQNGLSR AEAEAQAEEL SFPRSVVEFL QGYIGVPHGG FPEPFRSKVL KDLPRVEGRP GASLPPLDLQ ALEKELVDRH GEEVTPEDVL SAAMYPDVFA HFKDFTATFG PLDSLNTRLF LQGPKIAEEF EVELERGKTL HIKALAVSDL NRAGQRQVFF ELNGQLRSIL VKDTQAMKEM HFHPKALKDV KGQIGAPMPG KVIDIKVVAG AKVAKGQPLC VLSAMKMETV VTSPMEGTVR KVHVTKDMTL EGDDLILEIE
Target Information
Pyruvate Carboxylase requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 6.4.1.1; PCB; PYC; Pyruvate carboxylase, mitochondrial; pyruvate decarboxylase; Pyruvic carboxylase
Gene Aliases: PC; PCB; Pcx
UniProt ID: (Human) P11498, (Rat) P52873
Entrez Gene ID: (Human) 5091, (Rat) 25104, (Mouse) 18563
pyruvate metabolic process
gluconeogenesis
oxaloacetate metabolic process
lipid metabolic process
metabolic process
negative regulation of gene expression
viral RNA genome packaging
positive regulation by host of viral release from host cell
positive regulation by host of viral process
positive regulation of phospholipid biosynthetic process
biotin metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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